R3R311 last accessed: 2022-11-04

metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:58.354927

swiss-model_repository
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:58.354927

Other names: SWISS-MODEL, SWISS-MODEL Repository, swiss-model_repository

The SWISS-MODEL Repository is a database of annotated 3D protein structure models generated by the SWISS-MODEL homology-modelling pipeline for protein sequences of selected model organisms.

Webpage:

https://swissmodel.expasy.org/repository/

Licence:

Name: Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0)
URL: https://creativecommons.org/licenses/by-sa/4.0/

Publications:

Publications
More detailed information about this field from each metasource.

SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information
PMID: 24782522
metasource: Fairsharing.org
version: FAIRsharing.org: SWISS-MODEL; SWISS-MODEL Repository of 3D protein structure models; DOI: https://doi.org/10.25504/FAIRsharing.vxz9pn; Last edited: March 19, 2021, 11:40 a.m.; Last accessed: Jan 03 2022 7:09 p.m.

The SWISS-MODEL Repository and associated resources
PMID: 18931379
metasource: Fairsharing.org
version: FAIRsharing.org: SWISS-MODEL; SWISS-MODEL Repository of 3D protein structure models; DOI: https://doi.org/10.25504/FAIRsharing.vxz9pn; Last edited: March 19, 2021, 11:40 a.m.; Last accessed: Jan 03 2022 7:09 p.m.

The SWISS-MODEL Repository-new features and functionality
PMID: 27899672
metasource: Fairsharing.org
version: FAIRsharing.org: SWISS-MODEL; SWISS-MODEL Repository of 3D protein structure models; DOI: https://doi.org/10.25504/FAIRsharing.vxz9pn; Last edited: March 19, 2021, 11:40 a.m.; Last accessed: Jan 03 2022 7:09 p.m.

http://dx.doi.org/10.1093/nar/gkw1132
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:58.354927

SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information PubMed citations: 1821.

1821 articles citing: SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information

