Repertoire analysis of γδ T cells in the chicken enables functional annotation of the genomic region revealing highly variable pan-tissue TCR gamma V gene usage as well as identifying public and private repertoires.
PMID:34610803
Enhancing B-Cell Malignancies-On Repurposing Enhancer Activity towards Cancer.
PMID:34210001
V(DD)J recombination is an important and evolutionarily conserved mechanism for generating antibodies with unusually long CDR3s.
PMID:32948615
Brain cell somatic gene recombination and its phylogenetic foundations.
PMID:32699111
Intra-Vκ Cluster Recombination Shapes the Ig Kappa Locus Repertoire.
PMID:31875554
RAG-2 deficiency results in fewer phosphorylated histone H2AX foci, but increased retinal ganglion cell death and altered axonal growth.
PMID:31811168
Germline DNA Retention in Murine and Human Rearranged T Cell Receptor Gene Coding Joints: Alternative Recombination Signal Sequences and V(D)J Recombinase Errors.
PMID:31781122
Cross-Reactivity to Kynureninase Tolerizes B Cells That Express the HIV-1 Broadly Neutralizing Antibody 2F5.
PMID:31732530
The fundamental role of chromatin loop extrusion in physiological V(D)J recombination.
PMID:31511698
Epigenetic Enhancer Marks and Transcription Factor Binding Influence Vκ Gene Rearrangement in Pre-B Cells and Pro-B Cells.
PMID:30271408
Loss-of-function but not dominant-negative intragenic IKZF1 deletions are associated with an adverse prognosis in adult BCR-ABL-negative acute lymphoblastic leukemia.
PMID:28751559
HIV Tat induces a prolonged MYC relocalization next to IGH in circulating B-cells.
PMID:28360415
RAG1/2 induces genomic insertions by mobilizing DNA into RAG1/2-independent breaks.
PMID:28179379
RAG Recombinase as a Selective Pressure for Genome Evolution.
PMID:27979968
The Genome Conformation As an Integrator of Multi-Omic Data: The Example of Damage Spreading in Cancer.
PMID:27895661
COBL is a novel hotspot for IKZF1 deletions in childhood acute lymphoblastic leukemia.
PMID:27419633
Two Mutually Exclusive Local Chromatin States Drive Efficient V(D)J Recombination.
PMID:27264181
A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens.
PMID:26700814
Chromosomal Loop Domains Direct the Recombination of Antigen Receptor Genes.
PMID:26593423
RAG Represents a Widespread Threat to the Lymphocyte Genome.
PMID:26234156
Genomic landscape of cutaneous T cell lymphoma.
PMID:26192916
Characterization of chromosomal translocation breakpoint sequences in solid tumours: "an in silico analysis".
PMID:25972994
The proximal J kappa germline-transcript promoter facilitates receptor editing through control of ordered recombination.
PMID:25559567
Mechanisms that can promote peripheral B-cell lymphoma in ATM-deficient mice.
PMID:24913718
Illegitimate V(D)J recombination-mediated deletions in Notch1 and Bcl11b are not sufficient for extensive clonal expansion and show minimal age or sex bias in frequency or junctional processing.
PMID:24530429
NuChart: an R package to study gene spatial neighbourhoods with multi-omics annotations.
PMID:24069388
Breakpoint sites disclose the role of the V(D)J recombination machinery in the formation of T-cell receptor (TCR) and non-TCR associated aberrations in T-cell acute lymphoblastic leukemia.
PMID:23904235
Deep sequencing of the murine IgH repertoire reveals complex regulation of nonrandom V gene rearrangement frequencies.
PMID:23898036
Chromatin conformation governs T-cell receptor Jβ gene segment usage.
PMID:22984176
The DSIF subunits Spt4 and Spt5 have distinct roles at various phases of immunoglobulin class switch recombination.
PMID:22570620
Recombination centres and the orchestration of V(D)J recombination.
PMID:21394103