FAIRsharing.t58zhj; Last edited: Jan. 8, 2019, 1:31 p.m.; Last accessed: Jan 03 2022 7:12 p.m.

Other names: ARRIVE

The ARRIVE (Animal Research: Reporting In Vivo Experiments) guidelines are intended to improve the reporting of research using animals - maximising information published and minimising unnecessary studies. The ARRIVE guidelines were developed in consultation with the scientific community as part of an NC3Rs initiative to improve the standard of reporting of research using animals. They are available in Chinese (Mandarin), French, Italian, Japanese, Korean, Portuguese (including Brazilian Portuguese) and Spanish as well as the original English.

Webpage:

http://www.nc3rs.org.uk/arrive-guidelines

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Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research
PMID: 20613859
metasource: Fairsharing.org
version: FAIRsharing.org: ARRIVE; Animals in Research: Reporting In Vivo Experiments; DOI: https://doi.org/10.25504/FAIRsharing.t58zhj; Last edited: Jan. 8, 2019, 1:31 p.m.; Last accessed: Jan 03 2022 7:12 p.m.

Survey of the quality of experimental design, statistical analysis and reporting of research using animals
PMID: 19956596
metasource: Fairsharing.org
version: FAIRsharing.org: ARRIVE; Animals in Research: Reporting In Vivo Experiments; DOI: https://doi.org/10.25504/FAIRsharing.t58zhj; Last edited: Jan. 8, 2019, 1:31 p.m.; Last accessed: Jan 03 2022 7:12 p.m.

Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research PubMed citations: 2468.

2468 articles citing: Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research

Ischemic Preconditioning Modulates the Peripheral Innate Immune System to Promote Anti-Inflammatory and Protective Responses in Mice Subjected to Focal Cerebral Ischemia. PMID:35359933
Bridging the Transient Intraluminal Stroke Preclinical Model to Clinical Practice: From Improved Surgical Procedures to a Workflow of Functional Tests. PMID:35359638
Computational analysis of cortical neuronal excitotoxicity in a large animal model of neonatal brain injury. PMID:35351004
Ageing is associated with maladaptive immune response and worse outcome after traumatic brain injury. PMID:35350551
Caspase Inhibition Restores NEP Expression and Rescues Olfactory Deficit in Rats Caused by Prenatal Hypoxia. PMID:35344141
Distribution and possible function of galanin about headache and immune system in the rat dura mater. PMID:35338230
Phosphodiesterase 2A inhibition corrects the aberrant behavioral traits observed in genetic and environmental preclinical models of Autism Spectrum Disorder. PMID:35338117
Supervised machine learning for automatic classification of in vivo scald and contact burn injuries using the terahertz Portable Handheld Spectral Reflection (PHASR) Scanner. PMID:35332207
Effects of a Fully Humanized Type II Anti-CD20 Monoclonal Antibody on Peripheral and CNS B Cells in a Transgenic Mouse Model of Multiple Sclerosis. PMID:35328594
The Reconstitution Dynamics of Cultivated Hematopoietic Stem Cells and Progenitors Is Independent of Age. PMID:35328579
Quantitative Metabolomics of Tissue, Perfusate, and Bile from Rat Livers Subjected to Normothermic Machine Perfusion. PMID:35327340
Theophylline-encapsulated Nile Tilapia fish scale-based collagen nanoparticles effectively target the lungs of male Sprague-Dawley rats. PMID:35319009
Effects of acute ischemia and hypoxia in young and adult calsequestrin (CSQ2) knock-out and wild-type mice. PMID:35312907
Statistical practice and transparent reporting in the neurosciences: Preclinical motor behavioral experiments. PMID:35312695
Gut microbiota analysis of Blenniidae fishes including an algae-eating fish and clear boundary formation among isolated Vibrio strains. PMID:35301363
Protective effect of Sophora pachycarpa seed extract on carbon tetrachloride-induced toxicity in rats. PMID:35300676
The effect of stromal vascular fraction and Platelet-Rich Plasma combination on basic Fibroblast Growth Factor serum level during anal trauma healing in a Wistar rat model. PMID:35295741
Frontiers in Pain Research: A Scope of Its Focus and Content. PMID:35295691
Methodological Approaches To Assess Innate Immunity and Innate Memory in Marine Invertebrates and Humans. PMID:35295223
Neonatal Impedance Cardiography in Asphyxiated Piglets-A Feasibility Study. PMID:35281226
Piezo2 expression and its alteration by mechanical forces in mouse mesangial cells and renin-producing cells. PMID:35273307
Scanning laser-induced endothelial injury: a standardized and reproducible thrombosis model for intravital microscopy. PMID:35273275
Short-Term Pharmacological Induction of Arterial Stiffness and Hypertension with Angiotensin II Does Not Affect Learning and Memory and Cerebral Amyloid Load in Two Murine Models of Alzheimer's Disease. PMID:35269879
Ghrelin Regulates Expression of the Transcription Factor Pax6 in Hypoxic Brain Progenitor Cells and Neurons. PMID:35269403
Repurposing monoamine oxidase inhibitors (MAOI) for the treatment of rheumatoid arthritis possibly through modulating reactive oxidative stress mediated inflammatory cytokines. PMID:35266068
Exercise Rehabilitation and/or Astragaloside Attenuate Amyloid-beta Pathology by Reversing BDNF/TrkB Signaling Deficits and Mitochondrial Dysfunction. PMID:35262870
Biomechanical and structural responses of the aorta to intermittent hypobaric hypoxia in a rat model. PMID:35260626
Human infrapatellar fat pad mesenchymal stem cells show immunomodulatory exosomal signatures. PMID:35246587
Analysis of mRNA and protein kidney injury Molecule-1 (KIM-1) expression in a kidney model during the initiation phase of ischemia reperfusion injury. PMID:35242323
Diet-Induced High Serum Levels of Trimethylamine-N-oxide Enhance the Cellular Inflammatory Response without Exacerbating Acute Intracerebral Hemorrhage Injury in Mice. PMID:35242275
Tissue Clearing Approaches in Atherosclerosis. PMID:35237999
Design and Synthesis of Brain Penetrant Glycopeptide Analogues of PACAP With Neuroprotective Potential for Traumatic Brain Injury and Parkinsonism. PMID:35237767
Citrus Extract as a Perspective for the Control of Dyslipidemia: A Systematic Review With Meta-Analysis From Animal Models to Human Studies. PMID:35237168
Antibody cross-reactivity between casein and myelin-associated glycoprotein results in central nervous system demyelination. PMID:35235454
The minipig intraoral dental implant model: A systematic review and meta-analysis. PMID:35226690
Toxicity study in a pig model of intraperitoneal collagenase as an "enzymatic scalpel" directed to break stroma in order to generate a new perspective for peritoneal carcinomatosis approach: an experimental research. PMID:35216593
First Isolation of Virulent Tenacibaculum maritimum Isolates from Diseased Orbicular Batfish (Platax orbicularis) Farmed in Tahiti Island. PMID:35215075
Metabolic Impact of Anticancer Drugs Pd2Spermine and Cisplatin on the Brain of Healthy Mice. PMID:35213994
Asymptomatic Hyperuricemia Promotes Recovery from Ischemic Organ Injury by Modulating the Phenotype of Macrophages. PMID:35203277
Eye Region Surface Temperature and Corticosterone Response to Acute Stress in a High-Arctic Seabird, the Little Auk. PMID:35203208
Environmental Enrichment for Rats and Mice Housed in Laboratories: A Metareview. PMID:35203123
Triiodothyronine or Antioxidants Block the Inhibitory Effects of BDE-47 and BDE-49 on Axonal Growth in Rat Hippocampal Neuron-Glia Co-Cultures. PMID:35202279
A Study to Assess the Quality of Reporting of Animal Research Studies Published in PubMed Indexed Journals: A Retrospective, Cross-Sectional Content Analysis. PMID:35198334
The effect of progesteron for expression delta (δ) opioid receptor spinal cord through peripheral nerve injury. PMID:35198196
Animal studies for the evaluation of in situ tissue-engineered vascular grafts - a systematic review, evidence map, and meta-analysis. PMID:35197483
Altered TGFB1 regulated pathways promote accelerated tendon healing in the superhealer MRL/MpJ mouse. PMID:35194136
Between two stools: preclinical research, reproducibility, and statistical design of experiments. PMID:35189946
LncAABR07025387.1 Enhances Myocardial Ischemia/Reperfusion Injury Via miR-205/ACSL4-Mediated Ferroptosis. PMID:35186915
The effect of ChAdOx1 nCov-19 vaccine on arterial thrombosis development and platelet aggregation in female rats. PMID:35183388
Melatonin enhances osteogenic differentiation of dental pulp mesenchymal stem cells by regulating MAPK pathways and promotes the efficiency of bone regeneration in calvarial bone defects. PMID:35183254
Iron from nanostructured ferric phosphate: absorption and biodistribution in mice and bioavailability in iron deficient anemic women. PMID:35181698
Transcriptional changes in dendritic cells underlying allergen specific induced tolerance in a mouse model. PMID:35181694
Endothelin-Converting Enzyme 1 and Vascular Endothelial Growth Factor as Potential Biomarkers during Ex Vivo Lung Perfusion with Prolonged Hypothermic Lung-Sparing. PMID:35178130
Modern livestock farming under tropical conditions using sensors in grazing systems. PMID:35173245