Investigation of Interferon Gamma Activity Using Bioinformatics Methods. PMID:35355749
The Family Keeps on Growing: Four Novel Fungal OYEs Characterized. PMID:35328465
Detection of αB-Conotoxin VxXXIVA (αB-CTX) by ic-ELISA Based on an Epitope-Specific Monoclonal Antibody. PMID:35324663
The MreA Metal-Binding Sites C40, H65, and C69 Play a Critical Role in the Metal Tolerance of Pseudomonas putida KT2440. PMID:35322302
Identifying potential natural inhibitors of Brucella melitensis Methionyl-tRNA synthetase through an in-silico approach. PMID:35312681
Genetic heterogeneity in GJB2, COL4A3, ATP6V1B1 and EDNRB variants detected among hearing impaired families in Morocco. PMID:35301649
Phylogenetic and Expression Studies of Small GTP-Binding Proteins in Solanum lycopersicum Super Strain B. PMID:35270112
Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog. PMID:35256607
Molecular characterization of alpha subunit 1 of sodium pump (ATP1A1) gene in Camelus dromedarius: its differential tissue expression potentially interprets the role in osmoregulation. PMID:35235155
Novel Loss of Function Variant in BCKDK Causes a Treatable Developmental and Epileptic Encephalopathy. PMID:35216372
Acetylation at Lysine 86 of Escherichia coli HUβ Modulates the DNA-Binding Capability of the Protein. PMID:35185833
A Phagosomally Expressed Gene, rv0428c, of Mycobacterium tuberculosis Demonstrates Acetyl Transferase Activity and Plays a Protective Role Under Stress Conditions. PMID:35175508
Molecular docking analysis of Clostridium perfringens beta toxin model with potential inhibitors from the ZINC database. PMID:35173385
Molecular characterization of the serotonergic transporter from the cestode Echinococcus granulosus: pharmacology and potential role in the nervous system. PMID:35169884
A splice altering variant in NDRG1 gene causes Charcot-Marie-Tooth disease, type 4D. PMID:35149926
Sequence Analysis and Comparison of TCTP Proteins from Human Protozoan Parasites. PMID:35138574
Unusual substrate specificity in GH family 12: structure-function analysis of glucanases Bgh12A and Xgh12B from Aspergillus cervinus, and Egh12 from Thielavia terrestris. PMID:35129654
Bi-allelic variants in neuronal cell adhesion molecule cause a neurodevelopmental disorder characterized by developmental delay, hypotonia, neuropathy/spasticity. PMID:35108495
Analytical Computation of Interleukin17A Activity in Breast Cancer Patients Using Bioinformatics Methods. PMID:35096325
Novel Mutations in β-MYH7 Gene in Indian Patients With Dilated Cardiomyopathy. PMID:35072022
Mutations in the helix αC of the catalytic domain from the EGFR affect its activity in cervical cancer cell lines. PMID:35069880
Genomic characterization unravelling the causative role of SARS-CoV-2 Delta variant of lineage B.1.617.2 in 2nd wave of COVID-19 pandemic in Chhattisgarh, India. PMID:35065253
Role of Probiotics in the Management of COVID-19: A Computational Perspective. PMID:35057455
Circulating Phylotypes of White Spot Syndrome Virus in Bangladesh and Their Virulence. PMID:35056639
Activity- and Enrichment-Based Metaproteomics Insights into Active Urease from the Rumen Microbiota of Cattle. PMID:35055002
The Effects of Tetrapeptides Designed to Fit the Androgen Binding Site of ZIP9 on Myogenic and Osteogenic Cells. PMID:35053017
NOG-Derived Peptides Can Restore Neuritogenesis on a CRASH Syndrome Cell Model. PMID:35052783
The Preservation of PPARγ Genome Duplicates in Some Teleost Lineages: Insights into Lipid Metabolism and Xenobiotic Exploitation. PMID:35052447
Computer-Aided Drug Design (CADD) to De-Orphanize Marine Molecules: Finding Potential Therapeutic Agents for Neurodegenerative and Cardiovascular Diseases. PMID:35049908
Analysis of NIA and GSNOR family genes and nitric oxide homeostasis in response to wheat-leaf rust interaction. PMID:35039546
A Peptide from Budding Yeast GAPDH Serves as a Promising Antifungal against Cryptococcus neoformans. PMID:35019693
Inducible knockdown of Mycobacterium smegmatis MSMEG_2975 (glyoxalase II) affected bacterial growth, antibiotic susceptibility, biofilm, and transcriptome. PMID:34964907
Mapping cross-variant neutralizing sites on the SARS-CoV-2 spike protein. PMID:34964428
Identification of Reticulocyte Binding Domain of Plasmodium ovale curtisi Duffy Binding Protein (PocDBP) Involved in Reticulocyte Invasion. PMID:34956929
Integrative Proteomic and Phosphoproteomic Analyses of Pattern- and Effector-Triggered Immunity in Tomato. PMID:34925416
Toxic Peptide From Palythoa caribaeorum Acting on the TRPV1 Channel Prevents Pentylenetetrazol-Induced Epilepsy in Zebrafish Larvae. PMID:34925021
Functional and structural analysis of non-synonymous single nucleotide polymorphisms (nsSNPs) in the MYB oncoproteins associated with human cancer. PMID:34921182
Eruca sativa seed napin structural insights and thorough functional characterization. PMID:34911985
Structural basis of inhibition of the human SGLT2-MAP17 glucose transporter. PMID:34880493
Architecture of the chloroplast PSI-NDH supercomplex in Hordeum vulgare. PMID:34879391
Red Clover HDT, a BAHD Hydroxycinnamoyl-Coenzyme A:L-3,4-Dihydroxyphenylalanine (L-DOPA) Hydroxycinnamoyl Transferase That Synthesizes Clovamide and Other N-Hydroxycinnamoyl-Aromatic Amino Acid Amides. PMID:34868112
Gene mining, codon optimization and analysis of binding mechanism of an aldo-keto reductase with high activity, better substrate specificity and excellent solvent tolerance. PMID:34855894
Fermentation optimization of cellulase production from sugarcane bagasse by Bacillus pseudomycoides and molecular modeling study of cellulase. PMID:34841306
Engineering of Ocriplasmin Variants by Bioinformatics Methods for the Reduction of Proteolytic and Autolytic Activities. PMID:34840386
Engineering a feedback inhibition-insensitive plant dihydrodipicolinate synthase to increase lysine content in Camelina sativa seeds. PMID:34802109
Phosphoinositide regulates dynamic movement of the S4 voltage sensor in the second repeat in two-pore channel 3. PMID:34800436
MSMEG_3955 from Mycobacterium smegmatis is a FMN bounded homotrimeric NAD(P)H:Flavin mononucleotide (FMN) oxidoreductase. PMID:34798816
Modified Rhodopsins From Aureobasidium pullulans Excel With Very High Proton-Transport Rates. PMID:34790700
Structure, function and pharmacology of human itch receptor complexes. PMID:34789875
Decreased Methylenetetrahydrofolate Reductase Activity Leads to Increased Sensitivity to para-Aminosalicylic Acid in Mycobacterium tuberculosis. PMID:34780266
New Antagonists of the Membrane Androgen Receptor OXER1 from the ZINC Natural Product Database. PMID:34778638
Bio-Mechanism of Catechin as Pheromone Signal Inhibitor: Prediction of Antibacterial Agent Action Mode by In Vitro and In Silico Study. PMID:34770790
Characterization of a new type of neuronal 5-HT G- protein coupled receptor in the cestode nervous system. PMID:34762657
Structure of the hexameric fungal plasma membrane proton pump in its autoinhibited state. PMID:34757782
Evolution of the Cytokinin Dehydrogenase (CKX) Domain. PMID:34757471
Genomic diversity and molecular dynamics interaction on mutational variances among RB domains of SARS-CoV-2 interplay drug inactivation. PMID:34752930
The Role of Ku70 as a Cytosolic DNA Sensor in Innate Immunity and Beyond. PMID:34746031
Distance-based reconstruction of protein quaternary structures from inter-chain contacts. PMID:34716620
Kinetic proofreading of lipochitooligosaccharides determines signal activation of symbiotic plant receptors. PMID:34716271
Pan-ebolavirus protective therapy by two multifunctional human antibodies. PMID:34715022
TwinCons: Conservation score for uncovering deep sequence similarity and divergence. PMID:34714829
A conserved Neurite Outgrowth and Guidance motif with biomimetic potential in neuronal Cell Adhesion Molecules. PMID:34712402
The conformational cycle of prestin underlies outer-hair cell electromotility. PMID:34695838
GRP78: A possible relationship of COVID-19 and the mucormycosis; in silico perspective. PMID:34695683
Computational Analysis of Missense Variants in the Human Transmembrane Protease Serine 2 (TMPRSS2) and SARS-CoV-2. PMID:34692848
Staphylococcusaureus Transcriptome Data and Metabolic Modelling Investigate the Interplay of Ser/Thr Kinase PknB, Its Phosphatase Stp, the glmR/yvcK Regulon and the cdaA Operon for Metabolic Adaptation. PMID:34683468
TMEM16A, a Homoharringtonine Receptor, as a Potential Endogenic Target for Lung Cancer Treatment. PMID:34681590
Discovery of a Novel Tetrapeptide against Influenza A Virus: Rational Design, Synthesis, Bioactivity Evaluation and Computational Studies. PMID:34681184
Identification, Molecular Characterization, and Tissue Expression Profiles of Three Smad Genes from Water Buffalo (Bubalus bubalis). PMID:34680931
Structural basis of cytokine-mediated activation of ALK family receptors. PMID:34646012
Novel Antimicrobial Peptides from a Cecropin-Like Region of Heteroscorpine-1 from Heterometrus laoticus Venom with Membrane Disruption Activity. PMID:34641415
In-silico evidence for enhancement of avian influenza virus H9N2 virulence by modulation of its hemagglutinin (HA) antigen function and stability during co-infection with infectious bronchitis virus in chickens. PMID:34631979
Genome of Ganoderma Species Provides Insights Into the Evolution, Conifers Substrate Utilization, and Terpene Synthesis for Ganoderma tsugae. PMID:34603250
Molecular and genetic characterization of a large Brazilian cohort presenting hearing loss. PMID:34599368
Importance of Anion-π Interactions in RNA GAAA and GGAG Tetraloops: A Combined MD and QM Study. PMID:34586810
Evaluation of the relationship between the 14-3-3ε protein and LvRab11 in the shrimp Litopenaeus vannamei during WSSV infection. PMID:34584112
Naproxen Based 1,3,4-Oxadiazole Derivatives as EGFR Inhibitors: Design, Synthesis, Anticancer, and Computational Studies. PMID:34577570
Antimalarial Inhibitors Targeting Epigenetics or Mitochondria in Plasmodium falciparum: Recent Survey upon Synthesis and Biological Evaluation of Potential Drugs against Malaria. PMID:34577183
Exploring the immune evasion of SARS-CoV-2 variant harboring E484K by molecular dynamics simulations. PMID:34553217
Bacteriophage origin of some minimal ATP-dependent DNA ligases: a new structure from Burkholderia pseudomallei with striking similarity to Chlorella virus ligase. PMID:34548548
Genetic modification of Gossypium arboreum universal stress protein (GUSP1) improves drought tolerance in transgenic cotton (Gossypium hirsutum). PMID:34539116
Genome-wide detection and classification of terpene synthase genes in Aquilaria agallochum. PMID:34539112
Structural basis of human transcription-DNA repair coupling. PMID:34526721
Exploration of antigenic determinants in spike glycoprotein of SARS-CoV2 and identification of five salient potential epitopes. PMID:34514073
DeepComplex: A Web Server of Predicting Protein Complex Structures by Deep Learning Inter-chain Contact Prediction and Distance-Based Modelling. PMID:34497831
Ser253Leu substitution in PmrB contributes to colistin resistance in clinical Acinetobacter nosocomialis. PMID:34468294
Wheat pathogen Zymoseptoria tritici N-myristoyltransferase inhibitors: on-target antifungal activity and an unusual metabolic defense mechanism. PMID:34458749
Quercetin and/or Ascorbic Acid Modulatory Effect on Phenobarbital-Induced Sleeping Mice Possibly through GABAA and GABAB Receptor Interaction Pathway. PMID:34451819
Modeling and Structure Determination of Homo-Oligomeric Proteins: An Overview of Challenges and Current Approaches. PMID:34445785
Cytotoxicity of Frutalin on Distinct Cancer Cells Is Independent of Its Glycosylation. PMID:34443300
Fates of Sec, Tat, and YidC Translocases in Mitochondria and Other Eukaryotic Compartments. PMID:34436602
Kinetic studies and homology modeling of a dual-substrate linalool/nerolidol synthase from Plectranthus amboinicus. PMID:34429465
Unraveling the functions of uncharacterized transcription factors in Escherichia coli using ChIP-exo. PMID:34428301
The structure and flexibility analysis of the Arabidopsis synaptotagmin 1 reveal the basis of its regulation at membrane contact sites. PMID:34408000
Inverse molecular docking reveals a novel function of thymol: Inhibition of fat deposition induced by high-dose glucose in Caenorhabditis elegans. PMID:34401075
Molecular Characterization and Elucidation of Pathways to Identify Novel Therapeutic Targets in Pulmonary Arterial Hypertension. PMID:34366885
Identification and expression profiling of proline metabolizing genes in Arabidopsis thaliana and Oryza sativa to reveal their stress-specific transcript alteration. PMID:34366590
Cardiolipin-Containing Lipid Membranes Attract the Bacterial Cell Division Protein DivIVA. PMID:34361115
Protein Model and Function Analysis in Quorum-Sensing Pathway of Vibrio qinghaiensis sp.-Q67. PMID:34356493
Improved machine learning scoring functions for identification of Electrophorus electricus's acetylcholinesterase inhibitors. PMID:34328603
A secondary structure-based position-specific scoring matrix applied to the improvement in protein secondary structure prediction. PMID:34320027
The Fish Pathogen Aliivibrio salmonicida LFI1238 Can Degrade and Metabolize Chitin despite Gene Disruption in the Chitinolytic Pathway. PMID:34319813
A distinct assembly pathway of the human 39S late pre-mitoribosome. PMID:34315873
A pan-cancer analysis of alternative splicing of splicing factors in 6904 patients. PMID:34285345
Comparative analysis of two paradigm bacteriophytochromes reveals opposite functionalities in two-component signaling. PMID:34285211
Co-culturing experiments reveal the uptake of myo-inositol phosphate synthase (EC 5.5.1.4) in an inositol auxotroph of Saccharomyces cerevisiae. PMID:34281557
The influence of dataset homology and a rigorous evaluation strategy on protein secondary structure prediction. PMID:34260641
Multi-Omics Approach Reveals the Potential Core Vaccine Targets for the Emerging Foodborne Pathogen Campylobacter jejuni. PMID:34248875
Molecular characterization and nutritional regulation of sodium-dependent glucose cotransporter 1 (Sglt1) in blunt snout bream (Megalobrama amblycephala). PMID:34234240
Receptor Switching in Newly Evolved Adeno-associated Viruses. PMID:34232726
Repurposing proteases: An in-silico analysis of the binding potential of extracellular fungal proteases with selected viral proteins. PMID:34226889
NMR structure of the Vibrio vulnificus ribosomal protein S1 domains D3 and D4 provides insights into molecular recognition of single-stranded RNAs. PMID:34223902
The protective effects of the methylenetetrahydrofolate reductase rs1801131 variant among Saudi smokers. PMID:34220254
Identification of a novel B cell epitope on the nucleocapsid protein of porcine deltacoronavirus. PMID:34217778
Antiviral Activity of Metabolites from Peruvian Plants against SARS-CoV-2: An In Silico Approach. PMID:34202092
Identification of Glutathione S-Transferase Genes in Hami Melon (Cucumis melo var. saccharinus) and Their Expression Analysis Under Cold Stress. PMID:34168669
Gene and Phenotype Expansion of Unexplained Early Infantile Epileptic Encephalopathy. PMID:34163418
Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-β family. PMID:34155118
A chromosome-level Camptotheca acuminata genome assembly provides insights into the evolutionary origin of camptothecin biosynthesis. PMID:34112794
Bioinformatics Structural and Phylogenetic Characterization of Entamoeba histolytica Alcohol Dehydrogenase 2 (EhADH2). PMID:34103738
Delayed diagnosis of Peutz-Jeghers syndrome due to pathological information loss or mistake in family/personal history. PMID:34103092
Self-sufficient asymmetric reduction of β-ketoesters catalysed by a novel and robust thermophilic alcohol dehydrogenase co-immobilised with NADH. PMID:34094502
Identification of Rice Blast Loss-of-Function Mutant Alleles in the Wheat Genome as a New Strategy for Wheat Blast Resistance Breeding. PMID:34093638
The higBA-Type Toxin-Antitoxin System in IncC Plasmids Is a Mobilizable Ciprofloxacin-Inducible System. PMID:34077263
Exploring the biosynthetic pathway of lignin in Acorus tatarinowii Schott using de novo leaf and rhizome transcriptome analysis. PMID:34076245
NF-YB-Mediated Active Responses of Plant Growth under Salt and Temperature Stress in Eucalyptus grandis. PMID:34072675
Dasatinib-SIK2 Binding Elucidated by Homology Modeling, Molecular Docking, and Dynamics Simulations. PMID:34056256
Analysis of diverse eukaryotes suggests the existence of an ancestral mitochondrial apparatus derived from the bacterial type II secretion system. PMID:34011950
Voltage-clamp fluorometry analysis of structural rearrangements of ATP-gated channel P2X2 upon hyperpolarization. PMID:34009126
Biochemical and structural insights into Rab12 interactions with RILP and its family members. PMID:33986343
Computational Methods for the Elucidation of Protein Structure and Interactions. PMID:33950383
Effectiveness of Bioactive Compound as Antibacterial and Anti-Quorum Sensing Agent from Myrmecodia pendans: An In Silico Study. PMID:33922641
Molecular Dynamics Simulations Based on 1-Phenyl-4-Benzoyl-1-Hydro-Triazole ERRα Inverse Agonists. PMID:33918423
The OSMR Gene Is Involved in Hirschsprung Associated Enterocolitis Susceptibility through an Altered Downstream Signaling. PMID:33917126
Diaphorina citri Genome Possesses a Complete Melatonin Biosynthesis Pathway Differentially Expressed under the Influence of the Phytopathogenic Bacterium, Candidatus Liberibacter asiaticus. PMID:33916117
The structure of MgtE in the absence of magnesium provides new insights into channel gating. PMID:33905418
Structure-Based Virtual Screening to Identify Novel Potential Compound as an Alternative to Remdesivir to Overcome the RdRp Protein Mutations in SARS-CoV-2. PMID:33898520
Enhanced Glutamate Synthesis and Export by the Thermotolerant Emerging Industrial Workhorse Bacillus methanolicus in Response to High Osmolarity. PMID:33897645
In Silico Analysis of High-Risk Missense Variants in Human ACE2 Gene and Susceptibility to SARS-CoV-2 Infection. PMID:33884270
Genomic Evolution and Variation of SARS-CoV-2 in the Early Phase of COVID-19 Pandemic in Guangdong Province, China. PMID:33877539
Accurate contact-based modelling of repeat proteins predicts the structure of new repeats protein families. PMID:33857128
Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies. PMID:33852862
In Silico Approach for Phytocompound-Based Drug Designing to Fight Efflux Pump-Mediated Multidrug-Resistant Mycobacterium tuberculosis. PMID:33826064
Epitope-directed monoclonal antibody production using a mixed antigen cocktail facilitates antibody characterization and validation. PMID:33824395
Integrative omics identification, evolutionary and structural analysis of low affinity nitrate transporters in diatoms, diNPFs. PMID:33823659
Unravelling Regioselectivity of Leuconostoc citreum ABK-1 Alternansucrase by Acceptor Site Engineering. PMID:33810084
Molecular Modeling of Histamine Receptors-Recent Advances in Drug Discovery. PMID:33810008
3-Hydroxypropane-1,2-Diyl Dipalmitoleate-A Natural Compound with Dual Roles (CB1 Agonist/FAAH1 Blocker) in Inhibiting Ovarian Cancer Cell Line. PMID:33809034
Saccharomyces cerevisiae as a Toolkit for COP9 Signalosome Research. PMID:33806190
Actin-Resistant DNase1L2 as a Potential Therapeutics for CF Lung Disease. PMID:33802146
Brassinosteroid homeostasis is critical for the functionality of the Medicago truncatula pulvinus. PMID:33793936
In silico studies of selected multi-drug targeting against 3CLpro and nsp12 RNA-dependent RNA-polymerase proteins of SARS-CoV-2 and SARS-CoV. PMID:33786291
Structural-genetic insight and optimization of protease production from a novel strain of Aeromonas veronii CMF, a gut isolate of Chrysomya megacephala. PMID:33772325
Identification and functional characterization of odorant-binding proteins 69a and 76a of Drosophila suzukii. PMID:33748486
Autosomal Recessive Rod-Cone Dystrophy Associated With Compound Heterozygous Variants in ARL3 Gene. PMID:33748123
Spinocerebellar ataxia type 14: refining clinicogenetic diagnosis in a rare adult-onset disorder. PMID:33739604
Kinetic analysis of ASIC1a delineates conformational signaling from proton-sensing domains to the channel gate. PMID:33729158
A novel missense variant in TRAPPC2 causes X-linked spondyloepiphyseal dysplasia tarda: A case report. PMID:33726005
Natural combinatorial genetics and prolific polyamine production enable siderophore diversification in Serratia plymuthica. PMID:33722216
Cartilage Oligomeric Matrix Protein Induced Arthritis-A New Model for Rheumatoid Arthritis in the C57BL/6 Mouse. PMID:33708221
Immunoinformatic analysis of structural and epitope variations in the spike and Orf8 proteins of SARS-CoV-2/B.1.1.7. PMID:33704818
Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes. PMID:33692360
Expression, Characterization and Its Deinking Potential of a Thermostable Xylanase From Planomicrobium glaciei CHR43. PMID:33681158
Inhibition of Pyruvate Kinase From Thermoanaerobacterium saccharolyticum by IMP Is Independent of the Extra-C Domain. PMID:33679651
Purification and cryoelectron microscopy structure determination of human V-ATPase. PMID:33665630
In silico designing of putative peptides for targeting pathological protein Htt in Huntington's disease. PMID:33659724
Apigenin Attenuates Acetaminophen-Induced Hepatotoxicity by Activating AMP-Activated Protein Kinase/Carnitine Palmitoyltransferase I Pathway. PMID:33658919
The soybean (Glycine max L.) cytokinin oxidase/dehydrogenase multigene family; Identification of natural variations for altered cytokinin content and seed yield. PMID:33644633
Exposure of human intestinal epithelial cells and primary human hepatocytes to trypsin-like serine protease inhibitors with potential antiviral effect. PMID:33641565
Iris domestica (iso)flavone 7- and 3'-O-Glycosyltransferases Can Be Induced by CuCl2. PMID:33633770
Identification of Stress-Related Genes and a Comparative Analysis of the Amino Acid Compositions of Translated Coding Sequences Based on Draft Genome Sequences of Antarctic Yeasts. PMID:33633709
Effects of Conserved Wedge Domain Residues on DNA Binding Activity of Deinococcus radiodurans RecG Helicase. PMID:33613647
Genome-wide identification and expression profiling of glutathione S-transferase family under multiple abiotic and biotic stresses in Medicago truncatula L. PMID:33606812
Bacillus aryabhattai TFG5-mediated synthesis of humic substances from coir pith wastes. PMID:33596930
A novel mutation in the cathepsin C (CTSC) gene in Iranian family with Papillon-Lefevre syndrome. PMID:33586345
Plant drought tolerance provided through genome editing of the trehalase gene. PMID:33570447
Novel Roles of the N1 Loop and N4 Alpha-Helical Region of the Nipah Virus Fusion Glycoprotein in Modulating Early and Late Steps of the Membrane Fusion Cascade. PMID:33568505
The CRK2-CYC13 complex functions as an S-phase cyclin-dependent kinase to promote DNA replication in Trypanosoma brucei. PMID:33568178
Structural insights into the regulation of human serine palmitoyltransferase complexes. PMID:33558761
Effect of mutation at oxyanion hole residu (H110F) on activity of Lk4 lipase. PMID:33532247
Strategic aromatic residues in the catalytic cleft of the xyloglucanase MtXgh74 modifying thermostability, mode of enzyme action, and viscosity reduction ability. PMID:33521846
Identification and characterisation of putative drug binding sites in human ATP-binding cassette B5 (ABCB5) transporter. PMID:33510870
W196 and the β-Hairpin Motif Modulate the Redox Switch of Conformation and the Biomolecular Interaction Network of the Apoptosis-Inducing Factor. PMID:33510840
Genome-Wide Identification and Analysis of Chitinase GH18 Gene Family in Mycogone perniciosa. PMID:33505368
Glutamine Uptake via SNAT6 and Caveolin Regulates Glutamine-Glutamate Cycle. PMID:33503881
Influenza A Virus Hemagglutinin and Other Pathogen Glycoprotein Interactions with NK Cell Natural Cytotoxicity Receptors NKp46, NKp44, and NKp30. PMID:33494528
Bioaccessibility and In Vitro Intestinal Permeability of a Recombinant Lectin from Tepary Bean (Phaseolus acutifolius) Using the Everted Intestine Assay. PMID:33494324
Chimeric Cellobiose Dehydrogenases Reveal the Function of Cytochrome Domain Mobility for the Electron Transfer to Lytic Polysaccharide Monooxygenase. PMID:33489432
Immuno-informatics approach for B-cell and T-cell epitope based peptide vaccine design against novel COVID-19 virus. PMID:33478787
Novel nucleocytoplasmic protein O-fucosylation by SPINDLY regulates diverse developmental processes in plants. PMID:33476897
Completion of the AAV Structural Atlas: Serotype Capsid Structures Reveals Clade-Specific Features. PMID:33450892
Generation and functional characterization of a single-chain variable fragment (scFv) of the anti-FGF2 3F12E7 monoclonal antibody. PMID:33446839
Characterization of sucrose non-fermenting-1 (SNF1) homologue gene in Fusarium udum WSP-V2 and its regulation by the biocontrol agent Pseudomonas fluorescens OKC. PMID:33442517
Transcription Inhibitors with XRE DNA-Binding and Cupin Signal-Sensing Domains Drive Metabolic Diversification in Pseudomonas. PMID:33436508
Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections. PMID:33431876
Towards reproducible computational drug discovery. PMID:33430992
Identification and Functional Assessment of the First Placental Adhesin of Treponema pallidum That May Play Critical Role in Congenital Syphilis. PMID:33408711
Identification of a novel mutation in the KITLG gene in a Chinese family with familial progressive hyper- and hypopigmentation. PMID:33407466
Functional Prediction and Assignment of Methanobrevibacter ruminantium M1 Operome Using a Combined Bioinformatics Approach. PMID:33391347
OsMre11 Is Required for Mitosis during Rice Growth and Development. PMID:33375295
Genetic background and PfKelch13 affect artemisinin susceptibility of PfCoronin mutants in Plasmodium falciparum. PMID:33370279
Molecular simulation of the Kv7.4[ΔS269] mutant channel reveals that ion conduction in the cavity is perturbed due to hydrophobic gating. PMID:33367117
Spike Proteins of SARS-CoV and SARS-CoV-2 Utilize Different Mechanisms to Bind With Human ACE2. PMID:33363207
Antifungal Effect of All-trans Retinoic Acid against Aspergillus fumigatus In Vitro and in a Pulmonary Aspergillosis In Vivo Model. PMID:33361288
Generation of 4-vinylguaiacol through a novel high-affinity ferulic acid decarboxylase to obtain smoke flavours without carcinogenic contaminants. PMID:33347481
Pentafluoro-3-hydroxy-pent-2-en-1-ones Potently Inhibit FNT-Type Lactate Transporters from all Five Human-Pathogenic Plasmodium Species. PMID:33336890
Different mutations at position 562 of the hepatitis E virus capsid proteins exhibit differential effects on viral neutralizing activity. PMID:33335573
Membrane Proteocomplexome of Campylobacter jejuni Using 2-D Blue Native/SDS-PAGE Combined to Bioinformatics Analysis. PMID:33329413
Efficient photoactivatable Dre recombinase for cell type-specific spatiotemporal control of genome engineering in the mouse. PMID:33318209
SLC2A12 of SLC2 Gene Family in Bird Provides Functional Compensation for the Loss of SLC2A4 Gene in Other Vertebrates. PMID:33316072
Ritonavir may inhibit exoribonuclease activity of nsp14 from the SARS-CoV-2 virus and potentiate the activity of chain terminating drugs. PMID:33309661
Mutational Analysis of Ocriplasmin to Reduce Proteolytic and Autolytic Activity in Pichia pastoris. PMID:33308171
Homology modeling in the time of collective and artificial intelligence. PMID:33304450
Bioinformatic analysis and functional predictions of selected regeneration-associated transcripts expressed by zebrafish microglia. PMID:33287696
Sodium-bile acid co-transporter is crucial for survival of a carcinogenic liver fluke Clonorchis sinensis in the bile. PMID:33284789
Identification of Potential Key Agents for Targeting RNA-Dependent RNA Polymerase of SARS-CoV-2 by Integrated Analysis and Virtual Drug Screening. PMID:33281876
USP24 stabilizes bromodomain containing proteins to promote lung cancer malignancy. PMID:33257797
Multiple functions of TBCK protein in neurodevelopment disorders and tumors. PMID:33240423
In silico studies evidenced the role of structurally diverse plant secondary metabolites in reducing SARS-CoV-2 pathogenesis. PMID:33239694
Target-Centered Drug Repurposing Predictions of Human Angiotensin-Converting Enzyme 2 (ACE2) and Transmembrane Protease Serine Subtype 2 (TMPRSS2) Interacting Approved Drugs for Coronavirus Disease 2019 (COVID-19) Treatment through a Drug-Target Interaction Deep Learning Model. PMID:33218024
Fungal Shaker-like channels beyond cellular K+ homeostasis: A role in ectomycorrhizal symbiosis between Hebeloma cylindrosporum and Pinus pinaster. PMID:33216794
TCMP-2 affects tomato flowering and interacts with BBX16, a homolog of the arabidopsis B-box MiP1b. PMID:33204936
Antifungal Drug Repurposing. PMID:33203147
Structure-Based Design of Acetolactate Synthase From Bacillus licheniformis Improved Protein Stability Under Acidic Conditions. PMID:33193222
Isolation and thermal stabilization of mouse ferroportin. PMID:33190422
Functional Cross-Talk of MbtH-Like Proteins During Thaxtomin Biosynthesis in the Potato Common Scab Pathogen Streptomyces scabiei. PMID:33178168
Functional Characterization of Facilitative Glucose Transporter 4 With a Delay Responding to Plasma Glucose Level in Blunt Snout Bream (Megalobrama amblycephala). PMID:33178047
RNA-seq analysis identifies cytoskeletal structural genes and pathways for meat quality in beef. PMID:33175867
Computational Study of the Ion and Water Permeation and Transport Mechanisms of the SARS-CoV-2 Pentameric E Protein Channel. PMID:33173781
A clinically relevant polymorphism in the Na+/taurocholate cotransporting polypeptide (NTCP) occurs at a rheostat position. PMID:33168628
The Post-Translational Modifications, Localization, and Mode of Attachment of Non-Covalently Bound Glucanosyltransglycosylases of Yeast Cell Wall as a Key to Understanding their Functioning. PMID:33167499
Polymorphisms in STING Affect Human Innate Immune Responses to Poxviruses. PMID:33154747
When a foreign gene meets its native counterpart: computational biophysics analysis of two PgiC loci in the grass Festuca ovina. PMID:33127989
Citronellal perception and transmission by Anopheles gambiae s.s. (Diptera: Culicidae) females. PMID:33122679
Preventing Candida albicans from subverting host plasminogen for invasive infection treatment. PMID:33115324
Applying computer simulations in battling with COVID-19, using pre-analyzed molecular and chemical data to face the pandemic. PMID:33102687
Investigating the Role of the N-Terminal Loop of PD-1 in Binding Process Between PD-1 and Nivolumab via Molecular Dynamics Simulation. PMID:33102523
A putative chordate luciferase from a cosmopolitan tunicate indicates convergent bioluminescence evolution across phyla. PMID:33082360
Functional Characterization of Alr0765, A Hypothetical Protein from Anabaena PCC 7120 Involved in Cellular Energy Status Sensing, Iron Acquisition and Abiotic Stress Management in E. coli Using Molecular, Biochemical and Computational Approaches. PMID:33071622
Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly. PMID:33065002
Cyclodextrin inclusion complex inhibits circulating galectin-3 and FGF-7 and affects the reproductive integrity and mobility of Caco-2 cells. PMID:33060727
Site-Specific Mutations of GalR Affect Galactose Metabolism in Streptococcus pneumoniae. PMID:33046563
Chilling Stress Triggers VvAgo1-Mediated miRNA-Like RNA Biogenesis in Volvariella volvacea. PMID:33042047
Anti-quorum sensing activity of some marine bacteria isolated from different marine resources in Egypt. PMID:33034782
Bacterial genome-wide association study of hyper-virulent pneumococcal serotype 1 identifies genetic variation associated with neurotropism. PMID:33033372
Comparative genomics of Clostridioides difficile toxinotypes identifies module-based toxin gene evolution. PMID:33030421
Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56γ. PMID:33028863
Identification of transcobalamin deficiency with two novel mutations in the TCN2 gene in a Chinese girl with abnormal immunity: a case report. PMID:33023511
Modular and coordinated activity of AAA+ active sites in the double-ring ClpA unfoldase of the ClpAP protease. PMID:33020301
A Missense Mutation in a Large Subunit of Ribonucleotide Reductase Confers Temperature-Gated Tassel Formation. PMID:33020253
Revised annotation and extended characterizations of components of the Chlamydomonas reinhardtii SUMOylation system. PMID:33015534
Novel phospho-switch function of delta-catenin in dendrite development. PMID:33007084
First hybrid complete genome of Aeromonas veronii reveals chromosome-mediated novel structural variant mcr-3.30 from a human clinical sample. PMID:33005867
Biochemical characterization of a glycosyltransferase Gtf3 from Mycobacterium smegmatis: a case study of improved protein solubilization. PMID:32999813
Genetic variation and selection in the major histocompatibility complex Class II gene in the Guizhou pony. PMID:32999762
Cross-Protection by Inactivated H5 Prepandemic Vaccine Seed Strains against Diverse Goose/Guangdong Lineage H5N1 Highly Pathogenic Avian Influenza Viruses. PMID:32999029
Investigating the structural impacts of a novel missense variant identified with whole exome sequencing in an Egyptian patient with propionic acidemia. PMID:32995289
Directed Evolution of Pseudomonas fluorescens Lipase Variants With Improved Thermostability Using Error-Prone PCR. PMID:32984290
Kinetic and structural insights into enzymatic mechanism of succinic semialdehyde dehydrogenase from Cyanothece sp. ATCC51142. PMID:32966327
Plant Antimicrobial Peptides: State of the Art, In Silico Prediction and Perspectives in the Omics Era. PMID:32952397
Model prediction of a Kunitz-type trypsin inhibitor protein from seeds of Acacia nilotica L. with strong antimicrobial and insecticidal activity. PMID:32922126
Structural characterization and computational analysis of PDZ domains in Monosiga brevicollis. PMID:32914530
Evolution of dependoparvoviruses across geological timescales-implications for design of AAV-based gene therapy vectors. PMID:32913662
Pathogenic impact of transcript isoform switching in 1,209 cancer samples covering 27 cancer types using an isoform-specific interaction network. PMID:32879328
Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates. PMID:32866207
Enhancing cellulosic ethanol production through coevolution of multiple enzymatic characteristics of β-glucosidase from Penicillium oxalicum 16. PMID:32857198
Functional characterization of the chlorzoxazone 6-hydroxylation activity of human cytochrome P450 2E1 allelic variants in Han Chinese. PMID:32821545
Alternative N-terminal regions of Drosophila myosin heavy chain II regulate communication of the purine binding loop with the essential light chain. PMID:32817166
Vitamin B12 may inhibit RNA-dependent-RNA polymerase activity of nsp12 from the SARS-CoV-2 virus. PMID:32812340
Synthesis, molecular docking and molecular dynamic simulation studies of 2-chloro-5-[(4-chlorophenyl)sulfamoyl]-N-(alkyl/aryl)-4-nitrobenzamide derivatives as antidiabetic agents. PMID:32789301
Structure and mechanism of CutA, RNA nucleotidyl transferase with an unusual preference for cytosine. PMID:32785623
Inhibition of TMPRSS2 by HAI-2 reduces prostate cancer cell invasion and metastasis. PMID:32778768
Use Chou's 5-Step Rule to Predict DNA-Binding Proteins with Evolutionary Information. PMID:32775434
Molecular Dynamics Simulations of Mite Aquaporin DerfAQP1 from the Dust Mite Dermatophagoides farinae (Acariformes: Pyroglyphidae). PMID:32775433
First description of betalains biosynthesis in an aquatic organism: characterization of 4,5-DOPA-extradiol-dioxygenase activity in the cyanobacteria Anabaena cylindrica. PMID:32767544
Mutation of TWNK Gene Is One of the Reasons of Runting and Stunting Syndrome Characterized by mtDNA Depletion in Sex-Linked Dwarf Chicken. PMID:32766243
PSCs Reveal PUFA-Provoked Mitochondrial Stress as a Central Node Potentiating RPE Degeneration in Bietti's Crystalline Dystrophy. PMID:32755565
Vaccine candidate designed against carcinoembryonic antigen-related cell adhesion molecules using immunoinformatics tools. PMID:32720576
Modulation of Light Energy Transfer from Chromophore to Protein in the Channelrhodopsin ReaChR. PMID:32697975
Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes. PMID:32687489
Novel susceptibility loci for A(H7N9) infection identified by next generation sequencing and functional analysis. PMID:32678187
Computer-aided screening for potential TMPRSS2 inhibitors: a combination of pharmacophore modeling, molecular docking and molecular dynamics simulation approaches. PMID:32672528
Third Helical Domain of the Nipah Virus Fusion Glycoprotein Modulates both Early and Late Steps in the Membrane Fusion Cascade. PMID:32669342
A simple open source bioinformatic methodology for initial exploration of GPCR ligands' agonistic/antagonistic properties. PMID:32662237
A Novel Small-Molecule Inhibitor of Endosomal TLRs Reduces Inflammation and Alleviates Autoimmune Disease Symptoms in Murine Models. PMID:32660060
Using Random Forest Model Combined With Gabor Feature to Predict Protein-Protein Interaction From Protein Sequence. PMID:32655275
ASGR1 and Its Enigmatic Relative, CLEC10A. PMID:32650396
Generation and characterization of LPA-KIV9, a murine monoclonal antibody binding a single site on apolipoprotein (a). PMID:32641432
Leveraging Systematic Functional Analysis to Benchmark an In Silico Framework Distinguishes Driver from Passenger MEK Mutants in Cancer. PMID:32641410
Structural modeling, mutation analysis, and in vitro expression of usherin, a major protein in inherited retinal degeneration and hearing loss. PMID:32637036
Effect of Vitamin K3 Inhibiting the Function of NorA Efflux Pump and Its Gene Expression on Staphylococcus aureus. PMID:32630491
N-Ribosyltransferase From Archaeoglobus veneficus: A Novel Halotolerant and Thermostable Biocatalyst for the Synthesis of Purine Ribonucleoside Analogs. PMID:32612982
Structural and Functional Characteristics of Two Molecular Variants of the Nitrogen Sensor PII in Maritime Pine. PMID:32612622
Computational Chemogenomics Drug Repositioning Strategy Enables the Discovery of Epirubicin as a New Repurposed Hit for Plasmodium falciparum and P. vivax. PMID:32601162
Potential of MurA Enzyme and GBAP in Fsr Quorum Sensing System as Antibacterial Drugs Target: In vitro and In silico Study of Antibacterial Compounds from Myrmecodia pendans. PMID:32598250
Homology Modeling of Leishmanolysin (gp63) from Leishmania panamensis and Molecular Docking of Flavonoids. PMID:32596611
Co-evolution of β-glucosidase activity and product tolerance for increasing cellulosic ethanol yield. PMID:32583369
Functional Characterization of a Novel IRF6 Frameshift Mutation From a Van Der Woude Syndrome Family. PMID:32582293
A novel loss-of-function mutation of PBK associated with human kidney stone disease. PMID:32581305
Heterozygous mutations in ZP1 and ZP3 cause formation disorder of ZP and female infertility in human. PMID:32573113
E1784K, the most common Brugada syndrome and long-QT syndrome type 3 mutant, disrupts sodium channel inactivation through two separate mechanisms. PMID:32569350
High flavivirus structural plasticity demonstrated by a non-spherical morphological variant. PMID:32561757
Structural Characterization of Cuta- and Tusavirus: Insight into Protoparvoviruses Capsid Morphology. PMID:32560452
Theoretical insights on helix repacking as the origin of P-glycoprotein promiscuity. PMID:32555203
Linking Biochemical and Structural States of SERCA: Achievements, Challenges, and New Opportunities. PMID:32532023
ELA/APELA precursor cleaved by furin displays tumor suppressor function in renal cell carcinoma through mTORC1 activation. PMID:32516140
A substitution in cGMP-dependent protein kinase 1 associated with aortic disease induces an active conformation in the absence of cGMP. PMID:32506052
Attenuation of Heparan Sulfate Proteoglycan Binding Enhances In Vivo Transduction of Human Primary Hepatocytes with AAV2. PMID:32490035
Enzymatic and Mutational Analysis of the PruA Pteridine Reductase Required for Pterin-Dependent Control of Biofilm Formation in Agrobacterium tumefaciens. PMID:32482721
Electromechanical coupling in the hyperpolarization-activated K+ channel KAT1. PMID:32461693
Application of the Brown dynamics fluctuation-dissipation theorem to the study of Plasmodium berghei transporter protein PbAQP. PMID:32457897
Combining data integration and molecular dynamics for target identification in α-Synuclein-aggregating neurodegenerative diseases: Structural insights on Synaptojanin-1 (Synj1). PMID:32419904
ABC Transporter DerAB of Lactobacillus casei Mediates Resistance against Insect-Derived Defensins. PMID:32414796
Structural and Functional Analysis of Gly212 Mutants Reveals the Importance of Intersubunit Interactions in ASIC1a Channel Function. PMID:32411719
Protection against a chlamydial respiratory challenge by a chimeric vaccine formulated with the Chlamydia muridarum major outer membrane protein variable domains using the Neisseria lactamica porin B as a scaffold. PMID:32411400
A trimodular bacterial enzyme combining hydrolytic activity with oxidative glycosidic bond cleavage efficiently degrades chitin. PMID:32398257
A protein palmitoylation cascade regulates microtubule cytoskeleton integrity in Plasmodium. PMID:32395856
Identification and functional characterization of a hemizygous novel intronic variant in OCRL gene causes Lowe syndrome. PMID:32394213
Pharmacologic TWIK-Related Acid-Sensitive K+ Channel (TASK-1) Potassium Channel Inhibitor A293 Facilitates Acute Cardioversion of Paroxysmal Atrial Fibrillation in a Porcine Large Animal Model. PMID:32390491
Adaptations of Escherichia coli strains to oxidative stress are reflected in properties of their structural proteomes. PMID:32349661
Drosophila as a model for studying cystic fibrosis pathophysiology of the gastrointestinal system. PMID:32345720
Natural products may interfere with SARS-CoV-2 attachment to the host cell. PMID:32340551
SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: an in silico perspective. PMID:32338164
Different effects of carbohydrate binding modules on the viscoelasticity of nanocellulose gels. PMID:32337376
Mutational Analysis of the Putative Anti-Müllerian Hormone (AMH) Binding Interface on its Type II Receptor, AMHR2. PMID:32333774
Déjà vu: Stimulating open drug discovery for SARS-CoV-2. PMID:32320852
Copper/Zinc Superoxide Dismutase from the Crocodile Icefish Chionodraco hamatus: Antioxidant Defense at Constant Sub-Zero Temperature. PMID:32316382
Comparative Molecular Dynamics Simulations Provide Insight Into Antibiotic Interactions: A Case Study Using the Enzyme L,L-Diaminopimelate Aminotransferase (DapL). PMID:32274387
Structural Insights into the Mammalian Late-Stage Initiation Complexes. PMID:32268096
Dissecting the Interaction Deficiency of a Cartilaginous Fish Digestive Lipase with Pancreatic Colipase: Biochemical and Structural Insights. PMID:32258111
Monomeric NADH-Oxidizing Methylenetetrahydrofolate Reductases from Mycobacterium smegmatis Lack Flavin Coenzyme. PMID:32253341
Genome sequencing of Rigidoporus microporus provides insights on genes important for wood decay, latex tolerance and interspecific fungal interactions. PMID:32251355
Computational Study on the Effect of Inactivating/Activating Mutations on the Inhibition of MEK1 by Trametinib. PMID:32245216
Structural and Functional Analysis of PGRP-LC Indicates Exclusive Dap-Type PGN Binding in Bumblebees. PMID:32244587
Frontiers in biomolecular mesh generation and molecular visualization systems. PMID:32240387
Computational Inference of Selection Underlying the Evolution of the Novel Coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2. PMID:32238584
Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study. PMID:32222463
Insights into Interactions of Flavanones with Target Human Respiratory Syncytial Virus M2-1 Protein from STD-NMR, Fluorescence Spectroscopy, and Computational Simulations. PMID:32213871
Comprehensive Computational Analysis of Protein Phenotype Changes Due to Plausible Deleterious Variants of Human SPTLC1 Gene. PMID:32195206
The Atypical Protein Kinase C Small Molecule Inhibitor ζ-Stat, and Its Effects on Invasion Through Decreases in PKC-ζ Protein Expression. PMID:32175276
COVID-19 spike-host cell receptor GRP78 binding site prediction. PMID:32169481
Probing the Transition State in Enzyme Catalysis by High-Pressure NMR Dynamics. PMID:32159076
Comparative genomics analysis of c-di-GMP metabolism and regulation in Microcystis aeruginosa. PMID:32151246
Identification of a Pivotal Residue for Determining the Block Structure-Forming Properties of Alginate C-5 Epimerases. PMID:32149266
Structural and biochemical characterization of mitochondrial citrate synthase 4 from Arabidopsis thaliana. PMID:32133996
Anti-HCV, nucleotide inhibitors, repurposing against COVID-19. PMID:32119961
A Taxicab geometry quantification system to evaluate the performance of in silico methods: a case study on adenosine receptors ligands. PMID:32112287
Development of a DUB-selective fluorogenic substrate. PMID:32110315
Pre-arrayed Pan-AAV Peptide Display Libraries for Rapid Single-Round Screening. PMID:32105604
Enterovirus 71 Infection Shapes Host T Cell Receptor Repertoire and Presumably Expands VP1-Specific TCRβ CDR3 Cluster. PMID:32075096
Modulation of Symbiotic Compatibility by Rhizobial Zinc Starvation Machinery. PMID:32071267
Engineering Herbicide-Tolerance Rice Expressing an Acetohydroxyacid Synthase with a Single Amino Acid Deletion. PMID:32070060
Alanine Substitution Inactivates Cross-Reacting Epitopes in Dengue Virus Recombinant Envelope Proteins. PMID:32069839
Structural basis of keto acid utilization in nonribosomal depsipeptide synthesis. PMID:32066969
Dibenzofuranylethylamines as 5-HT2A/2C Receptor Agonists. PMID:32064387
Elongation Factor Tu Switch I Element is a Gate for Aminoacyl-tRNA Selection. PMID:32061931
Bioinformatics design and experimental validation of influenza A virus multi-epitopes that induce neutralizing antibodies. PMID:32060794
A SNP of bacterial blc disturbs gut lysophospholipid homeostasis and induces inflammation through epithelial barrier disruption. PMID:32058942
Epidemic and genetic characterization of porcine epidemic diarrhea virus strains circulating in the regions around Hunan, China, during 2017-2018. PMID:32056002
Characterization of the Goose CAPN3 Gene and its Expression Pattern in Muscle Tissues of Sichuan White Geese at Different Growth Stages. PMID:32055171
High-throughput quantification of protein structural change reveals potential mechanisms of temperature adaptation in Mytilus mussels. PMID:32054457
An ENU-induced mutation in Twist1 transactivation domain causes hindlimb polydactyly with complete penetrance and dominant-negatively impairs E2A-dependent transcription. PMID:32051525
Characterizing lineage-specific evolution and the processes driving genomic diversification in chordates. PMID:32046633
Novel Immunomodulatory Proteins Generated via Directed Evolution of Variant IgSF Domains. PMID:32038630
Identification and Comparative Analysis of Venom Proteins in a Pupal Ectoparasitoid, Pachycrepoideus vindemmiae. PMID:32038312
Transient States and Barriers from Molecular Simulations and the Milestoning Theory: Kinetics in Ligand-Protein Recognition and Compound Design. PMID:32031801
Phylogeography of Kyasanur Forest Disease virus in India (1957-2017) reveals evolution and spread in the Western Ghats region. PMID:32029759
Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization. PMID:32023489
A Genetic Toggle for Chemical Control of Individual Plk1 Substrates. PMID:32017920
Unique subsite specificity and potential natural function of a chitosan deacetylase from the human pathogen Cryptococcus neoformans. PMID:32015121
Integrated Computational Approaches and Tools forAllosteric Drug Discovery. PMID:32013012
MINI SEED 2 (MIS2) Encodes a Receptor-like Kinase that Controls Grain Size and Shape in Rice. PMID:32006119
Understanding and Controlling Food Protein Structure and Function in Foods: Perspectives from Experiments and Computer Simulations. PMID:31951485
The topology of the ER-resident phospholipid methyltransferase Opi3 of Saccharomyces cerevisiae is consistent with in trans catalysis. PMID:31932304
Functional Characterization of a Venom Protein Calreticulin in the Ectoparasitoid Pachycrepoideus vindemiae. PMID:31906042
Substrate specificity of thioredoxins and glutaredoxins - towards a functional classification. PMID:31890941
Finding small molecules with pan-serotype activity to target Dengue non-structural protein 1. PMID:31890750
Defining the function of SUMO system in pod development and abiotic stresses in Peanut. PMID:31884953
Uncovering the functional residues of Arabidopsis isoprenoid biosynthesis enzyme HDS. PMID:31879352
The Mitochondrial Small Heat Shock Protein HSP22 from Pea is a Thermosoluble Chaperone Prone to Co-Precipitate with Unfolding Client Proteins. PMID:31877784
Computational Modeling Explains the Multi Sterol Ligand Specificity of the N-Terminal Domain of Niemann-Pick C1-Like 1 Protein. PMID:31867479
Divalent cations promote TALE DNA-binding specificity. PMID:31863586
A prospective compound screening contest identified broader inhibitors for Sirtuin 1. PMID:31863054
Structure comparison of the chimeric AAV2.7m8 vector with parental AAV2. PMID:31859208
The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E-mediated pyroptosis. PMID:31852739
Toward the Accuracy and Speed of Protein Side-Chain Packing: A Systematic Study on Rotamer Libraries. PMID:31851497
Involvement of Exogenous N-Acyl-Homoserine Lactones in Spoilage Potential of Pseudomonas fluorescens Isolated From Refrigerated Turbot. PMID:31849873
Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AgRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-dPro] Decreases Melanocortin-4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin-5 Receptor Antagonists. PMID:31845801
Identification and validation of specific B-cell epitopes of hantaviruses associated to hemorrhagic fever and renal syndrome. PMID:31841521
Antiquorum sensing and antibiofilm potential of biosynthesized silver nanoparticles of Myristica fragrans seed extract against MDR Salmonella enterica serovar Typhi isolates from asymptomatic typhoid carriers and typhoid patients. PMID:31836973
Localization and enzyme kinetics of aminopeptidase N3 from Toxoplasma gondii. PMID:31836922
Structural insights into the mechanism of c-di-GMP-bound YcgR regulating flagellar motility in Escherichia coli. PMID:31836667
Comparative Analysis of the Capsid Structures of AAVrh.10, AAVrh.39, and AAV8. PMID:31826994
Integrative Multi-Kinase Approach for the Identification of Potent Antiplasmodial Hits. PMID:31824917
Docking analysis of models for 4-hydroxy-3-methylbut-2-enyl diphosphate reductase and a ferredoxin from Botryococcus braunii, race B. PMID:31819737
The Molecular Mechanism of Ginsenoside Analogs Activating TMEM16A. PMID:31818463
Effects of Synergistic Inhibition on α-glucosidase by Phytoalexins in Soybeans. PMID:31817312
Clinical utility of targeted gene enrichment and sequencing technique in the diagnosis of adult hereditary spherocytosis. PMID:31807509
Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds. PMID:31804182
Multiple selective sweeps of ancient polymorphisms in and around LTα located in the MHC class III region on chromosome 6. PMID:31791241
A molecular epidemiological investigation of PEDV in China: Characterization of co-infection and genetic diversity of S1-based genes. PMID:31785090
HKPocket: human kinase pocket database for drug design. PMID:31783725
Influenza H1 Mosaic Hemagglutinin Vaccine Induces Broad Immunity and Protection in Mice. PMID:31771231
In situ structure determination at nanometer resolution using TYGRESS. PMID:31768058
Actinomyces Produces Defensin-Like Bacteriocins (Actifensins) with a Highly Degenerate Structure and Broad Antimicrobial Activity. PMID:31767775
A Novel SLC1A4 Mutation (p.Y191*) Causes Spastic Tetraplegia, Thin Corpus Callosum, and Progressive Microcephaly (SPATCCM) With Seizure Disorder. PMID:31763347
Bioinformatics analysis of ubiquitin expression protein gene from Heterodera latipons. PMID:31762610
Characterization of Single Amino Acid Variations in an EDTA-Tolerating Non-specific Nuclease from the Ice-Nucleating Bacterium Pseudomonas syringae. PMID:31749083
Identification of lipid A deacylase as a novel, highly conserved and protective antigen against enterohemorrhagic Escherichia coli. PMID:31745113
Genome-Wide Identification and Characterization of FBA Gene Family in Polyploid Crop Brassica napus. PMID:31731804
Adaptive Laboratory Evolution of Cupriavidus necator H16 for Carbon Co-Utilization with Glycerol. PMID:31731699
Characterization of two thermophilic cellulases from Talaromyces leycettanus JCM12802 and their synergistic action on cellulose hydrolysis. PMID:31730665
Designing a less immunogenic nattokinase from Bacillus subtilis subsp. natto: a computational mutagenesis. PMID:31705312
Exfoliative toxin E, a new Staphylococcus aureus virulence factor with host-specific activity. PMID:31704997
Extracellular production of the engineered thermostable protease pernisine from Aeropyrum pernix K1 in Streptomyces rimosus. PMID:31699090
β-Xylosidases: Structural Diversity, Catalytic Mechanism, and Inhibition by Monosaccharides. PMID:31698702
Genome-wide analysis, transcription factor network approach and gene expression profile of GH3 genes over early somatic embryogenesis in Coffea spp. PMID:31694532
Curcumin Blocks Cytotoxicity of Enteroaggregative and Enteropathogenic Escherichia coli by Blocking Pet and EspC Proteolytic Release From Bacterial Outer Membrane. PMID:31681620
Monitoring Silent Spillovers Before Emergence: A Pilot Study at the Tick/Human Interface in Thailand. PMID:31681195
ACE gene missense mutation in a case with early-onset, rapid progressing dementia. PMID:31673674
A large intragenic deletion in the CLCN1 gene causes Hereditary Myotonia in pigs. PMID:31666547
Identification of linear epitopes in SjSP-13 of Schistosoma japonicum using a GST-peptide fusion protein microplate array. PMID:31666115
How oncogenic mutations activate human MAP kinase 1 (MEK1): a molecular dynamics simulation study. PMID:31658877
Simulation of Gating Currents of the Shaker K Channel Using a Brownian Model of the Voltage Sensor. PMID:31653450
A Novel Pathogenic Variant in NAGLU (N-Acetyl-Alpha-Glucosaminidase) gene Identified by Targeted Next-Generation Sequencing Followed by in Silico Analysis. PMID:31645877
Exceptionally high rates of positive selection on the rbcL gene in the genus Ilex (Aquifoliaceae). PMID:31638910
Biochemical and physiological flexibility accompanies reduced cellulose biosynthesis in Brachypodium cesa1 S830N. PMID:31636881
Conformational flexibility of fork-remodeling helicase Rad5 shown by full-ensemble hybrid methods. PMID:31626633
Differential mechanisms of tolerance to extreme environmental conditions in tardigrades. PMID:31624306
A docking-based structural analysis of geldanamycin-derived inhibitor binding to human or Leishmania Hsp90. PMID:31611575
MotifAnalyzer-PDZ: A computational program to investigate the evolution of PDZ-binding target specificity. PMID:31599029
Effects of the substituted amino acid residues on the thermal properties of monomeric isocitrate dehydrogenases from a psychrophilic bacterium, Psychromonas marina, and a mesophilic bacterium, Azotobacter vinelandii. PMID:31595369
Cryo-EM structure of the ClpXP protein degradation machinery. PMID:31582852
Generation and Characterization of Induced Pluripotent Stem Cells and Retinal Organoids From a Leber's Congenital Amaurosis Patient With Novel RPE65 Mutations. PMID:31572124
Chalcones as a basis for computer-aided drug design: innovative approaches to tackle malaria. PMID:31556721
Structural determinants underlying permeant discrimination of the Cx43 hemichannel. PMID:31554662
Crowder-Induced Conformational Ensemble Shift in Escherichia coli Prolyl-tRNA Synthetase. PMID:31542226
A processive endoglucanase with multi-substrate specificity is characterized from porcine gut microbiota. PMID:31541154
Characterization of Novel Fragment Antibodies Against TNF-alpha Isolated Using Phage Display Technique. PMID:31531059
Protamines from liverwort are produced by post-translational cleavage and C-terminal di-aminopropanelation of several male germ-specific H1 histones. PMID:31527083
HH-suite3 for fast remote homology detection and deep protein annotation. PMID:31521110
In Vivo Expression of NUP93 and Its Alteration by NUP93 Mutations Causing Focal Segmental Glomerulosclerosis. PMID:31517150
Effect of piceatannol-rich passion fruit seed extract on human glyoxalase I-mediated cancer cell growth. PMID:31517069
