LINCS Data Portal 2.0
Other names: LINCS_Data_Portal_2.0
next generation access point for perturbation-response signatures. The Library of Integrated Network-Based Cellular Signatures (LINCS) is an NIH Common Fund program with the goal of generating a large-scale and comprehensive catalogue of perturbation-response signatures by utilizing a diverse collection of perturbations across many model systems and assay types. The LINCS Data Portal (LDP) has been the primary access point for the compendium of LINCS data and has been widely utilized. Here, we report the first major update of LDP (http: lincsportal.ccs.miami.edu signatures) with substantial changes in the data architecture and APIs, a completely redesigned user interface, and enhanced curated metadata annotations to support more advanced, intuitive and deeper querying, exploration and analysis capabilities.
Description
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next generation access point for perturbation-response signatures. The Library of Integrated Network-Based Cellular Signatures (LINCS) is an NIH Common Fund program with the goal of generating a large-scale and comprehensive catalogue of perturbation-response signatures by utilizing a diverse collection of perturbations across many model systems and assay types. The LINCS Data Portal (LDP) has been the primary access point for the compendium of LINCS data and has been widely utilized. Here, we report the first major update of LDP (http: lincsportal.ccs.miami.edu signatures) with substantial changes in the data architecture and APIs, a completely redesigned user interface, and enhanced curated metadata annotations to support more advanced, intuitive and deeper querying, exploration and analysis capabilities.
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:29:08.465552
Webpage:
http://lincsportal.ccs.miami.edu/signaturesWebpage
More detailed information about this field from each metasource.
http://lincsportal.ccs.miami.edu/signatures
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:29:08.465552
Publications:
Publications
More detailed information about this field from each metasource.
LINCS Data Portal 2.0: next generation access point for perturbation-response signatures
PMID: 31701147
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:08.465552
Publications
More detailed information about this field from each metasource.
LINCS Data Portal 2.0: next generation access point for perturbation-response signatures
PMID: 31701147
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:08.465552
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LINCS Data Portal 2.0: next generation access point for perturbation-response signatures
PubMed citations: 39.
39 articles citing: LINCS Data Portal 2.0: next generation access point for perturbation-response signatures
Network Crosstalk as a Basis for Drug Repurposing. PMID:35350247
Prediction of drug candidates for clear cell renal cell carcinoma using a systems biology-based drug repositioning approach. PMID:35339898
Functional Enrichment Analysis of Regulatory Elements. PMID:35327392
The cellular response to drug perturbation is limited: comparison of large-scale chemogenomic fitness signatures. PMID:35277135
Single-Cell Sequencing Technologies in Precision Oncology. PMID:35230694
Investigating the Role of Obesity in Prostate Cancer and Identifying Biomarkers for Drug Discovery: Systems Biology and Deep Learning Approaches. PMID:35164166
A multiparametric pharmacogenomic strategy for drug repositioning predicts therapeutic efficacy for glioblastoma cell lines. PMID:35118385
Transcriptome-Guided Drug Repurposing for Aggressive SCCs. PMID:35055192
A human-based multi-gene signature enables quantitative drug repurposing for metabolic disease. PMID:35037854
BioProfiling.jl: Profiling biological perturbations with high-content imaging in single cells and heterogeneous populations. PMID:34935929
Transcriptional Profiles of Cell Fate Transitions Reveal Early Drivers of Neuronal Apoptosis and Survival. PMID:34831459
A Class of Protein-Coding RNAs Binds to Polycomb Repressive Complex 2 and Alters Histone Methylation. PMID:34804929
AI applications in functional genomics. PMID:34765093
A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individuals. PMID:34739849
Identification of Key Candidate Genes and Chemical Perturbagens in Diabetic Kidney Disease Using Integrated Bioinformatics Analysis. PMID:34557161
Protein-gene Expression Nexus: Comprehensive characterization of human cancer cell lines with proteogenomic analysis. PMID:34504668
Machine learning methods, databases and tools for drug combination prediction. PMID:34477201
Drug Discovery of Spinal Muscular Atrophy (SMA) from the Computational Perspective: A Comprehensive Review. PMID:34445667
Development of an adverse drug event network to predict drug toxicity. PMID:34345836
Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration. PMID:34333981
Precision omics data integration and analysis with interoperable ontologies and their application for COVID-19 research. PMID:34159360
Exploring Common Therapeutic Targets for Neurodegenerative Disorders Using Transcriptome Study. PMID:33815473
Integrating 3D structural information into systems biology. PMID:33744294
Alterations in the Global Proteome and Phosphoproteome in Third Generation EGFR TKI Resistance Reveal Drug Targets to Circumvent Resistance. PMID:33727228
Proteogenomic and metabolomic characterization of human glioblastoma. PMID:33577785
Artificial Intelligence in Drug Discovery: A Comprehensive Review of Data-driven and Machine Learning Approaches. PMID:33437151
Integrated molecular characterisation of the MAPK pathways in human cancers reveals pharmacologically vulnerable mutations and gene dependencies. PMID:33398072
HMPDACC: a Human Microbiome Project Multi-omic data resource. PMID:33305317
Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer. PMID:33242424
A Workflow of Integrated Resources to Catalyze Network Pharmacology Driven COVID-19 Research. PMID:33173863
TCRD and Pharos 2021: mining the human proteome for disease biology. PMID:33156327
iCSDB: an integrated database of CRISPR screens. PMID:33137185
Network-based machine learning in colorectal and bladder organoid models predicts anti-cancer drug efficacy in patients. PMID:33127883
signatureSearch: environment for gene expression signature searching and functional interpretation. PMID:33068417
Computational Methods and Software Tools for Functional Analysis of miRNA Data. PMID:32872205
A mass spectrometry-based proteome map of drug action in lung cancer cell lines. PMID:32690943
Expression of SARS-CoV-2 receptor ACE2 and coincident host response signature varies by asthma inflammatory phenotype. PMID:32531372
Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions. PMID:32499560
Drug Research Meets Network Science: Where Are We? PMID:32338900
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data architecture, analysis and design
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:08.465552
drug discovery
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:08.465552
database management
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:08.465552
Tags
More detailed information about this field from each metasource.
data architecture, analysis and design
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:29:08.465552
drug discovery
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:29:08.465552
database management
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:29:08.465552
data architecture, analysis and design drug discovery data management
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