OxVent: Design and evaluation of a rapidly-manufactured Covid-19 ventilator. PMID:35172957
Exercise against cocaine sensitization in mice: a [18F]fallypride micro-PET study. PMID:35169698
Human ARHGEF9 intellectual disability syndrome is phenocopied by a mutation that disrupts collybistin binding to the GABAA receptor α2 subunit. PMID:35169261
Amino Acids and IGF1 Regulation of Fish Muscle Growth Revealed by Transcriptome and microRNAome Integrative Analyses of Pacu (Piaractus mesopotamicus) Myotubes. PMID:35163102
Using Mice to Model Human Disease: Understanding the Roles of Baseline Housing-Induced and Experimentally Imposed Stresses in Animal Welfare and Experimental Reproducibility. PMID:35158694
The Effects of Different Pressure Pneumoperitoneum Models Created By Standard or Heated-Humidified CO2 Insufflation on Ovary and Peritoneum: an Experimental Study in Rats. PMID:35157261
Weaknesses in Experimental Design and Reporting Decrease the Likelihood of Reproducibility and Generalization of Recent Cardiovascular Research. PMID:35155034
Ubiquitin-specific peptidase 2 inhibits epithelial-mesenchymal transition in clear cell renal cell carcinoma metastasis by downregulating the NF-κB pathway. PMID:35152855
Bactericidal effect of hyperbaric oxygen therapy in burn injuries. PMID:35145678
Amylin-Calcitonin receptor signaling in the medial preoptic area mediates affiliative social behaviors in female mice. PMID:35136064
PTBP3 modulates P53 expression and promotes colorectal cancer cell proliferation by maintaining UBE4A mRNA stability. PMID:35136024
Stem cell therapy applied for digestive anastomosis: Current state and future perspectives. PMID:35126832
Role of Cholinergic Anti-Inflammatory Pathway in Protecting Sepsis-Induced Acute Lung Injury through Regulation of the Conventional Dendritic Cells. PMID:35125962
A biobank of small cell lung cancer CDX models elucidates inter- and intratumoral phenotypic heterogeneity. PMID:35121965
PET Imaging of Estrogen Receptors Using 18F-Based Radioligands. PMID:35119664
The natural extract degalactotigonin exerts antitumor effects on renal cell carcinoma cells through repressing YAP. PMID:35117355
Combination of GC-MS based metabolomics analysis with mouse xenograft models reveals a panel of dysregulated circulating metabolites and potential therapeutic targets for colorectal cancer. PMID:35116504
The anthelmintic drug niclosamide induces GSK-β-mediated β-catenin degradation to potentiate gemcitabine activity, reduce immune evasion ability and suppress pancreatic cancer progression. PMID:35115509
Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice. PMID:35115501
In-Depth Characterization of Somatic and Orofacial Sensitive Dysfunctions and Interfering-Symptoms in a Relapsing-Remitting Experimental Autoimmune Encephalomyelitis Mouse Model. PMID:35111128
IL10 trains macrophage profibrotic function after lung injury. PMID:35107021
Herbivorous fish (Medialuna ancietae) as a sustainable alternative for nutrition security in Northern Chile. PMID:35102159
A practical guide to setting up pig models for cardiovascular catheterization, electrophysiological assessment and heart disease research. PMID:35087256
The NKCC1 ion transporter modulates microglial phenotype and inflammatory response to brain injury in a cell-autonomous manner. PMID:35085235
Effect of data binning and frame averaging for micro-CT image acquisition on the morphometric outcome of bone repair assessment. PMID:35082347
Intense Acute Swimming Induces Delayed-Onset Muscle Soreness Dependent on Spinal Cord Neuroinflammation. PMID:35069187
Cumulative effects of human footprint, natural features and predation risk best predict seasonal resource selection by white-tailed deer. PMID:35058533
Triggering anti-GBM immune response with EGFR-mediated photoimmunotherapy. PMID:35057796
The Evaluation of Meloxicam Nanocrystals by Oral Administration with Different Particle Sizes. PMID:35056734
Maternal Fructose Intake Causes Developmental Reprogramming of Hepatic Mitochondrial Catalytic Activity and Lipid Metabolism in Weanling and Young Adult Offspring. PMID:35055185
Saracatinib, a Src Tyrosine Kinase Inhibitor, as a Disease Modifier in the Rat DFP Model: Sex Differences, Neurobehavior, Gliosis, Neurodegeneration, and Nitro-Oxidative Stress. PMID:35052568
Changes of FGF23 and the Renin-Angiotensin-System in Male Mouse Models of Chronic Kidney Disease and Cardiac Hypertrophy. PMID:35047715
Dysregulation of Npas4 and Inhba expression and an altered excitation-inhibition balance are associated with cognitive deficits in DBA/2 mice. PMID:35042829
The calcitonin receptor protects against bone loss and excessive inflammation in collagen antibody-induced arthritis. PMID:35036874
Fibroblast-derived prolargin is a tumor suppressor in hepatocellular carcinoma. PMID:35031773
High fat diet-induced obesity prolongs critical stages of the spermatogenic cycle in a Ldlr-/-.Leiden mouse model. PMID:35017550
Effectiveness of maturity of Rubus occidentalis on hyperalgesia induced by acidic saline injection in rats. PMID:35016667
Training associated alterations in equine respiratory immunity using a multiomics comparative approach. PMID:35013475
CRF-receptor1 modulation of the dopamine projection to prelimbic cortex facilitates cognitive flexibility after acute and chronic stress. PMID:35005102
Single-cell transcriptomics defines keratinocyte differentiation in avian scutate scales. PMID:34997067
O-ring-induced transverse aortic constriction (OTAC) is a new simple method to develop cardiac hypertrophy and heart failure in mice. PMID:34997065
In vivo Evidence for Brain Region-Specific Molecular Interactions Between Cannabinoid and Orexin Receptors. PMID:34992518
Digital research data: from analysis of existing standards to a scientific foundation for a modular metadata schema in nanosafety. PMID:34983569
The antioxidant and anti-inflammatory effects of Carica Papaya Linn. seeds extract on CCl4-induced liver injury in male rats. PMID:34969385
Yeast Beta-Glucans Ingestion Does Not Influence Body Weight: A Systematic Review and Meta-Analysis of Pre-Clinical Studies. PMID:34959802
CD4+/IL‑4+ lymphocytes of the lamina propria and substance P promote colonic protection during acute stress. PMID:34958108
Horses' (Equus caballus) Ability to Solve Visible but Not Invisible Displacement Tasks Is Associated With Frustration Behavior and Heart Rate. PMID:34955782
Translational science: a survey of US biomedical researchers' perspectives and practices. PMID:34949847
Long-Term Pharmacological Inhibition of the Activity of All NOS Isoforms Rather Than Genetic Knock-Out of Endothelial NOS Leads to Impaired Spatial Learning and Memory in C57BL/6 Mice. PMID:34944725
The Role of Farnesoid X Receptor in Accelerated Liver Regeneration in Rats Subjected to ALPPS. PMID:34940077
Developmental Exposure to a Human-Relevant Polychlorinated Biphenyl Mixture Causes Behavioral Phenotypes That Vary by Sex and Genotype in Juvenile Mice Expressing Human Mutations That Modulate Neuronal Calcium. PMID:34938155
Involvement of the zebrafish trrap gene in craniofacial development. PMID:34934055
Paradoxical Increase in Body Mass Induced by Beta-Guanidinopropionic Acid in Juvenile Spontaneously Hypertensive Rats. PMID:34925996
Preventive CCL2/CCR2 Axis Blockade Suppresses Osteoclast Activity in a Mouse Model of Rheumatoid Arthritis by Reducing Homing of CCR2hi Osteoclast Progenitors to the Affected Bone. PMID:34925336
Sex and Genotype Modulate the Dendritic Effects of Developmental Exposure to a Human-Relevant Polychlorinated Biphenyls Mixture in the Juvenile Mouse. PMID:34924936
Omeprazole Increases Survival Through the Inhibition of Inflammatory Mediaters in Two Rat Sepsis Models. PMID:34923545
Ectopic Bone Tissue Engineering in Mice Using Human Gingiva or Bone Marrow-Derived Stromal/Progenitor Cells in Scaffold-Hydrogel Constructs. PMID:34917602
Different doses of enoxaparin in the prevention of postoperative abdominal adhesions. Experimental study. PMID:34917351
Oral administration of thiol-reducing agents mitigates gut barrier disintegrity and bacterial lipopolysaccharide translocation in a rat model of biliary obstruction. PMID:34909638
Modulation of oxidative and nitrosative stress attenuates microvascular hyperpermeability in ovine model of Pseudomonas aeruginosa sepsis. PMID:34907252
Chitosan coatings with distinct innate immune bioactivities differentially stimulate angiogenesis, osteogenesis and chondrogenesis in poly-caprolactone scaffolds with controlled interconnecting pore size. PMID:34901558
Protein Kinase SGK2 Is Induced by the β3 Adrenergic Receptor-cAMP-PKA-PGC-1α/NT-PGC-1α Axis but Dispensable for Brown/Beige Adipose Tissue Thermogenesis. PMID:34899399
Tartary buckwheat flavonoids relieve the tendency of mammary fibrosis induced by HFD during pregnancy and lactation. PMID:34890369
The proteome, not the transcriptome, predicts that oocyte superovulation affects embryonic phenotypes in mice. PMID:34887460
Immunotherapeutic Targeting of Mesothelin Positive Pediatric AML Using Bispecific T Cell Engaging Antibodies. PMID:34885074