Synthesis, Antimicrobial Screening, Homology Modeling, and Molecular Docking Studies of a New Series of Schiff Base Derivatives as Prospective Fungal Inhibitor Candidates. PMID:31500095
Leishmania mexicana Trypanothione Reductase Inhibitors: Computational and Biological Studies. PMID:31487860
Protein model accuracy estimation based on local structure quality assessment using 3D convolutional neural network. PMID:31487288
Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification. PMID:31482124
Systematic Meta-Analysis Identifies Co-Expressed Kinases and GPCRs in Ovarian Cancer Tissues Revealing a Potential for Targeted Kinase Inhibitor Delivery. PMID:31480803
Interplay between Affinity and Valency in Effector Cell Degranulation: A Model System with Polcalcin Allergens and Human Patient-Derived IgE Antibodies. PMID:31462504
In Silico Structural Modeling and Analysis of Elongation Factor-1 Alpha and Elongation Factor-like Protein. PMID:31459830
Computational Study of the Loss-of-Function Mutations in the Kv1.5 Channel Associated with Atrial Fibrillation. PMID:31459020
Rose Bengal Binding to Collagen and Tissue Photobonding. PMID:31457260
Positive selection in dNTPase SAMHD1 throughout mammalian evolution. PMID:31451672
Polymerase δ deficiency causes syndromic immunodeficiency with replicative stress. PMID:31449058
Neuroprotective effects of melatonin and celecoxib against ethanol-induced neurodegeneration: a computational and pharmacological approach. PMID:31447548
Properties of a Non-canonical Complex Formed Between a Tepary Bean (Phaseolus acutifolius) Protease Inhibitor and α-Chymotrypsin. PMID:31435809
Gene Expression Profiling Analysis Reveals Putative Phytochemotherapeutic Target for Castration-Resistant Prostate Cancer. PMID:31428582
I-TASSER gateway: A protein structure and function prediction server powered by XSEDE. PMID:31427836
KAP1 is an antiparallel dimer with a functional asymmetry. PMID:31427381
Ammopiptanthus mongolicus stress-responsive NAC gene enhances the tolerance of transgenic Arabidopsis thaliana to drought and cold stresses. PMID:31424071
A hypomorphic allele of SLC35D1 results in Schneckenbecken-like dysplasia. PMID:31423530
Characterization of a bifunctional alginate lyase as a new member of the polysaccharide lyase family 17 from a marine strain BP-2. PMID:31418101
In silico evidence of de novo interactions between ribosomal and Epstein - Barr virus proteins. PMID:31416416
Serological Screening for Coronavirus Infections in Cats. PMID:31412572
UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase from the snail Biomphalaria glabrata - structural reflections. PMID:31396754
The CHD4-related syndrome: a comprehensive investigation of the clinical spectrum, genotype-phenotype correlations, and molecular basis. PMID:31388190
Three GLI2 mutations combined potentially underlie non-syndromic cleft lip with or without cleft palate in a Chinese pedigree. PMID:31386309
Posttranscriptional Regulation of RhBRC1 (Rosa hybrida BRANCHED1) in Response to Sugars is Mediated via its Own 3' Untranslated Region, with a Potential Role of RhPUF4 (Pumilio RNA-Binding Protein Family). PMID:31382685
NS2B/NS3 mutations enhance the infectivity of genotype I Japanese encephalitis virus in amplifying hosts. PMID:31381617
Defining a role for lung function associated gene GSTCD in cell homeostasis. PMID:31370853
Structural basis for broad substrate specificity of UDP-glucose 4-epimerase in the human milk oligosaccharide catabolic pathway of Bifidobacterium longum. PMID:31366978
A non-covalent inhibitor XMU-MP-3 overrides ibrutinib-resistant BtkC481S mutation in B-cell malignancies. PMID:31364164
Molecular characterization and functional analysis of the Schistosoma mekongi Ca2+-dependent cysteine protease (calpain). PMID:31362766
MAS NMR on a Red/Far-Red Photochromic Cyanobacteriochrome All2699 from Nostoc. PMID:31357417
Differential binding affinity of tau repeat region R2 with neuronal-specific β-tubulin isotypes. PMID:31346240
Identification of evolutionary and kinetic drivers of NAD-dependent signaling. PMID:31341085
Cryo-EM structures and functional characterization of murine Slc26a9 reveal mechanism of uncoupled chloride transport. PMID:31339488
Evolutionary couplings detect side-chain interactions. PMID:31328041
Bypassing pan-enterovirus host factor PLA2G16. PMID:31320648
Hook3 is a scaffold for the opposite-polarity microtubule-based motors cytoplasmic dynein-1 and KIF1C. PMID:31320392
The MarR-Type Repressor MhqR Confers Quinone and Antimicrobial Resistance in Staphylococcus aureus. PMID:31310152
Expression of different ParE toxins results in conserved phenotypes with distinguishable classes of toxicity. PMID:31309747
Atomistic Models from Orientation and Distance Constraints Using EPR of a Bifunctional Spin Label. PMID:31301803
Lamin A molecular compression and sliding as mechanisms behind nucleoskeleton elasticity. PMID:31296869
Purification and characterization of Terfezia claveryi TcCAT-1, a desert truffle catalase upregulated in mycorrhizal symbiosis. PMID:31291312
An array of basic residues is essential for the nucleolytic activity of the PHP domain of bacterial/archaeal PolX DNA polymerases. PMID:31289311
TP53, ETV6 and RUNX1 germline variants in a case series of patients developing secondary neoplasms after treatment for childhood acute lymphoblastic leukemia. PMID:31289210
Bacterial MbtH-like Proteins Stimulate Nonribosomal Peptide Synthetase-Derived Secondary Metabolism in Filamentous Fungi. PMID:31284717
Isolation and functional characterization of two dioxygenases putatively involved in bixin biosynthesis in annatto (Bixa orellana L.). PMID:31275744
A Human-Derived Monoclonal Antibody Targeting Extracellular Connexin Domain Selectively Modulates Hemichannel Function. PMID:31263420
Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations. PMID:31263112
Structural basis of TFIIH activation for nucleotide excision repair. PMID:31253769
Enzyme activity and structural features of three single-domain phloem cyclophilins from Brassica napus. PMID:31249367
Drug Repurposing for Paracoccidioidomycosis Through a Computational Chemogenomics Framework. PMID:31244810
A broadly neutralizing germline-like human monoclonal antibody against dengue virus envelope domain III. PMID:31242272
The R941L mutation in MYH14 disrupts mitochondrial fission and associates with peripheral neuropathy. PMID:31231018
Pathogenic Autoreactive T and B Cells Cross-React with Mimotopes Expressed by a Common Human Gut Commensal to Trigger Autoimmunity. PMID:31227334
Discovery of an intrasubunit nicotinic acetylcholine receptor-binding site for the positive allosteric modulator Br-PBTC. PMID:31221718
Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer. PMID:31215437
Identification and Functional Analysis of NLP-Encoding Genes from the Postharvest Pathogen Penicillium expansum. PMID:31208074
Immunoglobulin light chains generate proinflammatory and profibrotic kidney injury. PMID:31205024
A Genomic, Evolutionary, and Mechanistic Study of MCR-5 Action Suggests Functional Unification across the MCR Family of Colistin Resistance. PMID:31179217
Semi-rational evolution of the 3-(3-hydroxyalkanoyloxy)alkanoate (HAA) synthase RhlA to improve rhamnolipid production in Pseudomonas aeruginosa and Burkholderia glumae. PMID:31177633
Comparative genomics provides new insights into the remarkable adaptations of the African wild dog (Lycaon pictus). PMID:31171819
Trypanosoma brucei centrin5 is enriched in the flagellum and interacts with other centrins in a calcium-dependent manner. PMID:31161731
The enigmatic role of fungal annexins: the case of Cryptococcus neoformans. PMID:31140968
Elucidation of the biosynthesis pathway and heterologous construction of a sustainable route for producing umbelliferone. PMID:31139252
Metabolomics Studies To Decipher Stress Responses in Mycobacterium smegmatis Point to a Putative Pathway of Methylated Amine Biosynthesis. PMID:31138627
Novel Fluorescent Cyclic Nucleotide Derivatives to Study CNG and HCN Channel Function. PMID:31130235
In silico and in vitro studies of lupeol and iso-orientin as potential antidiabetic agents in a rat model. PMID:31123393
Default Activation and Nuclear Translocation of the Plant Cellular Energy Sensor SnRK1 Regulate Metabolic Stress Responses and Development. PMID:31123051
Structure-based inhibitory peptide design targeting peptide-substrate binding site in EGFR tyrosine kinase. PMID:31116768
Identification and first characterization of DinJ-YafQ toxin-antitoxin systems in Lactobacillus species of biotechnological interest. PMID:31114007
Investigating function roles of hypothetical proteins encoded by the Mycobacterium tuberculosis H37Rv genome. PMID:31113361
Specific Binding Peptides from Rv3632: A Strategy for Blocking Mycobacterium tuberculosis Entry to Target Cells? PMID:31111070
Functional specialization of UDP-glycosyltransferase 73P12 in licorice to produce a sweet triterpenoid saponin, glycyrrhizin. PMID:31095780
Truncating variant burden in high-functioning autism and pleiotropic effects of LRP1 across psychiatric phenotypes. PMID:31094488
Characterization of a class III peroxidase from Artemisia annua: relevance to artemisinin metabolism and beyond. PMID:31093899
Closing the gap: yeast electron-transferring flavoprotein links the oxidation of d-lactate and d-α-hydroxyglutarate to energy production via the respiratory chain. PMID:31081204
A Unique Presentation of Infantile-Onset Colitis and Eosinophilic Disease without Recurrent Infections Resulting from a Novel Homozygous CARMIL2 Variant. PMID:31079270
Modeling Conformationally Flexible Proteins With X-ray Scattering and Molecular Simulations. PMID:31073392
Early screening the small bowel is key to protect Peutz-Jeghers syndrome patients from surgery: a novel mutation c.243delG in STK11 gene. PMID:31072341
Familial Immune Thrombocytopenia Associated With a Novel Variant in IKZF1. PMID:31069201
In silico ADME and Toxicity Prediction of Ceftazidime and Its Impurities. PMID:31068821
A predicted plastid rhomboid protease affects phosphatidic acid metabolism in Arabidopsis thaliana. PMID:31062431
A 25-Residue Peptide From Botrytis cinerea Xylanase BcXyn11A Elicits Plant Defenses. PMID:31057580
The Early Asexual Development Regulator fluG Codes for a Putative Bifunctional Enzyme. PMID:31057506
PMS2 germline mutation c.943C>T (p.Arg315*)-induced Lynch syndrome-associated ovarian cancer. PMID:31056861
De Novo Duplication in the CHD7 Gene Associated With Severe CHARGE Syndrome. PMID:31043788
IFIT5 Participates in the Antiviral Mechanisms of Rainbow Trout Red Blood Cells. PMID:31040842
Modeling of Protein⁻Protein Interactions in Cytokinin Signal Transduction. PMID:31035389
Cryo-EM structures of the pore-forming A subunit from the Yersinia entomophaga ABC toxin. PMID:31028251
Deciphering the three-domain architecture in schlafens and the structures and roles of human schlafen12 and serpinB12 in transcriptional regulation. PMID:31026779
Opsin 1 and Opsin 2 of the Corn Smut Fungus Ustilago maydis Are Green Light-Driven Proton Pumps. PMID:31024506
Identification and Signature Sequences of Bacterial Δ4,5Hexuronate-2-O-Sulfatases. PMID:31024490
Evidence for relaxed selection of mitogenome in rapid-flow cyprinids. PMID:31016677
SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species. PMID:31002797
Characterization of putative proteins encoded by variable ORFs in white spot syndrome virus genome. PMID:30999895
In silico analysis of the V66M variant of human BDNF in psychiatric disorders: An approach to precision medicine. PMID:30998730
Interaction of carbohydrate-binding modules with poly(ethylene terephthalate). PMID:30993383
Coenzyme Q biosynthesis in the biopesticide Shenqinmycin-producing Pseudomonas aeruginosa strain M18. PMID:30989356
A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike. PMID:30989115
A photoswitchable GABA receptor channel blocker. PMID:30981211
In-silico analysis of novel p.(Gly14Ser) variant of ATOX1 gene: plausible role in modulating ATOX1-ATP7B interaction. PMID:30980273
Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM. PMID:30975770
Analysis of the coding sequences of clownfish reveals molecular convergence in the evolution of lifespan. PMID:30975078
Structural basis for auxiliary subunit KCTD16 regulation of the GABAB receptor. PMID:30971491
Impact of antibiotic treatment and host innate immune pressure on enterococcal adaptation in the human bloodstream. PMID:30971455
N-glycosylation-dependent regulation of hK2P17.1 currents. PMID:30969900
Using the Predicted Structure of the Amot Coiled Coil Homology Domain to Understand Lipid Binding. PMID:30957019
A unique dynamin-related protein is essential for mitochondrial fission in Toxoplasma gondii. PMID:30947298
In vivo recombination of Saccharomyces eubayanus maltose-transporter genes yields a chimeric transporter that enables maltotriose fermentation. PMID:30946741
Antioxidant activity and antibacterial evaluation of new thiazolin-4-one derivatives as potential tryptophanyl-tRNA synthetase inhibitors. PMID:30938216
Rational protein design of Bacillus sp. MN chitosanase for altered substrate binding and production of specific chitosan oligomers. PMID:30918529
Detection and characterization of an albumin-like protein in Leishmania donovani. PMID:30903348
A novel TUFM homozygous variant in a child with mitochondrial cardiomyopathy expands the phenotype of combined oxidative phosphorylation deficiency 4. PMID:30903008
Histone deacetylase enzymes as potential drug targets of Neglected Tropical Diseases caused by cestodes. PMID:30897528
First Betalain-Producing Bacteria Break the Exclusive Presence of the Pigments in the Plant Kingdom. PMID:30890610
Crystallographic Structures of IlvN·Val/Ile Complexes: Conformational Selectivity for Feedback Inhibition of Aceto Hydroxy Acid Synthases. PMID:30887800
The proton pumping bo oxidase from Vitreoscilla. PMID:30886219
From uncertainty to pathogenicity: clinical and functional interrogation of a rare TP53 in-frame deletion. PMID:30886117
DPH1 syndrome: two novel variants and structural and functional analyses of seven missense variants identified in syndromic patients. PMID:30877278
In Silico Analysis of Homologous Heterodimers of Cruzipain-Chagasin from Structural Models Built by Homology. PMID:30875920
Host adaptation and convergent evolution increases antibiotic resistance without loss of virulence in a major human pathogen. PMID:30875398
Meta-analysis suggests evidence of novel stress-related pathway components in Orsay virus - Caenorhabditis elegans viral model. PMID:30867481
A study of CCD8 genes/proteins in seven monocots and eight dicots. PMID:30861026
Decline of transmissible gastroenteritis virus and its complex evolutionary relationship with porcine respiratory coronavirus in the United States. PMID:30850666
Validation and Stabilization of a Prophage Lysin of Clostridium perfringens by Using Yeast Surface Display and Coevolutionary Models. PMID:30850429
Novel mutation in the MED23 gene for intellectual disability: A case report and literature review. PMID:30847200
Pectinase secreted by psychrotolerant fungi: identification, molecular characterization and heterologous expression of a cold-active polygalacturonase from Tetracladium sp. PMID:30845994
Structural organization and functional divergence of high isoelectric point α-amylase genes in bread wheat (Triticum aestivum L.) and barley (Hordeum vulgare L.). PMID:30845909
Insights into the dynamic nature of the dsRNA-bound TLR3 complex. PMID:30842554
Identification of a novel potassium channel (GiK) as a potential drug target in Giardia lamblia: Computational descriptions of binding sites. PMID:30834181
Darolutamide is a potent androgen receptor antagonist with strong efficacy in prostate cancer models. PMID:30828788
Temperature adaptation of DNA ligases from psychrophilic organisms. PMID:30826937
3D structure prediction of VAPC1 and identification of dual natural inhibitors for VPAC1 and EGFR. PMID:30810849
Molecular characterization and homology modeling of liver X receptor in Asian seabass, Lates calcarifer: predicted functions in reproduction and lipid metabolism. PMID:30806874
Naja atra venom peptide reduces pain by selectively blocking the voltage-gated sodium channel Nav1.8. PMID:30804211
Structural introspection of a putative fluoride transporter in plants. PMID:30800614
A sequestered fusion peptide in the structure of an HIV-1 transmitted founder envelope trimer. PMID:30787293
Deciphering structure, function and mechanism of Plasmodium IspD homologs from their evolutionary imprints. PMID:30783866
Protease-Activatable Adeno-Associated Virus Vector for Gene Delivery to Damaged Heart Tissue. PMID:30772143
A polyextremophilic alcohol dehydrogenase from the Atlantis II Deep Red Sea brine pool. PMID:30761247
Small Molecule Docking of DNA Repair Proteins Associated with Cancer Survival Following PCNA Metagene Adjustment: A Potential Novel Class of Repair Inhibitors. PMID:30759820
Microtubule plus-ends act as physical signaling hubs to activate RhoA during cytokinesis. PMID:30758285
Increased drug permeability of a stiffened mycobacterial outer membrane in cells lacking MFS transporter Rv1410 and lipoprotein LprG. PMID:30742339
Chaperone activation and client binding of a 2-cysteine peroxiredoxin. PMID:30737390
In silico characterization of multiple genes encoding the GP63 virulence protein from Leishmania braziliensis: identification of sources of variation and putative roles in immune evasion. PMID:30732584
Solution Conformation of Bovine Leukemia Virus Gag Suggests an Elongated Structure. PMID:30731090
Myxococcus xanthus truncated globin HbO: in silico analysis and functional characterization. PMID:30729391
Plasmodium falciparum specific helicase 2 is a dual, bipolar helicase and is crucial for parasite growth. PMID:30728406
The expression of a tubby-like protein from Malus domestica (MdTLP7) enhances abiotic stress tolerance in Arabidopsis. PMID:30727953
Discovery of novel dual-active 3-(4-(dimethylamino)phenyl)-7-aminoalcoxy-coumarin as potent and selective acetylcholinesterase inhibitor and antioxidant. PMID:30727776
Interaction between Cellobiose Dehydrogenase and Lytic Polysaccharide Monooxygenase. PMID:30715860
Genome-wide identification and expression analysis of expansin gene family in common wheat (Triticum aestivum L.). PMID:30709338
Structural and Phylogenetic Diversity of Anaerobic Carbon-Monoxide Dehydrogenases. PMID:30705673
Action and mechanism of the colistin resistance enzyme MCR-4. PMID:30701201
Plant organellar DNA polymerases repair double-stranded breaks by microhomology-mediated end-joining. PMID:30698803
The Amphibian Diacylglycerol O-acyltransferase 2 (DGAT2): a 'paleo-protein' with Conserved Function but Unique Folding. PMID:30697667
Lateral distribution of phosphatidylinositol 4,5-bisphosphate in membranes regulates formin- and ARP2/3-mediated actin nucleation. PMID:30692198
Stability of cytochromes c' from psychrophilic and piezophilic Shewanella species: implications for complex multiple adaptation to low temperature and high hydrostatic pressure. PMID:30689055
Loss-of-function mutations in QRICH2 cause male infertility with multiple morphological abnormalities of the sperm flagella. PMID:30683861
Spectrum of neurodevelopmental disease associated with the GNAO1 guanosine triphosphate-binding region. PMID:30682224
Asp305Gly mutation improved the activity and stability of the styrene monooxygenase for efficient epoxide production in Pseudomonas putida KT2440. PMID:30678678
Genetic evolution analysis and pathogenicity assessment of porcine epidemic diarrhea virus strains circulating in part of China during 2011-2017. PMID:30677534
Single-channel permeability and glycerol affinity of human aquaglyceroporin AQP3. PMID:30659792
Identification of selective inhibitors of Helicobacter pylori IMPDH as a targeted therapy for the infection. PMID:30655593
Hydroxycholesterol binds and enhances the anti-viral activities of zebrafish monomeric c-reactive protein isoforms. PMID:30653529
Chaperone-mediated secretion switching from early to middle substrates in the type III secretion system encoded by Salmonella pathogenicity island 2. PMID:30651351
An in silico structural, functional and phylogenetic analysis with three dimensional protein modeling of alkaline phosphatase enzyme of Pseudomonas aeruginosa. PMID:30647696
Toward fully exploiting the therapeutic potential of marketed pharmaceuticals: the use of octreotide and chloroquine in oncology. PMID:30643430
Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition. PMID:30643017
ClyJ Is a Novel Pneumococcal Chimeric Lysin with a Cysteine- and Histidine-Dependent Amidohydrolase/Peptidase Catalytic Domain. PMID:30642930
Discovery of a Thermostable GH10 Xylanase with Broad Substrate Specificity from the Arctic Mid-Ocean Ridge Vent System. PMID:30635385
Identification of a Novel Elastin-Degrading Enzyme from the Fish Pathogen Flavobacterium psychrophilum. PMID:30635380
Structure of the SLy1 SAM homodimer reveals a new interface for SAM domain self-association. PMID:30631134
The (R)-enantiomer of the 6-chromanol derivate SUL-121 improves renal graft perfusion via antagonism of the α1-adrenoceptor. PMID:30626882
Cluster expansion of apolipoprotein D (ApoD) genes in teleost fishes. PMID:30621595
Identification of Proteins Differentially Expressed in the Striatum by Melatonin in a Middle Cerebral Artery Occlusion Rat Model-a Proteomic and in silico Approach. PMID:30618542
Sequence analysis and confirmation of the type IV pili-associated proteins PilY1, PilW and PilV in Acidithiobacillus thiooxidans. PMID:30615628
Potent Antimalarial 2-Pyrazolyl Quinolone bc 1 (Qi) Inhibitors with Improved Drug-like Properties. PMID:30613327
Discovery of novel geranylgeranyl reductases and characterization of their substrate promiscuity. PMID:30607175
TGF-β2 uses the concave surface of its extended finger region to bind betaglycan's ZP domain via three residues specific to TGF-β and inhibin-α. PMID:30598510
ABCF ATPases Involved in Protein Synthesis, Ribosome Assembly and Antibiotic Resistance: Structural and Functional Diversification across the Tree of Life. PMID:30597160
De novo transcriptome analyses provide insights into opsin-based photoreception in the lanternshark Etmopterus spinax. PMID:30596723
Transcriptome Comparison Reveals Distinct Selection Patterns in Domesticated and Wild Agave Species, the Important CAM Plants. PMID:30596084
Thermococcus Eurythermalis Endonuclease IV Can Cleave Various Apurinic/Apyrimidinic Site Analogues in ssDNA and dsDNA. PMID:30586940
Mechanisms of opening and closing of the bacterial replicative helicase. PMID:30582519
Functional divergence of annotated l-isoaspartate O-methyltransferases in an α-proteobacterium. PMID:30578298
The catalytic mechanism of electron-bifurcating electron transfer flavoproteins (ETFs) involves an intermediary complex with NAD<sup/> PMID:30567738
Genome Mining of Plant NPFs Reveals Varying Conservation of Signature Motifs Associated With the Mechanism of Transport. PMID:30564251
Mosquito Bite-Induced Controlled Human Malaria Infection with Plasmodium vivax or P. falciparum Generates Immune Responses to Homologous and Heterologous Preerythrocytic and Erythrocytic Antigens. PMID:30559218
Mechanism of Tetramer Dissociation, Unfolding, and Oligomer Assembly of Pneumovirus M2-1 Transcription Antiterminators. PMID:30555987
Brettanomyces bruxellensis SSU1 Haplotypes Confer Different Levels of Sulfite Tolerance When Expressed in a Saccharomyces cerevisiae SSU1 Null Mutant. PMID:30552183
Molecular Mechanisms of Bacterial Bioluminescence. PMID:30546856
Genome-wide identification and characterization of gene family for RWP-RK transcription factors in wheat (Triticum aestivum L.). PMID:30540790
Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2. PMID:30532069
NFKB1 and MANBA Confer Disease Susceptibility to Primary Biliary Cholangitis via Independent Putative Primary Functional Variants. PMID:30528300
Molecular basis for the increased affinity of an RNA recognition motif with re-engineered specificity: A molecular dynamics and enhanced sampling simulations study. PMID:30521520
Cellulose-specific Type B carbohydrate binding modules: understanding oligomeric and non-crystalline substrate recognition mechanisms. PMID:30519283
Characterization and functionality of two members of the SPFH protein superfamily, prohibitin 1 and 2 in Leishmania major. PMID:30514373
The Challenges of Analysing Highly Diverse Picobirnavirus Sequence Data. PMID:30513931
CC2D1B Coordinates ESCRT-III Activity during the Mitotic Reformation of the Nuclear Envelope. PMID:30513301
Giant tortoise genomes provide insights into longevity and age-related disease. PMID:30510174
A strategy to identify a ketoreductase that preferentially synthesizes pharmaceutically relevant (S)-alcohols using whole-cell biotransformation. PMID:30509260
The Chaperone and Redox Properties of CnoX Chaperedoxins Are Tailored to the Proteostatic Needs of Bacterial Species. PMID:30482828
Integration of phylogenomics and molecular modeling reveals lineage-specific diversification of toxins in scorpions. PMID:30479892
Architecture and subunit arrangement of the complete Saccharomyces cerevisiae COMPASS complex. PMID:30479350
ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis. PMID:30478421
Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events. PMID:30465522
Structure and Function Studies of Asian Corn Borer Ostrinia furnacalis Pheromone Binding Protein2. PMID:30459333
Degradation of crude oil by mixed cultures of bacteria isolated from the Qinghai-Tibet plateau and comparative analysis of metabolic mechanisms. PMID:30456621
Formate-nitrite transporters carrying nonprotonatable amide amino acids instead of a central histidine maintain pH-dependent transport. PMID:30455351
Efficacy of sertraline against Trypanosoma cruzi: an in vitro and in silico study. PMID:30450114
Thermal Stability of a Mercuric Reductase from the Red Sea Atlantis II Hot Brine Environment as Analyzed by Site-Directed Mutagenesis. PMID:30446558
Characterization of a novel N-acylhomoserine lactonase, AidP, from Antarctic Planococcus sp. PMID:30445965
Identification of molecular determinants that govern distinct STIM2 activation dynamics. PMID:30444880
Effect of C-Terminus Modification in Salmonella typhimurium FliC on Protein Purification Efficacy and Bioactivity. PMID:30443852
Endogenous amdoparvovirus-related elements reveal insights into the biology and evolution of vertebrate parvoviruses. PMID:30443409
Dynamic interactions of type I cohesin modules fine-tune the structure of the cellulosome of Clostridium thermocellum. PMID:30429330
The toxin from a ParDE toxin-antitoxin system found in Pseudomonas aeruginosa offers protection to cells challenged with anti-gyrase antibiotics. PMID:30427086
MoImd4 mediates crosstalk between MoPdeH-cAMP signalling and purine metabolism to govern growth and pathogenicity in Magnaporthe oryzae. PMID:30426699
Structural Evidence for the Substrate Channeling of Rice Allene Oxide Cyclase in Biologically Analogous Nazarov Reaction. PMID:30425978
PSMD12 haploinsufficiency in a neurodevelopmental disorder with autistic features. PMID:30421579
Structural Variability of EspG Chaperones from Mycobacterial ESX-1, ESX-3, and ESX-5 Type VII Secretion Systems. PMID:30419243
The Human Gut Colonizer Blastocystis Respires Using Complex II and Alternative Oxidase to Buffer Transient Oxygen Fluctuations in the Gut. PMID:30406045
Discovery of CDK8/CycC Ligands with a New Virtual Screening Tool. PMID:30403831
In silico approach to identify non-synonymous SNPs with highest predicted deleterious effect on protein function in human obesity related gene, neuronal growth regulator 1 (NEGR1). PMID:30402368
Members of the Genus Methylobacter Are Inferred To Account for the Majority of Aerobic Methane Oxidation in Oxic Soils from a Freshwater Wetland. PMID:30401770
Novel sequence variants in the TLR6 gene associated with advanced breast cancer risk in the Saudi Arabian population. PMID:30388713
Dynein axonemal intermediate chain 2 plays a role in gametogenesis by activation of Stat3. PMID:30387321
The Interaction between the Drosophila EAG Potassium Channel and the Protein Kinase CaMKII Involves an Extensive Interface at the Active Site of the Kinase. PMID:30381148
Caligus rogercresseyi acetylcholinesterase types and variants: a potential marker for organophosphate resistance. PMID:30376873
The AB loop of oncostatin M (OSM) determines species-specific signaling in humans and mice. PMID:30373773
Screening of a Novel Polysaccharide Lyase Family 10 Pectate Lyase from Paenibacillus polymyxa KF-1: Cloning, Expression and Characterization. PMID:30373112
Characterization of Sphingomyelin Phosphodiesterase Expression in Bumblebee (Bombus lantschouensis). PMID:30371875
Structural consequences of hereditary spastic paraplegia disease-related mutations in kinesin. PMID:30366951
Structural Analysis of Variability and Interaction of the N-terminal of the Oncogenic Effector CagA of Helicobacter pylori with Phosphatidylserine. PMID:30360352
Structural and functional insights into the interaction and targeting hub TMD0 of the polypeptide transporter TAPL. PMID:30353140
Off-axis rotor in Enterococcus hirae V-ATPase visualized by Zernike phase plate single-particle cryo-electron microscopy. PMID:30353110
Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1. PMID:30349006
FK506 Resistance of Saccharomyces cerevisiae Pdr5 and Candida albicans Cdr1 Involves Mutations in the Transmembrane Domains and Extracellular Loops. PMID:30348662
Genome-wide identification of evolutionarily conserved Small Heat-Shock and eight other proteins bearing α-crystallin domain-like in kinetoplastid protists. PMID:30346990
4-Hydroxyphenylpyruvate Dioxygenase Thermolability Is Responsible for Temperature-Dependent Melanogenesis in Aeromonas salmonicida subsp. salmonicida. PMID:30341077
High-Resolution Structural Characterization of a New Adeno-associated Virus Serotype 5 Antibody Epitope toward Engineering Antibody-Resistant Recombinant Gene Delivery Vectors. PMID:30333169
Microevolution in response to transient heme-iron restriction enhances intracellular bacterial community development and persistence. PMID:30332468
Mapping of Neutralizing Antibody Epitopes on the Envelope of Viruses Obtained from Plasma Samples Exhibiting Broad Cross-Clade Neutralization Potential Against HIV-1. PMID:30328700
Relevance of Breast Cancer Resistance Protein to Pharmacokinetics of Florfenicol in Chickens: A Perspective from In Vivo and In Vitro Studies. PMID:30326566
Firefly genomes illuminate parallel origins of bioluminescence in beetles. PMID:30324905
Differential Effects of Autophagy-Related 10 Protein on HCV Replication and Autophagy Flux Are Mediated by Its Cysteine44 and Cysteine135. PMID:30319633
S-nitrosylation of the zinc finger protein SRG1 regulates plant immunity. PMID:30315167
A Viral Protein Restricts Drosophila RNAi Immunity by Regulating Argonaute Activity and Stability. PMID:30308158
Crystal structure of a dimerization domain of human Caprin-2: similar overall dimeric fold but different molecular surface properties to that of human Caprin-1. PMID:30304999
Carbamazepine-Mediated Adverse Drug Reactions: CBZ-10,11-epoxide but Not Carbamazepine Induces the Alteration of Peptides Presented by HLA-B∗15:02. PMID:30302345
Arylvinylpiperazine Amides, a New Class of Potent Inhibitors Targeting QcrB of Mycobacterium tuberculosis. PMID:30301850
Ligand binding properties of two Brugia malayi fatty acid and retinol (FAR) binding proteins and their vaccine efficacies against challenge infection in gerbils. PMID:30296268
Can alternative epitope mapping approaches increase the impact of B-cell epitopes in food allergy diagnostics? PMID:30294841
CCDC114 is mutated in patient with a complex phenotype combining primary ciliary dyskinesia, sensorineural deafness, and renal disease. PMID:30291279
Placenta-specific 9, a putative secretory protein, induces G2/M arrest and inhibits the proliferation of human embryonic hepatic cells. PMID:30291214
Pathogenic variants in glutamyl-tRNAGln amidotransferase subunits cause a lethal mitochondrial cardiomyopathy disorder. PMID:30283131
Antarctic marine ciliates under stress: superoxide dismutases from the psychrophilic Euplotes focardii are cold-active yet heat tolerant enzymes. PMID:30283056
RIP2 filament formation is required for NOD2 dependent NF-κB signalling. PMID:30279485
New N-(oxazolylmethyl)-thiazolidinedione Active against Candida albicans Biofilm: Potential Als Proteins Inhibitors. PMID:30279343
Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1. PMID:30279182
Molecular dynamics provides insight into how N251A and N251Y mutations in the active site of Bacillus licheniformis RN-01 levansucrase disrupt production of long-chain levan. PMID:30278092
Cryo-EM structure of respiratory complex I at work. PMID:30277212
Hits-to-Lead Optimization of the Natural Compound 2,4,6-Trihydroxy-3-geranyl-acetophenone (tHGA) as a Potent LOX Inhibitor: Synthesis, Structure-Activity Relationship (SAR) Study, and Computational Assignment. PMID:30274341
The Diversity of Mammalian Hemoproteins and Microbial Heme Scavengers Is Shaped by an Arms Race for Iron Piracy. PMID:30271410
The Origin of Mitochondria-Specific Outer Membrane β-Barrels from an Ancestral Bacterial Fragment. PMID:30265295
Molecular cloning and mRNA expression pattern of Sox4 in Misgurnus anguillicaudatus. PMID:30262698
Evolution of the calcium feedback steps of vertebrate phototransduction. PMID:30257895
Antagonistic Pleiotropy in the Bifunctional Surface Protein FadL (OmpP1) during Adaptation of Haemophilus influenzae to Chronic Lung Infection Associated with Chronic Obstructive Pulmonary Disease. PMID:30254117
Heterocycles 48. Synthesis, Characterization and Biological Evaluation of Imidazo[2,1-b][1,3,4]Thiadiazole Derivatives as Anti-Inflammatory Agents. PMID:30248903
TbUTP10, a protein involved in early stages of pre-18S rRNA processing in Trypanosoma brucei. PMID:30248370
Spontaneous severe hypercholesterolemia and atherosclerosis lesions in rabbits with deficiency of low-density lipoprotein receptor (LDLR) on exon 7. PMID:30243490
Mechanistic insights into the host-microbe interaction and pathogen exclusion mediated by the Mucus-binding protein of Lactobacillus plantarum. PMID:30242281
Deciphering genome-wide WRKY gene family of Triticum aestivum L. and their functional role in response to Abiotic stress. PMID:30238225
The intracellular parasite Toxoplasma gondii harbors three druggable FNT-type formate and l-lactate transporters in the plasma membrane. PMID:30237165
In silico identification of lipid-binding α helices of uncoupling protein 1. PMID:30233783
Combined functions of two RRMs in Dead-end1 mimic helicase activity to promote nanos1 translation in the germline. PMID:30230100
Structure of the membrane-assembled retromer coat determined by cryo-electron tomography. PMID:30224749
Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy. PMID:30221940
A New Group of Modular Xylanases in Glycoside Hydrolase Family 8 from Marine Bacteria. PMID:30217847
WW domain-mediated regulation and activation of E3 ubiquitin ligase Suppressor of Deltex. PMID:30213861
Glucosylceramide modifies the LPS-induced inflammatory response in macrophages and the orientation of the LPS/TLR4 complex in silico. PMID:30206272
Small membranous proteins of the TorE/NapE family, crutches for cognate respiratory systems in Proteobacteria. PMID:30206249
Crystal structure of the modification-dependent SRA-HNH endonuclease TagI. PMID:30202937
Sinorhizobium meliloti Chemoreceptor McpV Senses Short-Chain Carboxylates via Direct Binding. PMID:30201781
Mosquito-larvicidal binary toxin receptor protein (Cqm1): crystallization and X-ray crystallographic analysis. PMID:30198890
Mechanism(s) of action of heavy metals to investigate the regulation of plastidic glucose-6-phosphate dehydrogenase. PMID:30194387
Importance of Val567 on heme environment and substrate recognition of neuronal nitric oxide synthase. PMID:30186754
Structural Basis of Pan-Ebolavirus Neutralization by an Antibody Targeting the Glycoprotein Fusion Loop. PMID:30184505
Comparative sequence and structure analysis of eIF1A and eIF1AD. PMID:30180896
A new approach to understanding structure-function relationships in cytochromes P450 by targeting terpene metabolism in the wild. PMID:30170307
Respiratory chain Complex I of unparalleled divergence in diplonemids. PMID:30166340
Stabilization of the CD81 Large Extracellular Loop with De Novo Disulfide Bonds Improves Its Amenability for Peptide Grafting. PMID:30150531
A speculation on the tandem fasciclin 1 repeat of FLA4 proteins in angiosperms. PMID:30148420
Homology modeling, molecular docking, and dynamics of two α-methyl-D-mannoside-specific lectins from Arachis genus. PMID:30145634
Bi-allelic c.181_183delTGT in BTB domain of KLHL7 is associated with overlapping phenotypes of Crisponi/CISS1-like and Bohring-Opitz like syndrome. PMID:30142437
Systematic discovery of uncharacterized transcription factors in Escherichia coli K-12 MG1655. PMID:30137486
Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice. PMID:30135305
Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation. PMID:30135078
Prediction of the presence of a seventh ankyrin repeat in IκBε from homology modeling combined with hydrogen-deuterium exchange mass spectrometry (HDX-MS). PMID:30133030
Human BCDIN3D Is a Cytoplasmic tRNAHis-Specific 5'-Monophosphate Methyltransferase. PMID:30127802
Identification of novel sesquiterpene synthase genes that mediate the biosynthesis of valerianol, which was an unknown ingredient of tea. PMID:30127518
Functional characterization of a lytic polysaccharide monooxygenase from the thermophilic fungus Myceliophthora thermophila. PMID:30125294
Reflections on the evolution of the vertebrate tissue inhibitors of metalloproteinases. PMID:30125136
A novel glycosyltransferase catalyses the transfer of glucose to glucosylated anthocyanins in purple sweet potato. PMID:30124996
Conformational switch in the ribosomal protein S1 guides unfolding of structured RNAs for translation initiation. PMID:30124944
Characterization of the β-defensin genes in giant panda. PMID:30120296
hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia. PMID:30115739
Characterization and expression of a long neuropeptide F (NPF) receptor in the Chagas disease vector Rhodnius prolixus. PMID:30114273
Novel frame shift mutation in ERCC6 leads to a severe form of Cockayne syndrome with postnatal growth failure and early death: A case report and brief literature review. PMID:30113454
Contribution of RAD51D germline mutations in breast and ovarian cancer in Greece. PMID:30111881
Integrative metagenomic and biochemical studies on rifamycin ADP-ribosyltransferases discovered in the sediment microbiome. PMID:30108275
Discovery of nonnucleoside inhibitors of polymerase from infectious pancreatic necrosis virus (IPNV). PMID:30104863
The Intracellular Cyclophilin PpiB Contributes to the Virulence of Staphylococcus aureus Independently of Its Peptidyl-Prolyl cis/trans Isomerase Activity. PMID:30104214
Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2. PMID:30102747
Redox regulation of GRPEL2 nucleotide exchange factor for mitochondrial HSP70 chaperone. PMID:30098457
OpuF, a New Bacillus Compatible Solute ABC Transporter with a Substrate-Binding Protein Fused to the Transmembrane Domain. PMID:30097444
Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization. PMID:30097292
Inward- and outward-facing homology modeling of human concentrative nucleoside transporter 3 (hCNT3) predicts an elevator-type transport mechanism. PMID:30096006
The altered activity of P53 signaling pathway by STK11 gene mutations and its cancer phenotype in Peutz-Jeghers syndrome. PMID:30092773
Two Compound Heterozygous Were Identified in SLC26A4 Gene in Two Chinese Families With Enlarged Vestibular Aqueduct. PMID:30086623
Modeling the structural implications of an alternatively spliced Exoc3l2, a paralog of the tunneling nanotube-forming M-Sec. PMID:30086153
Incompatible Translation Drives a Convergent Evolution and Viral Attenuation During the Development of Live Attenuated Vaccine. PMID:30073153
Lysine-Specific Demethylase 1A as a Promising Target in Acute Myeloid Leukemia. PMID:30073149
Molecular characterization, modeling, and docking analysis of late phytic acid biosynthesis pathway gene, inositol polyphosphate 6-/3-/5-kinase, a potential candidate for developing low phytate crops. PMID:30073129
Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q58⁻K59 Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities. PMID:30071628
In silico analysis of SLC3A1 and SLC7A9 mutations in Iranian patients with Cystinuria. PMID:30069816
Deciphering the targets of retroviral protease inhibitors in Plasmodium berghei. PMID:30067811
Baicalin Depresses the Sympathoexcitatory Reflex Induced by Myocardial Ischemia via the Dorsal Root Ganglia. PMID:30065662
EGFL7 enhances surface expression of integrin α5β1 to promote angiogenesis in malignant brain tumors. PMID:30065025
Structure of a mitochondrial fission dynamin in the closed conformation. PMID:30061604
Spread of MCR-3 Colistin Resistance in China: An Epidemiological, Genomic and Mechanistic Study. PMID:30061009
Lytic gene expression in the temperate bacteriophage GIL01 is activated by a phage-encoded LexA homologue. PMID:30053203
Effect of Active Site Pocket Structure Modification of D-Stereospecific Amidohydrolase on the Recognition of Stereospecific and Hydrophobic Substrates. PMID:30051300
Structure-function analyses of the bacterial zinc metalloprotease effector protein GtgA uncover key residues required for deactivating NF-κB. PMID:30049795
In silico mutational analysis and identification of stability centers in human interleukin-4. PMID:30046620
Comparative Study of Carborane- and Phenyl-Modified Adenosine Derivatives as Ligands for the A2A and A3 Adenosine Receptors Based on a Rigid in Silico Docking and Radioligand Replacement Assay. PMID:30044380
Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA. PMID:30044221
Calcium-binding proteins that are type B″ regulatory subunits of phosphatase 2A in Giardia intestinalis. PMID:30043281
MtMTP2-Facilitated Zinc Transport Into Intracellular Compartments Is Essential for Nodule Development in Medicago truncatula. PMID:30042781
Arabidopsis Kunitz Trypsin Inhibitors in Defense Against Spider Mites. PMID:30042779
Whole genome SNP-associated signatures of local adaptation in honeybees of the Iberian Peninsula. PMID:30042407
Selection of an ASIC1a-blocking combinatorial antibody that protects cells from ischemic death. PMID:30042215
Improving the diagnosis of cobalamin and related defects by genomic analysis, plus functional and structural assessment of novel variants. PMID:30041674
Antifungal activity of Cardiospermum halicacabum L. (Sapindaceae) against Trichophyton rubrum occurs through molecular interaction with fungal Hsp90. PMID:30034223
The positive inotropic agent DPI-201106 selectively reverses ABCB1-mediated multidrug resistance in cancer cell lines. PMID:30031116
Human ATP-binding cassette transporters ABCB1 and ABCG2 confer resistance to histone deacetylase 6 inhibitor ricolinostat (ACY-1215) in cancer cell lines. PMID:30028995
Plasmodium falciparum RUVBL3 protein: a novel DNA modifying enzyme and an interacting partner of essential HAT protein MYST. PMID:30026605
SIS3, a specific inhibitor of Smad3 reverses ABCB1- and ABCG2-mediated multidrug resistance in cancer cell lines. PMID:30026175
Computational Study Reveals the Molecular Mechanism of the Interaction between the Efflux Inhibitor PAβN and the AdeB Transporter from Acinetobacter baumannii. PMID:30023681
Crystal structure of an L chain optimised 14F7 anti-ganglioside Fv suggests a unique tumour-specificity through an unusual H-chain CDR3 architecture. PMID:30022069
Monitoring Viral Genetic Variation as a Tool To Improve Molecular Diagnostics for Mumps Virus. PMID:30021826
Characterization of esterase activity from an Acetomicrobium hydrogeniformans enzyme with high structural stability in extreme conditions. PMID:30014242
Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin. PMID:30013126
Characterization of the AmpC β-Lactamase from Burkholderia multivorans. PMID:30012762
Refining a steroidogenic model: an analysis of RNA-seq datasets from insect prothoracic glands. PMID:30005604
In Silico evaluation and identification of fungi capable of producing endo-inulinase enzyme. PMID:30001376
Proteomics and Phosphoproteomics of Heat Stress-Responsive Mechanisms in Spinach. PMID:29997633
Mild clinical features of isolated methylmalonic acidemia associated with a novel variant in the MMAA gene in two Chinese siblings. PMID:29996803
The rice white green leaf 2 gene causes defects in chloroplast development and affects the plastid ribosomal protein S9. PMID:29995230
Study of specific nanoenvironments containing α-helices in all-α and (α+β)+(α/β) proteins. PMID:29990352
Computational approach to unravel the impact of missense mutations of proteins (D2HGDH and IDH2) causing D-2-hydroxyglutaric aciduria 2. PMID:29987523
Molecular Insights into Functional Differences between mcr-3- and mcr-1-Mediated Colistin Resistance. PMID:29987148
MORC Domain Definition and Evolutionary Analysis of the MORC Gene Family in Green Plants. PMID:29982569
Identification of Antifungal Targets Based on Computer Modeling. PMID:29973534
Stable isotope informed genome-resolved metagenomics reveals that Saccharibacteria utilize microbially-processed plant-derived carbon. PMID:29970182
Characterization of Three Small Proteins in Brucella abortus Linked to Fucose Utilization. PMID:29967118
Plasmodium vivax Merozoite Surface Protein 1 Paralog as a Mediator of Parasite Adherence to Reticulocytes. PMID:29967091
Computational identification and evolutionary analysis of toxins in Mosquitocidal Bacillus thuringiensis strain S2160-1. PMID:29963353
In Silico Screening of Isocitrate Lyase for Novel Anti-Buruli Ulcer Natural Products Originating from Africa. PMID:29954088
Identification of DEAD-Box RNA Helicase DDX41 as a Trafficking Protein That Involves in Multiple Innate Immune Signaling Pathways in a Zebrafish Model. PMID:29942316
Temperature-induced changes in the wheat phosphoproteome reveal temperature-regulated interconversion of phosphoforms. PMID:29939309
A Novel Tomato Fusarium Wilt Tolerance Gene. PMID:29937759
The Cyanobacterial Ribosomal-Associated Protein LrtA from Synechocystis sp. PCC 6803 Is an Oligomeric Protein in Solution with Chameleonic Sequence Properties. PMID:29937518
In Silico Analysis of the Quorum Sensing Metagenome in Environmental Biofilm Samples. PMID:29930547
Influenza D virus M2 protein exhibits ion channel activity in Xenopus laevis oocytes. PMID:29927982
Divergent Small Tim Homologues Are Associated with TbTim17 and Critical for the Biogenesis of TbTim17 Protein Complexes in Trypanosoma brucei. PMID:29925672
Synthesis and molecular modelling studies of pyrimidinones and pyrrolo[3,4-d]-pyrimidinodiones as new antiplasmodial compounds. PMID:29924131
Cryo-EM structure of human mitochondrial trifunctional protein. PMID:29915090
A Mechanism for the Activation of the Influenza Virus Transcriptase. PMID:29910112
Introduction of novel thermostable α-amylases from genus Anoxybacillus and proposing to group the Bacillaceae related α-amylases under five individual GH13 subfamilies. PMID:29904894
Costimulatory Function of Cd58/Cd2 Interaction in Adaptive Humoral Immunity in a Zebrafish Model. PMID:29904386
Enteric bacteria boost defences against oxidative stress in Entamoeba histolytica. PMID:29899530
NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension. PMID:29899023
Live and let die: Hydrogen peroxide production by the commensal flora and its role in maintaining a symbiotic microbiome. PMID:29897662
A Novel ShK-Like Toxic Peptide from the Transcriptome of the Cnidarian Palythoa caribaeorum Displays Neuroprotection and Cardioprotection in Zebrafish. PMID:29895785
Characterization of C-ring component assembly in flagellar motors from amino acid coevolution. PMID:29892378
Escherichia coli B2 strains prevalent in inflammatory bowel disease patients have distinct metabolic capabilities that enable colonization of intestinal mucosa. PMID:29890970
Pandemic Avian Influenza and Intra/Interhaemagglutinin Subtype Electrostatic Variation among Viruses Isolated from Avian, Mammalian, and Human Hosts. PMID:29888260
Adaptive genetic variation at three loci in South African vervet monkeys (Chlorocebus pygerythrus) and the role of selection within primates. PMID:29888138
Wireless control of cellular function by activation of a novel protein responsive to electromagnetic fields. PMID:29884813
Isolation and Semi Quantitative PCR of Na+/H+ Antiporter (SOS1 and NHX) Genes under Salinity Stress in Kochia scoparia. PMID:29881329
Characterization of a novel MYO3A missense mutation associated with a dominant form of late onset hearing loss. PMID:29880844
Venom allergen-like protein 28 in Clonorchis sinensis: four epitopes on its surface and the potential role of Cys124 for its conformational stability. PMID:29876859
Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state. PMID:29872228
Identification of Putative Precursor Genes for the Biosynthesis of Cannabinoid-Like Compound in Radula marginata. PMID:29868043
Convergent Loss of ABC Transporter Genes From Clostridioides difficile Genomes Is Associated With Impaired Tyrosine Uptake and p-Cresol Production. PMID:29867812
The Odorant Binding Protein 6 Expressed in Sensilla Chaetica Displays Preferential Binding Affinity to Host Plants Volatiles in Ectropis obliqua. PMID:29867573
Evolutionary convergence in lignin-degrading enzymes. PMID:29866821
In silico prediction of T- and B-cell epitopes in PmpD: First step towards to the design of a Chlamydia trachomatis vaccine. PMID:29866599
Large set data mining reveals overexpressed GPCRs in prostate and breast cancer: potential for active targeting with engineered anti-cancer nanomedicines. PMID:29861840
A dominant variant in the PDE1C gene is associated with nonsyndromic hearing loss. PMID:29860631
Engineering Bacillus pumilus alkaline serine protease to increase its low-temperature proteolytic activity by directed evolution. PMID:29859069
Specific binding between Bacillus thuringiensis Cry9Aa and Vip3Aa toxins synergizes their toxicity against Asiatic rice borer (Chilo suppressalis). PMID:29858245
Transcriptomics reveals the molecular processes of light-induced rapid darkening of the non-obligate cave dweller Oreolalax rhodostigmatus (Megophryidae, Anura) and their genetic basis of pigmentation strategy. PMID:29855256
Gain-of-function KCNJ6 Mutation in a Severe Hyperkinetic Movement Disorder Phenotype. PMID:29852244
Genome-Wide Identification and Characterization of Fox Genes in the Honeybee, Apis cerana, and Comparative Analysis with Other Bee Fox Genes. PMID:29850474
Salmonella enterica serovar Typhimurium has three transketolase enzymes contributing to the pentose phosphate pathway. PMID:29848552
HSYMDOCK: a docking web server for predicting the structure of protein homo-oligomers with Cn or Dn symmetry. PMID:29846641
Use of Protein Kinase-Focused Compound Libraries for the Discovery of New Inositol Phosphate Kinase Inhibitors. PMID:29842835
An orphan kinesin controls trypanosome morphology transitions by targeting FLAM3 to the flagellum. PMID:29813136
Cdc48-like protein of actinobacteria (Cpa) is a novel proteasome interactor in mycobacteria and related organisms. PMID:29809155
Computational-based structural, functional and phylogenetic analysis of Enterobacter phytases. PMID:29805952
Molecular characterization of canine parvovirus variants (CPV-2a, CPV-2b, and CPV-2c) based on the VP2 gene in affected domestic dogs in Ecuador. PMID:29805214
Cytokinin perception in potato: new features of canonical players. PMID:29800344
HotSpot Wizard 3.0: web server for automated design of mutations and smart libraries based on sequence input information. PMID:29796670
Comparative inhibitory profile and distribution of bacterial PARPs, using Clostridioides difficile CD160 PARP as a model. PMID:29795234
SWISS-MODEL: homology modelling of protein structures and complexes. PMID:29788355
A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency. PMID:29788236
Catalytic Bases and Stereocontrol in Lamiaceae Class II Diterpene Cyclases. PMID:29787239
Fungal-type carbohydrate binding modules from the coccolithophore Emiliania huxleyi show binding affinity to cellulose and chitin. PMID:29782536
Genome Sequencing and Analysis of the Peanut B-Genome Progenitor (Arachis ipaensis). PMID:29774047
The trimeric solution structure and fucose-binding mechanism of the core fucosylation-specific lectin PhoSL. PMID:29773815
A Pelota-like gene regulates root development and defence responses in rice. PMID:29771278
Novel aggrecan variant, p. Gln2364Pro, causes severe familial nonsyndromic adult short stature and poor growth hormone response in Chinese children. PMID:29769040
ScGAI is a key regulator of culm development in sugarcane. PMID:29767776
Computational analysis of the receptor binding specificity of novel influenza A/H7N9 viruses. PMID:29764421
Methylglucosylation of aromatic amino and phenolic moieties of drug-like biosynthons by combinatorial biosynthesis. PMID:29760061
Defining ICR-Mo, an intrinsic colistin resistance determinant from Moraxella osloensis. PMID:29758020
Exploring the Interaction Mechanism Between Cyclopeptide DC3 and Androgen Receptor Using Molecular Dynamics Simulations and Free Energy Calculations. PMID:29755968
Influenza Virus: A Master Tactician in Innate Immune Evasion and Novel Therapeutic Interventions. PMID:29755452
Pheromone Binding Protein EhipPBP1 Is Highly Enriched in the Male Antennae of the Seabuckthorn Carpenterworm and Is Binding to Sex Pheromone Components. PMID:29755369
Mutations in PPCS, Encoding Phosphopantothenoylcysteine Synthetase, Cause Autosomal-Recessive Dilated Cardiomyopathy. PMID:29754768
A Functional Study Identifying Critical Residues Involving Metal Transport Activity and Selectivity in Natural Resistance-Associated Macrophage Protein 3 in Arabidopsis thaliana. PMID:29748478
Expression and Interaction Analysis among Saffron ALDHs and Crocetin Dialdehyde. PMID:29747375
Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation. PMID:29745897
Comprehensive analyses of the BES1 gene family in Brassica napus and examination of their evolutionary pattern in representative species. PMID:29743014
A molecular dynamics investigation of CDK8/CycC and ligand binding: conformational flexibility and implication in drug discovery. PMID:29737445
MIKCC-type MADS-box genes in Rosa chinensis: the remarkable expansion of ABCDE model genes and their roles in floral organogenesis. PMID:29736250
A persulfidation-based mechanism controls aquaporin-8 conductance. PMID:29732408
Improved L-ornithine production in Corynebacterium crenatum by introducing an artificial linear transacetylation pathway. PMID:29728854
Isolation and characterization of 4-hydroxy-3-methylbut-2-enyl diphosphate reductase gene from Botryococcus braunii, race B. PMID:29725892
CD22-Binding Synthetic Sialosides Regulate B Lymphocyte Proliferation Through CD22 Ligand-Dependent and Independent Pathways, and Enhance Antibody Production in Mice. PMID:29725338
Species-Specific Involvement of Integrin αIIbβ3 in a Monoclonal Antibody CH12 Triggers Off-Target Thrombocytopenia in Cynomolgus Monkeys. PMID:29724685
A broadly conserved NERD genetically interacts with the exocyst to affect root growth and cell expansion. PMID:29722827
Glutathione modulates the expression of heat shock proteins via the transcription factors BZIP10 and MYB21 in Arabidopsis. PMID:29722824
Pathogen-Specific Binding Soluble Down Syndrome Cell Adhesion Molecule (Dscam) Regulates Phagocytosis via Membrane-Bound Dscam in Crab. PMID:29720978
Structural principles of distinct assemblies of the human α4β2 nicotinic receptor. PMID:29720657
Medicago Plants Control Nodulation by Regulating Proteolysis of the Receptor-Like Kinase DMI2. PMID:29717018
ELMOD3, a novel causative gene, associated with human autosomal dominant nonsyndromic and progressive hearing loss. PMID:29713870
Novel LAMA2 Gene Mutations Associated with Merosin-Deficient Congenital Muscular Dystrophy. PMID:29707938
Structural Insight Into the Role of Mutual Polymorphism and Conservatism in the Contact Zone of the NFR5-K1 Heterodimer With the Nod Factor. PMID:29706972
Phosphatidylinositol-3,5-bisphosphate lipid-binding-induced activation of the human two-pore channel 2. PMID:29705952
The Ustilago maydis repetitive effector Rsp3 blocks the antifungal activity of mannose-binding maize proteins. PMID:29703884
Structure-Function Mutational Analysis and Prediction of the Potential Impact of High Risk Non-Synonymous Single-Nucleotide Polymorphism on Poliovirus 2A Protease Stability Using Comprehensive Informatics Approaches. PMID:29701718
Structure of the receptor-activated human TRPC6 and TRPC3 ion channels. PMID:29700422
Isolation and molecular characterization of novel glucarpidases: Enzymes to improve the antibody directed enzyme pro-drug therapy for cancer treatment. PMID:29698433
