The NCI's Proteomic Data Commons has been created to make cancer-related proteomic datasets easily accessible to the public, and to facilitate multi-omic integration in support of precision medicine through interoperability with other resources. The PDC is one of several repositories within the NCI Cancer Research Data Commons (CRDC), a secure cloud-based infrastructure featuring diverse data sets and innovative analytic tools – all designed to advance data-driven scientific discovery. The CRDC enables researchers to link proteomic data with other data sets (e.g., genomic and imaging data) and to submit, collect, analyze, store, and share data throughout the cancer data ecosystem.