Analysis of Pain and Analgesia Protocols in Acute Cerulein-Induced Pancreatitis in Male C57BL/6 Mice. PMID:34880773
Cardiac myocyte intrinsic contractility and calcium handling deficits underlie heart organ dysfunction in murine cancer cachexia. PMID:34880268
reString: an open-source Python software to perform automatic functional enrichment retrieval, results aggregation and data visualization. PMID:34873191
Ellagic acid protects against non-alcoholic fatty liver disease in streptozotocin-diabetic rats by activating AMPK. PMID:34870551
Indicators of Health-Related Quality of Life in Cats With Degenerative Joint Disease: Systematic Review and Proposal of a Conceptual Framework. PMID:34869707
Starvation to Glucose Reprograms Development of Neurovascular Unit in Embryonic Retinal Cells. PMID:34869314
Berberine alleviates liver fibrosis through inducing ferrous redox to activate ROS-mediated hepatic stellate cells ferroptosis. PMID:34864819
Newcastle disease vaccine virus I-2 fails to acquire virulence during repeated passage in vivo. PMID:34859194
Oncogenic dependency on STAT3 serine phosphorylation in KRAS mutant lung cancer. PMID:34857889
Endogenous regulation of the Akt pathway by the aryl hydrocarbon receptor (AhR) in lung fibroblasts. PMID:34848742
GI-SleepNet: A Highly Versatile Image-Based Sleep Classification Using a Deep Learning Algorithm. PMID:34842647
Osteocalcin biomarker level evaluation on fracture healing with bone defect after stromal vascular fraction application in murine model. PMID:34840768
Infantile status epilepticus disrupts myelin development. PMID:34838665
Brain-Restricted Inhibition of IL-6 Trans-Signaling Mildly Affects Metabolic Consequences of Maternal Obesity in Male Offspring. PMID:34835991
Micronuclei and Nuclear Buds Induced by Cyclophosphamide in Crocodylus moreletii as Useful Biomarkers in Aquatic Environments. PMID:34827910
Functional Role of AKNA: A Scoping Review. PMID:34827707
Hesperidin Preserves Cognitive Functions and Hippocampus Histological Architecture in Albino Wistar Rats Subjected to Stress Through Enhancement of Brain-Derived Neurotrophic Factor. PMID:34826046
Potentilla reptans L. postconditioning protects reperfusion injury via the RISK/SAFE pathways in an isolated rat heart. PMID:34823510
Evaluation of Protection by Caffeic Acid, Chlorogenic Acid, Quercetin and Tannic Acid against the In Vitro Neurotoxicity and In Vivo Lethality of Crotalus durissus terrificus (South American Rattlesnake) Venom. PMID:34822584
Single-Cell RNA-Sequencing Identifies Infrapatellar Fat Pad Macrophage Polarization in Acute Synovitis/Fat Pad Fibrosis and Cell Therapy. PMID:34821732
Choice of anesthesia and data analysis method strongly increases sensitivity of 18F-FDG PET imaging during experimental epileptogenesis. PMID:34818362
Theaflavin-3,3'-digallate attenuates cigarette smoke extract-induced pulmonary emphysema in mice by suppressing necroptosis. PMID:34815763
Mild repetitive head impacts alter perivascular flow in the midbrain dopaminergic system in awake rats. PMID:34806002
Portulaca oleracea shows no ameliorative potential on ovariectomy-induced hormonal and estrous cycle dysregulation in normal cyclic rats: An experimental study. PMID:34805730
Evaluation of Kratom Opioid Derivatives as Potential Treatment Option for Alcohol Use Disorder. PMID:34803709
Leucine imparts cardioprotective effects by enhancing mTOR activity and mitochondrial fusion in a myocardial ischemia/reperfusion injury murine model. PMID:34801078
Transient Receptor Potential Channel 4 Small-Molecule Inhibition Alleviates Migraine-Like Behavior in Mice. PMID:34790097
A newly discovered behavior ('tail-belting') among wild rodents in sub zero conditions. PMID:34789796
Gpr19 is a circadian clock-controlled orphan GPCR with a role in modulating free-running period and light resetting capacity of the circadian clock. PMID:34789778
Resuscitative efficacy of hemoglobin vesicles for severe postpartum hemorrhage in pregnant rabbits. PMID:34785755
Climate change affects the parasitism rate and impairs the regulation of genes related to oxidative stress and ionoregulation of Colossoma macropomum. PMID:34785749
Identification of candidate genes and enriched biological functions for feed efficiency traits by integrating plasma metabolites and imputed whole genome sequence variants in beef cattle. PMID:34781903
Administration of red ginseng regulates microRNA expression in a mouse model of endometriosis. PMID:34781599
Exploring Refinement Strategies for Single Housing of Male C57BL/6JRj Mice: Effect of Cage Divider on Stress-Related Behavior and Hypothalamic-Pituitary-Adrenal-Axis Activity. PMID:34776890
Bone regeneration in rat calvarial defects using dissociated or spheroid mesenchymal stromal cells in scaffold-hydrogel constructs. PMID:34776000
Partial protective effects of melatonin on developing brain in a rat model of chorioamnionitis. PMID:34773065
Rotavirus spike protein ΔVP8* as a novel carrier protein for conjugate vaccine platform with demonstrated antigenic potential for use as bivalent vaccine. PMID:34764353
Regeneration of dentin-pulp complex by using dental pulp stem cells in dog. PMID:34760077
Genetic inhibition of RIPK3 ameliorates functional outcome in controlled cortical impact independent of necroptosis. PMID:34753914
Osteocrin ameliorates adriamycin nephropathy via p38 mitogen-activated protein kinase inhibition. PMID:34750411
Phillyrin Prevents Neuroinflammation-Induced Blood-Brain Barrier Damage Following Traumatic Brain Injury via Altering Microglial Polarization. PMID:34744713
Basolateral amygdala to posterior piriform cortex connectivity ensures precision in learned odor threat. PMID:34741138
Erythromycin reduces nasal inflammation by inhibiting immunoglobulin production, attenuating mucus secretion, and modulating cytokine expression. PMID:34741083
DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition. PMID:34737188
Magnetic resonance colonography assessment of acute trinitrobenzene sulfonic acid colitis in pre-pubertal rats. PMID:34735489
Morphological Assessment of the Effect of Nanosecond Diode Laser Radiation With a Wavelength of 1265 nm on Periodontal Tissue in the Treatment of Apical Periodontitis: An Experimental Study. PMID:34733766
Polyphenol-rich extract of Ocimum gratissimum leaves prevented toxic effects of cyclophosphamide on the kidney function of Wistar rats. PMID:34727903
The effectiveness of alprostadil in treating coronary microcirculation dysfunction following ST-segment elevation myocardial infarction in a pig model. PMID:34721691
Systematic review and meta-analysis of preclinical studies testing mesenchymal stromal cells for traumatic brain injury. PMID:34716332
NLRP3 associated with chronic kidney disease progression after ischemia/reperfusion-induced acute kidney injury. PMID:34716316
Sodium-Glucose Co-Transporter 2 Inhibition With Empagliflozin Improves Cardiac Function After Cardiac Arrest in Rats by Enhancing Mitochondrial Energy Metabolism. PMID:34712142
An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury. PMID:34706221
Stem cell, Granulocyte-Colony Stimulating Factor and/or Dihexa to promote limb function recovery in a rat sciatic nerve damage-repair model: Experimental animal studies. PMID:34703584
Transcriptomic and epigenomic analyses uncovered Lrrc15 as a contributing factor to cartilage damage in osteoarthritis. PMID:34702854
Impact of Hydrocortisone and of CRH Infusion on the Hypothalamus-Pituitary-Adrenocortical Axis of Septic Male Mice. PMID:34698826
Cardiovascular Progerin Suppression and Lamin A Restoration Rescue Hutchinson-Gilford Progeria Syndrome. PMID:34694158
Effect of erythropoietin administration on expression of mRNA brain-derived Neutrophic factor, levels of stromal cell-derived Factor-1, and neuron specific enolase in brain injury model Sprague Dawley. PMID:34691421
The influence of antineoplastic agents on the peri-implant bone around osseointegrated titanium implants: an in vivo histomorphometric and immunohistochemical study. PMID:34686918
Cisplatin Mouse Models: Treatment, Toxicity and Translatability. PMID:34680523
Modeling Functional Limitations, Gait Impairments, and Muscle Pathology in Alzheimer's Disease: Studies in the 3xTg-AD Mice. PMID:34680482
Radiation-Induced Fibrotic Tumor Microenvironment Regulates Anti-Tumor Immune Response. PMID:34680381
Changes in Functional Glucocorticoid Sensitivity of Isolated Splenocytes Induced by Chronic Psychosocial Stress - A Time Course Study. PMID:34675935
Olfactory Signatures in the Food Finding Test in Mice With Normal and Alzheimer's Disease-Pathological Aging With Special Concerns on the Effects of Social Isolation. PMID:34675767
Beneficial effects of a plant-fish oil, slow carbohydrate diet on cardio-metabolic health exceed the correcting effects of metformin-pioglitazone in diabetic pigs fed a fast-food diet. PMID:34669714
Sustained peripheral immune hyper-reactivity (SPIHR): an enduring biomarker of altered inflammatory responses in adult rats after perinatal brain injury. PMID:34666799