Putative Connections Between Nitrate Reductase S-Nitrosylation and NO Synthesis Under Pathogen Attacks and Abiotic Stresses. PMID:29696031
A structural study of the complex between neuroepithelial cell transforming gene 1 (Net1) and RhoA reveals a potential anticancer drug hot spot. PMID:29695506
Design, Synthesis, and Docking Studies of New Torin2 Analogs as Potential ATR/mTOR Kinase Inhibitors. PMID:29695073
Rotation-Activated and Cooperative Zipping Characterize Class I Viral Fusion Protein Dynamics. PMID:29694865
Non-canonical role of the SNARE protein Ykt6 in autophagosome-lysosome fusion. PMID:29694367
Involvement of a host Cathepsin L in symbiont-induced cell death. PMID:29692003
A homozygous mutation p.Arg2167Trp in FREM2 causes isolated cryptophthalmos. PMID:29688405
The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation. PMID:29686383
The Two-Component Signaling System VraSRss Is Critical for Multidrug Resistance and Full Virulence in Streptococcus suis Serotype 2. PMID:29685990
Close and regular surveillance is key to prevent severe complications for Peutz-Jeghers syndrome patients without gastrointestinal polyps: case report of a novel STK11 mutation (c.471_472delCT) in a Chinese girl. PMID:29685139
Molecular Cancer Imaging in the Second Near-Infrared Window Using a Renal-Excreted NIR-II Fluorophore-Peptide Probe. PMID:29682821
Structural Basis for Teneurin Function in Circuit-Wiring: A Toxin Motif at the Synapse. PMID:29677516
An innovative immunotherapeutic strategy for ovarian cancer: CLEC10A and glycomimetic peptides. PMID:29665849
Structural studies on radiopharmaceutical DOTA-minigastrin analogue (CP04) complexes and their interaction with CCK2 receptor. PMID:29663167
HU of Streptococcus pneumoniae Is Essential for the Preservation of DNA Supercoiling. PMID:29662473
Genetic variability in the sdrD gene in Staphylococcus aureus from healthy nasal carriers. PMID:29661152
Structural basis for ATP-dependent chromatin remodelling by the INO80 complex. PMID:29643509
An m6A-YTH Module Controls Developmental Timing and Morphogenesis in Arabidopsis. PMID:29643069
Glycosylation of Hemagglutinin and Neuraminidase of Influenza A Virus as Signature for Ecological Spillover and Adaptation among Influenza Reservoirs. PMID:29642453
Biophysical characterization and molecular simulation of electrostatically driven self-association of a single-chain antibody. PMID:29637646
Analysis of HIV-1 envelope evolution suggests antibody-mediated selection of common epitopes among Chinese former plasma donors from a narrow-source outbreak. PMID:29636501
An Evolutionarily Conserved Mechanism for Intrinsic and Transferable Polymyxin Resistance. PMID:29636432
New World feline APOBEC3 potently controls inter-genus lentiviral transmission. PMID:29636069
The single berberine bridge enzyme homolog of Physcomitrella patens is a cellobiose oxidase. PMID:29633551
Disentangling the molecular determinants for Cenp-F localization to nuclear pores and kinetochores. PMID:29632243
Insight into the Significance of Aspergillus fumigatus cyp51A Polymorphisms. PMID:29632011
Disease-Causing Mutations in the G Protein Gαs Subvert the Roles of GDP and GTP. PMID:29628140
Substituents at the C3' and C3'N positions are critical for taxanes to overcome acquired resistance of cancer cells to paclitaxel. PMID:29625142
Mutations Conferring Increased Sensitivity to Tripartite Motif 22 Restriction Accumulated Progressively in the Nucleoprotein of Seasonal Influenza A (H1N1) Viruses between 1918 and 2009. PMID:29624498
Patient with multiple acyl-CoA dehydrogenase deficiency disease and ETFDH mutations benefits from riboflavin therapy: a case report. PMID:29615056
Multilevel Differential Control of Hormone Gene Expression Programs by hnRNP L and LL in Pituitary Cells. PMID:29610151
Solution scattering study of the Bacillus subtilis PgdS enzyme involved in poly-γ-glutamic acids degradation. PMID:29608608
Mutations in the voltage-sensing domain affect the alternative ion permeation pathway in the TRPM3 channel. PMID:29604058
Computational Insight Into the Structural Organization of Full-Length Toll-Like Receptor 4 Dimer in a Model Phospholipid Bilayer. PMID:29593733
Amino Acid Substitutions HA A150V, PA A343T, and PB2 E627K Increase the Virulence of H5N6 Influenza Virus in Mice. PMID:29593694
The degenerin region of the human bile acid-sensitive ion channel (BASIC) is involved in channel inhibition by calcium and activation by bile acids. PMID:29589117
Long-lived rodents reveal signatures of positive selection in genes associated with lifespan. PMID:29570707
Dual binding in cohesin-dockerin complexes: the energy landscape and the role of short, terminal segments of the dockerin module. PMID:29568013
Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1. PMID:29567962
Molecular control of gene expression by Brucella BaaR, an IclR-type transcriptional repressor. PMID:29567835
Role of the Extremolytes Ectoine and Hydroxyectoine as Stress Protectants and Nutrients: Genetics, Phylogenomics, Biochemistry, and Structural Analysis. PMID:29565833
Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex. PMID:29559617
Cryo-EM structure of an early precursor of large ribosomal subunit reveals a half-assembled intermediate. PMID:29557065
Duplicated TLR5 of zebrafish functions as a heterodimeric receptor. PMID:29555749
Retinal isomerization and water-pore formation in channelrhodopsin-2. PMID:29555736
A novel cold-adapted esterase from Enterobacter cloacae: Characterization and improvement of its activity and thermostability via the site of Tyr193Cys. PMID:29554914
A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein. PMID:29554084
Neurobehavioral Effects of Cephalosporins: Assessment of Locomotors Activity, Motor and Sensory Development in Zebrafish. PMID:29551974
Characterization and expression analyses of somatolactin-α and -β genes in rare minnows (Gobiocypris rarus) following waterborne cadmium exposure. PMID:29550894
Chimeric Fatty Acyl-Acyl Carrier Protein Thioesterases Provide Mechanistic Insight into Enzyme Specificity and Expression. PMID:29549102
Structures of Teneurin adhesion receptors reveal an ancient fold for cell-cell interaction. PMID:29540701
Molecular Insights into the Mechanisms of SUN1 Oligomerization in the Nuclear Envelope. PMID:29539404
Cooperative recruitment of Yan via a high-affinity ETS supersite organizes repression to confer specificity and robustness to cardiac cell fate specification. PMID:29535190
A horizontally gene transferred copper resistance locus confers hyper-resistance to antibacterial copper toxicity and enables survival of community acquired methicillin resistant Staphylococcus aureus USA300 in macrophages. PMID:29521441
Association of μ-Calpain and Calpastatin Polymorphisms with Meat Tenderness in a Brahman-Angus Population. PMID:29520298
Novel mutations associated with pyruvate kinase deficiency in Brazil. PMID:29519373
Coevolution of the Toll-Like Receptor 4 Complex with Calgranulins and Lipopolysaccharide. PMID:29515592
The FBH family of bHLH transcription factors controls ACC synthase expression in sugarcane. PMID:29514290
Phenotype of CNTNAP1: a study of patients demonstrating a specific severe congenital hypomyelinating neuropathy with survival beyond infancy. PMID:29511323
The corticotropin releasing factor binding protein: A strange case of Dr. Jekyll and Mr. Hyde in the stress system? PMID:29510883
A recombinant Fasciola gigantica 14-3-3 epsilon protein (rFg14-3-3e) modulates various functions of goat peripheral blood mononuclear cells. PMID:29510740
A novel, homozygous mutation in desert hedgehog (DHH) in a 46, XY patient with dysgenetic testes presenting with primary amenorrhoea: a case report. PMID:29507583
Clinical phenotype and molecular analysis of a homozygous ABCB11 mutation responsible for progressive infantile cholestasis. PMID:29507376
There's no place like OM: Vesicular sorting and secretion of the peptidylarginine deiminase of Porphyromonas gingivalis. PMID:29505395
SIRT2 deacetylase regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation. PMID:29504933
Structural and functional studies on Pseudomonas aeruginosa DspI: implications for its role in DSF biosynthesis. PMID:29500457
Molecular docking based screening of Noggin inhibitors. PMID:29497255
Mycobacterium tuberculosis H37Rv LpqG Protein Peptides Can Inhibit Mycobacterial Entry through Specific Interactions. PMID:29495456
Characterization of the Lytic Capability of a LysK-Like Endolysin, Lys-phiSA012, Derived from a Polyvalent Staphylococcus aureus Bacteriophage. PMID:29495305
Molecular docking, molecular modeling, and molecular dynamics studies of azaisoflavone as dual COX-2 inhibitors and TP receptor antagonists. PMID:29480373
Novel CARMIL2 Mutations in Patients with Variable Clinical Dermatitis, Infections, and Combined Immunodeficiency. PMID:29479355
Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA. PMID:29478808
Biallelic Mutations in ATP5F1D, which Encodes a Subunit of ATP Synthase, Cause a Metabolic Disorder. PMID:29478781
A chemical genetic approach to engineer phototropin kinases for substrate labeling. PMID:29475950
Error-prone PCR mutagenesis and reverse bacterial two-hybrid screening identify a mutation in asparagine 53 of the Staphylococcus aureus ESAT6-like component EsxB that perturbs interaction with EsxD. PMID:29473132
The C-terminal helix of ribosomal P stalk recognizes a hydrophobic groove of elongation factor 2 in a novel fashion. PMID:29471537
Formation of RNA Granule-Derived Capsid Assembly Intermediates Appears To Be Conserved between Human Immunodeficiency Virus Type 1 and the Nonprimate Lentivirus Feline Immunodeficiency Virus. PMID:29467316
Unraveling the sequence of cytosolic reactions in the export of GspB adhesin from Streptococcus gordonii. PMID:29462788
Mechanistic insights into transferable polymyxin resistance among gut bacteria. PMID:29462787
Transient receptor potential vanilloid 4 (TRPV4) activation by arachidonic acid requires protein kinase A-mediated phosphorylation. PMID:29462784
Circulatory white spot syndrome virus in South-West region of Bangladesh from 2014 to 2017: molecular characterization and genetic variation. PMID:29460184
Molecular, biochemical and kinetic analysis of a novel, thermostable lipase (LipSm) from Stenotrophomonas maltophilia Psi-1, the first member of a new bacterial lipase family (XVIII). PMID:29456971
Comparative phylogenetic and expression analysis of small GTPases families in legume and non-legume plants. PMID:29452030
Novel hereditary spherocytosis-associated splice site mutation in the ANK1 gene caused by parental gonosomal mosaicism. PMID:29449435
Structural basis for the glycosyltransferase activity of the Salmonella effector SseK3. PMID:29449376
The synaptotagmin C2B domain calcium-binding loops modulate the rate of fusion pore expansion. PMID:29444959
A Comparative Study of Human Saposins. PMID:29443946
Differential Expression of Six Rnase2 and Three Rnase3 Paralogs Identified in Blunt Snout Bream in Response to Aeromonas hydrophila Infection. PMID:29443944
Comparative analysis of plant isochorismate synthases reveals structural mechanisms underlying their distinct biochemical properties. PMID:29436485
Insight into Phosphatidylinositol-Dependent Membrane Localization of the Innate Immune Adaptor Protein Toll/Interleukin 1 Receptor Domain-Containing Adaptor Protein. PMID:29434596
The Extracellular Domain of Pollen Receptor Kinase 3 is structurally similar to the SERK family of co-receptors. PMID:29434276
The C-terminal cytosolic domain of the human zinc transporter ZnT8 and its diabetes risk variant. PMID:29430817
Characterization of OglDREB2A gene from African rice (Oryza glaberrima), comparative analysis and its transcriptional regulation under salinity stress. PMID:29430353
Oral recombinant Lactobacillus vaccine targeting the intestinal microfold cells and dendritic cells for delivering the core neutralizing epitope of porcine epidemic diarrhea virus. PMID:29426335
Unique pharmacological properties of serotoninergic G-protein coupled receptors from cestodes. PMID:29425245
Nanoparticle-Encapsulated Curcumin Inhibits Diabetic Neuropathic Pain Involving the P2Y12 Receptor in the Dorsal Root Ganglia. PMID:29422835
Importance of a Laccase Gene (Lcc1) in the Development of Ganoderma tsugae. PMID:29415422
Analysis of Homologs of Cry-toxin Receptor-Related Proteins in the Midgut of a Non-Bt Target, Nilaparvata lugens (Stål) (Hemiptera: Delphacidae). PMID:29415259
NS2 proteases from hepatitis C virus and related hepaciviruses share composite active sites and previously unrecognized intrinsic proteolytic activities. PMID:29415072
Molecular characterization of the recombinant protein RmLTI-BmCG-LTB: Protective immunity against Rhipicephalus (Boophilus) microplus. PMID:29415034
Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp. PMID:29410413
SAAMP 2.0: An algorithm to predict genotype-phenotype correlation of lysosomal storage diseases. PMID:29396849
Molecular Docking, Pharmacophore, and 3D-QSAR Approach: Can Adenine Derivatives Exhibit Significant Inhibitor Towards Ebola Virus? PMID:29387271
The PUF Protein Family: Overview on PUF RNA Targets, Biological Functions, and Post Transcriptional Regulation. PMID:29385744
The C-terminal region of translesion synthesis DNA polymerase η is partially unstructured and has high conformational flexibility. PMID:29385534
Two novel deep-sea sediment metagenome-derived esterases: residue 199 is the determinant of substrate specificity and preference. PMID:29382330
Discovery of Selective, Substrate-Competitive, and Passive Membrane Permeable Glycogen Synthase Kinase-3β Inhibitors: Synthesis, Biological Evaluation, and Molecular Modeling of New C-Glycosylflavones. PMID:29381861
Hydrogen sulfide increases glutathione biosynthesis, and glucose uptake and utilisation in C2C12 mouse myotubes. PMID:29378451
Fungal Screening on Olive Oil for Extracellular Triacylglycerol Lipases: Selection of a Trichoderma harzianum Strain and Genome Wide Search for the Genes. PMID:29370083
Shielding and activation of a viral membrane fusion protein. PMID:29367607
Three-dimensional spatial analysis of missense variants in RTEL1 identifies pathogenic variants in patients with Familial Interstitial Pneumonia. PMID:29361909
The common bean COK-4 and the Arabidopsis FER kinase domain share similar functions in plant growth and defence. PMID:29352746
Phosphate signaling through alternate conformations of the PstSCAB phosphate transporter. PMID:29351743
A homozygous missense variant in VWA2, encoding an interactor of the Fraser-complex, in a patient with vesicoureteral reflux. PMID:29351342
6-OHDA-induced dopaminergic neurodegeneration in Caenorhabditis elegans is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33. PMID:29346382
Mutations in Caenorhabditis elegans neuroligin-like glit-1, the apoptosis pathway and the calcium chaperone crt-1 increase dopaminergic neurodegeneration after 6-OHDA treatment. PMID:29346364
Remarkable similarity in Plasmodium falciparum and Plasmodium vivax geranylgeranyl diphosphate synthase dynamics and its implication for antimalarial drug design. PMID:29345110
A search for ceramide binding proteins using bifunctional lipid analogs yields CERT-related protein StarD7. PMID:29343537
Copy Number Variation in SOX6 Contributes to Chicken Muscle Development. PMID:29342086
In silico identification and experimental validation of amino acid motifs required for the Rho-of-plants GTPase-mediated activation of receptor-like cytoplasmic kinases. PMID:29340786
Assessment of antimicrobial and wound healing effects of Brevinin-2Ta against the bacterium Klebsiella pneumoniae in dermally-wounded rats. PMID:29340060
Biochemical and genetic characterization of a novel metallo-β-lactamase from marine bacterium Erythrobacter litoralis HTCC 2594. PMID:29339760
New Shuttle Vectors for Gene Cloning and Expression in Multidrug-Resistant Acinetobacter Species. PMID:29339383
Cryo-EM structure of the exocyst complex. PMID:29335562
Identification of Cross Reactive Antigens of C. botulinum Types A, B, E & F by Immunoproteomic Approach. PMID:29332140
Role of N-glycosylation in activation of proMMP-9. A molecular dynamics simulations study. PMID:29329315
The role of IL‑16 gene polymorphisms in endometriosis. PMID:29328375
Antimicrobial peptide gene BdPho responds to peptidoglycan infection and mating stimulation in oriental fruit fly, Bactrocera dorsalis (Hendel). PMID:29327267
Antibacterial Evaluation and Virtual Screening of New Thiazolyl-Triazole Schiff Bases as Potential DNA-Gyrase Inhibitors. PMID:29324679
Expression of cry2Ah1 and two domain II mutants in transgenic tobacco confers high resistance to susceptible and Cry1Ac-resistant cotton bollworm. PMID:29323243
Signaling ammonium across membranes through an ammonium sensor histidine kinase. PMID:29323112
Evolution of the shut-off steps of vertebrate phototransduction. PMID:29321241
Similar localization of conformational IgE epitopes on the house dust mite allergens Der p 5 and Der p 21 despite limited IgE cross-reactivity. PMID:29319884
Multiple mutations and overexpression of the MdaE7 carboxylesterase gene associated with male-linked malathion resistance in housefly, Musca domestica (Diptera: Muscidae). PMID:29317643
Tyrosine kinase inhibitor sensitive PDGFRΑ mutations in GIST: Two cases and review of the literature. PMID:29312652
Structural analysis of mtEXO mitochondrial RNA degradosome reveals tight coupling of nuclease and helicase components. PMID:29311576
Molecular mechanisms of cutis laxa- and distal renal tubular acidosis-causing mutations in V-ATPase a subunits, ATP6V0A2 and ATP6V0A4. PMID:29311258
Structure and Function of Caltrin (Calcium Transport Inhibitor) Proteins. PMID:29308010
Muscle-Specific Mis-Splicing and Heart Disease Exemplified by RBM20. PMID:29304022
Systematic Identification of Lysine 2-hydroxyisobutyrylated Proteins in Proteus mirabilis. PMID:29298837
A sparse autoencoder-based deep neural network for protein solvent accessibility and contact number prediction. PMID:29297299
Structural and Immunological Characterization of Novel Recombinant MOMP-Based Chlamydial Antigens. PMID:29295593
Structural Analysis and Epitope Prediction of MHC Class-1-Chain Related Protein-A for Cancer Vaccine Development. PMID:29295563
Sodium taurocholate cotransporting polypeptide (NTCP) deficiency: Identification of a novel SLC10A1 mutation in two unrelated infants presenting with neonatal indirect hyperbilirubinemia and remarkable hypercholanemia. PMID:29290974
Human oncoprotein Musashi-2 N-terminal RNA recognition motif backbone assignment and identification of RNA-binding pocket. PMID:29290973
The gene product of a Trypanosoma equiperdum ortholog of the cAMP-dependent protein kinase regulatory subunit is a monomeric protein that is not capable of binding cyclic nucleotides. PMID:29288679
Characterization of a novel variant in siblings with Asparagine Synthetase Deficiency. PMID:29279279
Broadly neutralizing antiviral responses induced by a single-molecule HPV vaccine based on thermostable thioredoxin-L2 multiepitope nanoparticles. PMID:29269879
A Single Mechanosensitive Channel Protects Francisella tularensis subsp. holarctica from Hypoosmotic Shock and Promotes Survival in the Aquatic Environment. PMID:29269496
Ascorbic acid may not be involved in cryptochrome-based magnetoreception. PMID:29263128
Peptide Uptake Is Essential for Borrelia burgdorferi Viability and Involves Structural and Regulatory Complexity of its Oligopeptide Transporter. PMID:29259089
Structural, expression and evolutionary analysis of the non-specific phospholipase C gene family in Gossypium hirsutum. PMID:29258435
Mapping genetic variations to three-dimensional protein structures to enhance variant interpretation: a proposed framework. PMID:29254494
The amino-terminus of the hepatitis C virus (HCV) p7 viroporin and its cleavage from glycoprotein E2-p7 precursor determine specific infectivity and secretion levels of HCV particle types. PMID:29253880
Chicken GRIFIN: Structural characterization in crystals and in solution. PMID:29248541
Structural basis for lipid binding and mechanism of the Mycobacterium tuberculosis Rv3802 phospholipase. PMID:29247008
A novel germline mutation (c.A527G) in STK11 gene causes Peutz-Jeghers syndrome in a Chinese girl: A case report. PMID:29245219
Engineering thermal stability and solvent tolerance of the soluble quinoprotein PedE from Pseudomonas putida KT2440 with a heterologous whole-cell screening approach. PMID:29239114
Redox-Sensing Under Hypochlorite Stress and Infection Conditions by the Rrf2-Family Repressor HypR in Staphylococcus aureus. PMID:29237286
Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase. PMID:29235475
Evolution and Expansion of the Prokaryote-Like Lipoxygenase Family in the Brown Alga Saccharina japonica. PMID:29234336
Acetylome of Acinetobacter baumannii SK17 Reveals a Highly-Conserved Modification of Histone-Like Protein HU. PMID:29230394
Characterization of auxiliary iron-sulfur clusters in a radical S-adenosylmethionine enzyme PqqE from Methylobacterium extorquens AM1. PMID:29226074
In Silico Validation of D7 Salivary Protein-derived B- and T-cell Epitopes of Aedes aegypti as Potential Vaccine to Prevent Transmission of Flaviviruses and Togaviruses to Humans. PMID:29225429
Structural Dynamics of the MscL C-terminal Domain. PMID:29222414
Diverse effects of distance cutoff and residue interval on the performance of distance-dependent atom-pair potential in protein structure prediction. PMID:29221443
Prediction on the risk population of idiosyncratic adverse reactions based on molecular docking with mutant proteins. PMID:29221149
The Neutralizing Linear Epitope of Human Herpesvirus 6A Glycoprotein B Does Not Affect Virus Infectivity. PMID:29212944
Experimental Adaptive Evolution of Simian Immunodeficiency Virus SIVcpz to Pandemic Human Immunodeficiency Virus Type 1 by Using a Humanized Mouse Model. PMID:29212937
Betanodavirus B2 protein triggers apoptosis and necroptosis in lung cancer cells that suppresses autophagy. PMID:29212215
Allosteric Control of a Plant Receptor Kinase through S-Glutathionylation. PMID:29211989
PvdO is required for the oxidation of dihydropyoverdine as the last step of fluorophore formation in Pseudomonas fluorescens. PMID:29208656
In vivo tropism of Salmonella Typhi toxin to cells expressing a multiantennal glycan receptor. PMID:29203881
In Vitro, In Silico, and In Vivo Analyses of Novel Aromatic Amidines against Trypanosoma cruzi. PMID:29203486
Exposing the Molecular Screening Method of Indonesian Natural Products Derivate as Drug Candidates for Cervical Cancer. PMID:29201098
Computationally-driven identification of antibody epitopes. PMID:29199956
Conserved Lipid and Small-Molecule Modulation of COQ8 Reveals Regulation of the Ancient Kinase-like UbiB Family. PMID:29198567
The P-type ATPase CtpG preferentially transports Cd2+ across the Mycobacterium tuberculosis plasma membrane. PMID:29197950
Autopolysialylation of polysialyltransferases is required for polysialylation and polysialic acid chain elongation on select glycoprotein substrates. PMID:29183999
Transition metal binding selectivity in proteins and its correlation with the phylogenomic classification of the cation diffusion facilitator protein family. PMID:29180655
Continuous Automated Model EvaluatiOn (CAMEO) complementing the critical assessment of structure prediction in CASP12. PMID:29178137
Characterization of an acetohydroxy acid synthase mutant conferring tolerance to imidazolinone herbicides in rice (Oryza sativa). PMID:29170911
Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2. PMID:29170376
Planarian cholinesterase: molecular and functional characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity. PMID:29167930
Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes. PMID:29167449
Characterization of the inner membrane protein BB0173 from Borrelia burgdorferi. PMID:29166863
Identification and Initial Characterization of the Effectors of an Anther Smut Fungus and Potential Host Target Proteins. PMID:29165363
Conserved Molecular Mechanism of TyrA Dehydrogenase Substrate Specificity Underlying Alternative Tyrosine Biosynthetic Pathways in Plants and Microbes. PMID:29164132
Harnessing fungal nonribosomal cyclodepsipeptide synthetases for mechanistic insights and tailored engineering. PMID:29163920
Human canonical CD157/Bst1 is an alternatively spliced isoform masking a previously unidentified primate-specific exon included in a novel transcript. PMID:29162908
An orphan cbb3-type cytochrome oxidase subunit supports Pseudomonas aeruginosa biofilm growth and virulence. PMID:29160206
Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers. PMID:29150600
Cry64Ba and Cry64Ca, Two ETX/MTX2-Type Bacillus thuringiensis Insecticidal Proteins Active against Hemipteran Pests. PMID:29150505
Structural Basis of Mitochondrial Transcription Initiation. PMID:29149603
A G3P[13] porcine group A rotavirus emerging in China is a reassortant and a natural recombinant in the VP4 gene. PMID:29148270
Structure of FlgK reveals the divergence of the bacterial Hook-Filament Junction of Campylobacter. PMID:29147015
Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5. PMID:29146912
Localization and functional characterization of the p.Asn965Ser (N965S) ABCA4 variant in mice reveal pathogenic mechanisms underlying Stargardt macular degeneration. PMID:29145636
Sanger sequencing in exonic regions of STK11 gene uncovers a novel de-novo germline mutation (c.962_963delCC) associated with Peutz-Jeghers syndrome and elevated cancer risk: case report of a Chinese patient. PMID:29141581
Structure-function relationships in ABCG2: insights from molecular dynamics simulations and molecular docking studies. PMID:29138424
Association of predicted pathogenic mutations in mitochondrial ND genes with distant metastasis in NSCLC and colon cancer. PMID:29138417
Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein. PMID:29138320
KNOTTIN: the database of inhibitor cystine knot scaffold after 10 years, toward a systematic structure modeling. PMID:29136213
Effect of two non-synonymous ecto-5'-nucleotidase variants on the genetic architecture of inosine 5'-monophosphate (IMP) and its degradation products in Japanese Black beef. PMID:29132308
Unraveling the key to the resistance of canids to prion diseases. PMID:29131852
OsMTP11 is localised at the Golgi and contributes to Mn tolerance. PMID:29127328
Structural insight into activation of homoserine dehydrogenase from the archaeon Sulfolobus tokodaii via reduction. PMID:29124164
Interaction of the Saccharomyces cerevisiae RING-domain protein Nse1 with Nse3 and the Smc5/6 complex is required for chromosome replication and stability. PMID:29119272
The Kunitz Domain I of Hepatocyte Growth Factor Activator Inhibitor-2 Inhibits Matriptase Activity and Invasive Ability of Human Prostate Cancer Cells. PMID:29118397
Selectivity analyses of γ-benzylidene digoxin derivatives to different Na,K-ATPase α isoforms: a molecular docking approach. PMID:29115894
Structure and function of yeast Atg20, a sorting nexin that facilitates autophagy induction. PMID:29114050
Structure-function analyses reveal key features in Staphylococcus aureus IsdB-associated unfolding of the heme-binding pocket of human hemoglobin. PMID:29109153
Structure and function of a CE4 deacetylase isolated from a marine environment. PMID:29107991
Prediction of Host-Pathogen Interactions for Helicobacter pylori by Interface Mimicry and Implications to Gastric Cancer. PMID:29106933
Bioinformatics on a national scale: an example from Switzerland. PMID:29106442
Enhancing the Thermostability of Rhizomucor miehei Lipase with a Limited Screening Library by Rational-Design Point Mutations and Disulfide Bonds. PMID:29101200
Evolution of Single-Domain Globins in Hydrothermal Vent Scale-Worms. PMID:29094190
Identification of a Critical and Conformational Neutralizing Epitope in Human Adenovirus Type 4 Hexon. PMID:29093098
Discovery of the Membrane Binding Domain in Trifunctional Proline Utilization A. PMID:29090935
Structures of transcription pre-initiation complex with TFIIH and Mediator. PMID:29088706
Genome-wide identification and expression profile analysis of CCH gene family in Populus. PMID:29085758
Proton-solute coupling mechanism of the maltose transporter from Saccharomyces cerevisiae. PMID:29084970
Broadening the functionality of a J-protein/Hsp70 molecular chaperone system. PMID:29084221
An intrinsically disordered linker controlling the formation and the stability of the bacterial flagellar hook. PMID:29078764
Membrane alterations induced by nonstructural proteins of human norovirus. PMID:29077760
Functional analyses of the CIF1-CIF2 complex in trypanosomes identify the structural motifs required for cytokinesis. PMID:29074577
Assessment of protein assembly prediction in CASP12. PMID:29071742
Tracing the Evolutionary History of the CAP Superfamily of Proteins Using Amino Acid Sequence Homology and Conservation of Splice Sites. PMID:29071358
Assessment of vocation of rifabutin and rifapentine in replace of rifampcin in drug resistance leprosy patients: a molecular simulation study. PMID:29071280
Structure, Immunogenicity, and Protective Mechanism of an Engineered Enterovirus 71-Like Particle Vaccine Mimicking 80S Empty Capsid. PMID:29070691
The six metal binding domains in human copper transporter, ATP7B: molecular biophysics and disease-causing mutations. PMID:29063292
Steered molecular dynamics simulation of the binding of the bovine auxilin J domain to the Hsc70 nucleotide-binding domain. PMID:29063205
Structural and functional characterization of the Helicobacter pylori cytidine 5'-monophosphate-pseudaminic acid synthase PseF: molecular insight into substrate recognition and catalysis mechanism. PMID:29062238
Cytolytic toxin production by Staphylococcus aureus is dependent upon the activity of the protoheme IX farnesyltransferase. PMID:29062030
A Canonical Biotin Synthesis Enzyme, 8-Amino-7-Oxononanoate Synthase (BioF), Utilizes Different Acyl Chain Donors in Bacillus subtilis and Escherichia coli. PMID:29054876
Enhanced biodegradation of mixed PAHs by mutated naphthalene 1,2-dioxygenase encoded by Pseudomonas putida strain KD6 isolated from petroleum refinery waste. PMID:29051846
De novo mutations of TUBA3D are associated with keratoconus. PMID:29051577
KIT performed as a driver gene candidate affecting the survival status of patients with stomach adenocarcinoma. PMID:29050270
Structural prediction of two novel human atypical SLC transporters, MFSD4A and MFSD9, and their neuroanatomical distribution in mice. PMID:29049335
Cox2A/Cox2B subunit interaction in Polytomella sp. cytochrome c oxidase: role of the Cox2B subunit extension. PMID:29043530
A plasma proteomics method reveals links between ischemic stroke and MTHFR C677T genotype. PMID:29042595
Transcription factor 19 interacts with histone 3 lysine 4 trimethylation and controls gluconeogenesis via the nucleosome-remodeling-deacetylase complex. PMID:29042441
A cell-penetrating antibody inhibits human RAD51 via direct binding. PMID:29036688
Plasmodium falciparum specific helicase 3 is nucleocytoplasmic protein and unwinds DNA duplex in 3' to 5' direction. PMID:29030567
Investigating the bifunctionality of cyclizing and "classical" 5-aminolevulinate synthases. PMID:29027286
A chemical and biological toolbox for Type Vd secretion: Characterization of the phospholipase A1 autotransporter FplA from Fusobacterium nucleatum. PMID:29021252
Molecular Insights into the Potential Insecticidal Interaction of β-Dihydroagarofuran Derivatives with the H Subunit of V-ATPase. PMID:29019960
A 23-Nucleotide Deletion in STK11 Gene Causes Peutz-Jeghers Syndrome and Malignancy in a Chinese Patient Without a Positive Family History. PMID:28986664
Digging Deeper into CYP3A Testosterone Metabolism: Kinetic, Regioselectivity, and Stereoselectivity Differences between CYP3A4/5 and CYP3A7. PMID:28986474
Novel CH1:CL interfaces that enhance correct light chain pairing in heterodimeric bispecific antibodies. PMID:28981885
Computationally Optimized Broadly Reactive Hemagglutinin Elicits Hemagglutination Inhibition Antibodies against a Panel of H3N2 Influenza Virus Cocirculating Variants. PMID:28978710
Cmr1 enables efficient RNA and DNA interference of a III-B CRISPR-Cas system by binding to target RNA and crRNA. PMID:28977458
Heterologous Expression, Purification and Characterization of a Peroxidase Isolated from Lepidium draba. PMID:28975545
TUBB4A mutations result in specific neuronal and oligodendrocytic defects that closely match clinically distinct phenotypes. PMID:28973395
A unique cysteine-rich zinc finger domain present in a majority of class II ribonucleotide reductases mediates catalytic turnover. PMID:28972190
A lower isoelectric point increases signal sequence-mediated secretion of recombinant proteins through a bacterial ABC transporter. PMID:28972172
Substrate Specificity and Inhibitor Sensitivity of Plant UDP-Sugar Producing Pyrophosphorylases. PMID:28970843
Biochemical efficacy, molecular docking and inhibitory effect of 2, 3-dimethylmaleic anhydride on insect acetylcholinesterase. PMID:28970561
3.2-Å-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage. PMID:28967883
Folding Membrane Proteins by Deep Transfer Learning. PMID:28957654
Functional significance of active site residues in the enzymatic component of the Clostridium difficile binary toxin. PMID:28955942
The unusual substrate specificity of a virulence associated serine hydrolase from the highly toxic bacterium, Francisella tularensis. PMID:28955933
Investigation of the key factors on 3-hydroxypropionic acid production with different recombinant strains. PMID:28955611
Allosteric-activation mechanism of BK channel gating ring triggered by calcium ions. PMID:28953901
A Novel Multifunctional β-N-Acetylhexosaminidase Revealed through Metagenomics of an Oil-Spilled Mangrove. PMID:28952541
Novel compound heterozygous mutations in the GPR98 (USH2C) gene identified by whole exome sequencing in a Moroccan deaf family. PMID:28951997
Structural Basis for EarP-Mediated Arginine Glycosylation of Translation Elongation Factor EF-P. PMID:28951478
A single point mutation in a TssB/VipA homolog disrupts sheath formation in the type VI secretion system of Proteus mirabilis. PMID:28949977
A two-step transport pathway allows the mother cell to nurture the developing spore in Bacillus subtilis. PMID:28945739
Redox state-dependent modulation of plant SnRK1 kinase activity differs from AMPK regulation in animals. PMID:28940407
Visualisation of a flexible modular structure of the ER folding-sensor enzyme UGGT. PMID:28939828
Periodontal-induced chronic inflammation triggers macrophage secretion of Ccl12 to inhibit fibroblast-mediated cardiac wound healing. PMID:28931761
DNA Ligase IV Guides End-Processing Choice during Nonhomologous End Joining. PMID:28930678
Rethinking the Origin of Primates by Reconstructing Their Diel Activity Patterns Using Genetics and Morphology. PMID:28928374
The periplasmic transaminase PtaA of Pseudomonas fluorescens converts the glutamic acid residue at the pyoverdine fluorophore to α-ketoglutaric acid. PMID:28912270
Importance of the REM (Ras exchange) domain for membrane interactions by RasGRP3. PMID:28912101
Structure-based domain assignment in Leishmania infantum EndoG: characterization of a pH-dependent regulatory switch and a C-terminal extension that largely dictates DNA substrate preferences. PMID:28911117
Leukoencephalopathy-causing CLCN2 mutations are associated with impaired Cl- channel function and trafficking. PMID:28905383
Structural and functional diversity arising from intra- and inter-haplotype combinations of duplicated DQA and B loci within the ovine MHC. PMID:28889256
Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein. PMID:28886386
Genomic Analysis of Terpene Synthase Family and Functional Characterization of Seven Sesquiterpene Synthases from Citrus sinensis. PMID:28883829
Molecular modeling and structure-based drug discovery approach reveals protein kinases as off-targets for novel anticancer drug RH1. PMID:28879492
Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression. PMID:28878041
Different Routes for Conifer- and Sinapaldehyde and Higher Saccharification upon Deficiency in the Dehydrogenase CAD1. PMID:28878036
Crystal structures of a ZIP zinc transporter reveal a binuclear metal center in the transport pathway. PMID:28875161
Modeling protein quaternary structure of homo- and hetero-oligomers beyond binary interactions by homology. PMID:28874689
TRIM23 mediates virus-induced autophagy via activation of TBK1. PMID:28871090
Vps13-Mcp1 interact at vacuole-mitochondria interfaces and bypass ER-mitochondria contact sites. PMID:28864540
Pulling MscL open via N-terminal and TM1 helices: A computational study towards engineering an MscL nanovalve. PMID:28859093
Developmentally Regulated GTP binding protein 1 (DRG1) controls microtubule dynamics. PMID:28855639
The Treponema pallidum Outer Membrane. PMID:28849315
TAF10 and TAF10b partially redundant roles during Drosophila melanogaster morphogenesis. PMID:28841365
Modelling of microbial polyhydroxyalkanoate surface binding protein PhaP for rational mutagenesis. PMID:28840964
In silico analysis of protein toxin and bacteriocins from Lactobacillus paracasei SD1 genome and available online databases. PMID:28837656
One-domain CD4 Fused to Human Anti-CD16 Antibody Domain Mediates Effective Killing of HIV-1-Infected Cells. PMID:28831040
The Non-Lantibiotic Bacteriocin Garvicin Q Targets Man-PTS in a Broad Spectrum of Sensitive Bacterial Genera. PMID:28827688
Characterization of a novel class A carbapenemase PAD-1 from Paramesorhizobium desertii A-3-ET, a strain highly resistant to β-lactam antibiotics. PMID:28827656
Curcumin liposomes interfere with quorum sensing system of Aeromonas sobria and in silico analysis. PMID:28819178
Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins. PMID:28817804
Defining Electron Bifurcation in the Electron-Transferring Flavoprotein Family. PMID:28808132
Activity of the β-Lactamase Inhibitor LN-1-255 against Carbapenem-Hydrolyzing Class D β-Lactamases from Acinetobacter baumannii. PMID:28807908
Crystal Structure and Substrate Specificity Modification of Acetyl Xylan Esterase from Aspergillus luchuensis. PMID:28802264
Molecular characterization of EcCIPK24 gene of finger millet (Eleusine coracana) for investigating its regulatory role in calcium transport. PMID:28794922
A family of archaea-like carboxylesterases preferentially expressed in the symbiotic phase of the mychorrizal fungus Tuber melanosporum. PMID:28794466
Structural Rearrangement upon Fragmentation of the Stability Core of the ALS-Linked Protein TDP-43. PMID:28793209
Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE. PMID:28784764
Structure and application of antifreeze proteins from Antarctic bacteria. PMID:28784139
An overview of comparative modelling and resources dedicated to large-scale modelling of genome sequences. PMID:28777078
Insights into the role of 3-O-sulfotransferase in heparan sulfate biosynthesis. PMID:28770943
Conformational and chemical selection by a trans-acting editing domain. PMID:28768811
Molecular evolutionary patterns of NAD+/Sirtuin aging signaling pathway across taxa. PMID:28767699
Bradyrhizobium elkanii nod regulon: insights through genomic analysis. PMID:28767122
Microtubule-dependent ribosome localization in C. elegans neurons. PMID:28767038
Impact of LCA-Associated E14L LRAT Mutation on Protein Stability and Retinoid Homeostasis. PMID:28758396
Antivirals for allosteric inhibition of Zika virus using a homology model and experimentally determined structure of envelope protein. PMID:28754167
Colorful Packages: Encapsulation of Fluorescent Proteins in Complex Coacervate Core Micelles. PMID:28753915
New findings on phosphodiesterases, MoPdeH and MoPdeL, in Magnaporthe oryzae revealed by structural analysis. PMID:28752677
Gene Expression and Molecular Characterization of a Xylanase from Chicken Cecum Metagenome. PMID:28751915
Biochemical characterization of a new nicotinamidase from an unclassified bacterium thriving in a geothermal water stream microbial mat community. PMID:28750065
Predictive Structure and Topology of Peroxisomal ATP-Binding Cassette (ABC) Transporters. PMID:28737695
Multiomics analysis of the giant triton snail salivary gland, a crown-of-thorns starfish predator. PMID:28729681
The whole-genome landscape of medulloblastoma subtypes. PMID:28726821
Characterization of the cytochrome P450 monooxygenase genes (P450ome) from the carotenogenic yeast Xanthophyllomyces dendrorhous. PMID:28724407
MAST-like protein kinase IREH1 from Arabidopsis thaliana co-localizes with the centrosome when expressed in animal cells. PMID:28717875
Random mutagenesis analysis and identification of a novel C2H2-type transcription factor from the nematode-trapping fungus Arthrobotrys oligospora. PMID:28717216
Biophysical investigation of type A PutAs reveals a conserved core oligomeric structure. PMID:28710792
Rapid identification of genes controlling virulence and immunity in malaria parasites. PMID:28704525
Biochemical characterization of aminopeptidase N2 from Toxoplasma gondii. PMID:28701624
Identification, classification and transcriptional profiles of dirigent domain-containing proteins in sugarcane. PMID:28699001
Crystal structure of the N-terminal domain of VqsR from Pseudomonas aeruginosa at 2.1 Å resolution. PMID:28695853
Crystal structure of the UBR-box from UBR6/FBXO11 reveals domain swapping mediated by zinc binding. PMID:28691247
Altered paracellular cation permeability due to a rare CLDN10B variant causes anhidrosis and kidney damage. PMID:28686597
Structure and catalytic activation of the TRIM23 RING E3 ubiquitin ligase. PMID:28681414
A channelopathy mutation in the voltage-sensor discloses contributions of a conserved phenylalanine to gating properties of Kv1.1 channels and ataxia. PMID:28676720
Interactions between LHX3- and ISL1-family LIM-homeodomain transcription factors are conserved in Caenorhabditis elegans. PMID:28676648
Generation of monoclonal pan-hemagglutinin antibodies for the quantification of multiple strains of influenza. PMID:28662134
Hydrocinnamic Acid Inhibits the Currents of WT and SQT3 Syndrome-Related Mutants of Kir2.1 Channel. PMID:28660286
Phylogeography of Coxsackievirus A16 Reveals Global Transmission Pathways and Recent Emergence and Spread of a Recombinant Genogroup. PMID:28659474
Proton transfer reactions in the red light-activatable channelrhodopsin variant ReaChR and their relevance for its function. PMID:28659342
Functional Role of Lanthanides in Enzymatic Activity and Transcriptional Regulation of Pyrroloquinoline Quinone-Dependent Alcohol Dehydrogenases in Pseudomonas putida KT2440. PMID:28655819
Antibody against Microbial Neuraminidases Recognizes Human Sialidase 3 (NEU3): the Neuraminidase/Sialidase Superfamily Revisited. PMID:28655817
The Structure of the R2TP Complex Defines a Platform for Recruiting Diverse Client Proteins to the HSP90 Molecular Chaperone System. PMID:28648606
Structures and dynamics of hibernating ribosomes from Staphylococcus aureus mediated by intermolecular interactions of HPF. PMID:28645916
Alpha-Mangostin Reverses Multidrug Resistance by Attenuating the Function of the Multidrug Resistance-Linked ABCG2 Transporter. PMID:28641010
Mutations in human AID differentially affect its ability to deaminate cytidine and 5-methylcytidine in ssDNA substrates in vitro. PMID:28634398
Exploration of binding and inhibition mechanism of a small molecule inhibitor of influenza virus H1N1 hemagglutinin by molecular dynamics simulation. PMID:28630402
EV-3, an endogenous human erythropoietin isoform with distinct functional relevance. PMID:28623280
Structural basis for the regulatory interactions of proapoptotic Par-4. PMID:28622290
Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104. PMID:28619716
New adenovirus-based vaccine vectors targeting Pfs25 elicit antibodies that inhibit Plasmodium falciparum transmission. PMID:28619071
A Conserved Leucine Zipper Motif in Gammaherpesvirus ORF52 Is Critical for Distinct Microtubule Rearrangements. PMID:28615210
Spacer capture and integration by a type I-F Cas1-Cas2-3 CRISPR adaptation complex. PMID:28611213
Novel Class IIa-Selective Histone Deacetylase Inhibitors Discovered Using an in Silico Virtual Screening Approach. PMID:28607401
Zinc-dependent regulation of zinc import and export genes by Zur. PMID:28598435
Structural insight into the role of Gln293Met mutation on the Peloruside A/Laulimalide association with αβ-tubulin from molecular dynamics simulations, binding free energy calculations and weak interactions analysis. PMID:28597356
Alternative splicing of CNOT7 diversifies CCR4-NOT functions. PMID:28591869
De novo non-synonymous TBL1XR1 mutation alters Wnt signaling activity. PMID:28588275
Biochemical and Computational Insights on a Novel Acid-Resistant and Thermal-Stable Glucose 1-Dehydrogenase. PMID:28587256
Engineering affinity agents for the detection of hemi-methylated CpG sites in DNA. PMID:28580176
An Atlas of β-Glucuronidases in the Human Intestinal Microbiome. PMID:28578872
Identification of diagnostic peptide regions that distinguish Zika virus from related mosquito-borne Flaviviruses. PMID:28562637
Prokaryotic expression, purification and characterization of human cyclooxygenase-2. PMID:28560423
Molecular dynamics simulations reveal the conformational dynamics of Arabidopsis thaliana BRI1 and BAK1 receptor-like kinases. PMID:28559283
Structural Insights into TMB-1 and the Role of Residues 119 and 228 in Substrate and Inhibitor Binding. PMID:28559248
Activation of Aedes aegypti prophenoloxidase-3 and its role in the immune response against entomopathogenic fungi. PMID:28556276
Site-specific His/Asp phosphoproteomic analysis of prokaryotes reveals putative targets for drug resistance. PMID:28545444
The LOTUS domain is a conserved DEAD-box RNA helicase regulator essential for the recruitment of Vasa to the germ plasm and nuage. PMID:28536148
Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes. PMID:28504929
Design and Properties of Genetically Encoded Probes for Sensing Macromolecular Crowding. PMID:28494963
Time-resolved dual transcriptomics reveal early induced Nicotiana benthamiana root genes and conserved infection-promoting Phytophthora palmivora effectors. PMID:28494759
Acetyl group coordinated progression through the catalytic cycle of an arylalkylamine N-acetyltransferase. PMID:28486510
Web3DMol: interactive protein structure visualization based on WebGL. PMID:28482028
Molecular Mechanism of Substrate Processing by the Cdc48 ATPase Complex. PMID:28475898
Structure and Dynamics of a 197 bp Nucleosome in Complex with Linker Histone H1. PMID:28475873
Aromatic amino acids in the cellulose binding domain of Penicillium crustosum endoglucanase EGL1 differentially contribute to the cellulose affinity of the enzyme. PMID:28475645
Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes. PMID:28472657
Fluoride export (FEX) proteins from fungi, plants and animals are 'single barreled' channels containing one functional and one vestigial ion pore. PMID:28472134
Hypokalemia, hypomagnesemia, hypocalciuria, and recurrent tetany: Gitelman syndrome in a Chinese pedigree and literature review. PMID:28469853
CRISPR-Cpf1 assisted genome editing of Corynebacterium glutamicum. PMID:28469274
Dominant ER Stress-Inducing WFS1 Mutations Underlie a Genetic Syndrome of Neonatal/Infancy-Onset Diabetes, Congenital Sensorineural Deafness, and Congenital Cataracts. PMID:28468959
Purification and characterization of a novel cold adapted fungal glucoamylase. PMID:28464820
Structure and function of seed storage proteins in faba bean (Vicia faba L.). PMID:28452019
Substrate selectivity of an isolated enoyl reductase catalytic domain from an iterative highly reducing fungal polyketide synthase reveals key components of programming. PMID:28451251
Molecular fingerprinting of complex grass allergoids: size assessments reveal new insights in epitope repertoires and functional capacities. PMID:28451054
SGNH hydrolase-type esterase domain containing Cbes-AcXE2: a novel and thermostable acetyl xylan esterase from Caldicellulosiruptor bescii. PMID:28444450
Associations of maternal PLA2G4C and PLA2G4D polymorphisms with the risk of spontaneous preterm birth in a Chinese population. PMID:28440406
Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP7. PMID:28435883
Computer-aided discovery of two novel chalcone-like compounds active and selective against Leishmania infantum. PMID:28434763
The Lon protease-like domain in the bacterial RecA paralog RadA is required for DNA binding and repair. PMID:28432121
Cloning retinoid and peroxisome proliferator-activated nuclear receptors of the Pacific oyster and in silico binding to environmental chemicals. PMID:28426724
Invasion of Ancestral Mammals into Dim-light Environments Inferred from Adaptive Evolution of the Phototransduction Genes. PMID:28425474
β-Carboxysome bioinformatics: identification and evolution of new bacterial microcompartment protein gene classes and core locus constraints. PMID:28419380
Structural insights into type I and type II of nsp4 porcine reproductive and respiratory syndrome virus (nsp4 PRRSV) by molecular dynamics simulations. PMID:28411461
Arabidopsis leucine-rich repeat receptor-like kinase NILR1 is required for induction of innate immunity to parasitic nematodes. PMID:28406987
Subcellular Localization of Arabidopsis Pathogenesis-Related 1 (PR1) Protein. PMID:28406455
Genetic resistance - an alternative for controlling PRRS? PMID:28405453
GalaxyHomomer: a web server for protein homo-oligomer structure prediction from a monomer sequence or structure. PMID:28387820
Substituted cysteine accessibility method (SCAM) analysis of the transport domain of human concentrative nucleoside transporter 3 (hCNT3) and other family members reveals features of structural and functional importance. PMID:28385889
Cell Attachment Domains of the Porcine Epidemic Diarrhea Virus Spike Protein Are Key Targets of Neutralizing Antibodies. PMID:28381581
Inclusion of an Arg-Gly-Asp receptor-recognition motif into the capsid protein of rabbit hemorrhagic disease virus enables culture of the virus in vitro. PMID:28381555
N6-Substituted 5'-N-Methylcarbamoyl-4'-selenoadenosines as Potent and Selective A3 Adenosine Receptor Agonists with Unusual Sugar Puckering and Nucleobase Orientation. PMID:28380296
Exome Sequencing Identified a Novel FBN2 Mutation in a Chinese Family with Congenital Contractural Arachnodactyly. PMID:28379158
Bactericidal Permeability-Increasing Proteins Shape Host-Microbe Interactions. PMID:28377525
SlpE is a calcium-dependent cytotoxic metalloprotease associated with clinical isolates of Serratia marcescens. PMID:28366837
TMPL: a database of experimental and theoretical transmembrane protein models positioned in the lipid bilayer. PMID:28365741
Allosteric modulation model of the mu opioid receptor by herkinorin, a potent not alkaloidal agonist. PMID:28364251
Electrostatic attraction of weak monoacid anions increases probability for protonation and passage through aquaporins. PMID:28360107
Homozygous p.(Glu87Lys) variant in ISCA1 is associated with a multiple mitochondrial dysfunctions syndrome. PMID:28356563
Heterologous biosynthesis and manipulation of crocetin in Saccharomyces cerevisiae. PMID:28356104
The toxicity of angiotensin converting enzyme inhibitors to larvae of the disease vectors Aedes aegypti and Anopheles gambiae. PMID:28345667
Protein interaction evolution from promiscuity to specificity with reduced flexibility in an increasingly complex network. PMID:28337996
Experimental recreation of the evolution of lignin-degrading enzymes from the Jurassic to date. PMID:28331543
Epigallocatechin Gallate Inhibits Macaque SEVI-Mediated Enhancement of SIV or SHIV Infection. PMID:28328549
Structure-based functional annotation of hypothetical proteins from Candida dubliniensis: a quest for potential drug targets. PMID:28324558
Negative allosteric regulation of Enterococcus faecalis small alarmone synthetase RelQ by single-stranded RNA. PMID:28320944
Novel fimbrilin PGN_1808 in Porphyromonas gingivalis. PMID:28296909
Antagonizing effects of membrane-acting androgens on the eicosanoid receptor OXER1 in prostate cancer. PMID:28290516
Role and convergent evolution of competing RNA secondary structures in mutually exclusive splicing. PMID:28277933
Computational Modeling of complete HOXB13 protein for predicting the functional effect of SNPs and the associated role in hereditary prostate cancer. PMID:28272408
An Eight-Residue Deletion in Escherichia coli FabG Causes Temperature-Sensitive Growth and Lipid Synthesis Plus Resistance to the Calmodulin Inhibitor Trifluoperazine. PMID:28264990
Structural Alteration of OmpR as a Source of Ertapenem Resistance in a CTX-M-15-Producing Escherichia coli O25b:H4 Sequence Type 131 Clinical Isolate. PMID:28264855
Comparative visualization of protein secondary structures. PMID:28251875
The Arabidopsis O-fucosyltransferase SPINDLY activates nuclear growth repressor DELLA. PMID:28244988
Molecular architecture of the 90S small subunit pre-ribosome. PMID:28244370
The Echinococcus canadensis (G7) genome: a key knowledge of parasitic platyhelminth human diseases. PMID:28241794
Experimental Evolution of Escherichia coli Harboring an Ancient Translation Protein. PMID:28233029
Bioinformatic Analysis Reveals Archaeal tRNATyr and tRNATrp Identities in Bacteria. PMID:28230768
A hydrophobic patch surrounding Trp154 in human neuroserpin controls the helix F dynamics with implications in inhibition and aggregation. PMID:28230174
A Novel Mutation in the Pyrin Domain of the NOD-like Receptor Family Pyrin Domain Containing Protein 3 in Muckle-Wells Syndrome. PMID:28229991
Anaplasma phagocytophilum Infection Subverts Carbohydrate Metabolic Pathways in the Tick Vector, Ixodes scapularis. PMID:28229048
Proteasome Activity Profiling Uncovers Alteration of Catalytic β2 and β5 Subunits of the Stress-Induced Proteasome during Salinity Stress in Tomato Roots. PMID:28217134
Ketoacylsynthase Domains of a Polyunsaturated Fatty Acid Synthase in Thraustochytrium sp. Strain ATCC 26185 Can Effectively Function as Stand-Alone Enzymes in Escherichia coli. PMID:28213537
Involvement of three putative glucosyltransferases from the UGT72 family in flavonol glucoside/rhamnoside biosynthesis in Lotus japonicus seeds. PMID:28204516
Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1. PMID:28191893
SEPIa, a knowledge-driven algorithm for predicting conformational B-cell epitopes from the amino acid sequence. PMID:28183272
Involvement of β-defensin 130 (DEFB130) in the macrophage microbicidal mechanisms for killing Plasmodium falciparum. PMID:28181499
Kinetics, subcellular localization, and contribution to parasite virulence of a Trypanosoma cruzi hybrid type A heme peroxidase (TcAPx-CcP). PMID:28179568
Identification of Novel Functions for Hepatitis C Virus Envelope Glycoprotein E1 in Virus Entry and Assembly. PMID:28179528
Nidovirus RNA polymerases: Complex enzymes handling exceptional RNA genomes. PMID:28174054
The structurally disordered paramyxovirus nucleocapsid protein tail domain is a regulator of the mRNA transcription gradient. PMID:28168220
Two Novel Fungal Phenolic UDP Glycosyltransferases from Absidia coerulea and Rhizopus japonicus. PMID:28159792
Molecular modeling of NK-CT1, from Indian monocellate cobra (Naja kaouthia) and its docking interaction with human DNA topoisomerase II alpha. PMID:28149043
Allelic Polymorphism Determines Surface Expression or Intracellular Retention of the Human NK Cell Receptor KIR2DL5A (CD158f). PMID:28144240
Ruxolitinib reverses dysregulated T helper cell responses and controls autoimmunity caused by a novel signal transducer and activator of transcription 1 (STAT1) gain-of-function mutation. PMID:28139313
Short stature and hypoparathyroidism in a child with Kenny-Caffey syndrome type 2 due to a novel mutation in FAM111A gene. PMID:28138333
Genomic and structural investigation on dolphin morbillivirus (DMV) in Mediterranean fin whales (Balaenoptera physalus). PMID:28134317
GRIN3B missense mutation as an inherited risk factor for schizophrenia: whole-exome sequencing in a family with a familiar history of psychotic disorders. PMID:28132660
The IDL of E. coli SSB links ssDNA and protein binding by mediating protein-protein interactions. PMID:28127816
STAC3 stably interacts through its C1 domain with CaV1.1 in skeletal muscle triads. PMID:28112192
Design, Synthesis and Antifungal Activity Evaluation of New Thiazolin-4-ones as Potential Lanosterol 14α-Demethylase Inhibitors. PMID:28106743
Homology modeling and molecular dynamics provide structural insights into tospovirus nucleoprotein. PMID:28105914
Construction of a novel lipolytic fusion biocatalyst GDEst-lip for industrial application. PMID:28105534
Molecular Characterization of Nippostrongylus brasiliensis (Nematoda: Heligmosomatidae) from Mus musculus in India. PMID:28095659