Conserved and breed-specific differences in the cervical transcriptome of sheep with divergent fertility at the follicular phase of a natural oestrus cycle. PMID:34666676
Effect of intra-abdominal administration of ascites fluid on postoperative peritoneal adhesion in rat model: A randomized controlled trail. PMID:34659745
Inhibition of vascular adhesion protein 1 protects dopamine neurons from the effects of acute inflammation and restores habit learning in the striatum. PMID:34654450
The Combination of Gefitinib With ATRA and ATO Induces Myeloid Differentiation in Acute Promyelocytic Leukemia Resistant Cells. PMID:34650910
Manual Acupuncture at ST37 Modulates TRPV1 in Rats with Acute Visceral Hyperalgesia via Phosphatidylinositol 3-Kinase/Akt Pathway. PMID:34646326
Impact of the Pd2Spm (Spermine) Complex on the Metabolism of Triple-Negative Breast Cancer Tumors of a Xenograft Mouse Model. PMID:34639114
Rice (Oryza sativa L.) bran preserves cardiac function by modulating pro-inflammatory cytokines and redox state in the myocardium from obese rats. PMID:34636986
The gut microbiota modulates brain network connectivity under physiological conditions and after acute brain ischemia. PMID:34622150
Endogenous Interleukin-33 Acts as an Alarmin in Liver Ischemia-Reperfusion and Is Associated With Injury After Human Liver Transplantation. PMID:34621275
Engineering a genome-reduced bacterium to eliminate Staphylococcus aureus biofilms in vivo. PMID:34612607
Pulmonary valve tissue engineering strategies in large animal models. PMID:34610023
Distinct timescales for the neuronal encoding of vocal signals in a high-order auditory area. PMID:34608248
Chronic Porphyromonas gingivalis lipopolysaccharide induces adverse myocardial infarction wound healing through activation of CD8+ T cells. PMID:34597184
Time-Dependent Dynamics Required for the Degradation and Restoration of the Vascular Endothelial Glycocalyx Layer in Lipopolysaccharide-Treated Septic Mice. PMID:34595224
Network pharmacology-based investigation of potential targets of astragalus membranaceous-angelica sinensis compound acting on diabetic nephropathy. PMID:34593896
A Meta-Analysis of Rhesus Macaques (Macaca mulatta), Cynomolgus Macaques (Macaca fascicularis), African green monkeys (Chlorocebus aethiops), and Ferrets (Mustela putorius furo) as Large Animal Models for COVID-19. PMID:34588096
Protein Aggregation Is an Early Manifestation of Phospholamban p.(Arg14del)-Related Cardiomyopathy: Development of PLN-R14del-Related Cardiomyopathy. PMID:34587756
Optimum biscuit from Musa sapientum L. and Vigna unguiculata L. composite flour: effect on pancreatic histology, biochemical and hematological parameters of diabetic rats. PMID:34585009
The effect of Platelet-Rich Plasma and Stromal Vascular Fraction combination on Epidermal Growth Factor serum level for anal trauma healing in the Wistar rat model. PMID:34584679
The localization of amyloid precursor protein to ependymal cilia in vertebrates and its role in ciliogenesis and brain development in zebrafish. PMID:34580355
Treatment with Edoxaban Attenuates Acute Stroke Severity in Mice by Reducing Blood-Brain Barrier Damage and Inflammation. PMID:34576055
CD146 Delineates an Interfascicular Cell Sub-Population in Tendon That Is Recruited during Injury through Its Ligand Laminin-α4. PMID:34575887
Effects of a BMI1008 mixture on postoperative pain in a rat model of incisional pain. PMID:34570780
Functional Assessment of Stroke-Induced Regulation of miR-20a-3p and Its Role as a Neuroprotectant. PMID:34570349
Effects of long-term infliximab and tocilizumab treatment on anxiety-like behavior and cognitive function in naive rats. PMID:34569017
Roles of Suaeda vermiculata Aqueous-Ethanolic Extract, Its Subsequent Fractions, and the Isolated Compounds in Hepatoprotection against Paracetamol-Induced Toxicity as Compared to Silymarin. PMID:34567411
Acute and subacute toxicity evaluation of hydroalcoholic extract from the stem bark of Bois Bande (Parinari campestris Aubl.1772) in rats. PMID:34563262
Triple Oxygen Isotope Measurements (Δ'17O) of Body Water Reflect Water Intake, Metabolism, and δ18O of Ingested Water in Passerines. PMID:34552501
Improving rigor and reproducibility in nonhuman primate research. PMID:34541703
Covalent linkage of sulfated hyaluronan to the collagen scaffold Mucograft® enhances scaffold stability and reduces proinflammatory macrophage activation in vivo. PMID:34541411
Transfer factor treatment in management of peritonitis condition: An experimental study in rat. PMID:34527231
Hybrid derivative of cathelicidin and human beta defensin-2 against Gram-positive bacteria: A novel approach for the treatment of bacterial keratitis. PMID:34526600
GAS6-AS1 Overexpression Increases GIMAP6 Expression and Inhibits Lung Adenocarcinoma Progression by Sponging miR-24-3p. PMID:34513660
Stimulation of the Epithelial Na+ Channel in Renal Principal Cells by Gs-Coupled Designer Receptors Exclusively Activated by Designer Drugs. PMID:34512393
Plasma and rhADAMTS13 reduce trauma-induced organ failure by restoring the ADAMTS13-VWF axis. PMID:34505883
Chemogenetic modulation of histaminergic neurons in the tuberomamillary nucleus alters territorial aggression and wakefulness. PMID:34504120
Evaluation of Loco-Regional Skin Toxicity Induced by an In Situ Forming Depot after a Single Subcutaneous Injection at Different Volumes and Flow Rates in Göttingen Minipigs. PMID:34502155
Murine norovirus virulence factor 1 (VF1) protein contributes to viral fitness during persistent infection. PMID:34491891
Serum inflammatory profiles in cystic fibrosis mice with and without Bordetella pseudohinzii infection. PMID:34475490
Intra-Articular Injections of Curcumin Monoglucuronide TBP1901 Suppresses Articular Cartilage Damage and Regulates Subchondral Bone Alteration in an Osteoarthritis Rat Model. PMID:34474599
Early life stress induces age-dependent epigenetic changes in p11 gene expression in male mice. PMID:34471143
A fructosylated peptide derived from a collagen II T cell epitope for long-term treatment of arthritis (FIA-CIA) in mice. PMID:34462464
Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy. PMID:34462437
Pro-inflammatory immunity supports fibrosis advancement in epidermolysis bullosa: intervention with Ang-(1-7). PMID:34459121
Preclinical Experiments for Hypospadias Surgery: Systematic Review and Quality Assessment. PMID:34458213
Neurovascular imaging with QUTE-CE MRI in APOE4 rats reveals early vascular abnormalities. PMID:34449808
Role of Pial Microvasospasms and Leukocyte Plugging for Parenchymal Perfusion after Subarachnoid Hemorrhage Assessed by In Vivo Multi-Photon Microscopy. PMID:34445151
Modification of Hemodialysis Membranes for Efficient Circulating Tumor Cell Capture for Cancer Therapy. PMID:34443432
Different Patterns of Kidney Fibrosis Are Indicative of Injury to Distinct Renal Compartments. PMID:34440782
Sex-Dependent Signatures, Time Frames and Longitudinal Fine-Tuning of the Marble Burying Test in Normal and AD-Pathological Aging Mice. PMID:34440198
A Systematic Review of Therapeutic Approaches Used in Experimental Models of Interstitial Cystitis/Bladder Pain Syndrome. PMID:34440069
Quality of Reporting in Preclinical Urethral Tissue Engineering Studies: A Systematic Review to Assess Adherence to the ARRIVE Guidelines. PMID:34438913
Distinct contributions of meprins to skin regeneration after injury - Meprin α a physiological processer of pro-collagen VII. PMID:34435182
Dexamethasone-loaded thermo-sensitive hydrogel attenuates osteoarthritis by protecting cartilage and providing effective pain relief. PMID:34430561
Systemic lidocaine administration influences NF-kβ gene expression, NF-kβ and TNF- α protein levels on BALB/c mice with musculoskeletal injury. PMID:34429946
Effects of dietary forage to concentrate ratio on nutrient digestibility, ruminal fermentation and rumen bacterial composition in Angus cows. PMID:34426627
The GLP-1 receptor agonist, liraglutide, fails to slow disease progression in SOD1G93A and TDP-43Q331K transgenic mouse models of ALS. PMID:34426623
Imaging asparaginyl endopeptidase (AEP) in the live brain as a biomarker for Alzheimer's disease. PMID:34412639
Extensive phenotypic characterisation of a human TDP-43Q331K transgenic mouse model of amyotrophic lateral sclerosis (ALS). PMID:34404845
RIPK1 or RIPK3 deletion prevents progressive neuronal cell death and improves memory function after traumatic brain injury. PMID:34404478
Analysis of CD4 and CD8 expression in multidrug-resistant tuberculosis infection with diabetes mellitus: An experimental study in mice. PMID:34401121
Suppression of joint pain in transient receptor potential vanilloid 4 knockout rats with monoiodoacetate-induced osteoarthritis. PMID:34396019
Injuries in Muscle-Tendon-Bone Units: A Systematic Review Considering the Role of Passive Tissue Fatigue. PMID:34395681
Antineoplastic agents aggravate the damages caused by nicotine on the peri-implant bone: an in vivo histomorphometric and immunohistochemical study in rats. PMID:34386857
Influence of immunosuppression on the progression of experimental periodontitis and on healthy periodontal tissue: A rat in vivo study. PMID:34386179
Pedunculoside protects against LPS-induced mastitis in mice by inhibiting inflammation and maintaining the integrity of blood-milk barrier. PMID:34383710
A Subpopulation of Microglia Generated in the Adult Mouse Brain Originates from Prominin-1-Expressing Progenitors. PMID:34380760
Measuring and interpreting pervasive heterogeneity, poikilosis. PMID:34377957
Exposure to methylphenidate during peri-adolescence decouples the prefrontal cortex: a multimodal MRI study. PMID:34377346
A performance comparison of the most commonly used minimally invasive monitors of cardiac output. PMID:34374024
Identification of intima-to-media signals for flow-induced vascular remodeling using correlative gene expression analysis. PMID:34373496
Cholesterol-Ester Transfer Protein Alters M1 and M2 Macrophage Polarization and Worsens Experimental Elastase-Induced Pulmonary Emphysema. PMID:34367144
Systems analysis identifies endothelin 1 axis blockade for enhancing the anti-tumor effect of multikinase inhibitor. PMID:34363028
Effect of Different Bone Grafting Materials and Mesenchymal Stem Cells on Bone Regeneration: A Micro-Computed Tomography and Histomorphometric Study in a Rabbit Calvarial Defect Model. PMID:34360864
Doxycycline rescues recognition memory and circadian motor rhythmicity but does not prevent terminal disease in fatal familial insomnia mice. PMID:34358614
Randomized Trial of Oxygen Saturation Targets during and after Resuscitation and Reversal of Ductal Flow in an Ovine Model of Meconium Aspiration and Pulmonary Hypertension. PMID:34356574
Unilateral Ureteral Obstruction for 28 Days in Rats Is Not Associated with Changes in Cardiac Function or Alterations in Mitochondrial Function. PMID:34356526
Mice and Rats Exhibit Striking Inter-species Differences in Gene Response to Acute Stroke. PMID:34350530
Keratinocyte-Like Cells Trans-Differentiated from Human Adipose-Derived Stem Cells, Facilitate Skin Wound Healing in Mice. PMID:34341633
Pertussis toxin-induced inflammatory response exacerbates intracerebral haemorrhage and ischaemic stroke in mice. PMID:34341068
A comprehensive tool box for large animal studies of intervertebral disc degeneration. PMID:34337336
Spared Nerve Injury Causes Sexually Dimorphic Mechanical Allodynia and Differential Gene Expression in Spinal Cords and Dorsal Root Ganglia in Rats. PMID:34331199
A chromosome-level genome assembly of Cairina moschata and comparative genomic analyses. PMID:34330207
INFRAFRONTIER quality principles in systemic phenotyping. PMID:34328547
Does Retrograde Femoral Nailing through a Normal Physis Impair Growth? An Experimental Porcine Model. PMID:34326896
Robust chitinolytic activity of crab-eating monkey (Macaca fascicularis) acidic chitinase under a broad pH and temperature range. PMID:34326426
Intranasal insulin rescues repeated anesthesia-induced deficits in synaptic plasticity and memory and prevents apoptosis in neonatal mice via mTORC1. PMID:34326413
Torpor enhances synaptic strength and restores memory performance in a mouse model of Alzheimer's disease. PMID:34326412
Osseodensification enables bone healing chambers with improved low-density bone site primary stability: an in vivo study. PMID:34326400
The Impacts of Surgery and Intracerebral Electrodes in C57BL/6J Mouse Kainate Model of Epileptogenesis: Seizure Threshold, Proteomics, and Cytokine Profiles. PMID:34322075
The Impact of Voluntary Exercise on Stroke Recovery. PMID:34321996
Leech therapy (Hirudo medicinalis) attenuates testicular damages induced by testicular ischemia/reperfusion in an animal model. PMID:34315461
The Mutant Mouse Resource and Research Center (MMRRC): the NIH-supported National Public Repository and Distribution Archive of Mutant Mouse Models in the USA. PMID:34313795
Cyclooxygenase-dependent mechanisms mediate in part the anti-dilatory effects of perivascular adipose tissue in uterine arteries from pregnant rats. PMID:34311071
The impact of hindlimb disuse on sepsis-induced myopathy in mice. PMID:34309237
Dual targeting of the DNA damage response pathway and BCL-2 in diffuse large B-cell lymphoma. PMID:34304248
Reporting stAndards for research in PedIatric Dentistry (RAPID): an expert consensus-based statement. PMID:34301229
Profiling the Effects of Repetitive Morphine Administration on Motor Behavior in Rats. PMID:34299631
In Utero Exposure to Δ9-Tetrahydrocannabinol Leads to Postnatal Catch-Up Growth and Dysmetabolism in the Adult Rat Liver. PMID:34299119
An insight on the impact of teleost whole genome duplication on the regulation of the molecular networks controlling skeletal muscle growth. PMID:34293047
Near infrared light amplifies endothelial progenitor cell accumulation after stroke. PMID:34291201
Top Priorities for Cerebroprotective Studies-A Paradigm Shift: Report From STAIR XI. PMID:34289707
Refinement of the spinal cord injury rat model and validation of its applicability as a model for memory loss and chronic pain. PMID:34286145
Visual instrumental learning in blindsight monkeys. PMID:34285293
Sustained Inflation During Chest Compression: A New Technique of Pediatric Cardiopulmonary Resuscitation That Improves Recovery and Survival in a Pediatric Porcine Model. PMID:34284596
No effect of deleted in malignant brain tumors 1 deficiency on chemotherapy induced murine intestinal mucositis. PMID:34282203
Electrophysiological characterization of a diverse group of sugar transporters from Trichoderma reesei. PMID:34282161
TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain. PMID:34274354
The rodent object-in-context task: A systematic review and meta-analysis of important variables. PMID:34270575
The Combination of Stromal Vascular Fraction Cells and Platelet-Rich Plasma Reduces Malondialdehyde and Nitric Oxide Levels in Deep Dermal Burn Injury. PMID:34267534
Cannabidiol and Sertraline Regulate Behavioral and Brain Gene Expression Alterations in an Animal Model of PTSD. PMID:34262461
Application across species of a one health approach to liquid sample handling for respiratory based -omics analysis. PMID:34253818
Exocrine Pancreatic Maturation in Pre-term and Term Piglets Supplemented With Bovine Colostrum. PMID:34249996
PDE5 Inhibition Suppresses Ventricular Arrhythmias by Reducing SR Ca2+ Content. PMID:34247494
IRF8-Dependent Type I Conventional Dendritic Cells (cDC1s) Control Post-Ischemic Inflammation and Mildly Protect Against Post-Ischemic Acute Kidney Injury and Disease. PMID:34234783
Developmental environment shapes honeybee worker response to virus infection. PMID:34234217
Red Blood Cell and Endothelial eNOS Independently Regulate Circulating Nitric Oxide Metabolites and Blood Pressure. PMID:34229449
Spatial Distribution of Neuropathology and Neuroinflammation Elucidate the Biomechanics of Fluid Percussion Injury. PMID:34223546
Influence of Organic Solvents on Secondary Brain Damage after Experimental Traumatic Brain Injury. PMID:34223539
First-time evaluation of ascending compared to rectangular transthoracic defibrillation waveforms in modelled out-of-hospital cardiac arrest. PMID:34223293
Maternal cold exposure induces distinct transcriptome changes in the placenta and fetal brown adipose tissue in mice. PMID:34217204
Flutamide treatment reveals a relationship between steroidogenic activity of Leydig cells and ultrastructure of their mitochondria. PMID:34215832
Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus. PMID:34215285
Optimising Large Animal Models of Sustained Atrial Fibrillation: Relevance of the Critical Mass Hypothesis. PMID:34211405
A model of atherosclerosis using nicotine with balloon overdilation in a porcine. PMID:34211091
Communication breakdown: Limits of spectro-temporal resolution for the perception of bat communication calls. PMID:34211004
Activation of PI3K/Akt Signaling Pathway in Rat Hypothalamus Induced by an Acute Oral Administration of D-Pinitol. PMID:34209137
Measurement of Electrical Impedance Tomography-Based Regional Ventilation Delay for Individualized Titration of End-Expiratory Pressure. PMID:34208890
Effect of a Larger Flush Volume on Bioavailability and Efficacy of Umbilical Venous Epinephrine during Neonatal Resuscitation in Ovine Asphyxial Arrest. PMID:34205843
Reduction of the Adverse Impacts of Fungal Mycotoxin on Proximate Composition of Feed and Growth Performance in Broilers by Combined Adsorbents. PMID:34205524
Induction of Tertiary Phase Epileptiform Discharges after Postasphyxial Infusion of a Toll-Like Receptor 7 Agonist in Preterm Fetal Sheep. PMID:34205464
Fine-Tuning the PI3K/Akt Signaling Pathway Intensity by Sex and Genotype-Load: Sex-Dependent Homozygotic Threshold for Somatic Growth but Feminization of Anxious Phenotype in Middle-Aged PDK1 K465E Knock-In and Heterozygous Mice. PMID:34203450
Genotype Load Modulates Amyloid Burden and Anxiety-Like Patterns in Male 3xTg-AD Survivors despite Similar Neuro-Immunoendocrine, Synaptic and Cognitive Impairments. PMID:34201608
Stereotypies in the Autism Spectrum Disorder: Can We Rely on an Ethological Model? PMID:34201177