Structures of the Human HCN1 Hyperpolarization-Activated Channel. PMID:28086084
SSB and the RecG DNA helicase: an intimate association to rescue a stalled replication fork. PMID:28078722
Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome. PMID:28077875
Structure of a spliceosome remodelled for exon ligation. PMID:28076345
Biochemical and Structural Insights into a Novel Thermostable β-1,3-Galactosidase from Marinomonas sp. BSi20414. PMID:28075353
A Genomic and Protein-Protein Interaction Analyses of Nonsyndromic Hearing Impairment in Cameroon Using Targeted Genomic Enrichment and Massively Parallel Sequencing. PMID:28075205
O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies. PMID:28074064
Molecular and structural characteristics of multidrug resistance-associated protein 7 in Chinese liver fluke Clonorchis sinensis. PMID:28058535
Characterization of the Porphyromonas gingivalis Type IX Secretion Trans-envelope PorKLMNP Core Complex. PMID:28057754
Accurate De Novo Prediction of Protein Contact Map by Ultra-Deep Learning Model. PMID:28056090
The 24th annual Nucleic Acids Research database issue: a look back and upcoming changes. PMID:28053160
Identification and population history of CYP4V2 mutations in patients with Bietti crystalline corneoretinal dystrophy. PMID:28051075
Difference in NaCl tolerance of membrane-bound 5'-nucleotidases purified from deep-sea and brackish water Shewanella species. PMID:28050644
Widespread Historical Contingency in Influenza Viruses. PMID:28049709
Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death. PMID:28045099
Regulation of XIAP Turnover Reveals a Role for USP11 in Promotion of Tumorigenesis. PMID:28040451
SDH6 and SDH7 Contribute to Anchoring Succinate Dehydrogenase to the Inner Mitochondrial Membrane in Arabidopsis thaliana. PMID:28039307
Autographa californica Multiple Nucleopolyhedrovirus AC83 is a Per Os Infectivity Factor (PIF) Protein Required for Occlusion-Derived Virus (ODV) and Budded Virus Nucleocapsid Assembly as well as Assembly of the PIF Complex in ODV Envelopes. PMID:28031365
Human Neuronal Calcium Sensor-1 Protein Avoids Histidine Residues To Decrease pH Sensitivity. PMID:28030949
Redox Balance in Lactobacillus reuteri DSM20016: Roles of Iron-Dependent Alcohol Dehydrogenases in Glucose/ Glycerol Metabolism. PMID:28030590
Combined Whole-Cell High-Throughput Functional Screening for Identification of New Nicotinamidases/Pyrazinamidases in Metagenomic/Polygenomic Libraries. PMID:28018295
Selective evolution of Toll-like receptors 3, 7, 8, and 9 in bats. PMID:28013457
High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5. PMID:28012961
The ferredoxin-dependent glutamate synthase (OsFd-GOGAT) participates in leaf senescence and the nitrogen remobilization in rice. PMID:28012016
The DE and FG loops of the HPV major capsid protein contribute to the epitopes of vaccine-induced cross-neutralising antibodies. PMID:28004837
Contribution of target alteration, protection and efflux pump in achieving high ciprofloxacin resistance in Enterobacteriaceae. PMID:28004362
Angucycline antibiotic waldiomycin recognizes common structural motif conserved in bacterial histidine kinases. PMID:27999439
Trimeric gp120-specific bovine monoclonal antibodies require cysteine and aromatic residues in CDRH3 for high affinity binding to HIV Env. PMID:27996375
Stabilization of Nucleotide Binding Domain Dimers Rescues ABCC6 Mutants Associated with Pseudoxanthoma Elasticum. PMID:27994049
Conserved ABC Transport System Regulated by the General Stress Response Pathways of Alpha- and Gammaproteobacteria. PMID:27994018
The biosynthetic pathway of 2-azahypoxanthine in fairy-ring forming fungus. PMID:27991529
Metagenomic mining for thermostable esterolytic enzymes uncovers a new family of bacterial esterases. PMID:27991516
Functional Analysis of the Fusarielin Biosynthetic Gene Cluster. PMID:27983606
The Novel Membrane-Bound Proteins MFSD1 and MFSD3 are Putative SLC Transporters Affected by Altered Nutrient Intake. PMID:27981419
Characterization of an Immunodominant Epitope in the Endodomain of the Coronavirus Membrane Protein. PMID:27973413
Structural Basis for Regulation and Specificity of Fructooligosaccharide Import in Streptococcus pneumoniae. PMID:27939783
Functional and structural characterization of a novel putative cysteine protease cell wall-modifying multi-domain enzyme selected from a microbial metagenome. PMID:27934875
Oligomerization and chaperone-like activity of Drosophila melanogaster small heat shock protein DmHsp27 and three arginine mutants in the alpha-crystallin domain. PMID:27933579
Systematic site-directed mutagenesis of the Helicobacter pylori CagL protein of the Cag type IV secretion system identifies novel functional domains. PMID:27922023
Malate Synthase and β-Methylmalyl Coenzyme A Lyase Reactions in the Methylaspartate Cycle in Haloarcula hispanica. PMID:27920298
The Streptococcus gordonii Adhesin CshA Protein Binds Host Fibronectin via a Catch-Clamp Mechanism. PMID:27920201
New Insights into Molecular Organization of Human Neuraminidase-1: Transmembrane Topology and Dimerization Ability. PMID:27917893
A Venom Serpin Splicing Isoform of the Endoparasitoid Wasp Pteromalus puparum Suppresses Host Prophenoloxidase Cascade by Forming Complexes with Host Hemolymph Proteinases. PMID:27913622
Structure of the 70S ribosome from human pathogen Staphylococcus aureus. PMID:27906650
De Novo Pyrimidine Biosynthesis Connects Cell Integrity to Amphotericin B Susceptibility in Cryptococcus neoformans. PMID:27904878
In silico analysis of surface structure variation of PCV2 capsid resulting from loop mutations of its capsid protein (Cap). PMID:27902320
The SWISS-MODEL Repository-new features and functionality. PMID:27899672
Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain. PMID:27882919
Structure of protein O-mannose kinase reveals a unique active site architecture. PMID:27879205
Mechanism of cargo-directed Atg8 conjugation during selective autophagy. PMID:27879200
Computer-Aided Drug Design Methods. PMID:27873247
Molecular architecture of the yeast Elongator complex reveals an unexpected asymmetric subunit arrangement. PMID:27872205
Structure of the transmembrane domain of HIV-1 envelope glycoprotein. PMID:27868386
Integration of ruxolitinib into dose-intensified therapy targeted against a novel JAK2 F694L mutation in B-precursor acute lymphoblastic leukemia. PMID:27860260
PRIMO: An Interactive Homology Modeling Pipeline. PMID:27855192
Bioinformatics and Drug Discovery. PMID:27848897
Crystal Structure and Conformational Change Mechanism of a Bacterial Nramp-Family Divalent Metal Transporter. PMID:27839948
The tale of SSB. PMID:27838363
Insights from molecular structure predictions of the infectious bronchitis virus S1 spike glycoprotein. PMID:27836775
Differences in amino acid frequency in CagA and VacA sequences of Helicobacter pylori distinguish gastric cancer from gastric MALT lymphoma. PMID:27833662
Drosophila Enhancer of Rudimentary Homolog, ERH, Is a Binding Partner of RPS3, RPL19, and DDIT4, Suggesting a Mechanism for the Nuclear Localization of ERH. PMID:27830090
Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence. PMID:27827986
Cloning and expression of SgCYP450-4 from Siraitia grosvenorii. PMID:27818929
Structural Prediction and In Silico Physicochemical Characterization for Mouse Caltrin I and Bovine Caltrin Proteins. PMID:27812283
Complete structure of the bacterial flagellar hook reveals extensive set of stabilizing interactions. PMID:27811912
CD72 negatively regulates B lymphocyte responses to the lupus-related endogenous toll-like receptor 7 ligand Sm/RNP. PMID:27810925
Structural Insights into the Drosophila melanogaster Retinol Dehydrogenase, a Member of the Short-Chain Dehydrogenase/Reductase Family. PMID:27809489
Exploring Human Diseases and Biological Mechanisms by Protein Structure Prediction and Modeling. PMID:27807743
Looking for inhibitors of the dengue virus NS5 RNA-dependent RNA-polymerase using a molecular docking approach. PMID:27784988
GPCR and IR genes in Schistosoma mansoni miracidia. PMID:27784323
NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors. PMID:27782878
Structural Stability, Transitions, and Interactions within SoxYZCD-Thiosulphate from Sulfurimonas denitrificans: An In Silico Molecular Outlook for Maintaining Environmental Sulphur Cycle. PMID:27777586
Genome-Wide Analysis, Classification, Evolution, and Expression Analysis of the Cytochrome P450 93 Family in Land Plants. PMID:27760179
Characterization of Triticum aestivum Abscisic Acid Receptors and a Possible Role for These in Mediating Fusairum Head Blight Susceptibility in Wheat. PMID:27755583
Nanomechanical properties of MscL α helices: A steered molecular dynamics study. PMID:27753526
Structural characterization of the circadian clock protein complex composed of KaiB and KaiC by inverse contrast-matching small-angle neutron scattering. PMID:27752127
Barley Yellow Mosaic Virus VPg Is the Determinant Protein for Breaking eIF4E-Mediated Recessive Resistance in Barley Plants. PMID:27746794
Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex. PMID:27746017
Identification of the critical residues responsible for differential reactivation of the triosephosphate isomerases of two trypanosomes. PMID:27733588
The C-terminal dimerization motif of cyclase-associated protein is essential for actin monomer regulation. PMID:27729544
SARAH Domain-Mediated MST2-RASSF Dimeric Interactions. PMID:27716844
Identification of high-affinity anti-CD16A allotype-independent human antibody domains. PMID:27712994
Broad phylogeny and functionality of cellulosomal components in the bovine rumen microbiome. PMID:27712009
A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119. PMID:27708348
The Architecture of Trypanosoma brucei editosomes. PMID:27708162
Metabolomics and Cheminformatics Analysis of Antifungal Function of Plant Metabolites. PMID:27706030
Stargazin Modulation of AMPA Receptors. PMID:27705782
Structure of myosin filaments from relaxed Lethocerus flight muscle by cryo-EM at 6 Å resolution. PMID:27704041
PvdN Enzyme Catalyzes a Periplasmic Pyoverdine Modification. PMID:27703013
Ohgata, the Single Drosophila Ortholog of Human Cereblon, Regulates Insulin Signaling-dependent Organismic Growth. PMID:27702999
Three pairs of weak interactions precisely regulate the G-loop gate of Kir2.1 channel. PMID:27699887
X-ray structure of the human α4β2 nicotinic receptor. PMID:27698419
Cofactors-loaded quaternary structure of lysine-specific demethylase 5C (KDM5C) protein: Computational model. PMID:27696497
Redox-assisted regulation of Ca2+ homeostasis in the endoplasmic reticulum by disulfide reductase ERdj5. PMID:27694578
APSA Awardee Submission: Tumor/cancer stem cell marker doublecortin-like kinase 1 in liver diseases. PMID:27694285
Characterization of Two Monoclonal Antibodies That Recognize Linker Region and Carboxyl Terminal Domain of Coronavirus Nucleocapsid Protein. PMID:27689694
An Approach for Zika Virus Inhibition Using Homology Structure of the Envelope Protein. PMID:27683255
Rapid Electron Transfer within the III-IV Supercomplex in Corynebacterium glutamicum. PMID:27682138
Structural and Functional Characterization of a Ruminal β-Glycosidase Defines a Novel Subfamily of Glycoside Hydrolase Family 3 with Permuted Domain Topology. PMID:27679487
Selective activation of vascular Kv 7.4/Kv 7.5 K+ channels by fasudil contributes to its vasorelaxant effect. PMID:27677924
Data set for phylogenetic tree and RAMPAGE Ramachandran plot analysis of SODs in Gossypium raimondii and G. arboreum. PMID:27672674
Protein sequences bound to mineral surfaces persist into deep time. PMID:27668515
Induction of anti-EGFR immune response with mimotopes identified from a phage display peptide library by panitumumab. PMID:27659529
Clinically Significant Unclassified Variants in BRCA1 and BRCA2 genes among Korean Breast Cancer Patients. PMID:27658390
The Effectiveness of Natural Diarylheptanoids against Trypanosoma cruzi: Cytotoxicity, Ultrastructural Alterations and Molecular Modeling Studies. PMID:27658305
The Protective Effect against Extracellular Histones Afforded by Long-Pentraxin PTX3 as a Regulator of NETs. PMID:27656184
modPDZpep: a web resource for structure based analysis of human PDZ-mediated interaction networks. PMID:27655048
Cyclic di-GMP mediates a histidine kinase/phosphatase switch by noncovalent domain cross-linking. PMID:27652341
Structural basis for disruption of claudin assembly in tight junctions by an enterotoxin. PMID:27647526
Cloning, expression, and characterization of a peptidoglycan hydrolase from the Burkholderia pseudomallei phage ST79. PMID:27637947
Organization, Function, and Therapeutic Targeting of the Morbillivirus RNA-Dependent RNA Polymerase Complex. PMID:27626440
Protein Carbonylation of an Amino Acid Residue of the Na/K-ATPase α1 Subunit Determines Na/K-ATPase Signaling and Sodium Transport in Renal Proximal Tubular Cells. PMID:27613772
The genome of the largest bony fish, ocean sunfish (Mola mola), provides insights into its fast growth rate. PMID:27609345
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. PMID:27602946
PCP-B class pollen coat proteins are key regulators of the hydration checkpoint in Arabidopsis thaliana pollen-stigma interactions. PMID:27596924
Atomic structure of the entire mammalian mitochondrial complex I. PMID:27595392
HSAF-induced antifungal effects in Candida albicans through ROS-mediated apoptosis. PMID:27594989
Discovery of Novel Bacterial Cell-Penetrating Phylloseptins in Defensive Skin Secretions of the South American Hylid Frogs, Phyllomedusa duellmani and Phyllomedusa coelestis. PMID:27589802
OCT4 spliced variants are highly expressed in brain cancer tissues and inhibition of OCT4B1 causes G2/M arrest in brain cancer cells. PMID:27585657
The CXCL8-CXCR1/2 pathways in cancer. PMID:27578214
Genomic Analyses of Cladophialophora bantiana, a Major Cause of Cerebral Phaeohyphomycosis Provides Insight into Its Lifestyle, Virulence and Adaption in Host. PMID:27570972
In silico studies of the interaction between BRN2 protein and MORE DNA. PMID:27568376
Immobilization of LccC Laccase from Aspergillus nidulans on Hard Surfaces via Fungal Hydrophobins. PMID:27565614
Molecular and immunological characterization of cathepsin L-like cysteine protease of Paragonimus pseudoheterotremus. PMID:27562899
Corynebacterium diphtheriae HmuT: dissecting the roles of conserved residues in heme pocket stabilization. PMID:27561288
Molecular cloning and characterization of a novel freezing-inducible DREB1/CBF transcription factor gene in boreal plant Iceland poppy (Papaver nudicaule). PMID:27560992
A Family of Negative Regulators Targets the Committed Step of de Novo Fatty Acid Biosynthesis. PMID:27559025
High-specificity synthesis of novel monomers by remodeled alcohol hydroxylase. PMID:27557638
A mutagenic study identifying critical residues for the structure and function of rice manganese transporter OsMTP8.1. PMID:27555514
A functional BH3 domain in an aquaporin from Leishmania infantum. PMID:27551533
Disease-Homologous Mutation in the Cation Diffusion Facilitator Protein MamM Causes Single-Domain Structural Loss and Signifies Its Importance. PMID:27550551
Peptides from American alligator plasma are antimicrobial against multi-drug resistant bacterial pathogens including Acinetobacter baumannii. PMID:27542832
High-throughput screening for the identification of small-molecule inhibitors of the flaviviral protease. PMID:27539384
Structural photoactivation of a full-length bacterial phytochrome. PMID:27536728
Differential Roles for VviGST1, VviGST3, and VviGST4 in Proanthocyanidin and Anthocyanin Transport in Vitis vinífera. PMID:27536314
An Alkaline Protease from Bacillus pumilus MP 27: Functional Analysis of Its Binding Model toward Its Applications As Detergent Additive. PMID:27536284
Structural conservation in the template/pseudoknot domain of vertebrate telomerase RNA from teleost fish to human. PMID:27531956
Ultra-dense SNP genetic map construction and identification of SiDt gene controlling the determinate growth habit in Sesamum indicum L. PMID:27527492
Mapping N-linked glycosylation of carbohydrate-active enzymes in the secretome of Aspergillus nidulans grown on lignocellulose. PMID:27508003
Molecular Characterization of the 14-3-3 Gene Family in Brachypodium distachyon L. Reveals High Evolutionary Conservation and Diverse Responses to Abiotic Stresses. PMID:27507982
Conformational dynamics of cancer-associated MyD88-TIR domain mutant L252P (L265P) allosterically tilts the landscape toward homo-dimerization. PMID:27503954
Adaptive evolution of virus-sensing toll-like receptor 8 in bats. PMID:27502317
The structural basis of the dominant negative phenotype of the Gαi1β1γ2 G203A/A326S heterotrimer. PMID:27498775
Microscopic Characterization of Membrane Transporter Function by In Silico Modeling and Simulation. PMID:27497175
The Lp_3561 and Lp_3562 Enzymes Support a Functional Divergence Process in the Lipase/Esterase Toolkit from Lactobacillus plantarum. PMID:27486450
Comparative and evolutionary analysis of α-amylase gene across monocots and dicots. PMID:27481351
Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation. PMID:27478928
Whole genome sequencing identifies ANXA3 and MTHFR mutations in a large family with an unknown equinus deformity associated genetic disorder. PMID:27475959
Diaphragmatic Eventration in Sisters with Asparagine Synthetase Deficiency: A Novel Homozygous ASNS Mutation and Expanded Phenotype. PMID:27469131
Validation of a multi-omics strategy for prioritizing personalized candidate driver genes. PMID:27469031
The 3-D Structural Basis for the Pgi Genotypic Differences in the Performance of the Butterfly Melitaea cinxia at Different Temperatures. PMID:27462709
Cryo-EM structure of the spliceosome immediately after branching. PMID:27459055
Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity. PMID:27457813
Co-evolution of SNF spliceosomal proteins with their RNA targets in trans-splicing nematodes. PMID:27450547
The matrix gene of influenza A H5N1 in Egypt, 2006-2016: molecular insights and distribution of amantadine-resistant variants. PMID:27448682
Neisserial Opa Protein-CEACAM Interactions: Competition for Receptors as a Means of Bacterial Invasion and Pathogenesis. PMID:27442026
Structural study of the G57W mutant of human gamma-S-crystallin, associated with congenital cataract. PMID:27440995
EctD-mediated biotransformation of the chemical chaperone ectoine into hydroxyectoine and its mechanosensitive channel-independent excretion. PMID:27439307
Reciprocal genomic evolution in the ant-fungus agricultural symbiosis. PMID:27436133
Lupin Peptides Modulate the Protein-Protein Interaction of PCSK9 with the Low Density Lipoprotein Receptor in HepG2 Cells. PMID:27424515
Amyotrophic Lateral Sclerosis Type 20 - In Silico Analysis and Molecular Dynamics Simulation of hnRNPA1. PMID:27414033
Osmoadaptative Strategy and Its Molecular Signature in Obligately Halophilic Heterotrophic Protists. PMID:27412608
Functional conservation and diversification of the soybean maturity gene E1 and its homologs in legumes. PMID:27405888
Genomic characterization of plant cell wall degrading enzymes and in silico analysis of xylanases and polygalacturonases of Fusarium virguliforme. PMID:27405320
Insights into Brain Glycogen Metabolism: THE STRUCTURE OF HUMAN BRAIN GLYCOGEN PHOSPHORYLASE. PMID:27402852
Identification, Functional Characterization and Regulon Prediction of a Novel Two Component System Comprising BAS0540-BAS0541 of Bacillus anthracis. PMID:27392063
Exome sequencing identifies highly recurrent somatic GATA2 and CEBPA mutations in acute erythroid leukemia. PMID:27389056
Discovery of new cellulases from the metagenome by a metagenomics-guided strategy. PMID:27382415
Reconstruction of the High-Osmolarity Glycerol (HOG) Signaling Pathway from the Halophilic Fungus Wallemia ichthyophaga in Saccharomyces cerevisiae. PMID:27379041
Germline viral "fossils" guide in silico reconstruction of a mid-Cenozoic era marsupial adeno-associated virus. PMID:27377618
The Sam68 nuclear body is composed of two RNase-sensitive substructures joined by the adaptor HNRNPL. PMID:27377249
Alteramide B is a microtubule antagonist of inhibiting Candida albicans. PMID:27373684
Structural Features and Functional Dependency on β-Clamp Define Distinct Subfamilies of Bacterial Mismatch Repair Endonuclease MutL. PMID:27369079
Elucidation of AMPA receptor-stargazin complexes by cryo-electron microscopy. PMID:27365450
Three duplication events and variable molecular evolution characteristics involved in multiple GGPS genes of six Solanaceae species. PMID:27350691
Nipah virus matrix protein: expert hacker of cellular machines. PMID:27350027
ICP35 Is a TREX-Like Protein Identified in White Spot Syndrome Virus. PMID:27348862
Structural basis of potent Zika-dengue virus antibody cross-neutralization. PMID:27338953
A study of the mutational landscape of pediatric-type follicular lymphoma and pediatric nodal marginal zone lymphoma. PMID:27338637
Molecular Cloning of HbPR-1 Gene from Rubber Tree, Expression of HbPR-1 Gene in Nicotiana benthamiana and Its Inhibition of Phytophthora palmivora. PMID:27337148
Cloning, molecular characterization, and expression analysis of the unc45 myosin chaperone b(unc45b)gene of grass carp (Ctenopharyngodon idellus). PMID:27334505
The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels. PMID:27329693
Structure-based virtual screening of hypothetical inhibitors of the enzyme longiborneol synthase-a potential target to reduce Fusarium head blight disease. PMID:27324634
Heparanase Activates Antithrombin through the Binding to Its Heparin Binding Site. PMID:27322195
Crystal structure of linoleate 13R-manganese lipoxygenase in complex with an adhesion protein. PMID:27313058
Molecular classification based on apomorphic amino acids (Arthropoda, Hexapoda): Integrative taxonomy in the era of phylogenomics. PMID:27312960
Predicting Zika virus structural biology: Challenges and opportunities for intervention. PMID:27296393
Genome sequence of Perigonia lusca single nucleopolyhedrovirus: insights into the evolution of a nucleotide metabolism enzyme in the family Baculoviridae. PMID:27273152
Horizontal gene transfer events reshape the global landscape of arm race between viruses and homo sapiens. PMID:27270140
Systematic Targeting of Protein-Protein Interactions. PMID:27267699
Structure and mechanism of assembly line polyketide synthases. PMID:27266330
Plasmodium falciparum Hep1 Is Required to Prevent the Self Aggregation of PfHsp70-3. PMID:27253881
Ionotropic Receptors Identified within the Tentacle of the Freshwater Snail Biomphalaria glabrata, an Intermediate Host of Schistosoma mansoni. PMID:27253696
Expression and Characterization of a Novel Glycerophosphodiester Phosphodiesterase from Pyrococcus furiosus DSM 3638 That Possesses Lysophospholipase D Activity. PMID:27248999
Identification of variants in MBNL1 in patients with a myotonic dystrophy-like phenotype. PMID:27222292
Computational Framework for Prediction of Peptide Sequences That May Mediate Multiple Protein Interactions in Cancer-Associated Hub Proteins. PMID:27218803
VNAR single-domain antibodies specific for BAFF inhibit B cell development by molecular mimicry. PMID:27213814
Defining the SUMO System in Maize: SUMOylation Is Up-Regulated during Endosperm Development and Rapidly Induced by Stress. PMID:27208252
C-Terminal Region of Sulfite Reductase Is Important to Localize to Chloroplast Nucleoids in Land Plants. PMID:27189994
What Characteristics Confer Proteins the Ability to Induce Allergic Responses? IgE Epitope Mapping and Comparison of the Structure of Soybean 2S Albumins and Ara h 2. PMID:27187334
Norovirus (NoV) specific protective immune responses induced by recombinant P dimer vaccine are enhanced by the mucosal adjuvant FlaB. PMID:27184355
Visualizing ensembles in structural biology. PMID:27179343
Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits. PMID:27161536
The Quantum Nature of Drug-Receptor Interactions: Deuteration Changes Binding Affinities for Histamine Receptor Ligands. PMID:27159606
A novel heterozygous mutation in cardiac calsequestrin causes autosomal dominant catecholaminergic polymorphic ventricular tachycardia. PMID:27157848
Independent Evolution of Six Families of Halogenating Enzymes. PMID:27153321
RNA helicase SACY-1 is required for longevity caused by various genetic perturbations in Caenorhabditis elegans. PMID:27153157
The TatD-like DNase of Plasmodium is a virulence factor and a potential malaria vaccine candidate. PMID:27151551
The Cell Surface Receptor CD44: NMR-Based Characterization of Putative Ligands. PMID:27144715
Open drug discovery for the Zika virus. PMID:27134728
Identification of (Z)-3:(E)-2-Hexenal Isomerases Essential to the Production of the Leaf Aldehyde in Plants. PMID:27129773
Tighter Control by Chymotrypsin C (CTRC) Explains Lack of Association between Human Anionic Trypsinogen and Hereditary Pancreatitis. PMID:27129265
In Vivo Selection Yields AAV-B1 Capsid for Central Nervous System and Muscle Gene Therapy. PMID:27117222
High-resolution mapping of a novel rat blood pressure locus on chromosome 9 to a region containing the Spp2 gene and colocalization of a QTL for bone mass. PMID:27113531
Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity. PMID:27111144
Rational Design of Disulfide Bonds Increases Thermostability of a Mesophilic 1,3-1,4-β-Glucanase from Bacillus terquilensis. PMID:27100881
ProViz-a web-based visualization tool to investigate the functional and evolutionary features of protein sequences. PMID:27085803
Genome-wide analysis and expression profiling of glyoxalase gene families in soybean (Glycine max) indicate their development and abiotic stress specific response. PMID:27083416
Integrating Genomics Into Clinical Pediatric Oncology Using the Molecular Tumor Board at the Memorial Sloan Kettering Cancer Center. PMID:27082517
Bioinformatics and Molecular Analysis of the Evolutionary Relationship between Bovine Rhinitis A Viruses and Foot-And-Mouth Disease Virus. PMID:27081310
Synergistic Modification Induced Specific Recognition between Histone and TRIM24 via Fluctuation Correlation Network Analysis. PMID:27079666
Replenishing the cyclic-di-AMP pool: regulation of diadenylate cyclase activity in bacteria. PMID:27074767
The dynamic organization of fungal acetyl-CoA carboxylase. PMID:27073141
A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation. PMID:27066836
Mps1 (Monopolar Spindle 1) Protein Inhibition Affects Cellular Growth and Pro-Embryogenic Masses Morphology in Embryogenic Cultures of Araucaria angustifolia (Araucariaceae). PMID:27064899
Mechanism of NMDA Receptor Inhibition and Activation. PMID:27062927
Defining the roles for Vpr in HIV-1-associated neuropathogenesis. PMID:27056720
Genome-wide mitochondrial DNA sequence variations and lower expression of OXPHOS genes predict mitochondrial dysfunction in oral cancer tissue. PMID:27055661
Pseudomonas aeruginosa phage PaP1 DNA polymerase is an A-family DNA polymerase demonstrating ssDNA and dsDNA 3'-5' exonuclease activity. PMID:27052734
Dual Acting Neuraminidase Inhibitors Open New Opportunities to Disrupt the Lethal Synergism between Streptococcus pneumoniae and Influenza Virus. PMID:27047471
Structural Analysis of the Myo1c and Neph1 Complex Provides Insight into the Intracellular Movement of Neph1. PMID:27044863
Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism. PMID:27043298
Recessive Inactivating Mutations in TBCK, Encoding a Rab GTPase-Activating Protein, Cause Severe Infantile Syndromic Encephalopathy. PMID:27040692
Phylogenetic analysis of β-xylanase SRXL1 of Sporisorium reilianum and its relationship with families (GH10 and GH11) of Ascomycetes and Basidiomycetes. PMID:27040368
Identification and Assessment of the Potential Allergenicity of 7S Vicilins in Olive (Olea europaea L.) Seeds. PMID:27034939
In Silico Approach for SAR Analysis of the Predicted Model of DEPDC1B: A Novel Target for Oral Cancer. PMID:27034663
Oligomerization as a strategy for cold adaptation: Structure and dynamics of the GH1 β-glucosidase from Exiguobacterium antarcticum B7. PMID:27029646
Crystal Structure of Human Myotubularin-Related Protein 1 Provides Insight into the Structural Basis of Substrate Specificity. PMID:27018598
Sequencing the GRHL3 Coding Region Reveals Rare Truncating Mutations and a Common Susceptibility Variant for Nonsyndromic Cleft Palate. PMID:27018475
Genomic Insight into the Host-Endosymbiont Relationship of Endozoicomonas montiporae CL-33(T) with its Coral Host. PMID:27014194
Both Epistasis and Diversifying Selection Drive the Structural Evolution of the Ebola Virus Glycoprotein Mucin-Like Domain. PMID:27009964
Structure of promoter-bound TFIID and model of human pre-initiation complex assembly. PMID:27007846
A simple method for studying the molecular mechanisms of ultraviolet and violet reception in vertebrates. PMID:27001075
SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture. PMID:26999736
Mechanism of Germacradien-4-ol Synthase-Controlled Water Capture. PMID:26998816
Targeted Genes Sequencing Identified a Novel 15 bp Deletion on GJA8 in a Chinese Family with Autosomal Dominant Congenital Cataracts. PMID:26996484
Exclusion of small terminase mediated DNA threading models for genome packaging in bacteriophage T4. PMID:26984529
Whole-Genome Identification, Phylogeny, and Evolution of the Cytochrome P450 Family 2 (CYP2) Subfamilies in Birds. PMID:26979796
Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases. PMID:26976449
Two highly similar LAEDDTNAQKT and LTDKIGTEI epitopes in G glycoprotein may be useful for effective epitope based vaccine design against pathogenic Henipavirus. PMID:26970211
Allantoin transport protein, PucI, from Bacillus subtilis: evolutionary relationships, amplified expression, activity and specificity. PMID:26967546
Ion Channel Function and Cross-Species Determinants in Viral Assembly of Nonprimate Hepacivirus p7. PMID:26962224
Functional Transplant of a Dengue Virus Serotype 3 (DENV3)-Specific Human Monoclonal Antibody Epitope into DENV1. PMID:26962223
NETTAB 2014: From high-throughput structural bioinformatics to integrative systems biology. PMID:26960985
The Most Prevalent Freeman-Sheldon Syndrome Mutations in the Embryonic Myosin Motor Share Functional Defects. PMID:26945064
New insights into the roles of the N-terminal region of the ABCC6 transporter. PMID:26942607
A Heterologous Multiepitope DNA Prime/Recombinant Protein Boost Immunisation Strategy for the Development of an Antiserum against Micrurus corallinus (Coral Snake) Venom. PMID:26938217
Statistical prediction of protein structural, localization and functional properties by the analysis of its fragment mass distributions after proteolytic cleavage. PMID:26924271
Genome-Wide Identification of Mitogen-Activated Protein Kinase Gene Family across Fungal Lineage Shows Presence of Novel and Diverse Activation Loop Motifs. PMID:26918378
CRISPR/Cas9-mediated GJA8 knockout in rabbits recapitulates human congenital cataracts. PMID:26912477
cDNA sequence and protein bioinformatics analyses of MSTN in African catfish (Clarias gariepinus). PMID:26912268
Evolutionary Dynamics of Floral Homeotic Transcription Factor Protein-Protein Interactions. PMID:26908583
The Proliferating Cell Nuclear Antigen (PCNA)-interacting Protein (PIP) Motif of DNA Polymerase η Mediates Its Interaction with the C-terminal Domain of Rev1. PMID:26903512
A novel mutation in TRPV3 gene causes atypical familial Olmsted syndrome. PMID:26902751
Sequence Requirements for Neuropilin-2 Recognition by ST8SiaIV and Polysialylation of Its O-Glycans. PMID:26884342
Product Rearrangement from Altering a Single Residue in the Rice syn-Copalyl Diphosphate Synthase. PMID:26878189
The next generation of metastatic melanoma: uncovering the genetic variants for anti-BRAF therapy response. PMID:26863566
Identification and Characterization of IgdE, a Novel IgG-degrading Protease of Streptococcus suis with Unique Specificity for Porcine IgG. PMID:26861873
WrpA Is an Atypical Flavodoxin Family Protein under Regulatory Control of the Brucella abortus General Stress Response System. PMID:26858101
Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation. PMID:26854665
A trehalase from Zunongwangia sp.: characterization and improving catalytic efficiency by directed evolution. PMID:26822136
Comparative genome-wide analysis and evolutionary history of haemoglobin-processing and haem detoxification enzymes in malarial parasites. PMID:26821618
Systems-Wide Prediction of Enzyme Promiscuity Reveals a New Underground Alternative Route for Pyridoxal 5'-Phosphate Production in E. coli. PMID:26821166
Autosomal-Recessive Hearing Impairment Due to Rare Missense Variants within S1PR2. PMID:26805784
The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes. PMID:26792178
Evolution of the Plant Reproduction Master Regulators LFY and the MADS Transcription Factors: The Role of Protein Structure in the Evolutionary Development of the Flower. PMID:26779227
Characterization of a New M13 Metallopeptidase from Deep-Sea Shewanella sp. E525-6 and Mechanistic Insight into Its Catalysis. PMID:26779153
Characterization of the First α-(1→3) Branching Sucrases of the GH70 Family. PMID:26763236
Critical Molecular Determinants of α7 Nicotinic Acetylcholine Receptor Allosteric Activation: SEPARATION OF DIRECT ALLOSTERIC ACTIVATION AND POSITIVE ALLOSTERIC MODULATION. PMID:26742843
Creation of chimeric human/rabbit APOBEC1 with HIV-1 restriction and DNA mutation activities. PMID:26738439
Redirection of the Reaction Specificity of a Thermophilic Acetolactate Synthase toward Acetaldehyde Formation. PMID:26731734
Evaluation of a DLA-79 allele associated with multiple immune-mediated diseases in dogs. PMID:26711123
Structural Evolution of the Emerging 2014-2015 GII.17 Noroviruses. PMID:26699640
Analysis of the interaction between host factor Sam68 and viral elements during foot-and-mouth disease virus infections. PMID:26695943
Protein Structure and Function Prediction Using I-TASSER. PMID:26678386
The Potential Mutation of GAK Gene in the Typical Sporadic Parkinson's Disease from the Han Population of Chinese Mainland. PMID:26676575
Purification, Cloning and Immuno-Biochemical Characterization of a Fungal Aspartic Protease Allergen Rhi o 1 from the Airborne Mold Rhizopus oryzae. PMID:26672984
Functional prediction of hypothetical proteins in human adenoviruses. PMID:26664031
Missense mutations in progranulin gene associated with frontotemporal lobar degeneration: study of pathogenetic features. PMID:26652843
Signal transduction in light-oxygen-voltage receptors lacking the adduct-forming cysteine residue. PMID:26648256
Structural Insight into How Bacteria Prevent Interference between Multiple Divergent Type IV Secretion Systems. PMID:26646013
Dimerization of the SP1 Region of HIV-1 Gag Induces a Helical Conformation and Association into Helical Bundles: Implications for Particle Assembly. PMID:26637452
Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Parallelism at the Molecular Sequence Level. PMID:26637114
Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:26634371
Engineering a novel glucose-tolerant β-glucosidase as supplementation to enhance the hydrolysis of sugarcane bagasse at high glucose concentration. PMID:26628916
Targeted silencing of the Aquaporin 2 gene of Rhipicephalus (Boophilus) microplus reduces tick fitness. PMID:26626727
The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases. PMID:26615188
Genomic and evolutionary inferences between American and global strains of porcine epidemic diarrhea virus. PMID:26611651
A mechanism of glucose tolerance and stimulation of GH1 β-glucosidases. PMID:26603650
Boramino acid as a marker for amino acid transporters. PMID:26601275
Characterizing non-hydrolyzing Neisseria meningitidis serogroup A UDP-N-acetylglucosamine (UDP-GlcNAc) 2-epimerase using UDP-N-acetylmannosamine (UDP-ManNAc) and derivatives. PMID:26598987
The peptide agonist-binding site of the glucagon-like peptide-1 (GLP-1) receptor based on site-directed mutagenesis and knowledge-based modelling. PMID:26598711
Regulation of a Protein Acetyltransferase in Myxococcus xanthus by the Coenzyme NADP. PMID:26598367
Structural Studies of Geosmin Synthase, a Bifunctional Sesquiterpene Synthase with αα Domain Architecture That Catalyzes a Unique Cyclization-Fragmentation Reaction Sequence. PMID:26598179
The activity of protein phosphatase 5 towards native clients is modulated by the middle- and C-terminal domains of Hsp90. PMID:26593036
The N-terminal Helical Region of the Hepatitis C Virus p7 Ion Channel Protein Is Critical for Infectious Virus Production. PMID:26588073
The Relay/Converter Interface Influences Hydrolysis of ATP by Skeletal Muscle Myosin II. PMID:26586917
Lignocellulose degradation mechanisms across the Tree of Life. PMID:26583519
Structural basis for antagonizing a host restriction factor by C7 family of poxvirus host-range proteins. PMID:26578811
Interaction of the N-(3-Methylpyridin-2-yl)amide Derivatives of Flurbiprofen and Ibuprofen with FAAH: Enantiomeric Selectivity and Binding Mode. PMID:26565710
Cross-linking immunoprecipitation-MS (xIP-MS): Topological Analysis of Chromatin-associated Protein Complexes Using Single Affinity Purification. PMID:26560067
Guanine nucleotide binding to the Bateman domain mediates the allosteric inhibition of eukaryotic IMP dehydrogenases. PMID:26558346
Identification of a Novel Di-D-Fructofuranose 1,2':2,3' Dianhydride (DFA III) Hydrolysis Enzyme from Arthrobacter aurescens SK8.001. PMID:26555784
Gene Mutation Analysis in 253 Chinese Children with Unexplained Epilepsy and Intellectual/Developmental Disabilities. PMID:26544041
Functional characterization of a yellow laccase from Leucoagaricus gongylophorus. PMID:26543788
HOXB9 induction of mesenchymal-to-epithelial transition in gastric carcinoma is negatively regulated by its hexapeptide motif. PMID:26536658
Biophysical Studies of Bacterial Topoisomerases Substantiate Their Binding Modes to an Inhibitor. PMID:26536273
Identification and Characterization of the Interaction Site between cFLIPL and Calmodulin. PMID:26529318
Identification and Characterization of a New 7-Aminocephalosporanic Acid Deacetylase from Thermophilic Bacterium Alicyclobacillus tengchongensis. PMID:26527640
A bioinformatic survey of RNA-binding proteins in Plasmodium. PMID:26525978
Non-classical amine recognition evolved in a large clade of olfactory receptors. PMID:26519734
Evaluation of the Conformational Stability of Recombinant Desulfurizing Enzymes from a Newly Isolated Rhodococcus sp. PMID:26515071
Understanding the fabric of protein crystals: computational classification of biological interfaces and crystal contacts. PMID:26508758
Phylogenomics and sequence-structure-function relationships in the GmrSD family of Type IV restriction enzymes. PMID:26493560
Mixed-mode resins: taking shortcut in downstream processing of raw-starch digesting α-amylases. PMID:26492875
A Naturally Occurring Domestic Cat APOBEC3 Variant Confers Resistance to Feline Immunodeficiency Virus Infection. PMID:26491161
A Nucleolar PUF RNA-binding Protein with Specificity for a Unique RNA Sequence. PMID:26487722
Inhibition on JAK-STAT3 Signaling Transduction Cascade Is Taken by Bioactive Peptide Alpha-S2 Casein Protein from Goat Ethawah Breed Milk. PMID:26483598
Molecular pathogenesis of H5 highly pathogenic avian influenza: the role of the haemagglutinin cleavage site motif. PMID:26467906
Structural and functional features of a developmentally regulated lipopolysaccharide-binding protein. PMID:26463160
Contribution of a mutational hot spot to hemoglobin adaptation in high-altitude Andean house wrens. PMID:26460028
Structure of the response regulator RPA3017 involved in red-light signaling in Rhodopseudomonas palustris. PMID:26457509
Biochemical Characterization and Substrate Specificity of Autophagin-2 from the Parasite Trypanosoma cruzi. PMID:26446788
A Functional EXXEK Motif is Essential for Proton Coupling and Active Glucosinolate Transport by NPF2.11. PMID:26443378
Long-term survival of Borrelia burgdorferi lacking the hibernation promotion factor homolog in the unfed tick vector. PMID:26438790
Peroxiredoxin 6 from the Antarctic emerald rockcod: molecular characterization of its response to warming. PMID:26433650
Divergence and adaptive evolution of the gibberellin oxidase genes in plants. PMID:26416509
Structural analysis of tumor-related single amino acid mutations in human MxA protein. PMID:26411585
Bioinformatic characterization of glycyl radical enzyme-associated bacterial microcompartments. PMID:26407889
Independent Mechanisms Target SMCHD1 to Trimethylated Histone H3 Lysine 9-Modified Chromatin and the Inactive X Chromosome. PMID:26391951
Characterization and directed evolution of a methyl-binding domain protein for high-sensitivity DNA methylation analysis. PMID:26384511
Epigallocatechin gallate affects glucose metabolism and increases fitness and lifespan in Drosophila melanogaster. PMID:26375250
Identification by Random Mutagenesis of Functional Domains in KREPB5 That Differentially Affect RNA Editing between Life Cycle Stages of Trypanosoma brucei. PMID:26370513
Structure and Mechanism of a Viral Collagen Prolyl Hydroxylase. PMID:26368022
A Cell-based Fluorescence Resonance Energy Transfer (FRET) Sensor Reveals Inter- and Intragenogroup Variations in Norovirus Protease Activity and Polyprotein Cleavage. PMID:26363064
Inhibition of elongin C promotes longevity and protein homeostasis via HIF-1 in C. elegans. PMID:26361075
Growth-Phase-Specific Modulation of Cell Morphology and Gene Expression by an Archaeal Histone Protein. PMID:26350964
Epitopes in α8β1 and other RGD-binding integrins delineate classes of integrin-blocking antibodies and major binding loops in α subunits. PMID:26349930
The Structural Characterization of Tumor Fusion Genes and Proteins. PMID:26347798
Phosphorylation at serine 52 and 635 does not alter the transport properties of glucosinolate transporter AtGTR1. PMID:26340317
Streamlined Construction of the Cyanobacterial CO2-Fixing Organelle via Protein Domain Fusions for Use in Plant Synthetic Biology. PMID:26320224
YjeH Is a Novel Exporter of l-Methionine and Branched-Chain Amino Acids in Escherichia coli. PMID:26319875
Structural Basis for Substrate Specificity in Adenosylcobalamin-dependent Isobutyryl-CoA Mutase and Related Acyl-CoA Mutases. PMID:26318610
Characterization of the Role of β-Carotene 9,10-Dioxygenase in Macular Pigment Metabolism. PMID:26307071
Differential Editosome Protein Function between Life Cycle Stages of Trypanosoma brucei. PMID:26304125
Eﬄux-mediated resistance to a benzothiadiazol derivative effective against Burkholderia cenocepacia. PMID:26300878
Cardiolipin Interactions with Proteins. PMID:26300339
Assessing the genetic diversity of Cu resistance in mine tailings through high-throughput recovery of full-length copA genes. PMID:26286020
A Newly-Identified Polymorphism in Rhesus Macaque Complement Factor H Modulates Binding Affinity for Meningococcal FHbp. PMID:26285122
Functional properties and structural characterization of rice δ(1)-pyrroline-5-carboxylate reductase. PMID:26284087
Matrix Metalloproteinase (MMP) Proteolysis of the Extracellular Loop of Voltage-gated Sodium Channels and Potential Alterations in Pain Signaling. PMID:26283785
Crucial role of the orexin-B C-terminus in the induction of OX1 receptor-mediated apoptosis: analysis by alanine scanning, molecular modelling and site-directed mutagenesis. PMID:26282891
Characterization of the Catalytic Domain of Human APOBEC3B and the Critical Structural Role for a Conserved Methionine. PMID:26281709
Identification, Phylogeny, and Function of fabp2 Paralogs in Two Non-Model Teleost Fish Species. PMID:26272429
Structure of α-carbonic anhydrase from the human pathogen Helicobacter pylori. PMID:26249690
The Evolution of the Secreted Regulatory Protein Progranulin. PMID:26248158
Functionality of Class A and Class B J-protein co-chaperones with Hsp70. PMID:26247431
Two Novel NYX Gene Mutations in the Chinese Families with X-linked Congenital Stationary Night Blindness. PMID:26234941
Identification of two novel critical mutations in PCNT gene resulting in microcephalic osteodysplastic primordial dwarfism type II associated with multiple intracranial aneurysms. PMID:26231886
Evidence of Positive Selection of Aquaporins Genes from Pontoporia blainvillei during the Evolutionary Process of Cetaceans. PMID:26226365
Study of the Binding Energies between Unnatural Amino Acids and Engineered Orthogonal Tyrosyl-tRNA Synthetases. PMID:26220470
Molecular basis of claudin-17 anion selectivity. PMID:26194246
Identification of interleukin-26 in the dromedary camel (Camelus dromedarius): Evidence of alternative splicing and isolation of novel splice variants. PMID:26190308
Mutations Affecting Keratin 10 Surface-Exposed Residues Highlight the Structural Basis of Phenotypic Variation in Epidermolytic Ichthyosis. PMID:26176760
Identification, mRNA expression profiling and activity characterization of cathepsin L from red drum (Sciaenops ocellatus). PMID:26164862
Against All Odds: Trehalose-6-Phosphate Synthase and Trehalase Genes in the Bdelloid Rotifer Adineta vaga Were Acquired by Horizontal Gene Transfer and Are Upregulated during Desiccation. PMID:26161530
Enhancement of E. coli acyl-CoA synthetase FadD activity on medium chain fatty acids. PMID:26157619
Known structure, unknown function: An inquiry-based undergraduate biochemistry laboratory course. PMID:26148241
Identification and Characterization of 40 Isolated Rehmannia glutinosa MYB Family Genes and Their Expression Profiles in Response to Shading and Continuous Cropping. PMID:26147429
AVP-NPII gene mutations and clinical characteristics of the patients with autosomal dominant familial central diabetes insipidus. PMID:26134705
Staphylococcus aureus PerR Is a Hypersensitive Hydrogen Peroxide Sensor using Iron-mediated Histidine Oxidation. PMID:26134568
Manganese lipoxygenase of F. oxysporum and the structural basis for biosynthesis of distinct 11-hydroperoxy stereoisomers. PMID:26113537
Identification and characterization of a HEPN-MNT family type II toxin-antitoxin in Shewanella oneidensis. PMID:26112399
Post-translationally-modified structures in the autophagy machinery: an integrative perspective. PMID:26108642
In Silico Prediction and Experimental Confirmation of HA Residues Conferring Enhanced Human Receptor Specificity of H5N1 Influenza A Viruses. PMID:26091504
Non-syndromic hearing loss caused by the dominant cis mutation R75Q with the recessive mutation V37I of the GJB2 (Connexin 26) gene. PMID:26088551
A Three-protein Charge Zipper Stabilizes a Complex Modulating Bacterial Gene Silencing. PMID:26085102
Identification of amino acids involved in histamine potentiation of GABA A receptors. PMID:26074818
Molecular Evolutionary Analysis of β-Defensin Peptides in Vertebrates. PMID:26056425
New Insights into the Coupling between Microtubule Depolymerization and ATP Hydrolysis by Kinesin-13 Protein Kif2C. PMID:26055718
Probing the Biology of Giardia intestinalis Mitosomes Using In Vivo Enzymatic Tagging. PMID:26055323
In silico identification of AMPylating enzymes and study of their divergent evolution. PMID:26039278
Identification of a putative quantitative trait nucleotide in guanylate binding protein 5 for host response to PRRS virus infection. PMID:26016888
Water-soluble chlorophyll protein is involved in herbivore resistance activation during greening of Arabidopsis thaliana. PMID:26016527
Molecular interactions of the Saccharomyces cerevisiae Atg1 complex provide insights into assembly and regulatory mechanisms. PMID:25998554
Bioinformatical analysis of the sequences, structures and functions of fungal polyketide synthase product template domains. PMID:25995122
Structural Insights into Substrate Specificity of Feruloyl-CoA 6'-Hydroxylase from Arabidopsis thaliana. PMID:25993561
ATP-dependent Conformational Changes Trigger Substrate Capture and Release by an ECF-type Biotin Transporter. PMID:25991724
A New Family of HEAT-Like Repeat Proteins Lacking a Critical Substrate Recognition Motif Present in Related DNA Glycosylases. PMID:25978435
Arg(1809) substitution in neurofibromin: further evidence of a genotype-phenotype correlation in neurofibromatosis type 1. PMID:25966637
NGL Viewer: a web application for molecular visualization. PMID:25925569
MJD and OTU deubiquitinating enzymes in Schistosoma mansoni. PMID:25924794
Dissecting the fungal biology of Bipolaris papendorfii: from phylogenetic to comparative genomic analysis. PMID:25922537
Incorporation of Peptides Targeting EGFR and FGFR1 into the Adenoviral Fiber Knob Domain and Their Evaluation as Targeted Cancer Therapies. PMID:25919378
A Moonlighting Human Protein Is Involved in Mitochondrial Import of tRNA. PMID:25918939
Identification and functional characterization of the CYP51 gene from the yeast Xanthophyllomyces dendrorhous that is involved in ergosterol biosynthesis. PMID:25906980
Characterization of the Ubiquitin-Conjugating Enzyme Gene Family in Rice and Evaluation of Expression Profiles under Abiotic Stresses and Hormone Treatments. PMID:25902049
RBO Aleph: leveraging novel information sources for protein structure prediction. PMID:25897112
The exchanged EF-hands in calmodulin and troponin C chimeras impair the Ca²⁺-induced hydrophobicity and alter the interaction with Orai1: a spectroscopic, thermodynamic and kinetic study. PMID:25888318
Expression of the Thermobifida fusca xylanase Xyn11A in Pichia pastoris and its characterization. PMID:25887328
Comparative analysis of cystatin superfamily in platyhelminths. PMID:25853513
Increased efficiency of Campylobacter jejuni N-oligosaccharyltransferase PglB by structure-guided engineering. PMID:25833378
Chlorotoxin: a helpful natural scorpion peptide to diagnose glioma and fight tumor invasion. PMID:25826056
The class III cyclobutane pyrimidine dimer photolyase structure reveals a new antenna chromophore binding site and alternative photoreduction pathways. PMID:25784552
The Radical S-Adenosyl-L-methionine Enzyme QhpD Catalyzes Sequential Formation of Intra-protein Sulfur-to-Methylene Carbon Thioether Bonds. PMID:25778402
Four crystal structures of human LLT1, a ligand of human NKR-P1, in varied glycosylation and oligomerization states. PMID:25760607
Structures of three polycystic kidney disease-like domains from Clostridium histolyticum collagenases ColG and ColH. PMID:25760606
MutT from the fish pathogen Aliivibrio salmonicida is a cold-active nucleotide-pool sanitization enzyme with unexpectedly high thermostability. PMID:25737836
Specific disulfide cross-linking to constrict the mobile carrier domain of nonribosomal peptide synthetases. PMID:25713404
Whole transcriptome analysis using next-generation sequencing of sterile-cultured Eisenia andrei for immune system research. PMID:25706644
Structural analysis of the complex between penta-EF-hand ALG-2 protein and Sec31A peptide reveals a novel target recognition mechanism of ALG-2. PMID:25667979
Propofol inhibits SIRT2 deacetylase through a conformation-specific, allosteric site. PMID:25666612
Two-tiered histidine kinase pathway involved in heat shock and salt sensing in the general stress response of Sphingomonas melonis Fr1. PMID:25666137
In silico analysis and developmental expression of ubiquitin-conjugating enzymes in Schistosoma mansoni. PMID:25663106
PICK1 is implicated in organelle motility in an Arp2/3 complex-independent manner. PMID:25657323
Mutagenesis and functional analysis of the pore-forming toxin HALT-1 from Hydra magnipapillata. PMID:25654788
In vitro activity of five quinolones and analysis of the quinolone resistance-determining regions of gyrA, gyrB, parC, and parE in Ureaplasma parvum and Ureaplasma urealyticum clinical isolates from perinatal patients in Japan. PMID:25645833
Limited effect of recombinant human mannose-binding lectin on the infection of novel influenza A (H7N9) virus in vitro. PMID:25634695
Local error estimates dramatically improve the utility of homology models for solving crystal structures by molecular replacement. PMID:25619999
Data to knowledge: how to get meaning from your result. PMID:25610627
Structure, bioactivity, and resistance mechanism of streptomonomicin, an unusual lasso Peptide from an understudied halophilic actinomycete. PMID:25601074
A mechanistic role of Helix 8 in GPCRs: Computational modeling of the dopamine D2 receptor interaction with the GIPC1-PDZ-domain. PMID:25592838
The CarO rhodopsin of the fungus Fusarium fujikuroi is a light-driven proton pump that retards spore germination. PMID:25589426
The Ordospora colligata genome: Evolution of extreme reduction in microsporidia and host-to-parasite horizontal gene transfer. PMID:25587016
A hypertrophic cardiomyopathy-associated MYBPC3 mutation common in populations of South Asian descent causes contractile dysfunction. PMID:25583989
Mechanistic insights into the recycling machine of the SNARE complex. PMID:25581794
Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy. PMID:25581430
The majority of transcripts in the squid nervous system are extensively recoded by A-to-I RNA editing. PMID:25569156
Protein sector analysis for the clustering of disease-associated mutations. PMID:25559331
Alginate lyases from alginate-degrading Vibrio splendidus 12B01 are endolytic. PMID:25556193
Identifying tandem Ankyrin repeats in protein structures. PMID:25547411
Conserved amino acid residues of the NuoD segment important for structure and function of Escherichia coli NDH-1 (complex I). PMID:25545070
Crystal structure of DNA cytidine deaminase ABOBEC3G catalytic deamination domain suggests a binding mode of full-length enzyme to single-stranded DNA. PMID:25542899
Two desmin gene mutations associated with myofibrillar myopathies in Polish families. PMID:25541946
Structure and function analysis of nucleocapsid protein of tomato spotted wilt virus interacting with RNA using homology modeling. PMID:25540203
Engineering of Glarea lozoyensis for exclusive production of the pneumocandin B0 precursor of the antifungal drug caspofungin acetate. PMID:25527531
The olfactomedin domain from gliomedin is a β-propeller with unique structural properties. PMID:25525261
Determinants of endogenous ligand specificity divergence among metabotropic glutamate receptors. PMID:25519912
Outward-facing conformers of LacY stabilized by nanobodies. PMID:25512549
Novel Anti-Nicotine Vaccine Using a Trimeric Coiled-Coil Hapten Carrier. PMID:25494044
Conformational dynamics in substrate-binding domains influences transport in the ABC importer GlnPQ. PMID:25486304
Exploring the interactions between isoprenoid chain and labdenediol diphosphate synthase based on molecular docking and quartz crystal microbalance. PMID:25472483
Unexpected challenges in treating multidrug-resistant Gram-negative bacteria: resistance to ceftazidime-avibactam in archived isolates of Pseudomonas aeruginosa. PMID:25451057
Characterization of the Drosophila group ortholog to the amino-terminus of the alpha-thalassemia and mental retardation X-Linked (ATRX) vertebrate protein. PMID:25437195
cDNA structure and the effect of fasting on myostatin expression in walking catfish (Clarias macrocephalus, Günther 1864). PMID:25432578
New Approaches to Comparative and Animal Stress Biology Research in the Post-genomic Era: A Contextual Overview. PMID:25408848
A review of metabolic and enzymatic engineering strategies for designing and optimizing performance of microbial cell factories. PMID:25379147
Identification and structural analysis of an L-asparaginase enzyme from guinea pig with putative tumor cell killing properties. PMID:25320094
Distinct conformational behaviors of four mammalian dual-flavin reductases (cytochrome P450 reductase, methionine synthase reductase, neuronal nitric oxide synthase, endothelial nitric oxide synthase) determine their unique catalytic profiles. PMID:25265015
Molecular modeling and MM-PBSA free energy analysis of endo-1,4-β-xylanase from Ruminococcus albus 8. PMID:25264743
Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands. PMID:25240283
Characterization of a broadly neutralizing monoclonal antibody that targets the fusion domain of group 2 influenza A virus hemagglutinin. PMID:25210195
Recombinant expression, purification, crystallization and preliminary X-ray diffraction analysis of the C-terminal DUF490(963-1138) domain of TamB from Escherichia coli. PMID:25195908
Assessing the local structural quality of transmembrane protein models using statistical potentials (QMEANBrane). PMID:25161240
Molecular and evolutionary analysis of NEAr-iron Transporter (NEAT) domains. PMID:25153520
Structure of the RNA polymerase assembly factor Crl and identification of its interaction surface with sigma S. PMID:25002538
Leveraging structure for enzyme function prediction: methods, opportunities, and challenges. PMID:24998033
Fifteen years SIB Swiss Institute of Bioinformatics: life science databases, tools and support. PMID:24792157
The SWISS-MODEL Repository and associated resources PubMed citations: 794.