Survival Bias and Crosstalk between Chronological and Behavioral Age: Age- and Genotype-Sensitivity Tests Define Behavioral Signatures in Middle-Aged, Old, and Long-Lived Mice with Normal and AD-Associated Aging. PMID:34199476
Diet, body weight and pain susceptibility - A systematic review of preclinical studies. PMID:34195483
TGF-β expression on different suturing technique for abdominal skin wound closure in rats. PMID:34194734
Immune Response to Therapeutic Staphylococcal Bacteriophages in Mammals: Kinetics of Induction, Immunogenic Structural Proteins, Natural and Induced Antibodies. PMID:34194425
Why the preclinical imaging field needs nuclear medicine technologists and radiographers? PMID:34191167
De novo deoxyribonucleotide biosynthesis regulates cell growth and tumor progression in small-cell lung carcinoma. PMID:34188151
Toxicity and bacterial anti-motility activities of the hydroethanolic extract of Acacia senegal (L.) Willd (Fabaceae) leaves. PMID:34187452
Quality of reporting of clinical trials in dogs and cats: An update. PMID:34184331
Glutamine supplementation stimulates cell proliferation in skeletal muscle and cultivated myogenic cells of low birth weight piglets. PMID:34183762
Porcine pancreatic ductal epithelial cells transformed with KRASG12D and SV40T are tumorigenic. PMID:34183736
Impact of topical nifedipine on wound healing in animal model (pig). PMID:34178060
Preservation of renal endothelial integrity and reduction of renal edema by aprotinin does not preserve renal perfusion and function following experimental cardiopulmonary bypass. PMID:34169407
Probiotics: their action against pathogens can be turned around. PMID:34168166
Co-editing PINK1 and DJ-1 Genes Via Adeno-Associated Virus-Delivered CRISPR/Cas9 System in Adult Monkey Brain Elicits Classical Parkinsonian Phenotype. PMID:34165772
Targeted SPION siderophore conjugate loaded with doxorubicin as a theranostic agent for imaging and treatment of colon carcinoma. PMID:34158526
Autophagy of mucin granules contributes to resolution of airway mucous metaplasia. PMID:34158522
The effect of pre-resection obesity on post-resection body composition after 75% small bowel resection in rats. PMID:34155300
Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response. PMID:34152608
Early-adolescent antibiotic exposure results in mitochondrial and behavioral deficits in adult male mice. PMID:34145328
The effect of glutathione as adjuvant therapy on levels of TNF-α and IL-10 in wistar rat peritonitis model. PMID:34136205
FasL Is Required for Osseous Healing in Extraction Sockets in Mice. PMID:34135904
The future of basic science in orthopaedics and traumatology: Cassandra or Prometheus? PMID:34127057
Gut microbiota-CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten-induced enteropathy. PMID:34125490
Myosin-based regulation of twitch and tetanic contractions in mammalian skeletal muscle. PMID:34121660
Repurposing ibuprofen-loaded microemulsion for the management of Alzheimer's disease: evidence of potential intranasal brain targeting. PMID:34121565
miR-1224 contributes to ischemic stroke-mediated natural killer cell dysfunction by targeting Sp1 signaling. PMID:34118948
Performance of nanoScan PET/CT and PET/MR for quantitative imaging of 18F and 89Zr as compared with ex vivo biodistribution in tumor-bearing mice. PMID:34117946
Spatiotemporal imaging and pharmacokinetics of fluorescent compounds in zebrafish eleuthero-embryos after different routes of administration. PMID:34108572
Comparative transcriptome analysis of inner blood-retinal barrier and blood-brain barrier in rats. PMID:34108511
Osmotically balanced, large unilamellar liposomes that enable sustained bupivacaine release for prolonged pain relief in in vivo rat models. PMID:34103656
Peganum harmala enhanced GLP-1 and restored insulin signaling to alleviate AlCl3-induced Alzheimer-like pathology model. PMID:34103557
Histone Deacetylase 2-Mediated Epigenetic Regulation is Involved in the Early Isoflurane Exposure-Related Increase in Susceptibility to Anxiety-Like Behaviour Evoked by Chronic Variable Stress in Mice. PMID:34101131
Molecular omics resources should require sex annotation: a call for action. PMID:34099934
The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. PMID:34095516
Additional partial hepatectomy at the time of portal vein ligation accelerates the regeneration of the future liver remnant. PMID:34083554
The Influence of Silver Nanoparticles Against Toxic Effects of Philodryas olfersii Venom. PMID:34079248
Immune and repair responses in joint tissues and lymph nodes after knee arthroplasty surgery in mice. PMID:34076292
A quinazoline-based bromodomain inhibitor, CN210, ameliorates indomethacin-induced ileitis in mice by inhibiting inflammatory cytokine expression. PMID:34075610
Spatial visualization of comprehensive brain neurotransmitter systems and neuroactive substances by selective in situ chemical derivatization mass spectrometry imaging. PMID:34075230
The Effect of Coronal Implant Design and Drilling Protocol on Bone-to-Implant Contact: A 3-Month Study in the Minipig Calvarium. PMID:34070127
Effects of (a Combination of) the Beta2-Adrenoceptor Agonist Indacaterol and the Muscarinic Receptor Antagonist Glycopyrrolate on Intrapulmonary Airway Constriction. PMID:34069899
Maternal Exercise Mediates Hepatic Metabolic Programming via Activation of AMPK-PGC1α Axis in the Offspring of Obese Mothers. PMID:34069390
Oxaliplatin Causes Transient Changes in TRPM8 Channel Activity. PMID:34066977
Intestinal Homeostasis under Stress Siege. PMID:34065791
Neuropeptide S-Mediated Modulation of Prepulse Inhibition Depends on Age, Gender, Stimulus-Timing, and Attention. PMID:34065431
Translational Block in Stroke: A Constructive and "Out-of-the-Box" Reappraisal. PMID:34054413
Magnesium supplementation alleviates corticosteroid-associated muscle atrophy in rats. PMID:34052917
Molecular mechanisms of Zika virus teratogenesis from animal studies: a systematic review protocol. PMID:34051864
Protective effect of alamandine on doxorubicin‑induced nephrotoxicity in rats. PMID:34049594
Immune spleen cells attenuate the inflammatory profile of the mesenteric perivascular adipose tissue in obese mice. PMID:34045574
p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation. PMID:34038735
Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies. PMID:34037669
Lidocaine and bupivacaine as part of multimodal pain management in a C57BL/6J laparotomy mouse model. PMID:34035397
Thioredoxin interacting protein regulates age-associated neuroinflammation. PMID:34029695
The effect of nano-hydroxyapatite/chitosan scaffolds on rat calvarial defects for bone regeneration. PMID:34027572
Hydrologic variation influences stream fish assemblage dynamics through flow regime and drought. PMID:34021176
The Atlantic salmon's stress- and immune-related transcriptional responses to moderate hypoxia, an incremental temperature increase, and these challenges combined. PMID:34015123
Assessment of select synthetic cannabinoid receptor agonist bias and selectivity between the type 1 and type 2 cannabinoid receptor. PMID:34012003
Patient-derived tumor xenograft and organoid models established from resected pancreatic, duodenal and biliary cancers. PMID:34011980
Kokumi taste perception is functional in a model carnivore, the domestic cat (Felis catus). PMID:34006911
Myomedin scaffold variants targeted to 10E8 HIV-1 broadly neutralizing antibody mimic gp41 epitope and elicit HIV-1 virus-neutralizing sera in mice. PMID:33993840
Stroke affects intestinal immune cell trafficking to the central nervous system. PMID:33989742
Proprieties of adhesive surface arrays to thyroid cartilage for recurrent laryngeal nerve monitoring. PMID:33987388
DXA reference values of the humanoid sheep model in preclinical studies. PMID:33986984
A descriptive analysis of the data availability statements accompanying medRxiv preprints and a comparison with their published counterparts. PMID:33983972
Infliximab prevents systemic bone loss and suppresses tendon inflammation in a collagen-induced arthritis rat model. PMID:33982199
Time-Restricted Feeding Regulates Circadian Rhythm of Murine Uterine Clock. PMID:33981944
Great tits who remember more accurately have difficulty forgetting, but variation is not driven by environmental harshness. PMID:33980907
Inhibition of hyaluronan secretion by novel coumarin compounds and chitin synthesis inhibitors. PMID:33978736
Development and characterization of two equine formulations towards SARS-CoV-2 proteins for the potential treatment of COVID-19. PMID:33972631
Figla promotes secondary follicle growth in mature mice. PMID:33972571
Histomorphometric Quantitative Evaluation of Long-Term Risedronate Use in a Knee Osteoarthritis Rabbit Model. PMID:33969044
Genetic Background but Not Intestinal Microbiota After Co-Housing Determines Hyperoxaluria-Related Nephrocalcinosis in Common Inbred Mouse Strains. PMID:33968083
Leaky barriers: leaky enough for fish to pass? PMID:33959345
Quality Considerations When Using Tissue Samples for Biomarker Studies in Cancer Research. PMID:33958852
Dynamic miRNA changes during the process of epileptogenesis in an infantile and adult-onset model. PMID:33958654