794 articles citing: The SWISS-MODEL Repository and associated resources

Targeting the Ubiquinol-Reduction (Qi) Site of the Mitochondrial Cytochrome bc1 Complex for the Development of Next Generation Quinolone Antimalarials. PMID:35892964
Molecular Characterization of Kunitz-Type Protease Inhibitors from Blister Beetles (Coleoptera, Meloidae). PMID:35883544
Cloning and Bioinformatics Analysis of GhArfGAP in Cotton (Gossypium hirsutum) Boll Abscission Layer With Ethylene Treatment. PMID:35812965
Insights from a computational analysis of the SARS-CoV-2 Omicron variant: Host-pathogen interaction, pathogenicity, and possible drug therapeutics. PMID:35759231
AlphaFold2 models indicate that protein sequence determines both structure and dynamics. PMID:35739160
Prediction and expression analysis of deleterious nonsynonymous SNPs of Arabidopsis ACD11 gene by combining computational algorithms and molecular docking approach. PMID:35709304
Computational design of Lactobacillus Acidophilus α-L-rhamnosidase to increase its structural stability. PMID:35613129
Determining KLF14 tertiary structure and diagnostic significance in brain cancer progression. PMID:35577881
Fragment-centric topographic mapping method guides the understanding of ABCG2-inhibitor interactions. PMID:35521159
Investigation of the target-site resistance of EPSP synthase mutants P106T and T102I/P106S against glyphosate. PMID:35517162
Whole-Exome Sequencing Identifies a Novel Variant (c.1538T > C) of TNNI3K in Arrhythmogenic Right Ventricular Cardiomyopathy. PMID:35274013
The atlas of ACE2 expression in fetal and adult human hearts reveals the potential mechanism of heart-injured patients infected with SARS-CoV-2. PMID:35138176
NOG-Derived Peptides Can Restore Neuritogenesis on a CRASH Syndrome Cell Model. PMID:35052783
Functional characterization of the methylarsenite-inducible arsRM operon from Noviherbaspirillum denitrificans HC18. PMID:35049138
LYRUS: a machine learning model for predicting the pathogenicity of missense variants. PMID:35036922
Biochemical, molecular and in silico characterization of arsenate reductase from Bacillus thuringiensis KPWP1 tolerant to salt, arsenic and a wide range of pH. PMID:34932145
Reverse Chemical Ecology Suggests Putative Primate Pheromones. PMID:34897488
Artemisinin Binds and Inhibits the Activity of Plasmodium falciparum Ddi1, a Retroviral Aspartyl Protease. PMID:34832620
Molecular Docking Simulation Studies Identifies Potential Natural Product Derived-Antiwolbachial Compounds as Filaricides against Onchocerciasis. PMID:34829911
1-Formyl-β-carboline Derivatives Block Newcastle Disease Virus Proliferation through Suppressing Viral Adsorption and Entry Processes. PMID:34827684
Characterisation of a putative M23-domain containing protein in Mycobacterium tuberculosis. PMID:34784363
Identification of a MarR Subfamily That Regulates Arsenic Resistance Genes. PMID:34613763
Discovery of potential SARS-CoV 3CL protease inhibitors from approved antiviral drugs using: virtual screening, molecular docking, pharmacophore mapping evaluation and dynamics simulation. PMID:34541995
A clubroot pathogen effector targets cruciferous cysteine proteases to suppress plant immunity. PMID:34515618
Thioredoxin reductase from Bacillus cereus exhibits distinct reduction and NADPH-binding properties. PMID:34492167
Design of a Multi-epitope Vaccine Against Acinetobacter baumannii Using Immunoinformatics Approach. PMID:34483787
Aphid Odorant-Binding Protein 9 Is Narrowly Tuned to Linear Alcohols and Aldehydes of Sixteen Carbon Atoms. PMID:34442308
Haemoglobin switching modulator SNPs rs5006884 is associated with increased HbA2 in β-thalassaemia carriers. PMID:34336034
Ovine CD14- an Immune Response Gene Has a Role Against Gastrointestinal Nematode Haemonchus contortus-A Novel Report. PMID:34335567
Databases for Protein-Protein Interactions. PMID:34236665
Molecular and Mechanistic Characterization of PddB, the First PLP-Independent 2,4-Diaminobutyric Acid Racemase Discovered in an Actinobacterial D-Amino Acid Homopolymer Biosynthesis. PMID:34177872
A Highly Active Chimeric Lysin with a Calcium-Enhanced Bactericidal Activity against Staphylococcus aureus In Vitro and In Vivo. PMID:33921682
Computational characterizations of GDP-mannose 4,6-dehydratase (NoeL) Rhizobial proteins. PMID:33837815
Epitope-directed monoclonal antibody production using a mixed antigen cocktail facilitates antibody characterization and validation. PMID:33824395
Unravelling Regioselectivity of Leuconostoc citreum ABK-1 Alternansucrase by Acceptor Site Engineering. PMID:33810084
CrfP, a fratricide protein, contributes to natural transformation in Streptococcus suis. PMID:33762005
In silico designing of putative peptides for targeting pathological protein Htt in Huntington's disease. PMID:33659724
A novel mutation in the cathepsin C (CTSC) gene in Iranian family with Papillon-Lefevre syndrome. PMID:33586345
Novel Roles of the N1 Loop and N4 Alpha-Helical Region of the Nipah Virus Fusion Glycoprotein in Modulating Early and Late Steps of the Membrane Fusion Cascade. PMID:33568505
Aquaglyceroporin AqpS from Sinorhizobium meliloti conducts both trivalent and pentavalent methylarsenicals. PMID:33418223
Identification of a novel mutation in the KITLG gene in a Chinese family with familial progressive hyper- and hypopigmentation. PMID:33407466
RNA-seq analysis identifies cytoskeletal structural genes and pathways for meat quality in beef. PMID:33175867
CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module. PMID:33139725
Three-Dimensional Structures of Carbohydrates and Where to Find Them. PMID:33081008
Identification of transcobalamin deficiency with two novel mutations in the TCN2 gene in a Chinese girl with abnormal immunity: a case report. PMID:33023511
Synthesis, in vitro inhibitory activity, kinetic study and molecular docking of novel N-alkyl-deoxynojirimycin derivatives as potential α-glucosidase inhibitors. PMID:33003963
Tick-Borne Encephalitis Virus Adaptation in Different Host Environments and Existence of Quasispecies. PMID:32824843
Synthetic Peptides as a Promising Alternative to Control Viral Infections in Atlantic Salmon. PMID:32717804
Third Helical Domain of the Nipah Virus Fusion Glycoprotein Modulates both Early and Late Steps in the Membrane Fusion Cascade. PMID:32669342
Cloning, Expression, and Structural Elucidation of a Biotechnologically Potential Alkaline Serine Protease From a Newly Isolated Haloalkaliphilic Bacillus lehensis JO-26. PMID:32582046
Leishmanicidal Potential of Hardwickiic Acid Isolated From Croton sylvaticus. PMID:32523532
ABC Transporter DerAB of Lactobacillus casei Mediates Resistance against Insect-Derived Defensins. PMID:32414796
Pharmacologic TWIK-Related Acid-Sensitive K+ Channel (TASK-1) Potassium Channel Inhibitor A293 Facilitates Acute Cardioversion of Paroxysmal Atrial Fibrillation in a Porcine Large Animal Model. PMID:32390491
A variant of human growth differentiation factor-9 that improves oocyte developmental competence. PMID:32350111
Comprehensive Computational Analysis of Protein Phenotype Changes Due to Plausible Deleterious Variants of Human SPTLC1 Gene. PMID:32195206
Molecular cloning of SLC35D3 and analysis of its role during porcine intramuscular preadipocyte differentiation. PMID:32087688
Identification, molecular characterization and expression of aminopeptidase N-1 (APN-1) from Anopheles stephensi in SF9 cell line as a candidate molecule for developing a vaccine that interrupt malaria transmission. PMID:32075635
Enterovirus 71 Infection Shapes Host T Cell Receptor Repertoire and Presumably Expands VP1-Specific TCRβ CDR3 Cluster. PMID:32075096
Elongation Factor Tu Switch I Element is a Gate for Aminoacyl-tRNA Selection. PMID:32061931
Bioinformatics design and experimental validation of influenza A virus multi-epitopes that induce neutralizing antibodies. PMID:32060794
An ENU-induced mutation in Twist1 transactivation domain causes hindlimb polydactyly with complete penetrance and dominant-negatively impairs E2A-dependent transcription. PMID:32051525
Unique subsite specificity and potential natural function of a chitosan deacetylase from the human pathogen Cryptococcus neoformans. PMID:32015121
Broadly Protective Multivalent OspA Vaccine against Lyme Borreliosis, Developed Based on Surface Shaping of the C-Terminal Fragment. PMID:31932330
Transcriptome Analysis Identifies Plasmodiophora brassicae Secondary Infection Effector Candidates. PMID:31925980
Structural and mechanistic insights into Hsp104 function revealed by synchrotron X-ray footprinting. PMID:31882541
Conformational States of Exchange Protein Directly Activated by cAMP (EPAC1) Revealed by Ensemble Modeling and Integrative Structural Biology. PMID:31877746
Novel findings to the biosynthetic pathway of magnoflorine and taspine through transcriptomic and metabolomic analysis of Croton draco (Euphorbiaceae). PMID:31852435
Dynamics, nanomechanics and signal transduction in reelin repeats. PMID:31831824
Molecular replacement using structure predictions from databases. PMID:31793899
A double-stranded RNA platform is required for the interaction between a host restriction factor and the NS1 protein of influenza A virus. PMID:31754723
Indomethacin Enhances Type 1 Cannabinoid Receptor Signaling. PMID:31680861
A Novel Pathogenic Variant in NAGLU (N-Acetyl-Alpha-Glucosaminidase) gene Identified by Targeted Next-Generation Sequencing Followed by in Silico Analysis. PMID:31645877
Genomewide Analysis of Mode of Action of the S-Adenosylmethionine Analogue Sinefungin in Leishmania infantum. PMID:31615876
Effects of the substituted amino acid residues on the thermal properties of monomeric isocitrate dehydrogenases from a psychrophilic bacterium, Psychromonas marina, and a mesophilic bacterium, Azotobacter vinelandii. PMID:31595369
Characterization of Novel Fragment Antibodies Against TNF-alpha Isolated Using Phage Display Technique. PMID:31531059
Molecular docking of genistein on estrogen receptors, promoter region of BCLX, caspase-3, Ki-67, cyclin D1, and telomere activity. PMID:31435394
Structural Insights into Hearing Loss Genetics from Polarizable Protein Repacking. PMID:31327459
Atomistic Models from Orientation and Distance Constraints Using EPR of a Bifunctional Spin Label. PMID:31301803
Granzyme A Stimulates pDCs to Promote Adaptive Immunity via Induction of Type I IFN. PMID:31293597
An array of basic residues is essential for the nucleolytic activity of the PHP domain of bacterial/archaeal PolX DNA polymerases. PMID:31289311
3D-PP: A Tool for Discovering Conserved Three-Dimensional Protein Patterns. PMID:31261733
Selection and characterization of ultrahigh potency designed ankyrin repeat protein inhibitors of C. difficile toxin B. PMID:31233493
Pathogenic Autoreactive T and B Cells Cross-React with Mimotopes Expressed by a Common Human Gut Commensal to Trigger Autoimmunity. PMID:31227334
In Silico Interaction of the Active Compounds of Scurrula Atropurpurea with the RANK/RANKL/OPG System in Diabetoporosis. PMID:31213736
A novel hydroxycinnamoyl transferase for synthesis of hydroxycinnamoyl spermine conjugates in plants. PMID:31208339
Immunoglobulin light chains generate proinflammatory and profibrotic kidney injury. PMID:31205024
N-glycosylation-dependent regulation of hK2P17.1 currents. PMID:30969900
Using the Predicted Structure of the Amot Coiled Coil Homology Domain to Understand Lipid Binding. PMID:30957019
Thermostability of tropomyosins from the fast skeletal muscles of tropical fish species. PMID:30945041
Docking analysis of hexanoic acid and quercetin with seven domains of polyketide synthase A provided insight into quercetin-mediated aflatoxin biosynthesis inhibition in Aspergillus flavus. PMID:30944796
Rational protein design of Bacillus sp. MN chitosanase for altered substrate binding and production of specific chitosan oligomers. PMID:30918529
Detection and characterization of an albumin-like protein in Leishmania donovani. PMID:30903348
Molecular Characterization of Microtubule Affinity-Regulating Kinase4 from Sus scrofa and Promotion of Lipogenesis in Primary Porcine Placental Trophoblasts. PMID:30857324
In Silico Characterization of Structural Distinctions between Isoforms of Human and Mouse Sphingosine Kinases for Accelerating Drug Discovery. PMID:30844267
The rs61742690 (S783N) single nucleotide polymorphism is a suitable target for disrupting BCL11A-mediated foetal-to-adult globin switching. PMID:30768627
The Amphibian Diacylglycerol O-acyltransferase 2 (DGAT2): a 'paleo-protein' with Conserved Function but Unique Folding. PMID:30697667
Molecular Docking for Active Compounds of Scurrula Atropurpurea as Anti-inflammatory Candidate in Endometriosis. PMID:30692709
Newly Discovered Occurrences and Gene Tree of the Extracellular Globins and Linker Chains from the Giant Hexagonal Bilayer Hemoglobin in Metazoans. PMID:30668717
Structural characterization of a pathogenicity-related superoxide dismutase codified by a probably essential gene in Xanthomonas citri subsp. citri. PMID:30615696
De novo transcriptome analyses provide insights into opsin-based photoreception in the lanternshark Etmopterus spinax. PMID:30596723
Functional divergence of annotated l-isoaspartate O-methyltransferases in an α-proteobacterium. PMID:30578298
Molecular basis for the increased affinity of an RNA recognition motif with re-engineered specificity: A molecular dynamics and enhanced sampling simulations study. PMID:30521520
Dynamic interactions of type I cohesin modules fine-tune the structure of the cellulosome of Clostridium thermocellum. PMID:30429330
Engineering allosteric regulation in protein kinases. PMID:30401787
The structure of PghL hydrolase bound to its substrate poly-γ-glutamate. PMID:30387270
Off-axis rotor in Enterococcus hirae V-ATPase visualized by Zernike phase plate single-particle cryo-electron microscopy. PMID:30353110
Mutational analysis of the conserved carboxylates of anion channelrhodopsin-2 (ACR2) expressed in Escherichia coli and their roles in anion transport. PMID:30349802
Molecular dynamics provides insight into how N251A and N251Y mutations in the active site of Bacillus licheniformis RN-01 levansucrase disrupt production of long-chain levan. PMID:30278092
THE-DB: a threading model database for comparative protein structure analysis of the E. coli K12 and human proteomes. PMID:30239678
Sinorhizobium meliloti Chemoreceptor McpV Senses Short-Chain Carboxylates via Direct Binding. PMID:30201781
Identification, expression and characterization of the recombinant Sol g 4.1 protein from the venom of the tropical fire ant Solenopsis geminata. PMID:30181738
hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia. PMID:30115739
Design, synthesis and evaluation of indole derivatives as multifunctional agents against Alzheimer's disease. PMID:30108930
In silico analysis of SLC3A1 and SLC7A9 mutations in Iranian patients with Cystinuria. PMID:30069816
Gating mechanisms during actin filament elongation by formins. PMID:30035712
Computational Study Reveals the Molecular Mechanism of the Interaction between the Efflux Inhibitor PAβN and the AdeB Transporter from Acinetobacter baumannii. PMID:30023681
In Silico evaluation and identification of fungi capable of producing endo-inulinase enzyme. PMID:30001376
MORC Domain Definition and Evolutionary Analysis of the MORC Gene Family in Green Plants. PMID:29982569
Allosteric and orthosteric pharmacology of cannabidiol and cannabidiol-dimethylheptyl at the type 1 and type 2 cannabinoid receptors. PMID:29981240
Molecular Modeling of Drug-Transporter Interactions-An International Transporter Consortium Perspective. PMID:29981151
Computational identification and evolutionary analysis of toxins in Mosquitocidal Bacillus thuringiensis strain S2160-1. PMID:29963353
Molecular characterization of microtubule-associated protein 1-light chain 3B in Megalobrama amblycephala fed with high fat/berberine diets. PMID:29951891
Divergent Small Tim Homologues Are Associated with TbTim17 and Critical for the Biogenesis of TbTim17 Protein Complexes in Trypanosoma brucei. PMID:29925672
Wireless control of cellular function by activation of a novel protein responsive to electromagnetic fields. PMID:29884813
Isolation and Semi Quantitative PCR of Na+/H+ Antiporter (SOS1 and NHX) Genes under Salinity Stress in Kochia scoparia. PMID:29881329
Gain-of-function KCNJ6 Mutation in a Severe Hyperkinetic Movement Disorder Phenotype. PMID:29852244
HotSpot Wizard 3.0: web server for automated design of mutations and smart libraries based on sequence input information. PMID:29796670
Computational analysis of the receptor binding specificity of novel influenza A/H7N9 viruses. PMID:29764421
Exploring the Interaction Mechanism Between Cyclopeptide DC3 and Androgen Receptor Using Molecular Dynamics Simulations and Free Energy Calculations. PMID:29755968
Mutations in PPCS, Encoding Phosphopantothenoylcysteine Synthetase, Cause Autosomal-Recessive Dilated Cardiomyopathy. PMID:29754768
In vitro and in silico studies of terpenes, terpenoids and related compounds with larvicidal and pupaecidal activity against Culex quinquefasciatus Say (Diptera: Culicidae). PMID:29748726
A Functional Study Identifying Critical Residues Involving Metal Transport Activity and Selectivity in Natural Resistance-Associated Macrophage Protein 3 in Arabidopsis thaliana. PMID:29748478
Characterization of recombinant dihydrodipicolinate synthase from the bread wheat Triticum aestivum. PMID:29744651
Various Bee Pheromones Binding Affinity, Exclusive Chemosensillar Localization, and Key Amino Acid Sites Reveal the Distinctive Characteristics of Odorant-Binding Protein 11 in the Eastern Honey Bee, Apis cerana. PMID:29740337
Anticancer Activity of Bacterial Proteins and Peptides. PMID:29710857
Phosphatidylinositol-3,5-bisphosphate lipid-binding-induced activation of the human two-pore channel 2. PMID:29705952
Involvement of a host Cathepsin L in symbiont-induced cell death. PMID:29692003
The Two-Component Signaling System VraSRss Is Critical for Multidrug Resistance and Full Virulence in Streptococcus suis Serotype 2. PMID:29685990
Comparative Analysis of WUSCHEL-Related Homeobox Genes Revealed Their Parent-of-Origin and Cell Type-Specific Expression Pattern During Early Embryogenesis in Tobacco. PMID:29662495
Structure and regulation of the human INO80-nucleosome complex. PMID:29643506
Analysis of HIV-1 envelope evolution suggests antibody-mediated selection of common epitopes among Chinese former plasma donors from a narrow-source outbreak. PMID:29636501
The degenerin region of the human bile acid-sensitive ion channel (BASIC) is involved in channel inhibition by calcium and activation by bile acids. PMID:29589117
Opportunities and Challenges in Building a Spatiotemporal Multi-scale Model of the Human Pancreatic β Cell. PMID:29570991
Chimeric Fatty Acyl-Acyl Carrier Protein Thioesterases Provide Mechanistic Insight into Enzyme Specificity and Expression. PMID:29549102
Cooperative recruitment of Yan via a high-affinity ETS supersite organizes repression to confer specificity and robustness to cardiac cell fate specification. PMID:29535190
Association of μ-Calpain and Calpastatin Polymorphisms with Meat Tenderness in a Brahman-Angus Population. PMID:29520298
A DNA Vaccine Expressing Consensus Hemagglutinin-Esterase Fusion Protein Protected Guinea Pigs from Infection by Two Lineages of Influenza D Virus. PMID:29514906
Characterization of the Lytic Capability of a LysK-Like Endolysin, Lys-phiSA012, Derived from a Polyvalent Staphylococcus aureus Bacteriophage. PMID:29495305
Niemann-Pick C2 Proteins: A New Function for an Old Family. PMID:29472868
Formation of RNA Granule-Derived Capsid Assembly Intermediates Appears To Be Conserved between Human Immunodeficiency Virus Type 1 and the Nonprimate Lentivirus Feline Immunodeficiency Virus. PMID:29467316
Unraveling the sequence of cytosolic reactions in the export of GspB adhesin from Streptococcus gordonii. PMID:29462788
Comparative analysis of plant isochorismate synthases reveals structural mechanisms underlying their distinct biochemical properties. PMID:29436485
Unique pharmacological properties of serotoninergic G-protein coupled receptors from cestodes. PMID:29425245
Analysis of Homologs of Cry-toxin Receptor-Related Proteins in the Midgut of a Non-Bt Target, Nilaparvata lugens (Stål) (Hemiptera: Delphacidae). PMID:29415259
The PUF Protein Family: Overview on PUF RNA Targets, Biological Functions, and Post Transcriptional Regulation. PMID:29385744
KLF1 gene and borderline hemoglobin A2 in Saudi population. PMID:29379553
A search for ceramide binding proteins using bifunctional lipid analogs yields CERT-related protein StarD7. PMID:29343537
Assessment of antimicrobial and wound healing effects of Brevinin-2Ta against the bacterium Klebsiella pneumoniae in dermally-wounded rats. PMID:29340060
Multiple mutations and overexpression of the MdaE7 carboxylesterase gene associated with male-linked malathion resistance in housefly, Musca domestica (Diptera: Muscidae). PMID:29317643
The phosphorelay signal transduction system in Candida glabrata: an in silico analysis. PMID:29248994
Experimental Adaptive Evolution of Simian Immunodeficiency Virus SIVcpz to Pandemic Human Immunodeficiency Virus Type 1 by Using a Humanized Mouse Model. PMID:29212937
Canis familiaris allergen Can f 6: expression, purification and analysis of B-cell epitopes in Chinese dog allergic children. PMID:29207604
Cinnamomum burmanini Blume increases bone turnover marker and induces tibia's granule formation in ovariectomized rats. PMID:29198835
Autopolysialylation of polysialyltransferases is required for polysialylation and polysialic acid chain elongation on select glycoprotein substrates. PMID:29183999
Transition metal binding selectivity in proteins and its correlation with the phylogenomic classification of the cation diffusion facilitator protein family. PMID:29180655
Arsenic methylation by a novel ArsM As(III) S-adenosylmethionine methyltransferase that requires only two conserved cysteine residues. PMID:29134708
Unraveling the key to the resistance of canids to prion diseases. PMID:29131852
Interaction of the Saccharomyces cerevisiae RING-domain protein Nse1 with Nse3 and the Smc5/6 complex is required for chromosome replication and stability. PMID:29119272
Genome-wide identification and expression profile analysis of CCH gene family in Populus. PMID:29085758
PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels. PMID:29078287
Tracing the Evolutionary History of the CAP Superfamily of Proteins Using Amino Acid Sequence Homology and Conservation of Splice Sites. PMID:29071358
Population Genomic Analysis of a Pitviper Reveals Microevolutionary Forces Underlying Venom Chemistry. PMID:29048530
Investigating the bifunctionality of cyclizing and "classical" 5-aminolevulinate synthases. PMID:29027286
Computationally Optimized Broadly Reactive Hemagglutinin Elicits Hemagglutination Inhibition Antibodies against a Panel of H3N2 Influenza Virus Cocirculating Variants. PMID:28978710
Cmr1 enables efficient RNA and DNA interference of a III-B CRISPR-Cas system by binding to target RNA and crRNA. PMID:28977458
A unique cysteine-rich zinc finger domain present in a majority of class II ribonucleotide reductases mediates catalytic turnover. PMID:28972190
A lower isoelectric point increases signal sequence-mediated secretion of recombinant proteins through a bacterial ABC transporter. PMID:28972172
Functional significance of active site residues in the enzymatic component of the Clostridium difficile binary toxin. PMID:28955942
Allosteric-activation mechanism of BK channel gating ring triggered by calcium ions. PMID:28953901
Structural Basis for EarP-Mediated Arginine Glycosylation of Translation Elongation Factor EF-P. PMID:28951478
Prevalence of TECTA mutation in patients with mid-frequency sensorineural hearing loss. PMID:28946916
Docking analysis of verteporfin with YAP WW domain. PMID:28943729
A Protocol for Generating and Exchanging (Genome-Scale) Metabolic Resource Allocation Models. PMID:28878200
A novel MAs(III)-selective ArsR transcriptional repressor. PMID:28861914
Pulling MscL open via N-terminal and TM1 helices: A computational study towards engineering an MscL nanovalve. PMID:28859093
TAF10 and TAF10b partially redundant roles during Drosophila melanogaster morphogenesis. PMID:28841365
Modeling of RAS complexes supports roles in cancer for less studied partners. PMID:28815022
Role of Electrostatics in Protein-RNA Binding: The Global vs the Local Energy Landscape. PMID:28806086
Low renal but high extrarenal phenotype variability in Schimke immuno-osseous dysplasia. PMID:28796785
Structural Rearrangement upon Fragmentation of the Stability Core of the ALS-Linked Protein TDP-43. PMID:28793209
NLScore: a novel quantitative algorithm based on 3 dimensional structural determinants to predict the probability of nuclear localization in proteins containing classical nuclear localization signals. PMID:28791516
Colorful Packages: Encapsulation of Fluorescent Proteins in Complex Coacervate Core Micelles. PMID:28753915
Rapid identification of genes controlling virulence and immunity in malaria parasites. PMID:28704525
Mutations in human AID differentially affect its ability to deaminate cytidine and 5-methylcytidine in ssDNA substrates in vitro. PMID:28634398
EV-3, an endogenous human erythropoietin isoform with distinct functional relevance. PMID:28623280
FTR83, a Member of the Large Fish-Specific finTRIM Family, Triggers IFN Pathway and Counters Viral Infection. PMID:28603526
Structural insight into the role of Gln293Met mutation on the Peloruside A/Laulimalide association with αβ-tubulin from molecular dynamics simulations, binding free energy calculations and weak interactions analysis. PMID:28597356
Tacrine, Trolox and Tryptoline as Lead Compounds for the Design and Synthesis of Multi-target Agents for Alzheimer's Disease Therapy. PMID:28567126
Prokaryotic expression, purification and characterization of human cyclooxygenase-2. PMID:28560423
Celecoxib affects estrogen sulfonation catalyzed by several human hepatic sulfotransferases, but does not stimulate 17-sulfonation in rat liver. PMID:28552400
Expression and Activity of the BioH Esterase of Biotin Synthesis is Independent of Genome Context. PMID:28526858
Cinnamaldehyde and eugenol change the expression folds of AKT1 and DKC1 genes and decrease the telomere length of human adipose-derived stem cells (hASCs): An experimental and in silico study. PMID:28392905
Bactericidal Permeability-Increasing Proteins Shape Host-Microbe Interactions. PMID:28377525
Distinct domains of the β1-subunit cytosolic N terminus control surface expression and functional properties of large-conductance calcium-activated potassium (BK) channels. PMID:28373283
Protein interaction evolution from promiscuity to specificity with reduced flexibility in an increasingly complex network. PMID:28337996
Critical evaluation of bioinformatics tools for the prediction of protein crystallization propensity. PMID:28334201
Structure-based functional annotation of hypothetical proteins from Candida dubliniensis: a quest for potential drug targets. PMID:28324558
Electron transfer pathways in a multiheme cytochrome MtrF. PMID:28265060
An Eight-Residue Deletion in Escherichia coli FabG Causes Temperature-Sensitive Growth and Lipid Synthesis Plus Resistance to the Calmodulin Inhibitor Trifluoperazine. PMID:28264990
Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites. PMID:28263315
The Echinococcus canadensis (G7) genome: a key knowledge of parasitic platyhelminth human diseases. PMID:28241794
Probing the influence of carboxyalkyl groups on the molecular flexibility and the charge density of apigenin derivatives. PMID:28197841
Identification of Inhibitors of CD36-Amyloid Beta Binding as Potential Agents for Alzheimer's Disease. PMID:28150942
Catalytic Interactions and Molecular Docking of Bile Salt Hydrolase (BSH) from L. plantarum RYPR1 and Its Prebiotic Utilization. PMID:28111569
Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth. PMID:28107750
Nucleoplasmin-like domain of FKBP39 from Drosophila melanogaster forms a tetramer with partly disordered tentacle-like C-terminal segments. PMID:28074868
O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies. PMID:28074064
Molecular cloning and characterization of porcine ribosomal protein L21. PMID:28057907
Human Neuronal Calcium Sensor-1 Protein Avoids Histidine Residues To Decrease pH Sensitivity. PMID:28030949
TIMP-1 and CD82, a promising combined evaluation marker for PDAC. PMID:28030805
Characterization of spermidine hydroxycinnamoyl transferases from eggplant (Solanum melongena L.) and its wild relative Solanum richardii Dunal. PMID:28018606
Trimeric gp120-specific bovine monoclonal antibodies require cysteine and aromatic residues in CDRH3 for high affinity binding to HIV Env. PMID:27996375
The NS4A Cofactor Dependent Enhancement of HCV NS3 Protease Activity Correlates with a 4D Geometrical Measure of the Catalytic Triad Region. PMID:27936126
The Streptococcus gordonii Adhesin CshA Protein Binds Host Fibronectin via a Catch-Clamp Mechanism. PMID:27920201
The SWISS-MODEL Repository-new features and functionality. PMID:27899672
Conserved chemosensory proteins in the proboscis and eyes of Lepidoptera. PMID:27877091
Mutation near the binding interfaces at α-hemoglobin stabilizing protein is highly pathogenic. PMID:27830006
Cloning and expression of SgCYP450-4 from Siraitia grosvenorii. PMID:27818929
Establishing the involvement of the novel gene AGBL5 in retinitis pigmentosa by whole genome sequencing. PMID:27764769
Convert your favorite protein modeling program into a mutation predictor: "MODICT". PMID:27760515
Structural characterization of the circadian clock protein complex composed of KaiB and KaiC by inverse contrast-matching small-angle neutron scattering. PMID:27752127
SARAH Domain-Mediated MST2-RASSF Dimeric Interactions. PMID:27716844
A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119. PMID:27708348
Parallel Mutations Result in a Wide Range of Cooperation and Community Consequences in a Two-Species Bacterial Consortium. PMID:27617746
Calcium/calmodulin alleviates substrate inhibition in a strawberry UDP-glucosyltransferase involved in fruit anthocyanin biosynthesis. PMID:27609111
PCP-B class pollen coat proteins are key regulators of the hydration checkpoint in Arabidopsis thaliana pollen-stigma interactions. PMID:27596924
HSAF-induced antifungal effects in Candida albicans through ROS-mediated apoptosis. PMID:27594989
In Silico Analysis of the Potential of the Active Compounds Fucoidan and Alginate Derived from Sargassum Sp. as Inhibitors of COX-1 and COX-2. PMID:27594740
Discovery of Novel Bacterial Cell-Penetrating Phylloseptins in Defensive Skin Secretions of the South American Hylid Frogs, Phyllomedusa duellmani and Phyllomedusa coelestis. PMID:27589802
A R2R3-MYB transcription factor from Lablab purpureus induced by drought increases tolerance to abiotic stress in Arabidopsis. PMID:27565983
High-specificity synthesis of novel monomers by remodeled alcohol hydroxylase. PMID:27557638
A mutagenic study identifying critical residues for the structure and function of rice manganese transporter OsMTP8.1. PMID:27555514
Disease-Homologous Mutation in the Cation Diffusion Facilitator Protein MamM Causes Single-Domain Structural Loss and Signifies Its Importance. PMID:27550551
Peptides from American alligator plasma are antimicrobial against multi-drug resistant bacterial pathogens including Acinetobacter baumannii. PMID:27542832
An Alkaline Protease from Bacillus pumilus MP 27: Functional Analysis of Its Binding Model toward Its Applications As Detergent Additive. PMID:27536284
Identification of candidate genes related to calanolide biosynthesis by transcriptome sequencing of Calophyllum brasiliense (Calophyllaceae). PMID:27527830
Understanding the molecular basis of substrate binding specificity of PTB domains. PMID:27526776
Conformational dynamics of cancer-associated MyD88-TIR domain mutant L252P (L265P) allosterically tilts the landscape toward homo-dimerization. PMID:27503954
The Genomic Scrapheap Challenge; Extracting Relevant Data from Unmapped Whole Genome Sequencing Reads, Including Strain Specific Genomic Segments, in Rats. PMID:27501045
Neisserial Opa Protein-CEACAM Interactions: Competition for Receptors as a Means of Bacterial Invasion and Pathogenesis. PMID:27442026
Spatial Patterns of bphA Gene Diversity Reveal Local Adaptation of Microbial Communities to PCB and PAH Contaminants. PMID:27430632
Targeted next-generation sequencing extends the phenotypic and mutational spectrums for EYS mutations. PMID:27375351
Alteramide B is a microtubule antagonist of inhibiting Candida albicans. PMID:27373684
Structural Features and Functional Dependency on β-Clamp Define Distinct Subfamilies of Bacterial Mismatch Repair Endonuclease MutL. PMID:27369079
Nipah virus matrix protein: expert hacker of cellular machines. PMID:27350027
Comparative Protein Structure Modeling Using MODELLER. PMID:27322406
Natural Phenolic Inhibitors of Trichothecene Biosynthesis by the Wheat Fungal Pathogen Fusarium culmorum: A Computational Insight into the Structure-Activity Relationship. PMID:27294666
Binding of the Fkh1 Forkhead Associated Domain to a Phosphopeptide within the Mph1 DNA Helicase Regulates Mating-Type Switching in Budding Yeast. PMID:27257873
Orthology Analysis and In Vivo Complementation Studies to Elucidate the Role of DIR1 during Systemic Acquired Resistance in Arabidopsis thaliana and Cucumis sativus. PMID:27200039
Visualizing ensembles in structural biology. PMID:27179343
The Cell Surface Receptor CD44: NMR-Based Characterization of Putative Ligands. PMID:27144715
Type III polyketide synthase repertoire in Zingiberaceae: computational insights into the sequence, structure and evolution. PMID:27138283
Open drug discovery for the Zika virus. PMID:27134728
Paired octamer rings of retinoschisin suggest a junctional model for cell-cell adhesion in the retina. PMID:27114531
High-resolution mapping of a novel rat blood pressure locus on chromosome 9 to a region containing the Spp2 gene and colocalization of a QTL for bone mass. PMID:27113531
Bioinformatics and Molecular Analysis of the Evolutionary Relationship between Bovine Rhinitis A Viruses and Foot-And-Mouth Disease Virus. PMID:27081310
Mps1 (Monopolar Spindle 1) Protein Inhibition Affects Cellular Growth and Pro-Embryogenic Masses Morphology in Embryogenic Cultures of Araucaria angustifolia (Araucariaceae). PMID:27064899
Modulating the import of medium-chain alkanes in E. coli through tuned expression of FadL. PMID:27053948
In Silico Approach for SAR Analysis of the Predicted Model of DEPDC1B: A Novel Target for Oral Cancer. PMID:27034663
Maltose-Binding Protein (MBP), a Secretion-Enhancing Tag for Mammalian Protein Expression Systems. PMID:27029048
Functional Transplant of a Dengue Virus Serotype 3 (DENV3)-Specific Human Monoclonal Antibody Epitope into DENV1. PMID:26962223
Functional analysis of the binding model of microbial inulinases using docking and molecular dynamics simulation. PMID:26956120
The Most Prevalent Freeman-Sheldon Syndrome Mutations in the Embryonic Myosin Motor Share Functional Defects. PMID:26945064
Dihydrofolate-Reductase Mutations in Plasmodium knowlesi Appear Unrelated to Selective Drug Pressure from Putative Human-To-Human Transmission in Sabah, Malaysia. PMID:26930493
Engineering broad-spectrum digestion of polyuronides from an exolytic polysaccharide lyase. PMID:26913076
The Proliferating Cell Nuclear Antigen (PCNA)-interacting Protein (PIP) Motif of DNA Polymerase η Mediates Its Interaction with the C-terminal Domain of Rev1. PMID:26903512
Sequence Requirements for Neuropilin-2 Recognition by ST8SiaIV and Polysialylation of Its O-Glycans. PMID:26884342
Product Rearrangement from Altering a Single Residue in the Rice syn-Copalyl Diphosphate Synthase. PMID:26878189
A New Mutation, hap1-2, Reveals a C Terminal Domain Function in AtMago Protein and Its Biological Effects in Male Gametophyte Development in Arabidopsis thaliana. PMID:26867216
Identification and Characterization of IgdE, a Novel IgG-degrading Protease of Streptococcus suis with Unique Specificity for Porcine IgG. PMID:26861873
In-Silico Computing of the Most Deleterious nsSNPs in HBA1 Gene. PMID:26824843
Genetic Variation of SCN5A in Korean Patients with Sick Sinus Syndrome. PMID:26798387
Subunit stoichiometry and arrangement in a heteromeric glutamate-gated chloride channel. PMID:26792524
Leishmania infantum Asparagine Synthetase A Is Dispensable for Parasites Survival and Infectivity. PMID:26771178
Computational screen and experimental validation of anti-influenza effects of quercetin and chlorogenic acid from traditional Chinese medicine. PMID:26754609
The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins. PMID:26748706
Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity. PMID:26742086
Influence of Familial Renal Glycosuria Due to Mutations in the SLC5A2 Gene on Changes in Glucose Tolerance over Time. PMID:26735923
Evaluation of a DLA-79 allele associated with multiple immune-mediated diseases in dogs. PMID:26711123
Characterization of Aspartate Kinase from Corynebacterium pekinense and the Critical Site of Arg169. PMID:26633359
The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases. PMID:26615188
Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation. PMID:26601954
A phylogenetic approach to study the origin and evolution of the CRINKLY4 family. PMID:26557128
Identification of a Novel Di-D-Fructofuranose 1,2':2,3' Dianhydride (DFA III) Hydrolysis Enzyme from Arthrobacter aurescens SK8.001. PMID:26555784
AcrB-AcrA Fusion Proteins That Act as Multidrug Efflux Transporters. PMID:26527645
Mixed-mode resins: taking shortcut in downstream processing of raw-starch digesting α-amylases. PMID:26492875
A Naturally Occurring Domestic Cat APOBEC3 Variant Confers Resistance to Feline Immunodeficiency Virus Infection. PMID:26491161
Systematic evaluation of underlying defects in DNA repair as an approach to case-only assessment of familial prostate cancer. PMID:26485759
Inhibition on JAK-STAT3 Signaling Transduction Cascade Is Taken by Bioactive Peptide Alpha-S2 Casein Protein from Goat Ethawah Breed Milk. PMID:26483598
Regulation by Phloroglucinol of Nrf2/Maf-Mediated Expression of Antioxidant Enzymes and Inhibition of Osteoclastogenesis via the RANKL/RANK Signaling Pathway: In Silico study. PMID:26483597
Structural and functional features of a developmentally regulated lipopolysaccharide-binding protein. PMID:26463160
Cloning, Expression, Sequence Analysis and Homology Modeling of the Prolyl Endoprotease from Eurygaster integriceps Puton. PMID:26462938
Global redesign of a native β-barrel scaffold. PMID:26456555
Biochemical Characterization and Substrate Specificity of Autophagin-2 from the Parasite Trypanosoma cruzi. PMID:26446788
Long-term survival of Borrelia burgdorferi lacking the hibernation promotion factor homolog in the unfed tick vector. PMID:26438790
Variation in the ribosome interacting loop of the Sec61α from Giardia lamblia. PMID:26424409
Engineering a monolignol 4-O-methyltransferase with high selectivity for the condensed lignin precursor coniferyl alcohol. PMID:26378240
The Role of Cysteine Residues in Redox Regulation and Protein Stability of Arabidopsis thaliana Starch Synthase 1. PMID:26367870
Excessive caloric intake acutely causes oxidative stress, GLUT4 carbonylation, and insulin resistance in healthy men. PMID:26355033
Selectivity in the Use of Gi/o Proteins Is Determined by the DRF Motif in CXCR6 and Is Cell-Type Specific. PMID:26316539
The Polycystin-1, Lipoxygenase, and α-Toxin Domain Regulates Polycystin-1 Trafficking. PMID:26311459
Determination and validation of mTOR kinase-domain 3D structure by homology modeling. PMID:26257525
The Structure of YnaI Implies Structural and Mechanistic Conservation in the MscS Family of Mechanosensitive Channels. PMID:26256535
Adaptive mutations in sugar metabolism restore growth on glucose in a pyruvate decarboxylase negative yeast strain. PMID:26253003
Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation. PMID:26245380
Two Novel NYX Gene Mutations in the Chinese Families with X-linked Congenital Stationary Night Blindness. PMID:26234941
Identification of two novel critical mutations in PCNT gene resulting in microcephalic osteodysplastic primordial dwarfism type II associated with multiple intracranial aneurysms. PMID:26231886
Selective forces acting during multi-domain protein evolution: the case of multi-domain globins. PMID:26191481
Characterization of the periplasmic redox network that sustains the versatile anaerobic metabolism of Shewanella oneidensis MR-1. PMID:26175726
In vivo efficacy and molecular docking of designed peptide that exhibits potent antipneumococcal activity and synergises in combination with penicillin. PMID:26156658
A tale of two sisters: identical IL36RN mutations and discordant phenotypes. PMID:26147717
AVP-NPII gene mutations and clinical characteristics of the patients with autosomal dominant familial central diabetes insipidus. PMID:26134705
Receptor-mediated Endocytosis 8 Utilizes an N-terminal Phosphoinositide-binding Motif to Regulate Endosomal Clathrin Dynamics. PMID:26134565
Quantitative modeling of dose-response and drug combination based on pathway network. PMID:26101547
Building a virtual ligand screening pipeline using free software: a survey. PMID:26094053
Redox-dependent Ligand Switching in a Sensory Heme-binding GAF Domain of the Cyanobacterium Nostoc sp. PCC7120. PMID:26063806
Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase. PMID:26046350
Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae. PMID:26046345
Dystrophin hydrophobic regions in the pathogenesis of Duchenne and Becker muscular dystrophies. PMID:26042512
Exome-Wide Association Study Identifies New Low-Frequency and Rare UGT1A1 Coding Variants and UGT1A6 Coding Variants Influencing Serum Bilirubin in Elderly Subjects: A Strobe Compliant Article. PMID:26039129
Surface hydrolysis of sphingomyelin by the outer membrane protein Rv0888 supports replication of Mycobacterium tuberculosis in macrophages. PMID:26036301
The CYP51F1 Gene of Leptographium qinlingensis: Sequence Characteristic, Phylogeny and Transcript Levels. PMID:26016505
Differences in conformational dynamics within the Hsp90 chaperone family reveal mechanistic insights. PMID:25988145
Three Pseudomonas putida FNR Family Proteins with Different Sensitivities to O2. PMID:25971977
A novel caspase 8 selective small molecule potentiates TRAIL-induced cell death. PMID:25962125
Celecoxib influences steroid sulfonation catalyzed by human recombinant sulfotransferase 2A1. PMID:25960318
Molecular design of selective ligands of chemokine receptors. PMID:25937232
Calcium sensors of ciliary outer arm dynein: functions and phylogenetic considerations for eukaryotic evolution. PMID:25932323
Ozone-Induced Rice Grain Yield Loss Is Triggered via a Change in Panicle Morphology That Is Controlled by ABERRANT PANICLE ORGANIZATION 1 Gene. PMID:25923431
Characterization of the Ubiquitin-Conjugating Enzyme Gene Family in Rice and Evaluation of Expression Profiles under Abiotic Stresses and Hormone Treatments. PMID:25902049
Insight into the role of alternative splicing within the RBM10v1 exon 10 tandem donor site. PMID:25889998
Structure and function of a short LOV protein from the marine phototrophic bacterium Dinoroseobacter shibae. PMID:25887755
Heterologous expression and biochemical characterization of a highly active and stable chloroplastic CuZn-superoxide dismutase from Pisum sativum. PMID:25887674
The characterization of modified starch branching enzymes: toward the control of starch chain-length distributions. PMID:25874689
High-throughput screening-compatible assays of As(III) S-adenosylmethionine methyltransferase activity. PMID:25866076
Crystal structure of a light-driven sodium pump. PMID:25849142
ISOB: A Database of Indigenous Snake Species of Bangladesh with respective known venom composition. PMID:25848172
Optimal ligand descriptor for pocket recognition based on the Beta-shape. PMID:25835497
Chlorotoxin: a helpful natural scorpion peptide to diagnose glioma and fight tumor invasion. PMID:25826056
Small-angle X-ray scattering analysis reveals the ATP-bound monomeric state of the ATPase domain from the homodimeric MutL endonuclease, a GHKL phosphotransferase superfamily protein. PMID:25809295
Functional significance of calcium binding to tissue-nonspecific alkaline phosphatase. PMID:25775211
Targeted next-generation sequencing reveals novel EYS mutations in Chinese families with autosomal recessive retinitis pigmentosa. PMID:25753737
FR database 1.0: a resource focused on fruit development and ripening. PMID:25725058
Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation. PMID:25713363
Molecular bases of catalysis and ADP-ribose preference of human Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase and conversion by mutagenesis to a preferential cyclic ADP-ribose phosphohydrolase. PMID:25692488
Positions of the cytoplasmic end of BK α S0 helix relative to S1-S6 and of β1 TM1 and TM2 relative to S0-S6. PMID:25667410
Propofol inhibits SIRT2 deacetylase through a conformation-specific, allosteric site. PMID:25666612
p53-derived host restriction of HIV-1 replication by protein kinase R-mediated Tat phosphorylation and inactivation. PMID:25653431
Synthetic enzyme-substrate tethering obviates the Tolloid-ECM interaction during Drosophila BMP gradient formation. PMID:25642644
A bacterial hemerythrin-like protein MsmHr inhibits the SigF-dependent hydrogen peroxide response in mycobacteria. PMID:25642228
The Streptomyces coelicolor lipoate-protein ligase is a circularly permuted version of the Escherichia coli enzyme composed of discrete interacting domains. PMID:25631049
Localizing the RPGR protein along the cilium: a new method to determine efficacies to treat RPGR mutations. PMID:25630948
Functional and structural impact of the most prevalent missense mutations in classic galactosemia. PMID:25614870
A novel humanized antibody neutralizes H5N1 influenza virus via two different mechanisms. PMID:25609802
Structural and biochemical analysis of the essential diadenylate cyclase CdaA from Listeria monocytogenes. PMID:25605729
Ribose 5-phosphate isomerase B knockdown compromises Trypanosoma brucei bloodstream form infectivity. PMID:25568941
RNA helicase A activity is inhibited by oncogenic transcription factor EWS-FLI1. PMID:25564528
Expression, purification, and characterization of galactose oxidase of Fusarium sambucinum in E. coli. PMID:25543085
Crystal structure of DNA cytidine deaminase ABOBEC3G catalytic deamination domain suggests a binding mode of full-length enzyme to single-stranded DNA. PMID:25542899
Structural basis for heterogeneous phenotype of ERG11 dependent Azole resistance in C.albicans clinical isolates. PMID:25512882
Diversification and distinctive structural features of S-RNase alleles in the genus Solanum. PMID:25501309
Conformational dynamics in substrate-binding domains influences transport in the ABC importer GlnPQ. PMID:25486304
Genetic analysis of signal integration by the Sinorhizobium meliloti sensor kinase FeuQ. PMID:25479839
Phosphoinositide binding by the SNX27 FERM domain regulates its localization at the immune synapse of activated T-cells. PMID:25472716
Differential ubiquitin binding by the acidic loops of Ube2g1 and Ube2r1 enzymes distinguishes their Lys-48-ubiquitylation activities. PMID:25471371
Identification of two missense mutations of ERCC6 in three Chinese sisters with Cockayne syndrome by whole exome sequencing. PMID:25463447
Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding. PMID:25432241
Design and development of a novel vaccine for protection against Lyme borreliosis. PMID:25409015
Mechismo: predicting the mechanistic impact of mutations and modifications on molecular interactions. PMID:25392414
Autolytic activation of calpain 3 proteinase is facilitated by calmodulin protein. PMID:25389288
The discovery of Hsp70 domain with cell-penetrating activity. PMID:25387797
Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids. PMID:25378907
The MDM2 gene family. PMID:25372739
Lack of negatively charged residues at the external mouth of Kir2.2 channels enable the voltage-dependent block by external Mg2+. PMID:25350118
Application of a novel alkali-tolerant thermostable DyP-type peroxidase from Saccharomonospora viridis DSM 43017 in biobleaching of eucalyptus kraft pulp. PMID:25333297
Identification of antigenic proteins of the nosocomial pathogen Klebsiella pneumoniae. PMID:25333280
Exploring the genes of yerba mate (Ilex paraguariensis A. St.-Hil.) by NGS and de novo transcriptome assembly. PMID:25330175
Pathway of human AS3MT arsenic methylation. PMID:25325836
The Myb domain of the largest subunit of SNAPc adopts different architectural configurations on U1 and U6 snRNA gene promoter sequences. PMID:25324315
Molecular modeling and MM-PBSA free energy analysis of endo-1,4-β-xylanase from Ruminococcus albus 8. PMID:25264743
An Immuno-informatics driven Epitope study from the molecular interaction of JEV non-structural (NS) proteins with Ribophorin (RPN). PMID:25258484
Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands. PMID:25240283
Structural insights into the mechanism of negative regulation of single-box high mobility group proteins by the acidic tail domain. PMID:25190813
Voltage- and ATP-dependent structural rearrangements of the P2X2 receptor associated with the gating of the pore. PMID:25172943
Assessing the local structural quality of transmembrane protein models using statistical potentials (QMEANBrane). PMID:25161240
Chaperones rescue luciferase folding by separating its domains. PMID:25160632
Identification of a novel ARL13B variant in a Joubert syndrome-affected patient with retinal impairment and obesity. PMID:25138100
A novel methyltransferase from the intracellular pathogen Plasmodiophora brassicae methylates salicylic acid. PMID:25135243
Structural divergence of plant TCTPs. PMID:25120549
Comparative molecular dynamics simulation of Hepatitis C Virus NS3/4A protease (Genotypes 1b, 3a and 4b) predicts conformational instability of the catalytic triad in drug resistant strains. PMID:25111232
Exploring interaction of TNF and orthopoxviral CrmB protein by surface plasmon resonance and free energy calculation. PMID:25101631
De novo missense mutations in the NAA10 gene cause severe non-syndromic developmental delay in males and females. PMID:25099252
Molecular cloning and functional analysis of nine cinnamyl alcohol dehydrogenase family members in Populus tomentosa. PMID:25096165
A molecularly cloned, live-attenuated japanese encephalitis vaccine SA14-14-2 virus: a conserved single amino acid in the ij Hairpin of the Viral E glycoprotein determines neurovirulence in mice. PMID:25077483
Identification and use of an alkane transporter plug-in for applications in biocatalysis and whole-cell biosensing of alkanes. PMID:25068650
Aureochrome 1 illuminated: structural changes of a transcription factor probed by molecular spectroscopy. PMID:25058114
The metagenomic telescope. PMID:25054802
SFannotation: A Simple and Fast Protein Function Annotation System. PMID:25031571
ACE for all - a molecular perspective. PMID:25027949
Plasticity and evolution of (+)-3-carene synthase and (-)-sabinene synthase functions of a sitka spruce monoterpene synthase gene family associated with weevil resistance. PMID:25016016
Monte Carlo loop refinement and virtual screening of the thyroid-stimulating hormone receptor transmembrane domain. PMID:25012978
Comprehensive analysis of cystatin family genes suggests their putative functions in sexual reproduction, embryogenesis, and seed formation. PMID:24996653
Characterization of the calicheamicin orsellinate C2-O-methyltransferase CalO6. PMID:24978950
B-cell epitopes in GroEL of Francisella tularensis. PMID:24968190
Galactose oxidase from Fusarium oxysporum--expression in E. coli and P. pastoris and biochemical characterization. PMID:24967652
Maturation of Rhizobium leguminosarum hydrogenase in the presence of oxygen requires the interaction of the chaperone HypC and the scaffolding protein HupK. PMID:24942742
HIV-1 and HIV-2 Vif interact with human APOBEC3 proteins using completely different determinants. PMID:24942576
Novel mutation in FBN1 causes ectopia lentis and varicose great saphenous vein in one Chinese autosomal dominant family. PMID:24940037
Control of the diadenylate cyclase CdaS in Bacillus subtilis: an autoinhibitory domain limits cyclic di-AMP production. PMID:24939848
TNNI3K mutation in familial syndrome of conduction system disease, atrial tachyarrhythmia and dilated cardiomyopathy. PMID:24925317
Computational study on substrate specificity of a novel cysteine protease 1 precursor from Zea mays. PMID:24921705
Mechanism of ATPase-mediated Cu+ export and delivery to periplasmic chaperones: the interaction of Escherichia coli CopA and CusF. PMID:24917681
Stoichiometry of site-specific lysine acetylation in an entire proteome. PMID:24917678
Direct interaction between the WD40 repeat protein WDR-23 and SKN-1/Nrf inhibits binding to target DNA. PMID:24912676
Rare and common variants in extracellular matrix gene Fibrillin 2 (FBN2) are associated with macular degeneration. PMID:24899048
In Silico Prediction of T and B Cell Epitopes of Der f 25 in Dermatophagoides farinae. PMID:24895543
Crystal structures of ligand-bound octaprenyl pyrophosphate synthase from Escherichia coli reveal the catalytic and chain-length determining mechanisms. PMID:24895191
Massive gene transfer and extensive RNA editing of a symbiotic dinoflagellate plastid genome. PMID:24881086
Predicting enzyme adsorption to lignin films by calculating enzyme surface hydrophobicity. PMID:24876380
A novel universal neutralizing monoclonal antibody against enterovirus 71 that targets the highly conserved "knob" region of VP3 protein. PMID:24875055
Signal transmission within the P2X2 trimeric receptor. PMID:24863932
Evolution of the Phosphoenolpyruvate Carboxylase Protein Kinase Family in C3 and C4 Flaveria spp. PMID:24850859
Novel and recurrent MYO7A mutations in Usher syndrome type 1 and type 2. PMID:24831256
Successful conversion of the Bacillus subtilis BirA Group II biotin protein ligase into a Group I ligase. PMID:24816803
Alginate-dependent gene expression mechanism in Sphingomonas sp. strain A1. PMID:24816607
Integrating omics technologies to study pulmonary physiology and pathology at the systems level. PMID:24802001
SwissTargetPrediction: a web server for target prediction of bioactive small molecules. PMID:24792161
Fifteen years SIB Swiss Institute of Bioinformatics: life science databases, tools and support. PMID:24792157
Point mutations associated with organophosphate and carbamate resistance in Chinese strains of Culex pipiens quinquefasciatus (Diptera: Culicidae). PMID:24788312
Antenna-specific glutathione S-transferase in male silkmoth Bombyx mori. PMID:24786099
SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information. PMID:24782522
A role for [Fe4S4] clusters in tRNA recognition--a theoretical study. PMID:24753428
Mass spectrometry defines the C-terminal dimerization domain and enables modeling of the structure of full-length OmpA. PMID:24746938
Molecular characterization of Plasmodium falciparum uracil-DNA glycosylase and its potential as a new anti-malarial drug target. PMID:24742318
Nuclear trafficking of the HIV-1 pre-integration complex depends on the ADAM10 intracellular domain. PMID:24725932
Soybean (Glycine max) expansin gene superfamily origins: segmental and tandem duplication events followed by divergent selection among subfamilies. PMID:24720629
Mitochondrial D-loop and cytochrome oxidase C subunit I polymorphisms among the breast cancer patients of Mizoram, Northeast India. PMID:24719079
Computational enzyme design approaches with significant biological outcomes: progress and challenges. PMID:24688648
Structural insights into RNA encapsidation and helical assembly of the Toscana virus nucleoprotein. PMID:24688060
FreeContact: fast and free software for protein contact prediction from residue co-evolution. PMID:24669753
Cloning and characterization of a wheat homologue of apurinic/apyrimidinic endonuclease Ape1L. PMID:24667595
Molecular basis for specific recognition of bacterial ligands by NAIP/NLRC4 inflammasomes. PMID:24657167
Identification and suppression of the p-coumaroyl CoA:hydroxycinnamyl alcohol transferase in Zea mays L. PMID:24654730
Structural analysis of a glycoside hydrolase family 11 xylanase from Neocallimastix patriciarum: insights into the molecular basis of a thermophilic enzyme. PMID:24619408
In silico characterization of an atypical MAPK phosphatase of Plasmodium falciparum as a suitable target for drug discovery. PMID:24605883
Unraveling regulation of the small heat shock proteins by the heat shock factor HvHsfB2c in barley: its implications in drought stress response and seed development. PMID:24594978
Comparison of the intrinsic dynamics of aminoacyl-tRNA synthetases. PMID:24590670
Catalytic signature of a heat-stable, chimeric human alkaline phosphatase with therapeutic potential. PMID:24586729
Determining the Role of the Aromatic Ring of N-Arylmethyl ent-conduramine F-1 in their Interactions with α-Glucosidases by Saturation Transfer Difference NMR Spectroscopy Experiments. PMID:24551486
Effects of cadmium and mercury on the upper part of skeletal muscle glycolysis in mice. PMID:24489641
Signature motifs identify an Acinetobacter Cif virulence factor with epoxide hydrolase activity. PMID:24474692
Exploring the molecular basis for selective binding of homoserine dehydrogenase from Mycobacterium leprae TN toward inhibitors: a virtual screening study. PMID:24469317
Critical amino acids within the human immunodeficiency virus type 1 envelope glycoprotein V4 N- and C-terminals contribute to virus entry. PMID:24465884
Tracking molecular recognition at the atomic level with a new protein scaffold based on the OB-fold. PMID:24465865
Virtual screening of m3 protein antagonists for finding a model to study the gammaherpesvirus damaged immune system and chemokine related diseases. PMID:24455481
3D Structure Modeling of Alpha-Amino Acid Ester Hydrolase from Xanthomonas rubrilineans. PMID:24455184
Cryo-electron microscopic structure of SecA protein bound to the 70S ribosome. PMID:24443566
Virtual screening reveals allosteric inhibitors of the Toxoplasma gondii thymidylate synthase-dihydrofolate reductase. PMID:24440298
Computational methods in drug discovery. PMID:24381236
Homocysteine homeostasis and betaine-homocysteine S-methyltransferase expression in the brain of hibernating bats. PMID:24376891
Fusion with anticodon binding domain of GluRS is not sufficient to alter the substrate specificity of a chimeric Glu-Q-RS. PMID:24374508
An arginine-aspartate network in the active site of bacterial TruB is critical for catalyzing pseudouridine formation. PMID:24371284
Molecular characteristics of the HSP70 gene and its differential expression in female and male golden apple snails (Pomacea canaliculata) under temperature stimulation. PMID:24368711
Germline loss-of-function mutations in LZTR1 predispose to an inherited disorder of multiple schwannomas. PMID:24362817
The effect of conformational variability of phosphotriesterase upon N-acyl-L-homoserine lactone and paraoxon binding: insights from molecular dynamics studies. PMID:24352010
Critical assessment of methods of protein structure prediction (CASP)--round x. PMID:24344053
Knockdown of asparagine synthetase A renders Trypanosoma brucei auxotrophic to asparagine. PMID:24340117
Discovery of a metabolic alternative to the classical mevalonate pathway. PMID:24327557
Inhibition of rat muscle and liver phosphofructokinases by high doses of ethanol. PMID:24324886
Characteristics and function of sulfur dioxygenase in Echiuran worm Urechis unicinctus. PMID:24312599
Structure-function studies on non-synonymous SNPs of chemokine receptor gene implicated in cardiovascular disease: a computational approach. PMID:24293156
A small molecule glycosaminoglycan mimetic blocks Plasmodium invasion of the mosquito midgut. PMID:24278017
Modulating the RNA processing and decay by the exosome: altering Rrp44/Dis3 activity and end-product. PMID:24265673
Molecular cloning and characterization of a P-glycoprotein from the diamondback moth, Plutella xylostella (Lepidoptera: Plutellidae). PMID:24264038
Structure predictions of two Bauhinia variegata lectins reveal patterns of C-terminal properties in single chain legume lectins. PMID:24260572
Identification of a 31-bp deletion in the RELN gene causing lissencephaly with cerebellar hypoplasia in sheep. PMID:24260534
A polysaccharide lyase from Stenotrophomonas maltophilia with a unique, pH-regulated substrate specificity. PMID:24257754
A novel activation mechanism of avian influenza virus H9N2 by furin. PMID:24257604
Reducing IRS-1 Activation Cause Mutation of Tyrosine Kinase Domain hINSR Gene on Type-2 Diabetes Mellitus Patients. PMID:24250111
Integrating in silico resources to map a signaling network. PMID:24233784
Delineating the extracellular water-accessible surface of the proton-coupled folate transporter. PMID:24205192
Mmi1, the yeast homologue of mammalian TCTP, associates with stress granules in heat-shocked cells and modulates proteasome activity. PMID:24204967
Design of vaccine adjuvants incorporating TNF superfamily ligands and TNF superfamily molecular mimics. PMID:24198065
An estimated 5% of new protein structures solved today represent a new Pfam family. PMID:24189229
Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all. PMID:24189052
Identification of the ubiquitin-like domain of midnolin as a new glucokinase interaction partner. PMID:24187134
Expression and purification of ecdysteroid-regulated protein from Chinese mitten crab Eriocheir sinensis in E. coli. PMID:24178342
Fungal genomes mining to discover novel sterol esterases and lipases as catalysts. PMID:24138290
Extending RosettaDock with water, sugar, and pH for prediction of complex structures and affinities for CAPRI rounds 20-27. PMID:24123494
Functional and fluorescence analyses of tryptophan residues in H+-pyrophosphatase of Clostridium tetani. PMID:24121937
Sulfamethoxazole induces a switch mechanism in T cell receptors containing TCRVβ20-1, altering pHLA recognition. PMID:24116097
The α2B-adrenergic receptor is mutant in cortical myoclonus and epilepsy. PMID:24114805
Monopolar spindle 1 (MPS1) protein-dependent phosphorylation of RecQ-mediated genome instability protein 2 (RMI2) at serine 112 is essential for BLM-Topo III α-RMI1-RMI2 (BTR) protein complex function upon spindle assembly checkpoint (SAC) activation during mitosis. PMID:24108125
Structures of the Porphyromonas gingivalis OxyR regulatory domain explain differences in expression of the OxyR regulon in Escherichia coli and P. gingivalis. PMID:24100327
Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia. PMID:24076604
Structural and functional implication of RAP80 ΔGlu81 mutation. PMID:24039796
In silico analysis and experimental validation of molecular mechanisms of salvianolic acid A-inhibited LPS-stimulated inflammation, in RAW264.7 macrophages. PMID:24033467
Methylation impact analysis of erythropoietin (EPO) Gene to hypoxia inducible factor-1α (HIF-1α) activity. PMID:24023421
Protein modeling: what happened to the "protein structure gap"? PMID:24010712
Functions, compositions, and evolution of the two types of carboxysomes: polyhedral microcompartments that facilitate CO2 fixation in cyanobacteria and some proteobacteria. PMID:24006469
Molecular modeling and docking of microbial inulinases towards perceptive enzyme-substrate interactions. PMID:23997327
Vig r 6, the cytokinin-specific binding protein from mung bean (Vigna radiata) sprouts, cross-reacts with Bet v 1-related allergens and binds IgE from birch pollen allergic patients' sera. PMID:23996905
Shotgun metagenomics indicates novel family A DNA polymerases predominate within marine virioplankton. PMID:23985748
Identification and characterization of an unusual metallo-β-lactamase from Serratia proteamaculans. PMID:23982345
Structure of a dinuclear iron cluster-containing β-hydroxylase active in antibiotic biosynthesis. PMID:23980641
Uses of phage display in agriculture: sequence analysis and comparative modeling of late embryogenesis abundant client proteins suggest protein-nucleic acid binding functionality. PMID:23956788
A novel color change mechanism for breast cancer biomarker detection: naphthoquinones as specific ligands of human arylamine N-acetyltransferase 1. PMID:23940600
Functional divergence and convergent evolution in the plastid-targeted glyceraldehyde-3-phosphate dehydrogenases of diverse eukaryotic algae. PMID:23936198
Chiral hydroxylation at the mononuclear nonheme Fe(II) center of 4-(S) hydroxymandelate synthase--a structure-activity relationship analysis. PMID:23935907
Enterovirus 71 binding to PSGL-1 on leukocytes: VP1-145 acts as a molecular switch to control receptor interaction. PMID:23935488
Structural insights into adeno-associated virus serotype 5. PMID:23926356
Mutations of residues 249 and 256 in VP2 are involved in the replication and virulence of infectious Bursal disease virus. PMID:23923037
The P110 subunit of PI3-K is a therapeutic target of acacetin in skin cancer. PMID:23913940
Structural characterization of nitrosomonas europaea cytochrome c-552 variants with marked differences in electronic structure. PMID:23908017
snow white, a zebrafish model of Hermansky-Pudlak Syndrome type 5. PMID:23893484
Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1. PMID:23878397
Candida tropicalis antifungal cross-resistance is related to different azole target (Erg11p) modifications. PMID:23877676
Thermodynamic stability and flexibility characteristics of antibody fragment complexes. PMID:23855672
Long distance movement of DIR1 and investigation of the role of DIR1-like during systemic acquired resistance in Arabidopsis. PMID:23847635
Predictive model for epoxide hydrolase-generated stereochemistry in the biosynthesis of nine-membered enediyne antitumor antibiotics. PMID:23844627
The cardiac acetyl-lysine proteome. PMID:23844019
Two distinct states of the HAMP domain from sensory rhodopsin transducer observed in unbiased molecular dynamics simulations. PMID:23843970
The role of the RACK1 ortholog Cpc2p in modulating pheromone-induced cell cycle arrest in fission yeast. PMID:23843946
The molecular basis for recognition of bacterial ligands at equine TLR2, TLR1 and TLR6. PMID:23826682
Structural basis for the inhibition of bacterial multidrug exporters. PMID:23812586
α-Amylase: an enzyme specificity found in various families of glycoside hydrolases. PMID:23807207
Computational methods for constructing protein structure models from 3D electron microscopy maps. PMID:23796504
Biochemical characterization of UDP-N-acetylmuramoyl-L-alanyl-D-glutamate: meso-2,6-diaminopimelate ligase (MurE) from Verrucomicrobium spinosum DSM 4136(T.). PMID:23785498
Assessment of the assessment: evaluation of the model quality estimates in CASP10. PMID:23780644
A 3D structural model and dynamics of hepatitis C virus NS3/4A protease (genotype 4a, strain ED43) suggest conformational instability of the catalytic triad: implications in catalysis and drug resistivity. PMID:23768174
Molecular epidemiology of porcine Cytomegalovirus (PCMV) in Sichuan Province, China: 2010-2012. PMID:23762243
Substrate specificity and interferences of a direct-electron-transfer-based glucose biosensor. PMID:23759400
Crystal structure of the Golgi casein kinase. PMID:23754375
A frequent splicing mutation and novel missense mutations color the updated mutational spectrum of classic galactosemia in Portugal. PMID:23749220
Cloning and polymorphisms of yak lactate dehydrogenase B gene. PMID:23739677
Rapid identification of novel immunodominant proteins and characterization of a specific linear epitope of Campylobacter jejuni. PMID:23734261
Discovery of catalases in members of the Chlamydiales order. PMID:23729651
Structural basis of multisite single-stranded DNA recognition and ACTA2 repression by purine-rich element binding protein B (Purβ). PMID:23724822
Squeezing at entrance of proton transport pathway in proton-translocating pyrophosphatase upon substrate binding. PMID:23720778
Cryo-EM structures of the late-stage assembly intermediates of the bacterial 50S ribosomal subunit. PMID:23700310
The minimal Bacillus subtilis nonhomologous end joining repair machinery. PMID:23691176
Bacterial serine proteases secreted by the autotransporter pathway: classification, specificity, and role in virulence. PMID:23689588
Computational identification and analysis of arsenate reductase protein in Cronobacter sakazakii ATCC BAA-894 suggests potential microorganism for reducing arsenate. PMID:23666632
The highly dynamic oligomeric structure of bradavidin II is unique among avidin proteins. PMID:23661323
The Protein Model Portal--a comprehensive resource for protein structure and model information. PMID:23624946
Adaptation of phenylalanine and tyrosine catabolic pathway to hibernation in bats. PMID:23620802
Species-specific detection of the antiviral small-molecule compound CMA by STING. PMID:23604073
Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia. PMID:23596048
HDAC6 regulates mutant SOD1 aggregation through two SMIR motifs and tubulin acetylation. PMID:23580651
Predicting the next eye pathogen: analysis of a novel adenovirus. PMID:23572555
NemR is a bleach-sensing transcription factor. PMID:23536188
Structural model of a putrescine-cadaverine permease from Trypanosoma cruzi predicts residues vital for transport and ligand binding. PMID:23535070
Methylotrophic Bacillus methanolicus encodes two chromosomal and one plasmid born NAD+ dependent methanol dehydrogenase paralogs with different catalytic and biochemical properties. PMID:23527128
LEC-2, a highly variable lectin in the lichen Peltigera membranacea. PMID:23482294
Structural insight into the lactoferrin receptors from pathogenic Neisseria. PMID:23462098
Dual function of the NDR-kinase Dbf2 in the regulation of the F-BAR protein Hof1 during cytokinesis. PMID:23447700
Kinetic analyses guide the therapeutic decision in a novel form of moderate aromatic Acid decarboxylase deficiency. PMID:23430870
Spatial distribution and receptor specificity of zebrafish Kit system--evidence for a Kit-mediated bi-directional communication system in the preovulatory ovarian follicle. PMID:23409152
Comparison of Epothilone and Taxol Binding in Yeast Tubulin using Molecular Modeling. PMID:23407671
High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome. PMID:23395961
X-ray crystal structure of Escherichia coli RNA polymerase σ70 holoenzyme. PMID:23389035
Mutation in the PCSK9 Gene in Omani Arab Subjects with Autosomal Dominant Hypercholesterolemia and its Effect on PCSK9 Protein Structure. PMID:23386946
Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase/butyrylcholinesterase inhibitors: effect against amyloid-β-induced neurotoxicity. PMID:23379636
Type II kinase inhibitors show an unexpected inhibition mode against Parkinson's disease-linked LRRK2 mutant G2019S. PMID:23379419
Theoretical analysis of the neuraminidase epitope of the Mexican A H1N1 influenza strain, and experimental studies on its interaction with rabbit and human hosts. PMID:23371837
NrdH-redoxin of Mycobacterium tuberculosis and Corynebacterium glutamicum dimerizes at high protein concentration and exclusively receives electrons from thioredoxin reductase. PMID:23362277
Enhancement of Streptomyces transglutaminase activity and pro-peptide cleavage efficiency by introducing linker peptide in the C-terminus of the pro-peptide. PMID:23344500
PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. PMID:23340338
Identification and characterization of a type III polyketide synthase involved in quinolone alkaloid biosynthesis from Aegle marmelos Correa. PMID:23329842
Sequential duplications of an ancient member of the DnaJ-family expanded the functional chaperone network in the eukaryotic cytosol. PMID:23329686
Architecture and assembly of HIV integrase multimers in the absence of DNA substrates. PMID:23322775
Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy. PMID:23314057
ALDH1A3 mutations cause recessive anophthalmia and microphthalmia. PMID:23312594
Bacterial feeding, Leishmania infection and distinct infection routes induce differential defensin expression in Lutzomyia longipalpis. PMID:23311993
A LiTat 1.5 variant surface glycoprotein-derived peptide with diagnostic potential for Trypanosoma brucei gambiense. PMID:23289521
Modeling and structural analysis of cellulases using Clostridium thermocellum as template. PMID:23251045
STRING v9.1: protein-protein interaction networks, with increased coverage and integration. PMID:23203871
Folding of large multidomain proteins by partial encapsulation in the chaperonin TRiC/CCT. PMID:23197838
Cyclic di-AMP homeostasis in bacillus subtilis: both lack and high level accumulation of the nucleotide are detrimental for cell growth. PMID:23192352
Structural analyses of a constitutively active mutant of exchange protein directly activated by cAMP. PMID:23189173
A broad specificity nucleoside kinase from Thermoplasma acidophilum. PMID:23161756
Quaternary structure of the yeast Arc1p-aminoacyl-tRNA synthetase complex in solution and its compaction upon binding of tRNAs. PMID:23161686
Severe growth deficiency is associated with STAT5b mutations that disrupt protein folding and activity. PMID:23160480
Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function. PMID:23129762
Functional and structural divergence of an unusual LTR retrotransposon family in plants. PMID:23119066
Serine phosphorylation is critical for the activation of ubiquitin-specific protease 1 and its interaction with WD40-repeat protein UAF1. PMID:23116119
Comparative kinetic analysis of glycerol 3-phosphate cytidylyltransferase from Enterococcus faecalis and Listeria monocytogenes. PMID:23111733
Immunity to intracellular Salmonella depends on surface-associated antigens. PMID:23093937
Solution structure of IseA, an inhibitor protein of DL-endopeptidases from Bacillus subtilis, reveals a novel fold with a characteristic inhibitory loop. PMID:23091053
Molecular modeling and description of a newly characterized activating mutation of the EGFR gene in non-small cell lung cancer. PMID:23088930
Engineering a thermoregulated intein-modified xylanase into maize for consolidated lignocellulosic biomass processing. PMID:23086202
Dissection of functional sites in herpesvirus saimiri complement control protein homolog. PMID:23077301
Two structures of a thiazolinyl imine reductase from Yersinia enterocolitica provide insight into catalysis and binding to the nonribosomal peptide synthetase module of HMWP1. PMID:23066849
Intracellular NADPH levels affect the oligomeric state of the glucose 6-phosphate dehydrogenase. PMID:23064253
In silico modeling of the staphylococcal bacteriophage-derived peptidase CHAP(K). PMID:23050213
Architectural arrangement of the small nuclear RNA (snRNA)-activating protein complex 190 subunit (SNAP190) on U1 snRNA gene promoter DNA. PMID:23038247
The unique cysteine knot regulates the pleotropic hormone leptin. PMID:23029163
Evaluating caveolin interactions: do proteins interact with the caveolin scaffolding domain through a widespread aromatic residue-rich motif? PMID:23028656
Mining the Sinorhizobium meliloti transportome to develop FRET biosensors for sugars, dicarboxylates and cyclic polyols. PMID:23028462
Protein trans-splicing of an atypical split intein showing structural flexibility and cross-reactivity. PMID:23024818
The 70S ribosome modulates the ATPase activity of Escherichia coli YchF. PMID:22995830
Yeast Irc6p is a novel type of conserved clathrin coat accessory factor related to small G proteins. PMID:22993212
Juruin: an antifungal peptide from the venom of the Amazonian Pink Toe spider, Avicularia juruensis, which contains the inhibitory cystine knot motif. PMID:22973266
Pressure-selective modulation of NMDA receptor subtypes may reflect 3D structural differences. PMID:22973194
Homology modeling of dopamine D2 and D3 receptors: molecular dynamics refinement and docking evaluation. PMID:22970199
Homology modeling and analysis of structure predictions of the bovine rhinitis B virus RNA dependent RNA polymerase (RdRp). PMID:22942748
Exploiting the MDM2-CK1α protein-protein interface to develop novel biologics that induce UBL-kinase-modification and inhibit cell growth. PMID:22916255
A C1q domain containing protein from scallop Chlamys farreri serving as pattern recognition receptor with heat-aggregated IgG binding activity. PMID:22905248
Structural insights into the assembly of CARMA1 and BCL10. PMID:22880103
Bispecific engineered antibody domains (nanoantibodies) that interact noncompetitively with an HIV-1 neutralizing epitope and FcRn. PMID:22879932
Characterization of Danio rerio Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase, the structural prototype of the ADPRibase-Mn-like protein family. PMID:22848751
Immunodominance of antigenic site B over site A of hemagglutinin of recent H3N2 influenza viruses. PMID:22848649
DNA stabilization at the Bacillus subtilis PolX core--a binding model to coordinate polymerase, AP-endonuclease and 3'-5' exonuclease activities. PMID:22844091
Comparative modeling of retinol-binding protein-3 and retinal S-antigen in Eales' disease and prediction of their binding sites using computational methods. PMID:22833777
A novel HRAS substitution (c.266C>G; p.S89C) resulting in decreased downstream signaling suggests a new dimension of RAS pathway dysregulation in human development. PMID:22821884
Metabolic potential of a single cell belonging to one of the most abundant lineages in freshwater bacterioplankton. PMID:22810059
Enhancing catalytic activity of a hybrid xylanase through single substitution of Leu to Pro near the active site. PMID:22805813
Integrative structural modeling with small angle X-ray scattering profiles. PMID:22800408
Identification of mammalian target of rapamycin as a direct target of fenretinide both in vitro and in vivo. PMID:22798378
An integrin from shrimp Litopenaeus vannamei mediated microbial agglutination and cell proliferation. PMID:22792387
Characterisation of the first enzymes committed to lysine biosynthesis in Arabidopsis thaliana. PMID:22792278
High-throughput NMR assessment of the tertiary structure of food allergens. PMID:22768312
Evolution of thrombin and other hemostatic proteases by survey of protochordate, hemichordate, and echinoderm genomes. PMID:22752046
The subcellular localization of Tubby-like proteins and participation in stress signaling and root colonization by the mutualist Piriformospora indica. PMID:22751378
Casein kinase I-like protein linked to lipase in plant. PMID:22751325
Aromatic residues in the substrate cleft of RPE65 protein govern retinol isomerization and modulate its progression. PMID:22745121
Isolation of monoclonal antibodies with predetermined conformational epitope specificity. PMID:22737224
Identification of mimotopes with diagnostic potential for Trypanosoma brucei gambiense variant surface glycoproteins using human antibody fractions. PMID:22720103
Skipping of exons by premature termination of transcription and alternative splicing within intron-5 of the sheep SCF gene: a novel splice variant. PMID:22719917
Studies on New Delhi Metallo-Beta-Lactamse-1 producing Acinetobacter baumannii isolated from donor swab in a tertiary eye care centre, India and structural analysis of its antibiotic binding interactions. PMID:22715297
The computational-based structure of Dwarf14 provides evidence for its role as potential strigolactone receptor in plants. PMID:22713366
Structure of an As(III) S-adenosylmethionine methyltransferase: insights into the mechanism of arsenic biotransformation. PMID:22712827
HuR thermal stability is dependent on domain binding and upon phosphorylation. PMID:22706953
Three members of the Arabidopsis glycosyltransferase family 8 are xylan glucuronosyltransferases. PMID:22706449
Thermodynamic analysis of DNA binding by a Bacillus single stranded DNA binding protein. PMID:22698072
Mannan-binding lectin of the sea urchin Strongylocentrotus nudus. PMID:22696119
Proline rich motifs as drug targets in immune mediated disorders. PMID:22666276
A phylogenetic analysis of normal modes evolution in enzymes and its relationship to enzyme function. PMID:22651983
Modeling of the Full-Size 3D Structure of Human Chaperone Hsp70 and Study of Its Interdomain Interactions. PMID:22649666
A predictive model of intein insertion site for use in the engineering of molecular switches. PMID:22649521
Neurospora COP9 signalosome integrity plays major roles for hyphal growth, conidial development, and circadian function. PMID:22589747
Lead compound design for TPR/COX dual inhibition. PMID:22588583
Computational prediction of protein-protein interactions of human tyrosinase. PMID:22577521
Biophysical and structural characterization of a sequence-diverse set of solute-binding proteins for aromatic compounds. PMID:22577139
Arginine in α-defensins: differential effects on bactericidal activity correspond to geometry of membrane curvature generation and peptide-lipid phase behavior. PMID:22566697
The Drosophila orthologue of progeroid human WRN exonuclease, DmWRNexo, cleaves replication substrates but is inhibited by uracil or abasic sites : analysis of DmWRNexo activity in vitro. PMID:22562358
Comparative modeling of CCRL1, a key protein in masked immune diseases and virtual screening for finding inhibitor of this protein. PMID:22553392
Bioinformatics and variability in drug response: a protein structural perspective. PMID:22552919
Genetic background analysis of protein C deficiency demonstrates a recurrent mutation associated with venous thrombosis in Chinese population. PMID:22545135
Combining automated peak tracking in SAR by NMR with structure-based backbone assignment from 15N-NOESY. PMID:22536902
Capturing single cell genomes of active polysaccharide degraders: an unexpected contribution of Verrucomicrobia. PMID:22536372
Structural insight into the unique properties of adeno-associated virus serotype 9. PMID:22496238
Structural adaptation of a thermostable biotin-binding protein in a psychrophilic environment. PMID:22493427
Multi-LZerD: multiple protein docking for asymmetric complexes. PMID:22488467
Membrane protein stability analyses by means of protein energy profiles in case of nephrogenic diabetes insipidus. PMID:22474537
Candidate antibody-based therapeutics against HIV-1. PMID:22462520
Both Sm-domain and C-terminal extension of Lsm1 are important for the RNA-binding activity of the Lsm1-7-Pat1 complex. PMID:22450758
Molecular genetic and biochemical characterization of the vaccinia virus I3 protein, the replicative single-stranded DNA binding protein. PMID:22438556
In silico modeling of the pore region of a KCNQ4 missense mutant from a patient with hearing loss. PMID:22420747
The rnb gene of Synechocystis PCC6803 encodes a RNA hydrolase displaying RNase II and not RNase R enzymatic properties. PMID:22403697
Effects of the N-terminal and C-terminal domains of Meiothermus ruber CBS-01 trehalose synthase on thermostability and activity. PMID:22402678
Elevated gene expression in chalcone synthase enzyme suggests an increased production of flavonoids in skin and synchronized red cell cultures of North American native grape berries. PMID:22364203
Bak Conformational Changes Induced by Ligand Binding: Insight into BH3 Domain Binding and Bak Homo-Oligomerization. PMID:22355769
Dynamics of the regulation of Hsp90 by the co-chaperone Sti1. PMID:22354036
Automated protein structure modeling with SWISS-MODEL Workspace and the Protein Model Portal. PMID:22323219
Structural Basis for Species Selectivity in the HIV-1 gp120-CD4 Interaction: Restoring Affinity to gp120 in Murine CD4 Mimetic Peptides. PMID:22312332
Molecular cloning, characterization and predicted structure of a putative copper-zinc SOD from the camel, Camelus dromedarius. PMID:22312292
Identification of residues defining phospholipid flippase substrate specificity of type IV P-type ATPases. PMID:22308393
Systematic analysis of plant-specific B3 domain-containing proteins based on the genome resources of 11 sequenced species. PMID:22302388
Virtual screening and evaluation of Ketol-Acid Reducto-Isomerase (KARI) as a putative drug target for Aspergillosis. PMID:22300397
Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics. PMID:22277058
Structural model of channelrhodopsin. PMID:22241469
Identification of intersubunit domain interactions within eukaryotic initiation factor (eIF) 2B, the nucleotide exchange factor for translation initiation. PMID:22238343
Contribution of intra- and interhost dynamics to norovirus evolution. PMID:22205753
Kinetic properties of alternatively spliced isoforms of laccase-2 from Tribolium castaneum and Anopheles gambiae. PMID:22198355
AcrB trimer stability and efflux activity, insight from mutagenesis studies. PMID:22163011
Highly dynamic exon shuffling in candidate pathogen receptors ... what if brown algae were capable of adaptive immunity? PMID:22144640
neXtProt: a knowledge platform for human proteins. PMID:22139911
Molecular Characterization and SNP Detection of CD14 Gene of Crossbred Cattle. PMID:22132326
Terpene biosynthesis: modularity rules. PMID:22105807
Characterization of a novel Entamoeba histolytica strain from Burkina Faso, Africa, possessing a unique hexokinase-2 gene. PMID:22091458
EcoliWiki: a wiki-based community resource for Escherichia coli. PMID:22064863
Formins filter modified actin subunits during processive elongation. PMID:22056467
Regioselective glucosidation of trans-resveratrol in Escherichia coli expressing glucosyltransferase from Phytolacca americana. PMID:22048846
Predicting residue-residue contacts and helix-helix interactions in transmembrane proteins using an integrative feature-based random forest approach. PMID:22046350
Evaluation of model quality predictions in CASP9. PMID:21997462
Crystal structure of the catalytic domain of UCHL5, a proteasome-associated human deubiquitinating enzyme, reveals an unproductive form of the enzyme. PMID:21995438
An environment-dependent structural switch underlies the regulation of carnitine palmitoyltransferase 1A. PMID:21990363
Xenorhodopsins, an enigmatic new class of microbial rhodopsins horizontally transferred between archaea and bacteria. PMID:21985229
First-step mutations for adaptation at elevated temperature increase capsid stability in a virus. PMID:21980515
Evidence for ATP-dependent structural rearrangement of nuclease catalytic site in DNA mismatch repair endonuclease MutL. PMID:21953455
Chaperone-like properties of tobacco plastid thioredoxins f and m. PMID:21948853
A novel benzodioxole-containing inhibitor of Toxoplasma gondii growth alters the parasite cell cycle. PMID:21947387
The molecular and functional interaction between ICln and HSPC038 proteins modulates the regulation of cell volume. PMID:21917931
Beyond the frog: the evolution of homology models of human IKKβ. PMID:21911292
Molecular dynamics simulations of the Bcl-2 protein to predict the structure of its unordered flexible loop domain. PMID:21866316
Molecular dynamics analysis reveals structural insights into mechanism of nicotine N-demethylation catalyzed by tobacco cytochrome P450 mono-oxygenase. PMID:21858078
Interstitial contacts in an RNA-dependent RNA polymerase lattice. PMID:21839092
The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation. PMID:21822257
Structural and functional evaluation of C. elegans filamins FLN-1 and FLN-2. PMID:21799850
Putative molecular mechanisms underlying tandem CCCH zinc finger protein mediated plant growth, stress, and gene expression responses. PMID:21795857
Computational exploration of structural hypotheses for an additional sequence in a mammalian mitochondrial protein. PMID:21779343
Interaction between the human mitochondrial import receptors Tom20 and Tom70 in vitro suggests a chaperone displacement mechanism. PMID:21771790
Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization. PMID:21727192
Defining the turkey MHC: identification of expressed class I- and class IIB-like genes independent of the MHC-B. PMID:21710346
Importance of post-translational modifications for functionality of a chloroplast-localized carbonic anhydrase (CAH1) in Arabidopsis thaliana. PMID:21695217
Viral serpin therapeutics from concept to clinic. PMID:21683260
Diversification, phylogeny and evolution of auxin response factor (ARF) family: insights gained from analyzing maize ARF genes. PMID:21667107
Characterization of the MHC class II α-chain gene in ducks. PMID:21660591
Human polymorphisms in the glutathione transferase zeta 1/maleylacetoacetate isomerase gene influence the toxicokinetics of dichloroacetate. PMID:21642471
Pathogenity of some limb girdle muscular dystrophy mutations can result from reduced anchorage to myofibrils and altered stability of calpain 3. PMID:21624972
A synthetic system links FeFe-hydrogenases to essential E. coli sulfur metabolism. PMID:21615937
Specific conformational epitope features of pathogenesis-related proteins mediating cross-reactivity between pollen and food allergens. PMID:21598115
Distinctive receptor binding properties of the surface glycoprotein of a natural feline leukemia virus isolate with unusual disease spectrum. PMID:21569491
Characteristics and molecular basis of celecoxib modulation on K(v)7 potassium channels. PMID:21564087
Crystal structures of Staphylococcus epidermidis mevalonate diphosphate decarboxylase bound to inhibitory analogs reveal new insight into substrate binding and catalysis. PMID:21561869
Comparative fluorescence resonance energy transfer analysis of metabotropic glutamate receptors: implications about the dimeric arrangement and rearrangement upon ligand bindings. PMID:21550987
Study of the interaction between 8-azaguanine and bovine serum albumin using optical spectroscopy and molecular modeling methods. PMID:21541747
Nonspecific DNA binding and bending by HUαβ: interfaces of the three binding modes characterized by salt-dependent thermodynamics. PMID:21513716
Recent insights into the structure and function of comparative gene identification-58. PMID:21494142
Characterization of metalloproteins by high-throughput X-ray absorption spectroscopy. PMID:21482623
The Structural Biology Knowledgebase: a portal to protein structures, sequences, functions, and methods. PMID:21472436
Nanomechanics of Ig-like domains of human contactin (BIG-2). PMID:21445711
Molecular modeling and in silico characterization of Mycobacterium tuberculosis TlyA: possible misannotation of this tubercle bacilli-hemolysin. PMID:21443791
The Ca2+ pumps of the endoplasmic reticulum and Golgi apparatus. PMID:21441596
Structure modeling of novel DNA glycosylase enzyme from oral pathogen Streptococcus sanguinis. PMID:21364794
Emerging paradigms for the initiation of mucin-type protein O-glycosylation by the polypeptide GalNAc transferase family of glycosyltransferases. PMID:21349845
A New Zealand Black-derived locus suppresses chronic graft-versus-host disease and autoantibody production through nonlymphoid bone marrow-derived cells. PMID:21335485
Catalytic domain modification and viral gene delivery of activated factor VII confers hemostasis at reduced expression levels and vector doses in vivo. PMID:21325603
Evolutionary and structural features of the C2, V3 and C3 envelope regions underlying the differences in HIV-1 and HIV-2 biology and infection. PMID:21283793
The Prohead-I structure of bacteriophage HK97: implications for scaffold-mediated control of particle assembly and maturation. PMID:21276801
Blue and red light modulates SigB-dependent gene transcription, swimming motility and invasiveness in Listeria monocytogenes. PMID:21264304
Molecular cloning of Plasmodium vivax calcium-dependent protein kinase 4. PMID:21234235
Evolution of ligand specificity in vertebrate corticosteroid receptors. PMID:21232159
Somatic mutation profiles of MSI and MSS colorectal cancer identified by whole exome next generation sequencing and bioinformatics analysis. PMID:21203531
A new and unified nomenclature for male fertility restorer (RF) proteins in higher plants. PMID:21203394
Molecular mechanism by which palmitate inhibits PKR autophosphorylation. PMID:21192654
Molecular characterization and brain distribution of the progesterone receptor in whiptail lizards. PMID:21185292
The adsorption of biomolecules to multi-walled carbon nanotubes is influenced by both pulmonary surfactant lipids and surface chemistry. PMID:21159192
Metalloproteomics: forward and reverse approaches in metalloprotein structural and functional characterization. PMID:21130021
Computational study of the Na+/H + antiporter from Vibrio parahaemolyticus. PMID:21107625
Molecular cloning and analysis of the UDP-Glucose Pyrophosphorylase in Streptococcus equi subsp. zooepidemicus. PMID:21104023
Harderoporphyria due to homozygosity for coproporphyrinogen oxidase missense mutation H327R. PMID:21103937
Latex-allergic patients sensitized to the major allergen hevein and hevein-like domains of class I chitinases show no increased frequency of latex-associated plant food allergy. PMID:21095007
Lipolysis - a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores. PMID:21087632
Functional analysis of a novel motif conserved across geminivirus Rep proteins. PMID:21084480
BISC: binary subcomplexes in proteins database. PMID:21081561
Computational estimation of rainbow trout estrogen receptor binding affinities for environmental estrogens. PMID:21075131
Molecular cloning and expression analysis of a novel SANT/MYB gene from Gossypium barbadense. PMID:21069464
Engineering a novel c-di-GMP-binding protein for biofilm dispersal. PMID:21059164
Automated minimization of steric clashes in protein structures. PMID:21058396
Computational analysis and identification of an emergent human adenovirus pathogen implicated in a respiratory fatality. PMID:21056888
SAHG, a comprehensive database of predicted structures of all human proteins. PMID:21051360
The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored. PMID:21045058
A minimal Rac activation domain in the unconventional guanine nucleotide exchange factor Dock180. PMID:21033699
Natural and engineered photoactivated nucleotidyl cyclases for optogenetic applications. PMID:21030591
Optimizing structural modeling for a specific protein scaffold: knottins or inhibitor cystine knots. PMID:21029427
Molecular mechanisms of the whole DNA repair system: a comparison of bacterial and eukaryotic systems. PMID:20981145
Site-specific methylation in Bacillus subtilis chemotaxis: effect of covalent modifications to the chemotaxis receptor McpB. PMID:20864474
Mapping the ligand binding sites of kainate receptors: molecular determinants of subunit-selective binding of the antagonist [3H]UBP310. PMID:20837679
Post-transcriptional up-regulation of Tsc-22 by Ybx1, a target of miR-216a, mediates TGF-{beta}-induced collagen expression in kidney cells. PMID:20713358
The ATP-binding cassette transporter ABCA4: structural and functional properties and role in retinal disease. PMID:20711710
Upregulation of endogenous HMOX1 expression by a computer-designed artificial transcription factor. PMID:20706680
Leureptin: a soluble, extracellular leucine-rich repeat protein from Manduca sexta that binds lipopolysaccharide. PMID:20688162
An L1 box binding protein, GbML1, interacts with GbMYB25 to control cotton fibre development. PMID:20667961
Optimization of formaldehyde cross-linking for protein interaction analysis of non-tagged integrin beta1. PMID:20634879
Structural characterization of the rod cGMP phosphodiesterase 6. PMID:20600113
Gain-of-function mutations cluster in distinct regions associated with the signalling pathway in the PAS domain of the aerotaxis receptor, Aer. PMID:20545849
Feline congenital erythropoietic porphyria: two homozygous UROS missense mutations cause the enzyme deficiency and porphyrin accumulation. PMID:20485863
Location of modulatory beta subunits in BK potassium channels. PMID:20385746
Characterization of the transcriptional regulator Rv3124 of Mycobacterium tuberculosis identifies it as a positive regulator of molybdopterin biosynthesis and defines the functional consequences of a non-synonymous SNP in the Mycobacterium bovis BCG orthologue. PMID:20378651
Novel USH2A compound heterozygous mutations cause RP/USH2 in a Chinese family. PMID:20309401
Cofactor requirement of HpyAV restriction endonuclease. PMID:20140205
The phosphoproteome of the minimal bacterium Mycoplasma pneumoniae: analysis of the complete known Ser/Thr kinome suggests the existence of novel kinases. PMID:20097688
Predicting the pathway involved in post-translational modification of elongation factor P in a subset of bacterial species. PMID:20070887
Insights into the domain and repeat architecture of target of rapamycin. PMID:20060908
From protein sequences to 3D-structures and beyond: the example of the UniProt knowledgebase. PMID:20043185
Pathway projector: web-based zoomable pathway browser using KEGG atlas and Google Maps API. PMID:19907644
MetaBioME: a database to explore commercially useful enzymes in metagenomic datasets. PMID:19906710
A Novel extracytoplasmic function (ECF) sigma factor regulates virulence in Pseudomonas aeruginosa. PMID:19730690
QMEAN server for protein model quality estimation. PMID:19429685
Homology modelling: a review about the method on hand of the diabetic antigen GAD 65 structure prediction. PMID:19343288
The Protein Model Portal. PMID:19037750
Comparative protein structure modeling using Modeller. PMID:18428767
The SWISS-MODEL Repository-new features and functionality PubMed citations: 426.