Revision of the ARRIVE guidelines: rationale and scope. PMID:33954268
Airway gas temperature within endotracheal tube can be monitored using rapid response thermometer. PMID:33953212
Whole lung tissue is the preferred sampling method for amplicon-based characterization of murine lung microbiota. PMID:33952355
Quantitative fluorescence angiography aids novice and experienced surgeons in performing intestinal resection in well-perfused tissue. PMID:33942183
Randomized trial of oxygen weaning strategies following chest compressions during neonatal resuscitation. PMID:33941864
MDM2 inhibitor APG-115 exerts potent antitumor activity and synergizes with standard-of-care agents in preclinical acute myeloid leukemia models. PMID:33941774
Tertiary cystic white matter injury as a potential phenomenon after hypoxia-ischaemia in preterm f sheep. PMID:33937767
The Cytoskeletal Elements MAP2 and NF-L Show Substantial Alterations in Different Stroke Models While Elevated Serum Levels Highlight Especially MAP2 as a Sensitive Biomarker in Stroke Patients. PMID:33931805
Baricitinib Ameliorates Experimental Autoimmune Encephalomyelitis by Modulating the Janus Kinase/Signal Transducer and Activator of Transcription Signaling Pathway. PMID:33927721
Effects of Essential Oils of Elettaria cardamomum Grown in India and Guatemala on Gram-Negative Bacteria and Gastrointestinal Disorders. PMID:33925478
Osseointegration of Plasma Jet Treated Titanium Implant Surface in an Animal Model. PMID:33924487
Systematic Review and Quality Evaluation Using ARRIVE 2.0 Guidelines on Animal Models Used for Periosteal Distraction Osteogenesis. PMID:33923253
Social Nesting, Animal Welfare, and Disease Monitoring. PMID:33918975
The Impact of Dextran Sodium Sulfate-Induced Gastrointestinal Injury on the Pharmacokinetic Parameters of Donepezil and Its Active Metabolite 6-O-desmethyldonepezil, and Gastric Myoelectric Activity in Experimental Pigs. PMID:33918638
Tissue-specific regulatory mechanism of LncRNAs and methylation in sheep adipose and muscle induced by Allium mongolicum Regel extracts. PMID:33911127
CD244+ polymorphonuclear myeloid‑derived suppressor cells reflect the status of peritoneal dissemination in a colon cancer mouse model. PMID:33907826
Enhanced anti-melanoma efficacy through a combination of the armed oncolytic adenovirus ZD55-IL-24 and immune checkpoint blockade in B16-bearing immunocompetent mouse model. PMID:33903973
Increasing Natural Resistance Associated Macrophage Protein 1 serum level after Miana treatment in BALB/c induced Klebsiella pneumoniae experimental research. PMID:33898034
Combination of platelet rich plasma and stromal vascular fraction on the level of vascular endothelial growth factor in rat subjects experiencing deep dermal burn injury. PMID:33898027
Effects of estrogen deficiency during puberty on maxillary and mandibular growth and associated gene expression - an μCT study on rats. PMID:33888144
Biochemical characterization of the cyclooxygenase enzyme in penaeid shrimp. PMID:33886622
Behavioral characteristics as potential biomarkers of the development and phenotype of epilepsy in a rat model of temporal lobe epilepsy. PMID:33883658
Exposure to Δ9-tetrahydrocannabinol during rat pregnancy leads to impaired cardiac dysfunction in postnatal life. PMID:33879850
Salvia miltiorrhiza hydroalcoholic extract inhibits postoperative peritoneal adhesions in rats. PMID:33879143
A single intra-articular dose of vitamin D analog calcipotriol alleviates synovitis without adverse effects in rats. PMID:33878143
Improvement of HSV-1 based amplicon vectors for a safe and long-lasting gene therapy in non-replicating cells. PMID:33869657
High-fat diet increases the level of circulating Monocyte Chemoattractant Protein-1 in Wistar rats, independent of obesity. PMID:33868686
Functional Selectivity Does Not Predict Antinociceptive/Locomotor Impairing Potencies of NOP Receptor Agonists. PMID:33859548
Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice. PMID:33859334
A novel tissue specific alternative splicing variant mitigates phenotypes in Ets2 frame-shift mutant models. PMID:33859300
Methamphetamine facilitates pulmonary and splenic tissue injury and reduces T cell infiltration in C57BL/6 mice after antigenic challenge. PMID:33859291
Transcriptional profiles in Strongyloides stercoralis males reveal deviations from the Caenorhabditis sex determination model. PMID:33859232
Periodontal response to a tricalcium silicate material or resin composite placed in close contact to the supracrestal tissue attachment: a histomorphometric comparative study. PMID:33855658
Ethical and Welfare Implications of Genetically Altered Non-Human Primates for Biomedical Research. PMID:33851094
Verapamil as an Adjunct Therapy to Reduce tPA Toxicity in Hyperglycemic Stroke: Implication of TXNIP/NLRP3 Inflammasome. PMID:33847912
The transcriptomic responses of Atlantic salmon (Salmo salar) to high temperature stress alone, and in combination with moderate hypoxia. PMID:33845767
Reproductive toxicity potentials of methanolic extract of Portulaca oleracea in male rats: An experimental study. PMID:33842821
Autocrine IGF2 programmes β-cell plasticity under conditions of increased metabolic demand. PMID:33833312
CGRP protects bladder smooth muscle cells stimulated by high glucose through inhibiting p38 MAPK pathway in vitro. PMID:33828162
The effect of low versus high tidal volume ventilation on inflammatory markers in animal model undergoing lung ventilation: A prospective study. PMID:33824635
Integrative microRNAome analysis of skeletal muscle of Colossoma macropomum (tambaqui), Piaractus mesopotamicus (pacu), and the hybrid tambacu, based on next-generation sequencing data. PMID:33823787
Systematic Review of the Preclinical Technology Readiness of Orthopedic Gene Therapy and Outlook for Clinical Translation. PMID:33816447
Murine Esophagus Expresses Glial-Derived Central Nervous System Antigens. PMID:33810144
The Promise of Patient-Derived Preclinical Models to Accelerate the Implementation of Personalised Medicine for Children with Neuroblastoma. PMID:33808071
Acid Dentin Lysate Failed to Modulate Bone Formation in Rat Calvaria Defects. PMID:33807565
'Statistical Irreproducibility' Does Not Improve with Larger Sample Size: How to Quantify and Address Disease Data Multimodality in Human and Animal Research. PMID:33806843
Validation of an LC-MS/MS Method to Quantify the New TRPC6 Inhibitor SH045 (Larixyl N-methylcarbamate) and Its Application in an Exploratory Pharmacokinetic Study in Mice. PMID:33805686
Ascorbic Acid Supplementation Improves Skeletal Muscle Growth in Pacu (Piaractus mesopotamicus) Juveniles: In Vivo and In Vitro Studies. PMID:33804272
Effect of the Oral Administration of Common Evening Primrose Sprout (Oenothera biennis L.) Extract on Skin Function Improvement in UVB-irradiated Hairless Mice. PMID:33800871
Skeletal muscle fibers play a functional role in host defense during sepsis in mice. PMID:33795743
The microbiome and rodent models of immune mediated diseases. PMID:33792799
SUR1, newly expressed in astrocytes, mediates neuropathic pain in a mouse model of peripheral nerve injury. PMID:33788643
Periconceptional nutrition with spineless cactus (Opuntia ficus-indica) improves metabolomic profiles and pregnancy outcomes in sheep. PMID:33785817
Selective Ablation of BDNF from Microglia Reveals Novel Roles in Self-Renewal and Hippocampal Neurogenesis. PMID:33785644
Online resources for improving the care and use of non-human primates in research. PMID:33778154
Robotic infant surgery with 3 mm instruments: a study in piglets of less than 10 kg body weight. PMID:33772434
High-fiber diets attenuate emphysema development via modulation of gut microbiota and metabolism. PMID:33772084
Type of chemotherapy has substantial effects on the immune system in ovarian cancer. PMID:33770618
Cyclopiazonic Acid-Induced Ca2+ Store Depletion Initiates Endothelium-Dependent Hyperpolarization-Mediated Vasorelaxation of Mesenteric Arteries in Healthy and Colitis Mice. PMID:33767636
DMV extrasynaptic NMDA receptors regulate caloric intake in rats. PMID:33764905
Tian-Huang Formula, a Traditional Chinese Medicinal Prescription, Improves Hepatosteatosis and Glucose Intolerance Targeting AKT-SREBP Nexus in Diet-Induced Obese Rats. PMID:33763145
Dabigatran activates inflammation resolution by promoting fibrinogen-like protein 2 shedding and RvD5n-3 DPA production. PMID:33754059
Impact of hydroxytyrosol on stroke: tracking therapy response on neuroinflammation and cerebrovascular parameters using PET-MR imaging and on functional outcomes. PMID:33754046
Monitoring the variation in the gut microbiota of captive woolly monkeys related to changes in diet during a reintroduction process. PMID:33753830
Are Silver Nanoparticles Useful for Treating Second-Degree Burns? An Experimental Study in Rats. PMID:33747860
Moxibustion for cognitive impairment: a systematic review and meta-analysis of animal studies. PMID:33747784
Expression of histone deacetylase 2 in tracheal stenosis models and its relationship with tracheal granulation tissue proliferation. PMID:33747180