426 articles citing: The SWISS-MODEL Repository-new features and functionality

Assessing clinical utility of preconception expanded carrier screening regarding residual risk for neurodevelopmental disorders. PMID:35906228
Hydrophilic But Not Hydrophobic Surfactant Protein Genetic Variants Are Associated With Severe Acute Respiratory Syncytial Virus Infection in Children. PMID:35903101
Identification of Potential Insect Growth Inhibitor against Aedes aegypti: A Bioinformatics Approach. PMID:35897792
Design and Synthesis of Hepatitis B Virus (HBV) Capsid Assembly Modulators and Evaluation of Their Activity in Mammalian Cell Model. PMID:35890072
Speculation on How RIC-3 and Other Chaperones Facilitate α7 Nicotinic Receptor Folding and Assembly. PMID:35889400
Assessing the clinical utility of protein structural analysis in genomic variant classification: experiences from a diagnostic laboratory. PMID:35869530
Global protein dynamics as communication sensors in peptide synthetase domains. PMID:35857508
RNA Cleavage Properties of Nucleobase-Specific RNase MC1 and Cusativin Are Determined by the Dinucleotide-Binding Interactions in the Enzyme-Active Site. PMID:35806025
Molecular docking and nucleotide sequencing of successive expressed recombinant fungal peroxidase gene in E.coli. PMID:35776246
Synthesis of Coumarin and Homoisoflavonoid Derivatives and Analogs: The Search for New Antifungal Agents. PMID:35745631
AlphaFold2 models indicate that protein sequence determines both structure and dynamics. PMID:35739160
Identification and Functional Characterization of Peptides With Antimicrobial Activity From the Syphilis Spirochete, Treponema pallidum. PMID:35722306
Insights into the capsid structure of banana bunchy top virus. PMID:35694237
The 3D mutational constraint on amino acid sites in the human proteome. PMID:35672414
Identification of some dietary flavonoids as potential inhibitors of TMPRSS2 through protein-ligand interaction studies and binding free energy calculations. PMID:35645548
Computational Saturation Mutagenesis to Investigate the Effects of Neurexin-1 Mutations on AlphaFold Structure. PMID:35627176
Diagnoses Based on C-Reactive Protein Point-of-Care Tests. PMID:35624645
Anti-epileptic Kunitz-like peptides discovered in the branching coral Acropora digitifera through transcriptomic analysis. PMID:35604417
Mutations in RPS19 may affect ribosome function and biogenesis in Diamond Blackfan anemia. PMID:35583751
Case Report: A Novel Homozygous Frameshift Mutation of the SKIV2L Gene in a Trichohepatoenteric Syndrome Patient Presenting With Short Stature, Premature Ovarian Failure, and Osteoporosis. PMID:35571060
Antiviral Peptides (AVPs) of Marine Origin as Propitious Therapeutic Drug Candidates for the Treatment of Human Viruses. PMID:35565968
Transcriptional Contribution of Transposable Elements in Relation to Salinity Conditions in Teleosts and Silencing Mechanisms Involved. PMID:35563606
The Distribution of Glucosinolates in Different Phenotypes of Lepidium peruvianum and Their Role as Acetyl- and Butyrylcholinesterase Inhibitors-In Silico and In Vitro Studies. PMID:35563248
In silico study on identification of novel MALT1 allosteric inhibitors. PMID:35540679
Engineering substrate promiscuity in 2,4-dichlorophenol hydroxylase by in silico design. PMID:35539933
Enzymatic characterization and molecular mechanism of a novel aspartokinase mutant M372I/T379W from Corynebacterium pekinense. PMID:35521304
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2. PMID:35515752
Genetic validation of Aspergillus fumigatus phosphoglucomutase as a viable therapeutic target in invasive aspergillosis. PMID:35504355
Serine Palmitoyltransferase Subunit 3 and Metabolic Diseases. PMID:35503173
Synergistic activity and molecular modelling of fosfomycin combinations with some antibiotics against multidrug resistant Helicobacter pylori. PMID:35486219
Network Pharmacology-Based Approach Combined with Bioinformatic Analytics to Elucidate the Potential of Curcumol against Hepatocellular Carcinoma. PMID:35456457
Association of the receptor for activated C-kinase 1 with ribosomes in Plasmodium falciparum. PMID:35452681
A tRNA processing enzyme is a key regulator of the mitochondrial unfolded protein response. PMID:35451962
The Anti-Constipation Effects of Raffino-Oligosaccharide on Gut Function in Mice Using Neurotransmitter Analyses, 16S rRNA Sequencing and Targeted Screening. PMID:35408632
Wheat grain proteomic and protein-metabolite interactions analyses provide insights into plant growth promoting bacteria-arbuscular mycorrhizal fungi-wheat interactions. PMID:35396966
Predicted coronavirus Nsp5 protease cleavage sites in the human proteome. PMID:35379171
The chromatin remodeling protein CHD-1 and the EFL-1/DPL-1 transcription factor cooperatively down regulate CDK-2 to control SAS-6 levels and centriole number. PMID:35377871
Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function. PMID:35358180
Drug Discovery of Plausible Lead Natural Compounds That Target the Insulin Signaling Pathway: Bioinformatics Approaches. PMID:35356248
Structural Analysis of the Effect of Asn107Ser Mutation on Alg13 Activity and Alg13-Alg14 Complex Formation and Expanding the Phenotypic Variability of ALG13-CDG. PMID:35327592
A Computational Study of the Role of Secondary Metabolites for Mitigation of Acid Soil Stress in Cereals Using Dehydroascorbate and Mono-Dehydroascorbate Reductases. PMID:35326108
P2X2 receptor subunit interfaces are missense variant hotspots, where mutations tend to increase apparent ATP affinity. PMID:35285517
Response to Cold: A Comparative Transcriptomic Analysis in Eight Cold-Adapted Yeasts. PMID:35283858
mPGES-2 blockade antagonizes β-cell senescence to ameliorate diabetes by acting on NR4A1. PMID:35228744
Mutation of Serine protease 1 Induces Male Sterility in Bombyx mori. PMID:35222089
Common Molecular Targets of a Quinolone Based Bumped Kinase Inhibitor in Neospora caninum and Danio rerio. PMID:35216497
Phage-Displayed Mimotopes of SARS-CoV-2 Spike Protein Targeted to Authentic and Alternative Cellular Receptors. PMID:35215976
Novel nitrite reductase domain structure suggests a chimeric denitrification repertoire in the phylum Chloroflexi. PMID:35212484
Using Steady-State Kinetics to Quantitate Substrate Selectivity and Specificity: A Case Study with Two Human Transaminases. PMID:35209187
Acetylation at Lysine 86 of Escherichia coli HUβ Modulates the DNA-Binding Capability of the Protein. PMID:35185833
Zafirlukast inhibits the growth of lung adenocarcinoma via inhibiting TMEM16A channel activity. PMID:35176281
De Novo Transcriptome of Mammillaria bombycina (Cactaceae) under In Vitro Conditions and Identification of Glyoxalase Genes. PMID:35161380
Computational prediction of the effect of mutations in the receptor-binding domain on the interaction between SARS-CoV-2 and human ACE2. PMID:35138508
Tracking the circulating SARS-CoV-2 variant of concern in South Africa using wastewater-based epidemiology. PMID:35064174
Atoh8 in Development and Disease. PMID:35053134
Uncovering the Role of PhzC as DAHP Synthase in Shikimate Pathway of Pseudomonas chlororaphis HT66. PMID:35053084
An allosteric regulation mechanism of Arabidopsis Serine/Threonine kinase 1 (SIK1) through phosphorylation. PMID:35035789
Speed dating for enzymes! Finding the perfect phosphopantetheinyl transferase partner for your polyketide synthase. PMID:35012550
Purification, Characterization, and Structural Studies of a Sulfatase from Pedobacter yulinensis. PMID:35011319
Real-time sensing of neurotransmitters by functionalized nanopores embedded in a single live cell. PMID:35006433
Identification of vaccine and drug targets in Shigella dysenteriae sd197 using reverse vaccinology approach. PMID:34997046
Toward wide-spectrum antivirals against coronaviruses: Molecular characterization of SARS-CoV-2 NSP13 helicase inhibitors. PMID:34995115
Second Messenger c-di-GMP Modulates Exopolysaccharide Pea-Dependent Phenotypes via Regulation of eppA Expression in Pseudomonas putida. PMID:34985979
Loss-of-function SLC30A2 mutants are associated with gut dysbiosis and alterations in intestinal gene expression in preterm infants. PMID:34965180
Down-regulation of OsMYB103L distinctively alters beta-1,4-glucan polymerization and cellulose microfibers assembly for enhanced biomass enzymatic saccharification in rice. PMID:34961560
ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes. PMID:34912364
Corticotropin Releasing Factor Binding Protein as a Novel Target to Restore Brain Homeostasis: Lessons Learned From Alcohol Use Disorder Research. PMID:34912198
Exploring the Regulatory Function of the N-terminal Domain of SARS-CoV-2 Spike Protein through Molecular Dynamics Simulation. PMID:34901736
Cryo-EM structures of human RNA polymerase I. PMID:34887565
Intermolecular Interactions Drive Protein Adaptive and Coadaptive Evolution at Both Species and Population Levels. PMID:34878126
Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease. PMID:34857794
A new ALK inhibitor overcomes resistance to first- and second-generation inhibitors in NSCLC. PMID:34845836
Molecular Docking Simulation Studies Identifies Potential Natural Product Derived-Antiwolbachial Compounds as Filaricides against Onchocerciasis. PMID:34829911
Human Parainfluenza Virus 3 Phosphoprotein Is a Tetramer and Shares Structural and Interaction Features with Ebola Phosphoprotein VP35. PMID:34827601
Target identification for repurposed drugs active against SARS-CoV-2 via high-throughput inverse docking. PMID:34825285
Stress impact of liposomes loaded with ciprofloxacin on the expression level of MepA and NorB efflux pumps of methicillin-resistant Staphylococcus aureus. PMID:34822035
Peptide ligands targeting FGF receptors promote recovery from dorsal root crush injury via AKT/mTOR signaling. PMID:34815808
CD4+ effector T cells accelerate Alzheimer's disease in mice. PMID:34798897
Characterisation of a putative M23-domain containing protein in Mycobacterium tuberculosis. PMID:34784363
Modulating Glycoside Hydrolase Activity between Hydrolysis and Transfer Reactions Using an Evolutionary Approach. PMID:34770995
Cytotoxic and Antifungal Amides Derived from Ferulic Acid: Molecular Docking and Mechanism of Action. PMID:34761004
The AlphaFold Database of Protein Structures: A Biologist's Guide. PMID:34757056
Global diversity of the gene encoding the Pfs25 protein-a Plasmodium falciparum transmission-blocking vaccine candidate. PMID:34749796
Mouse-adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge. PMID:34735434
Broadening the Mutation Spectrum in GJA8 and CHMP4B: Novel Missense Variants and the Associated Phenotypes in Six Chinese Han Congenital Cataracts Families. PMID:34722561
A novel protein truncating mutation in L2HGDH causes L-2-hydroxyglutaric aciduria in a consanguineous Pakistani family. PMID:34719772
Proteome-pI 2.0: proteome isoelectric point database update. PMID:34718696
Beta turn propensity and a model polymer scaling exponent identify intrinsically disordered phase-separating proteins. PMID:34710373
Inhibition of viral RNA-dependent RNA polymerases with clinically relevant nucleotide analogs. PMID:34696837
Characterization of Inducible HSP70 Genes in an Antarctic Yeast, Glaciozyma antarctica PI12, in Response to Thermal Stress. PMID:34683390
Molecular dynamics: a powerful tool for studying the medicinal chemistry of ion channel modulators. PMID:34671734
Genetic and Phenotypic Characterization of the Novel Metallo-β-Lactamase NDM-29 From Escherichia coli. PMID:34659178
Cellular and Molecular Targets of Nucleotide-Tagged Trithiolato-Bridged Arene Ruthenium Complexes in the Protozoan Parasites Toxoplasma gondii and Trypanosoma brucei. PMID:34639127
Discovery and Validation of Lmj_04_BRCT Domain, a Novel Therapeutic Target: Identification of Candidate Drugs for Leishmaniasis. PMID:34638841
TSSK3, a novel target for male contraception, is required for spermiogenesis. PMID:34623009
COVIDrugNet: a network-based web tool to investigate the drugs currently in clinical trial to contrast COVID-19. PMID:34593915
Mutational spectrum of BRAF gene in colorectal cancer patients in Saudi Arabia. PMID:34588906
Whole Genome Analysis of Human Rotaviruses Reveals Single Gene Reassortant Rotavirus Strains in Zambia. PMID:34578453
Assessment of Antibiofilm Potencies of Nervonic and Oleic Acid against Acinetobacter baumannii Using In Vitro and Computational Approaches. PMID:34572317
Modeling-Assisted Design of Thermostable Benzaldehyde Lyases from Rhodococcus erythropolis for Continuous Production of α-Hydroxy Ketones. PMID:34558792
Molecular docking studies of Indian variants of pathophysiological proteins of SARS-CoV-2 with selected drug candidates. PMID:34553696
Identifying potential inhibitors of biofilm-antagonistic proteins to promote biofilm formation: a virtual screening and molecular dynamics simulations approach. PMID:34546549
Indomethacin-based PROTACs as pan-coronavirus antiviral agents. PMID:34534839
The role of Bruton's tyrosine kinase in the immune system and disease. PMID:34534359
Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy. PMID:34505572
The Antagonist pGlu-βGlu-Pro-NH2 Binds to an Allosteric Site of the Thyrotropin-Releasing Hormone Receptor. PMID:34500828
Exploring the cytotoxic mechanisms of Pediocin PA-1 towards HeLa and HT29 cells by comparison to known bacteriocins: Microcin E492, enterocin heterodimer and Divercin V41. PMID:34473709
Identifying cysteine residues susceptible to oxidation by photoactivatable atomic oxygen precursors using a proteome-wide analysis. PMID:34458801
Docking-generated multiple ligand poses for bootstrapping bioactivity classifying Machine Learning: Repurposing covalent inhibitors for COVID-19-related TMPRSS2 as case study. PMID:34426763
Characterization of UDP-glucose dehydrogenase isoforms in the medicinal legume Glycyrrhiza uralensis. PMID:34393599
Discovery of a novel and a rare Kristen rat sarcoma viral oncogene homolog (KRAS) gene mutation in colorectal cancer patients. PMID:34369256
Ribose-Binding Protein Mutants With Improved Interaction Towards the Non-natural Ligand 1,3-Cyclohexanediol. PMID:34368100
Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles. PMID:34362892
Associations between Varied Susceptibilities to PfATP4 Inhibitors and Genotypes in Ugandan Plasmodium falciparum Isolates. PMID:34339273
Atomic Scale Interactions between RNA and DNA Aptamers with the TNF-α Protein. PMID:34327241
How Do Shipworms Eat Wood? Screening Shipworm Gill Symbiont Genomes for Lignin-Modifying Enzymes. PMID:34322098
Structural determinants and distribution of phosphate specificity in ribonucleotide reductases. PMID:34314684
In Silico Prediction of the Mechanism of Action of Pyriproxyfen and 4'-OH-Pyriproxyfen against A. mellifera and H. sapiens Receptors. PMID:34299368
Virus-encoded histone doublets are essential and form nucleosome-like structures. PMID:34297924
Fission yeast Rad8/HLTF facilitates Rad52-dependent chromosomal rearrangements through PCNA lysine 107 ubiquitination. PMID:34292936
Structure-based in silico approaches for drug discovery against Mycobacterium tuberculosis. PMID:34285773
Accurate prediction of protein structures and interactions using a three-track neural network. PMID:34282049
Insights Into the Phylogenetic Distribution, Diversity, Structural Attributes, and Substrate Specificity of Putative Cyanobacterial Orthocaspases. PMID:34276616
A narrative review of the roles of muscle segment homeobox transcription factor family in cancer. PMID:34268423
Mandibular muscle troponin of the Florida carpenter ant Camponotus floridanus: extending our insights into invertebrate Ca2+ regulation. PMID:34255253
Whole-exome imputation within UK Biobank powers rare coding variant association and fine-mapping analyses. PMID:34226706
Epitope Peptide-Based Predication and Other Functional Regions of Antigenic F and HN Proteins of Waterfowl and Poultry Avian Avulavirus Serotype-1 Isolates From Uganda. PMID:34212016
Identification of Receptor Binding Proteins in Flagellotropic Agrobacterium Phage 7-7-1. PMID:34209785
Antiepileptic Drug Tiagabine Does Not Directly Target Key Cardiac Ion Channels Kv11.1, Nav1.5 and Cav1.2. PMID:34207748
Tropane alkaloids and terpenes synthase genes of Datura stramonium (Solanaceae). PMID:34178440
Identification of Glutathione S-Transferase Genes in Hami Melon (Cucumis melo var. saccharinus) and Their Expression Analysis Under Cold Stress. PMID:34168669
The Hsp70-Chaperone Machines in Bacteria. PMID:34164436
Potent Human Single-Domain Antibodies Specific for a Novel Prefusion Epitope of Respiratory Syncytial Virus F Glycoprotein. PMID:34160257
Why Should Metformin Not Be Given in Advanced Kidney Disease? Potential Leads from Computer Simulations. PMID:34151116
EPM2A in-frame deletion slows neurological decline in Lafora Disease. PMID:34147889
Molecular Dynamics Simulations Reveal the Modulated Mechanism of STING Conformation. PMID:34142362
A Novel GH Family 20 β-N-acetylhexosaminidase With Both Chitosanase and Chitinase Activity From Aspergillus oryzae. PMID:34095233
Yeast-based screening of cancer mutations in the DNA damage response protein Mre11 demonstrates importance of conserved capping domain residues. PMID:34075539
Peters plus syndrome mutations affect the function and stability of human β1,3-glucosyltransferase. PMID:34058199
MTR3D: identifying regions within protein tertiary structures under purifying selection. PMID:34050760
Structure-Guided Computational Approaches to Unravel Druggable Proteomic Landscape of Mycobacterium leprae. PMID:34026836
Genome-wide identification of the Tubby-Like Protein (TLPs) family in medicinal model plant Salvia miltiorrhiza. PMID:34026360
Non-coding region variants upstream of MEF2C cause severe developmental disorder through three distinct loss-of-function mechanisms. PMID:34022131
Sequence and structural analysis of COVID-19 E and M proteins with MERS virus E and M proteins-A comparative study. PMID:34013072
Analysis of diverse eukaryotes suggests the existence of an ancestral mitochondrial apparatus derived from the bacterial type II secretion system. PMID:34011950
Systematic in silico Evaluation of Leishmania spp. Proteomes for Drug Discovery. PMID:33987166
Mouse Adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge. PMID:33972939
Proteo3Dnet: a web server for the integration of structural information with interactomics data. PMID:33963857
Phosphorylation of the WH2 domain in yeast Las17/WASP regulates G-actin binding and protein function during endocytosis. PMID:33958621
Regulation of Phosphoinositide Levels in the Retina by Protein Tyrosine Phosphatase 1B and Growth Factor Receptor-Bound Protein 14. PMID:33921658
Pectin Dependent Cell Adhesion Restored by a Mutant Microtubule Organizing Membrane Protein. PMID:33918513
An efficient alpha helix model and simulation framework for stationary electrostatic interaction force estimation. PMID:33907198
Genetic and biological properties of H7N9 avian influenza viruses detected after application of the H7N9 poultry vaccine in China. PMID:33905456
Structural and Functional Features of the P2X4 Receptor: An Immunological Perspective. PMID:33897694
Deciphering the Relationship Between Cycloheximides Structures and Their Different Biological Activities. PMID:33897655
ATP1A3-Related Disorders: An Ever-Expanding Clinical Spectrum. PMID:33868146
Transcriptomic, Biochemical, and Morphological Study Reveals the Mechanism of Inhibition of Pseudopestalotiopsis camelliae-sinensis by Phenazine-1-Carboxylic Acid. PMID:33859623
Metabolic impact of pathogenic variants in the mitochondrial glutamyl-tRNA synthetase EARS2. PMID:33855712
Mutation of cysteine residues increases heterologous expression of peach expansin in the methylotrophic yeast Pichia pastoris. PMID:33850426
A systematic approach to inserting split inteins for Boolean logic gate engineering and basal activity reduction. PMID:33850130
Expasy, the Swiss Bioinformatics Resource Portal, as designed by its users. PMID:33849055
Computational screening of FDA approved drugs of fungal origin that may interfere with SARS-CoV-2 spike protein activation, viral RNA replication, and post-translational modification: a multiple target approach. PMID:33842191
Auranofin Resistance in Toxoplasma gondii Decreases the Accumulation of Reactive Oxygen Species but Does Not Target Parasite Thioredoxin Reductase. PMID:33816332
Functional Analysis of the Fusion and Attachment Glycoproteins of Mojiang Henipavirus. PMID:33809833
Two Key Amino Acids Variant of α-l-arabinofuranosidase from Bacillus subtilis Str. 168 with Altered Activity for Selective Conversion Ginsenoside Rc to Rd. PMID:33808840
Expression and Functional Analysis of the Argonaute Protein of Thermus thermophilus (TtAgo) in E. coli BL21(DE3). PMID:33807395
A Molecular Modeling Approach to Identify Potential Antileishmanial Compounds Against the Cell Division Cycle (cdc)-2-Related Kinase 12 (CRK12) Receptor of Leishmania donovani. PMID:33803906
Foamy Viruses, Bet, and APOBEC3 Restriction. PMID:33803830
Glyceraldehyde-3-phosphate Dehydrogenase Common Peptides of Listeria monocytogenes, Mycobacterium marinum and Streptococcus pneumoniae as Universal Vaccines. PMID:33802959
Molecular epidemiology analysis of early variants of SARS-CoV-2 reveals the potential impact of mutations P504L and Y541C (NSP13) in the clinical COVID-19 outcomes. PMID:33798758
TMPRSS2 inhibitor discovery facilitated through an in silico and biochemical screening platform. PMID:33791707
Structure of Gcn1 bound to stalled and colliding 80S ribosomes. PMID:33790014
QSAR Modeling for Multi-Target Drug Discovery: Designing Simultaneous Inhibitors of Proteins in Diverse Pathogenic Parasites. PMID:33777898
The molecular basis for sarcomere organization in vertebrate skeletal muscle. PMID:33765442
Herb-target virtual screening and network pharmacology for prediction of molecular mechanism of Danggui Beimu Kushen Wan for prostate cancer. PMID:33758314
What Are the Molecular Requirements for Protein Sliding along DNA? PMID:33754737
A Novel Frameshift Mutation, Deletion of HBB:c.199_202delAAAG [Codon 66/67 (-AAAG)] in β-Thalassemia Major Patients from the Western Region of Uttar Pradesh, India. PMID:33688235
The DBSAV Database: Predicting Deleteriousness of Single Amino Acid Variations in the Human Proteome. PMID:33676930
Developing a Vaccine to Block West Nile Virus Transmission: In Silico Studies, Molecular Characterization, Expression, and Blocking Activity of Culex pipiens mosGCTL-1. PMID:33671430
The Interplay of Cholesterol and Ligand Binding in hTSPO from Classical Molecular Dynamics Simulations. PMID:33652554
Affinity-matured HLA class II dimers for robust staining of antigen-specific CD4+ T cells. PMID:33649568
A novel D-xylose isomerase from the gut of the wood feeding beetle Odontotaenius disjunctus efficiently expressed in Saccharomyces cerevisiae. PMID:33637780
Identification and functional analysis of the SARS-COV-2 nucleocapsid protein. PMID:33618668
Emergence in late 2020 of multiple lineages of SARS-CoV-2 Spike protein variants affecting amino acid position 677. PMID:33594385
Genome-wide identification of chitinase genes in Thalassiosira pseudonana and analysis of their expression under abiotic stresses. PMID:33568068
The In Silico Identification of Potential Members of the Ded1/DDX3 Subfamily of DEAD-Box RNA Helicases from the Protozoan Parasite Leishmania infantum and Their Analyses in Yeast. PMID:33535521
A novel missense mutation in the gene encoding major intrinsic protein (MIP) in a Giant panda with unilateral cataract formation. PMID:33530927
Genomic analyses of glycine decarboxylase neurogenic mutations yield a large-scale prediction model for prenatal disease. PMID:33524012
Strategic aromatic residues in the catalytic cleft of the xyloglucanase MtXgh74 modifying thermostability, mode of enzyme action, and viscosity reduction ability. PMID:33521846
ProMod3-A versatile homology modelling toolbox. PMID:33507980
Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis. PMID:33494095
Site-1 protease controls osteoclastogenesis by mediating LC3 transcription. PMID:33469231
Carbapenem Use Is Driving the Evolution of Imipenemase 1 Variants. PMID:33468463
Molecular Characterization and Expression of Four Aquaporin Genes in Impatiens walleriana During Drought Stress and Recovery. PMID:33466920
HNF1A-MODY Mutations in Nuclear Localization Signal Impair HNF1A-Import Receptor KPNA6 Interactions. PMID:33459938
Strategies to Better Target Fungal Squalene Monooxygenase. PMID:33450973
Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box. PMID:33431834
A multi-pronged approach targeting SARS-CoV-2 proteins using ultra-large virtual screening. PMID:33426509
An in silico Study of Two Transcription Factors Controlling Diazotrophic Fates of the Azolla Major Cyanobiont Trichormus azollae. PMID:33402818
Design and in silico study of the novel coumarin derivatives against SARS-CoV-2 main enzymes. PMID:33357038
The impact of structural bioinformatics tools and resources on SARS-CoV-2 research and therapeutic strategies. PMID:33348379
Time-Resolved Fluorescence Anisotropy and Molecular Dynamics Analysis of a Novel GFP Homo-FRET Dimer. PMID:33345902
Identification of Host Cellular Protein Substrates of SARS-COV-2 Main Protease. PMID:33333742
Post-translational polymodification of β1-tubulin regulates motor protein localisation in platelet production and function. PMID:33327716
Cell-Permeable Bak BH3 Peptide Induces Chemosensitization of Hematologic Malignant Cells. PMID:33312200
Tissue-Nonspecific Alkaline Phosphatase-A Gatekeeper of Physiological Conditions in Health and a Modulator of Biological Environments in Disease. PMID:33302551
Motor control and cognition deficits associated with protein carbamoylation in food (cassava) cyanogenic poisoning: Neurodegeneration and genomic perspectives. PMID:33296712
Promotion of cadmium uptake and cadmium-induced toxicity by the copper transporter CTR1 in HepG2 and ZFL cells. PMID:33294387
HIGD-Driven Regulation of Cytochrome c Oxidase Biogenesis and Function. PMID:33291261
A structural inventory of native ribosomal ABCE1-43S pre-initiation complexes. PMID:33289941
Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene. PMID:33257846
Top-Down Proteomics of Endogenous Membrane Proteins Enabled by Cloud Point Enrichment and Multidimensional Liquid Chromatography-Mass Spectrometry. PMID:33231430
Discovery of Amoebicidal Compounds by Combining Computational and Experimental Approaches. PMID:33229426
Structural asymmetry governs the assembly and GTPase activity of McrBC restriction complexes. PMID:33219217
Peptide and peptide-based inhibitors of SARS-CoV-2 entry. PMID:33189768
New putative animal reservoirs of SARS-CoV-2 in Italian fauna: A bioinformatic approach. PMID:33173837
Defining the genotypic and phenotypic spectrum of X-linked MSL3-related disorder. PMID:33173220
Identification of therapeutic drugs against COVID-19 through computational investigation on drug repurposing and structural modification. PMID:33122473
Preventing Candida albicans from subverting host plasminogen for invasive infection treatment. PMID:33115324
Identification of evolutionarily stable sites across the SARS-CoV-2 proteome. PMID:33106800
Genomics, Computational Biology and Drug Discovery for Mycobacterial Infections: Fighting the Emergence of Resistance. PMID:33101362
The structure of APOBEC1 and insights into its RNA and DNA substrate selectivity. PMID:33094286
Cell-penetrating peptide-mediated cell entry of H5N1 highly pathogenic avian influenza virus. PMID:33093460
Three-Dimensional Structures of Carbohydrates and Where to Find Them. PMID:33081008
Facile Synthesis and Metabolic Incorporation of m-DAP Bioisosteres Into Cell Walls of Live Bacteria. PMID:33078931
Down-regulation of COX-2 activity by 1α,25(OH)2D3 is VDR dependent in endothelial cells transformed by Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. PMID:33072916
Association of host proteins with the broad host range filamentous phage NgoΦ6 of Neisseria gonorrhoeae. PMID:33057372
Does conserved domain SOD1 mutation has any role in ALS severity and therapeutic outcome? PMID:33036560
Current Understanding of the Structure and Function of Fungal Immunomodulatory Proteins. PMID:33015115
Genome-Wide Identification of DNA Methylases and Demethylases in Kiwifruit (Actinidia chinensis). PMID:33013956
Novel phospho-switch function of delta-catenin in dendrite development. PMID:33007084
Altered Metabolism of Polycyclic Aromatic Hydrocarbons by UDP-Glycosyltransferase 3A2 Missense Variants. PMID:32993298
Chemical IN04 Inhibits the Kinase Domain not the ROC Domain of LRRK1: Results from Homology Modeling and Molecular Docking. PMID:32972350
Functional analysis and cryo-electron microscopy of Campylobacter jejuni serine protease HtrA. PMID:32960677
A Novel Cytotoxic Conjugate Derived from the Natural Product Podophyllotoxin as a Direct-Target Protein Dual Inhibitor. PMID:32957517
Virtual screening of approved clinic drugs with main protease (3CLpro) reveals potential inhibitory effects on SARS-CoV-2. PMID:32909528
The Salmonella enterica serovar Typhimurium virulence factor STM3169 is a hexuronic acid binding protein component of a TRAP transporter. PMID:32894213
The ClpX and ClpP2 Orthologs of Chlamydia trachomatis Perform Discrete and Essential Functions in Organism Growth and Development. PMID:32873765
Furin Cleavage Site Is Key to SARS-CoV-2 Pathogenesis. PMID:32869021
Acetylation of Surface Carbohydrates in Bacterial Pathogens Requires Coordinated Action of a Two-Domain Membrane-Bound Acyltransferase. PMID:32843546
Amino acid variation analysis of surface spike glycoprotein at 614 in SARS-CoV-2 strains. PMID:32837981
Drug repurposing using computational methods to identify therapeutic options for COVID-19. PMID:32837954
Y44A Mutation in the Acidic Domain of HIV-2 Tat Impairs Viral Reverse Transcription and LTR-Transactivation. PMID:32824587
Allosteric regulation of thioesterase superfamily member 1 by lipid sensor domain binding fatty acids and lysophosphatidylcholine. PMID:32820071
The Pneumococcal Iron Uptake Protein A (PiuA) Specifically Recognizes Tetradentate FeIIIbis- and Mono-Catechol Complexes. PMID:32795535
The In Situ Structure of Parkinson's Disease-Linked LRRK2. PMID:32783917
Prediction of the Impact of Deleterious Nonsynonymous Single Nucleotide Polymorphisms on the Human RRM2B Gene: A Molecular Modeling Study. PMID:32775440
First description of betalains biosynthesis in an aquatic organism: characterization of 4,5-DOPA-extradiol-dioxygenase activity in the cyanobacteria Anabaena cylindrica. PMID:32767544
Role of ClpB From Corynebacterium crenatum in Thermal Stress and Arginine Fermentation. PMID:32765470
Three Alkaloids from an Apocynaceae Species, Aspidosperma spruceanum as Antileishmaniasis Agents by In Silico Demo-case Studies. PMID:32756456
A bioluminescent reporter for the halophilic archaeon Haloferax volcanii. PMID:32749548
A novel TIMP3 mutation associated with a retinitis pigmentosa-like phenotype. PMID:32715858
Dual inhibitors of SARS-CoV-2 proteases: pharmacophore and molecular dynamics based drug repositioning and phytochemical leads. PMID:32698693
Enhanced S-Cone Syndrome: Spectrum of Clinical, Imaging, Electrophysiologic, and Genetic Findings in a Retrospective Case Series of 56 Patients. PMID:32679203
First Reports of Effects of Insulin, Human-like Insulin Receptors and Adapter Proteins in Acanthamoeba castellanii. PMID:32678116
Alkyl and Aryl Derivatives Based on p-Coumaric Acid Modification and Inhibitory Action against Leishmania braziliensis and Plasmodium falciparum. PMID:32664596
Structural modeling, mutation analysis, and in vitro expression of usherin, a major protein in inherited retinal degeneration and hearing loss. PMID:32637036
Protein engineering strategies for microbial production of isoprenoids. PMID:32612930
Improving enzyme activity of glucosamine-6-phosphate synthase by semi-rational design strategy and computer analysis. PMID:32601959
Yaravirus: A novel 80-nm virus infecting Acanthamoeba castellanii. PMID:32601223
Bioactivity and Molecular Docking Studies of Derivatives from Cinnamic and Benzoic Acids. PMID:32596343
A second hybrid-binding domain modulates the activity of Drosophila ribonuclease H1. PMID:32589740
Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse. PMID:32555348
Signatures of TRI5, TRI8 and TRI11 Protein Sequences of Fusarium incarnatum-equiseti Species Complex (FIESC) Indicate Differential Trichothecene Analogue Production. PMID:32545314
Leishmanicidal Potential of Hardwickiic Acid Isolated From Croton sylvaticus. PMID:32523532
Expanding the clinical and phenotypic heterogeneity associated with biallelic variants in ACO2. PMID:32519519
Oncogenic Properties of the EBV ZEBRA Protein. PMID:32517128
Configuration of active site segments in lytic polysaccharide monooxygenases steers oxidative xyloglucan degradation. PMID:32514307
The Structural Basis of the Binding of Various Aminopolycarboxylates by the Periplasmic EDTA-Binding Protein EppA from Chelativorans sp. BNC1. PMID:32486296
Macromolecular modeling and design in Rosetta: recent methods and frameworks. PMID:32483333
Unexpected Genetic Diversity of Two Novel Swine MRVs in Italy. PMID:32456089
The Functional Role of CONNEXIN 26 Mutation in Nonsyndromic Hearing Loss, Demonstrated by Zebrafish Connexin 30.3 Homologue Model. PMID:32455934
Biochemical characterization and inhibition of the alternative oxidase enzyme from the fungal phytopathogen Moniliophthora perniciosa. PMID:32451394
De Novo SOX6 Variants Cause a Neurodevelopmental Syndrome Associated with ADHD, Craniosynostosis, and Osteochondromas. PMID:32442410
Multicopper oxidase laccases with distinguished spectral properties: A new outlook. PMID:32435715
Large scale analyses of genotype-phenotype relationships of glycine decarboxylase mutations and neurological disease severity. PMID:32421718
Inhibitory Effects of Fosmidomycin Against Babesia microti in vitro. PMID:32411701
In silico design of antiviral peptides targeting the spike protein of SARS-CoV-2. PMID:32380200
In-silico identification of the vaccine candidate epitopes against the Lassa virus hemorrhagic fever. PMID:32376973
SARS-CoV-2 and ORF3a: Nonsynonymous Mutations, Functional Domains, and Viral Pathogenesis. PMID:32371472
Putative Coiled-Coil Domain-Dependent Autoinhibition and Alternative Splicing Determine SHTN1's Actin-Binding Activity. PMID:32371045
A Computational Probe into the Structure and Dynamics of the Full-Length Toll-Like Receptor 3 in a Phospholipid Bilayer. PMID:32325904
The Peptidoglycan Biosynthesis Gene murC in Frankia: Actinorhizal vs. Plant Type. PMID:32316316
Reductive Evolution and Diversification of C5-Uracil Methylation in the Nucleic Acids of Mollicutes. PMID:32290235
Biological Machine Learning Combined with Campylobacter Population Genomics Reveals Virulence Gene Allelic Variants Cause Disease. PMID:32290186
Structural Insight into the Interactions between Structurally Similar Inhibitors and SIRT6. PMID:32283646
A novel p.A191D matrilin-3 variant in a Vietnamese family with multiple epiphyseal dysplasia: a case report. PMID:32264862
New genetic variant in the SERPINC1 gene: hereditary Antithrombin deficiency case report, familial thrombosis and considerations on genetic counseling. PMID:32252658
Complementary computational and experimental evaluation of missense variants in the ROMK potassium channel. PMID:32251469
Structural and functional characterization of the bestrophin-2 anion channel. PMID:32251414
A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. PMID:32191846
Structure of SWI/SNF chromatin remodeller RSC bound to a nucleosome. PMID:32188943
A guideline for homology modeling of the proteins from newly discovered betacoronavirus, 2019 novel coronavirus (2019-nCoV). PMID:32181901
Molecular Mechanisms and Structural Basis of Retigabine Analogues in Regulating KCNQ2 Channel. PMID:32170353
Biochemical and Genetic Analysis Identify CSLD3 as a beta-1,4-Glucan Synthase That Functions during Plant Cell Wall Synthesis. PMID:32169960
CosR Is a Global Regulator of the Osmotic Stress Response with Widespread Distribution among Bacteria. PMID:32169942
Antifungal Activity of Anionic Defense Peptides: Insight into the Action of Galleria mellonella Anionic Peptide 2. PMID:32168818
Cyclic di-GMP Signaling in Bacillus subtilis Is Governed by Direct Interactions of Diguanylate Cyclases and Cognate Receptors. PMID:32156823
A Pilot Study of All-Computational Drug Design Protocol-From Structure Prediction to Interaction Analysis. PMID:32117898
Disrupting Fluorescence by Mutagenesis in a Green Fluorescent Fatty Acid Binding Protein from a Marine Eel. PMID:32096074
Biosystem Analysis of the Hypoxia Inducible Domain Family Member 2A: Implications in Cancer Biology. PMID:32085461
Phenotypic expansion of KMT2D-related disorder: Beyond Kabuki syndrome. PMID:32083401
Engineering bacterial symbionts of nematodes improves their biocontrol potential to counter the western corn rootworm. PMID:32066956
Comprehensive Profiling of Tubby-Like Protein Expression Uncovers Ripening-Related TLP Genes in Tomato (Solanum lycopersicum). PMID:32028643
Molecular characterization of RNase III protein of Asaia sp. for developing a robust RNAi-based paratransgensis tool to affect the sexual life-cycle of Plasmodium or Anopheles fitness. PMID:31996254
Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm. PMID:31990523
A helitron-induced RabGDIα variant causes quantitative recessive resistance to maize rough dwarf disease. PMID:31980630
Molecular Modelling and Dynamics Study of nsSNP in STXBP1 Gene in Early Infantile Epileptic Encephalopathy Disease. PMID:31976320
Application of targeted panel sequencing and whole exome sequencing for 76 Chinese families with retinitis pigmentosa. PMID:31960602
In Silico design of AVP (4-5) peptide and synthesis, characterization and in vitro activity of chitosan nanoparticles. PMID:31942695
Optimizing the Design of Diatom Biosilica-Targeted Fusion Proteins in Biosensor Construction for Bacillus anthracis Detection. PMID:31936120
LONP1 de novo dominant mutation causes mitochondrial encephalopathy with loss of LONP1 chaperone activity and excessive LONP1 proteolytic activity. PMID:31923470
Using Omics Technologies and Systems Biology to Identify Epitope Targets for the Development of Monoclonal Antibodies Against Antibiotic-Resistant Bacteria. PMID:31921119
Looking for the X Factor in Bacterial Pathogenesis: Association of orfX-p47 Gene Clusters with Toxin Genes in Clostridial and Non-Clostridial Bacterial Species. PMID:31906154
A Novel SNPs in Alpha-Lactalbumin Gene Effects on Lactation Traits in Chinese Holstein Dairy Cows. PMID:31905734
Molecular Cloning, Characterisation, and Heterologous Expression of Farnesyl Diphosphate Synthase from Sanghuangporus baumii. PMID:31897972
Substrate specificity of thioredoxins and glutaredoxins - towards a functional classification. PMID:31890941
Prediction and Structural Comparison of Deleterious Coding Nonsynonymous Single Nucleotide Polymorphisms (nsSNPs) in Human LEP Gene Associated with Obesity. PMID:31871931
The structural bases for agonist diversity in an Arabidopsis thaliana glutamate receptor-like channel. PMID:31871183
Influence of Lytic Polysaccharide Monooxygenase Active Site Segments on Activity and Affinity. PMID:31835532
Molecular basis of methylation and chain-length programming in a fungal iterative highly reducing polyketide synthase. PMID:31803427
Live Attenuated Salmonella enterica Expressing and Releasing Cell-Permeable Bax BH3 Peptide Through the MisL Autotransporter System Elicits Antitumor Activity in a Murine Xenograft Model of Human B Non-hodgkin's Lymphoma. PMID:31798573
The Role of the Small Export Apparatus Protein, SctS, in the Activity of the Type III Secretion System. PMID:31798543
Identification of Circulating Genomic and Metabolic Biomarkers in Intrahepatic Cholangiocarcinoma. PMID:31795195
Computational Analysis of nsSNPs of ADA Gene in Severe Combined Immunodeficiency Using Molecular Modeling and Dynamics Simulation. PMID:31781678
Federating Structural Models and Data: Outcomes from A Workshop on Archiving Integrative Structures. PMID:31780431
Trypanocidal Mechanism of Action and in silico Studies of p-Coumaric Acid Derivatives. PMID:31775321
Hydrophobic residues of melittin mediate its binding to αA-crystallin. PMID:31762096
The lipid droplet-associated protein ABHD5 protects the heart through proteolysis of HDAC4. PMID:31742248
Special Issue: The Actin-Myosin Interaction in Muscle: Background and Overview. PMID:31739584
Conditional depletion of the RNA polymerase I subunit PAF53 reveals that it is essential for mitosis and enables identification of functional domains. PMID:31727736
Unusual Metabolism and Hypervariation in the Genome of a Gracilibacterium (BD1-5) from an Oil-Degrading Community. PMID:31719174
Rapid Biophysical Characterization and NMR Spectroscopy Structural Analysis of Small Proteins from Bacteria and Archaea. PMID:31705614
QMEANDisCo-distance constraints applied on model quality estimation. PMID:31697312
Antileishmanial activity of terpenylquinones on Leishmania infantum and their effects on Leishmania topoisomerase IB. PMID:31678841
Quercetin Directly Targets JAK2 and PKCδ and Prevents UV-Induced Photoaging in Human Skin. PMID:31652815
In silico Screening and Heterologous Expression of a Polyethylene Terephthalate Hydrolase (PETase)-Like Enzyme (SM14est) With Polycaprolactone (PCL)-Degrading Activity, From the Marine Sponge-Derived Strain Streptomyces sp. SM14. PMID:31632361
Mycobacterium tuberculosis β-Carbonic Anhydrases: Novel Targets for Developing Antituberculosis Drugs. PMID:31627429
The cysteine protease ApdS from Streptococcus suis promotes evasion of innate immune defenses by cleaving the antimicrobial peptide cathelicidin LL-37. PMID:31619521
Functional deficiency of DNA repair gene EXO5 results in androgen-induced genomic instability and prostate tumorigenesis. PMID:31616062
The Trypanosomal Transferrin Receptor of Trypanosoma Brucei-A Review. PMID:31581506
Widening of the genetic and clinical spectrum of Lamb-Shaffer syndrome, a neurodevelopmental disorder due to SOX5 haploinsufficiency. PMID:31578471
Genome-wide identification, characterization and expression pattern analysis of APYRASE family members in response to abiotic and biotic stresses in wheat. PMID:31565565
Mechanisms of iron- and O2-sensing by the [4Fe-4S] cluster of the global iron regulator RirA. PMID:31526471
In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila. PMID:31498321
Assessing circovirus gene flow in multiple spill-over events. PMID:31463770
Computationally optimized broadly reactive vaccine based upon swine H1N1 influenza hemagglutinin sequences protects against both swine and human isolated viruses. PMID:31448974
Marine-freshwater prokaryotic transitions require extensive changes in the predicted proteome. PMID:31439042
Differential long-term regulation of TAS2R14 by structurally distinct agonists. PMID:31430434
Structure of the Centromere Binding Factor 3 Complex from Kluyveromyces lactis. PMID:31425683
A consensus S. cerevisiae metabolic model Yeast8 and its ecosystem for comprehensively probing cellular metabolism. PMID:31395883
Modified substrate specificity of a methyltransferase domain by protein insertion into an adenylation domain of the bassianolide synthetase. PMID:31388353
Rad5 dysregulation drives hyperactive recombination at replication forks resulting in cisplatin sensitivity and genome instability. PMID:31350889
DNA gyrase could be a crucial regulatory factor for growth and survival of Mycobacterium leprae. PMID:31346236
Pathogenic variants in the DEAH-box RNA helicase DHX37 are a frequent cause of 46,XY gonadal dysgenesis and 46,XY testicular regression syndrome. PMID:31337883
Structural Insights into Hearing Loss Genetics from Polarizable Protein Repacking. PMID:31327459
Generation and Application of Fluorescent Anti-Human β2-Microglobulin VHHs via Amino Modification. PMID:31319525
Structural Features of Transcription Factors Associating with Nucleosome Binding. PMID:31303471
Whole-Cell Models and Simulations in Molecular Detail. PMID:31299173
A role for the Saccharomyces cerevisiae ABCF protein New1 in translation termination/recycling. PMID:31299085
Bimodal Nickel-Binding Site on Escherichia coli [NiFe]-Hydrogenase Metallochaperone HypA. PMID:31273981
NFBTA: A Potent Cytotoxic Agent against Glioblastoma. PMID:31261921
Enzyme activity and structural features of three single-domain phloem cyclophilins from Brassica napus. PMID:31249367
Solution Structure of SpoIVB Reveals Mechanism of PDZ Domain-Regulated Protease Activity. PMID:31244791
Immunoglobulin light chains generate proinflammatory and profibrotic kidney injury. PMID:31205024
The SOXE transcription factors-SOX8, SOX9 and SOX10-share a bi-partite transactivation mechanism. PMID:31194875
A glycan shield on chimpanzee CD4 protects against infection by primate lentiviruses (HIV/SIV). PMID:31113887
Specific Binding Peptides from Rv3632: A Strategy for Blocking Mycobacterium tuberculosis Entry to Target Cells? PMID:31111070
Pyrimidine Salvage: Physiological Functions and Interaction with Chloroplast Biogenesis. PMID:31101721
Structural prerequisites for CRM1-dependent nuclear export signaling peptides: accessibility, adapting conformation, and the stability at the binding site. PMID:31036839
The ABCB7-Like Transporter PexA in Rhodobacter capsulatus Is Involved in the Translocation of Reactive Sulfur Species. PMID:30918498
First Betalain-Producing Bacteria Break the Exclusive Presence of the Pigments in the Plant Kingdom. PMID:30890610
Paralogues From the Expanded Tlr11 Gene Family in Mudskipper (Boleophthalmus pectinirostris) Are Under Positive Selection and Respond Differently to LPS/Poly(I:C) Challenge. PMID:30873182
A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia. PMID:30850736
A Retro-biosynthesis-Based Route to Generate Pinene-Derived Polyesters. PMID:30793830
Reducing Quorum Sensing-Mediated Virulence Factor Expression and Biofilm Formation in Hafnia alvei by Using the Potential Quorum Sensing Inhibitor L-Carvone. PMID:30687295
The evolution of transcriptional repressors in the Notch signaling pathway: a computational analysis. PMID:30679936
De Novo SOX4 Variants Cause a Neurodevelopmental Disease Associated with Mild Dysmorphism. PMID:30661772
Single-channel permeability and glycerol affinity of human aquaglyceroporin AQP3. PMID:30659792
Toward fully exploiting the therapeutic potential of marketed pharmaceuticals: the use of octreotide and chloroquine in oncology. PMID:30643430
ClyJ Is a Novel Pneumococcal Chimeric Lysin with a Cysteine- and Histidine-Dependent Amidohydrolase/Peptidase Catalytic Domain. PMID:30642930
EF-Tu From Non-typeable Haemophilus influenzae Is an Immunogenic Surface-Exposed Protein Targeted by Bactericidal Antibodies. PMID:30619274
Research Advances and Prospects on Mechanism of Sinomenin on Histamine Release and the Binding to Histamine Receptors. PMID:30586944
Association of Copy Number Variation at Intron 3 of HMGA2 With Navel Length in Bos indicus. PMID:30581455
Cross-ID: Analysis and Visualization of Complex XL-MS-Driven Protein Interaction Networks. PMID:30575379
Mechanism of Tetramer Dissociation, Unfolding, and Oligomer Assembly of Pneumovirus M2-1 Transcription Antiterminators. PMID:30555987
A heterodimeric glutathione S-transferase that stereospecifically breaks lignin's β(R)-aryl ether bond reveals the diversity of bacterial β-etherases. PMID:30541921
Structural Characterization of Biomolecules through Atomistic Simulations Guided by DEER Measurements. PMID:30528595
Structure of a functional obligate complex III2IV2 respiratory supercomplex from Mycobacterium smegmatis. PMID:30518849
The Chaperone and Redox Properties of CnoX Chaperedoxins Are Tailored to the Proteostatic Needs of Bacterial Species. PMID:30482828
Mycobacterium tuberculosis ClpC1 N-Terminal Domain Is Dispensable for Adaptor Protein-Dependent Allosteric Regulation. PMID:30463272
Degradation of crude oil by mixed cultures of bacteria isolated from the Qinghai-Tibet plateau and comparative analysis of metabolic mechanisms. PMID:30456621
Identification of the Acinetobacter baumannii Ribonuclease P Catalytic Subunit: Cleavage of a Target mRNA in the Presence of an External Guide Sequence. PMID:30349524
Suppressor mutations reveal an NtrC-like response regulator, NmpR, for modulation of Type-IV Pili-dependent motility in Myxococcus xanthus. PMID:30346960
Analysis of impact metrics for the Protein Data Bank. PMID:30325351
Homozygosity for a mutation affecting the catalytic domain of tyrosyl-tRNA synthetase (YARS) causes multisystem disease. PMID:30304524
Can alternative epitope mapping approaches increase the impact of B-cell epitopes in food allergy diagnostics? PMID:30294841
Evidence for the critical role of transmembrane helices 1 and 7 in substrate transport by human P-glycoprotein (ABCB1). PMID:30265721
Molecular cloning, antiserum preparation and expression analysis during head regeneration of α-crystallin type heat shock protein in Hydra vulgaris. PMID:30262703
Spontaneous severe hypercholesterolemia and atherosclerosis lesions in rabbits with deficiency of low-density lipoprotein receptor (LDLR) on exon 7. PMID:30243490
Glucosylceramide modifies the LPS-induced inflammatory response in macrophages and the orientation of the LPS/TLR4 complex in silico. PMID:30206272
Small membranous proteins of the TorE/NapE family, crutches for cognate respiratory systems in Proteobacteria. PMID:30206249
Importance of Val567 on heme environment and substrate recognition of neuronal nitric oxide synthase. PMID:30186754
Stabilization of the CD81 Large Extracellular Loop with De Novo Disulfide Bonds Improves Its Amenability for Peptide Grafting. PMID:30150531
In Silico Analysis of Hepatitis B Virus Occult Associated Mutations in Botswana Using a Novel Algorithm. PMID:30134551
Conformational switch in the ribosomal protein S1 guides unfolding of structured RNAs for translation initiation. PMID:30124944
Papain Loaded Poly(ε-Caprolactone) Nanoparticles: In-silico and In-Vitro Studies. PMID:30097974
Characterization of the AmpC β-Lactamase from Burkholderia multivorans. PMID:30012762
Characterization of Three Small Proteins in Brucella abortus Linked to Fucose Utilization. PMID:29967118
MolArt: a molecular structure annotation and visualization tool. PMID:29931246
Salmonella enterica serovar Typhimurium has three transketolase enzymes contributing to the pentose phosphate pathway. PMID:29848552
SWISS-MODEL: homology modelling of protein structures and complexes. PMID:29788355
Exploring the Interaction Mechanism Between Cyclopeptide DC3 and Androgen Receptor Using Molecular Dynamics Simulations and Free Energy Calculations. PMID:29755968
Comparative systems analysis of the secretome of the opportunistic pathogen Aspergillus fumigatus and other Aspergillus species. PMID:29700415
A tandem array of UDP-glycosyltransferases from the UGT73C subfamily glycosylate sapogenins, forming a spectrum of mono- and bisdesmosidic saponins. PMID:29603041
Application of targeted mass spectrometry in bottom-up proteomics for systems biology research. PMID:29452276
A novel mutation (LEU396ARG) in OPA1 is associated with a severe phenotype in a large dominant optic atrophy pedigree. PMID:29350691
The PEG-responding desiccome of the alder microsymbiont Frankia alni. PMID:29335550
Structural Analysis and Epitope Prediction of MHC Class-1-Chain Related Protein-A for Cancer Vaccine Development. PMID:29295563
Acetylome of Acinetobacter baumannii SK17 Reveals a Highly-Conserved Modification of Histone-Like Protein HU. PMID:29230394
Betanodavirus B2 protein triggers apoptosis and necroptosis in lung cancer cells that suppresses autophagy. PMID:29212215
Protein Moonlighting Revealed by Noncatalytic Phenotypes of Yeast Enzymes. PMID:29127264
Overlooked Short Toxin-Like Proteins: A Shortcut to Drug Design. PMID:29109389
Critical assessment of methods of protein structure prediction (CASP)-Round XII. PMID:29082672
Three recombinantly expressed apple tyrosinases suggest the amino acids responsible for mono- versus diphenolase activity in plant polyphenol oxidases. PMID:28821733
An overview of comparative modelling and resources dedicated to large-scale modelling of genome sequences. PMID:28777078
http://dx.doi.org/10.1093/nar/gkw1132

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mathematical model
metasource: Fairsharing.org
version: FAIRsharing.org: SWISS-MODEL; SWISS-MODEL Repository of 3D protein structure models; DOI: https://doi.org/10.25504/FAIRsharing.vxz9pn; Last edited: March 19, 2021, 11:40 a.m.; Last accessed: Jan 03 2022 7:09 p.m.

molecular structure
metasource: Fairsharing.org
version: FAIRsharing.org: SWISS-MODEL; SWISS-MODEL Repository of 3D protein structure models; DOI: https://doi.org/10.25504/FAIRsharing.vxz9pn; Last edited: March 19, 2021, 11:40 a.m.; Last accessed: Jan 03 2022 7:09 p.m.

protein
metasource: Fairsharing.org
version: FAIRsharing.org: SWISS-MODEL; SWISS-MODEL Repository of 3D protein structure models; DOI: https://doi.org/10.25504/FAIRsharing.vxz9pn; Last edited: March 19, 2021, 11:40 a.m.; Last accessed: Jan 03 2022 7:09 p.m.

protein structure
metasource: Fairsharing.org
version: FAIRsharing.org: SWISS-MODEL; SWISS-MODEL Repository of 3D protein structure models; DOI: https://doi.org/10.25504/FAIRsharing.vxz9pn; Last edited: March 19, 2021, 11:40 a.m.; Last accessed: Jan 03 2022 7:09 p.m.

metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657

structure
metasource: Fairsharing.org
version: FAIRsharing.org: SWISS-MODEL; SWISS-MODEL Repository of 3D protein structure models; DOI: https://doi.org/10.25504/FAIRsharing.vxz9pn; Last edited: March 19, 2021, 11:40 a.m.; Last accessed: Jan 03 2022 7:09 p.m.

structure databases
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657

bakers yeast
metasource: re3data.org
version: re3data.org: SWISS-MODEL Repository; editing status 2020-04-24; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3R311 last accessed: 2022-11-04

covid-19
metasource: re3data.org
version: re3data.org: SWISS-MODEL Repository; editing status 2020-04-24; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3R311 last accessed: 2022-11-04

caenorhabditis elegans
metasource: re3data.org
version: re3data.org: SWISS-MODEL Repository; editing status 2020-04-24; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3R311 last accessed: 2022-11-04

caulobacter crescentus
metasource: re3data.org
version: re3data.org: SWISS-MODEL Repository; editing status 2020-04-24; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3R311 last accessed: 2022-11-04

escherichia coli
metasource: re3data.org
version: re3data.org: SWISS-MODEL Repository; editing status 2020-04-24; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3R311 last accessed: 2022-11-04

fruit fly
metasource: re3data.org
version: re3data.org: SWISS-MODEL Repository; editing status 2020-04-24; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3R311 last accessed: 2022-11-04

mouse-ear cress
metasource: re3data.org
version: re3data.org: SWISS-MODEL Repository; editing status 2020-04-24; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3R311 last accessed: 2022-11-04

mycobacterium tuberculosis
metasource: re3data.org
version: re3data.org: SWISS-MODEL Repository; editing status 2020-04-24; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3R311 last accessed: 2022-11-04

plasmodium falciparum
metasource: re3data.org
version: re3data.org: SWISS-MODEL Repository; editing status 2020-04-24; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3R311 last accessed: 2022-11-04

pseudomonas aeruginosa
metasource: re3data.org
version: re3data.org: SWISS-MODEL Repository; editing status 2020-04-24; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3R311 last accessed: 2022-11-04

staphylococcus aureus
metasource: re3data.org
version: re3data.org: SWISS-MODEL Repository; editing status 2020-04-24; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3R311 last accessed: 2022-11-04

macromolecular structure data
metasource: re3data.org
version: re3data.org: SWISS-MODEL Repository; editing status 2020-04-24; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3R311 last accessed: 2022-11-04

proteomics
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:58.354927

structure prediction
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:58.354927

structural biology
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:58.354927

biophysics
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:58.354927

molecular modelling
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:58.354927

mathematical model molecular structure protein protein structure structure structure bakers yeast covid-19 caenorhabditis elegans caulobacter crescentus escherichia coli fruit fly mouse-ear cress mycobacterium tuberculosis plasmodium falciparum pseudomonas aeruginosa staphylococcus aureus macromolecular structure data proteomics structure prediction structural biology biophysics molecular modelling

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ModBase database of comparative protein structure models

SWISS-2DPAGE

Protein Model Database

Protein Spotlight

Physiome Model Repository

Major Intrinsic Proteins Modification Database

BioModels

UniProtKB Swiss-Prot

Molecular Modeling Database

Model Archive

PDB_REDO databank

ExPASy Bioinformatics Resource Portal

Swiss HIV Cohort Study & Swiss Mother and Child HIV Cohort Study

UniProt Knowledgebase

Jenalib: Jena Library of Biological Macromolecules

Genome3D

TSTMP

PDBsum; at-a-glance overview of macromolecular structures

ProSAS

SUPERFAMILY