Remote ischemic preconditioning does not induce activation of Akt and STAT5 in the rat heart. PMID:33747171
The effects of myelin on macrophage activation are phenotypic specific via cPLA2 in the context of spinal cord injury inflammation. PMID:33737707
Differential role of SIRT1/MAPK pathway during cerebral ischemia in rats and humans. PMID:33737560
Colonization of distant organs by tumor cells generating circulating homotypic clusters adaptive to fluid shear stress. PMID:33731803
Validation of a high-fidelity training model for fetoscopic spina bifida surgery. PMID:33731777
Randomised trial of epinephrine dose and flush volume in term newborn lambs. PMID:33687959
Microcracks on the Rat Root Surface Induced by Orthodontic Force, Crack Extension Simulation, and Proteomics Study. PMID:33686616
A System-Agnostic, Adaptable and Extensible Animal Support Cradle System for Cardio-Respiratory-Synchronised, and Other, Multi-Modal Imaging of Small Animals. PMID:33681462
The gut mycobiome of healthy mice is shaped by the environment and correlates with metabolic outcomes in response to diet. PMID:33674757
Novel Insights into Mice Multi-Organ Metabolism upon Exposure to a Potential Anticancer Pd(II)-Agent. PMID:33671194
Impact of Food Additive Titanium Dioxide on Gut Microbiota Composition, Microbiota-Associated Functions, and Gut Barrier: A Systematic Review of In Vivo Animal Studies. PMID:33669592
Lyophilization Serves as an Effective Strategy for Drug Development of the α9α10 Nicotinic Acetylcholine Receptor Antagonist α-Conotoxin GeXIVA[1,2]. PMID:33668830
Neuron-specific spinal cord translatomes reveal a neuropeptide code for mouse dorsal horn excitatory neurons. PMID:33664406
Resequencing and SNP discovery of Amur ide (Leuciscus waleckii) provides insights into local adaptations to extreme environments. PMID:33658614
Non-monotonic kilohertz frequency neural block thresholds arise from amplitude- and frequency-dependent charge imbalance. PMID:33658552
Calf Diarrhea Caused by Prolonged Expansion of Autochthonous Gut Enterobacteriaceae and Their Lytic Bacteriophages. PMID:33653940
Use of miR‑145 and testicular nuclear receptor 4 inhibition to reduce chemoresistance to docetaxel in prostate cancer. PMID:33650661
Organoids as Novel Models for Embryo Implantation Study. PMID:33650092
An African tick flavivirus forming an independent clade exhibits unique exoribonuclease-resistant RNA structures in the genomic 3'-untranslated region. PMID:33649491
Toward assessing clinical trial publications for reporting transparency. PMID:33647518
Genome-wide interference of ZNF423 with B-lineage transcriptional circuitries in acute lymphoblastic leukemia. PMID:33646306
Ribosome induces transdifferentiation of A549 and H-111-TC cancer cell lines. PMID:33644423
Return of Spontaneous Circulation Depends on Cardiac Rhythm During Neonatal Cardiac Arrest in Asphyxiated Newborn Animals. PMID:33643979
Yersinia pseudotuberculosis serotype O:1 infection in a captive Seba's short tailed-fruit bat (Carollia perspicillata) colony in Switzerland. PMID:33639950
An immortalized porcine macrophage cell line competent for the isolation of African swine fever virus. PMID:33637799
Diverse patterns of bone regeneration in rabbit calvarial defects depending on the type of collagen membrane. PMID:33634614
Iohexol plasma clearance simplified by Dried Blood Spot (DBS) sampling to measure renal function in conscious mice. PMID:33633207
Role of Autophagy in Granulocyte-Colony Stimulating Factor Induced Anti-Apoptotic Effects in Diabetic Cardiomyopathy. PMID:33631916
Intraoperative ureter identification with a novel fluorescent catheter. PMID:33627768
Stable isotope turnover rates and fractionation in captive California yellowtail (Seriola dorsalis): insights for application to field studies. PMID:33627705
Reduction in pregnancies and litters in mice couples with splenectomized male. PMID:33624718
Preferred Reporting Items for study Designs in Endodontology (PRIDE): Guiding authors to produce high-quality manuscripts. PMID:33623229
Platelets and lymphocytes drive progressive penumbral tissue loss during middle cerebral artery occlusion in mice. PMID:33602266
Effect of platelet-rich and platelet-poor plasma on 3D bone-to-implant contact: a preclinical micro-CT study. PMID:33598799
Zebrafish and Artemia salina in vivo evaluation of the recreational 25C-NBOMe drug demonstrates its high toxicity. PMID:33598409
Interleukin-4 Induces the Release of Opioid Peptides from M1 Macrophages in Pathological Pain. PMID:33593854
The role of pro-opiomelanocortin in the ACTH-cortisol dissociation of sepsis. PMID:33593393
Hemodynamic effects of high frequency oscillatory ventilation with volume guarantee in a piglet model of respiratory distress syndrome. PMID:33592023
Brain morphological and connectivity changes on MRI after stem cell therapy in a rat stroke model. PMID:33592008
Activation-induced cytidine deaminase is a possible regulator of cross-talk between oocytes and granulosa cells through GDF-9 and SCF feedback system. PMID:33589683
Exercise alters the mitochondrial proteostasis and induces the mitonuclear imbalance and UPRmt in the hypothalamus of mice. PMID:33589652
Experimental Myocardial Infarction Elicits Time-Dependent Patterns of Vascular Hypoxia in Peripheral Organs and in the Brain. PMID:33585582
Radiographic Imaging to Evaluate Food Passage Rate in Preterm Piglets as a Model for Preterm Infants. PMID:33585369
Cerebral blood flow and cerebrovascular reactivity are preserved in a mouse model of cerebral microvascular amyloidosis. PMID:33577447
Club Cell Protein 16 Attenuates CD16brightCD62dim Immunosuppressive Neutrophils in Damaged Tissue upon Posttraumatic Sepsis-Induced Lung Injury. PMID:33575362
A 90-Day Oral Toxicity Study of an Ethanolic Root Extract of Caesalpinia bonduc (L.) Roxb. in Wistar Rats. PMID:33574881
Clinical relevance assessment of animal preclinical research (RAA) tool: development and explanation. PMID:33569250
Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis. PMID:33565962
Insufficient transparency of statistical reporting in preclinical research: a scoping review. PMID:33558615
Rats show direct reciprocity when interacting with multiple partners. PMID:33547347
Nature Exposure and Its Effects on Immune System Functioning: A Systematic Review. PMID:33546397
The safety and efficacy of BCG encapsulated alginate particle (BEAP) against M.tb H37Rv infection in Macaca mulatta : A pilot study. PMID:33542363
Sequence characterisation and novel insights into bovine mastitis-associated Streptococcus uberis in dairy herds. PMID:33542314
Open Transparent Communication about Animals in Laboratories: Dialog for Multiple Voices and Multiple Audiences. PMID:33540590
Digging Signatures in 13-Month-Old 3xTg-AD Mice for Alzheimer's Disease and Its Disruption by Isolation Despite Social Life Since They Were Born. PMID:33536883
The acidified drinking water-induced changes in the behavior and gut microbiota of wild-type mice depend on the acidification mode. PMID:33536529
Graphene-Doped Poly (Methyl-Methacrylate) (Pmma) Implants: A Micro-CT and Histomorphometrical Study in Rabbits. PMID:33535482
Using multimodal MRI to investigate alterations in brain structure and function in the BBZDR/Wor rat model of type 2 diabetes. PMID:33532703
The bovine dialysable leukocyte extract IMMUNEPOTENT CRP induces immunogenic cell death in breast cancer cells leading to long-term antitumour memory. PMID:33531687
An Ethical Assessment Tool (ETHAS) to Evaluate the Application of Assisted Reproductive Technologies in Mammals' Conservation: The Case of the Northern White Rhinoceros (Ceratotherium simum cottoni). PMID:33530613
A pharmacological characterization of Cannabis sativa chemovar extracts. PMID:33526117
Pseudomonas aeruginosa Elastase Contributes to the Establishment of Chronic Lung Colonization and Modulates the Immune Response in a Murine Model. PMID:33510733
Ultrasound mediated delivery of quantum dots from a proof of concept capsule endoscope to the gastrointestinal wall. PMID:33510366
Protective effect of thymoquinone against lung intoxication induced by malathion inhalation. PMID:33510276
Assessment of the biological potential of diaryltriazene-derived triazene compounds. PMID:33510223
The impact of transcranial direct current stimulation on cerebral vasospasm in a rat model of subarachnoid hemorrhage. PMID:33504272
Evolution of mirror-image pain in temporomandibular joint osteoarthritis mouse model. PMID:33503223
Earlier preterm birth is associated with a worse neurocognitive outcome in a rabbit model. PMID:33503047
Sex-Dependent End-of-Life Mental and Vascular Scenarios for Compensatory Mechanisms in Mice with Normal and AD-Neurodegenerative Aging. PMID:33498895
A randomized porcine study of the hemodynamic and metabolic effects of combined endovascular occlusion of the vena cava and the aorta in normovolemia and in hemorrhagic shock. PMID:33496552
What Is the Impact of Depletion of Immunoregulatory Genes on Wound Healing? A Systematic Review of Preclinical Evidence. PMID:33488938
A Systematic Review and Meta-Analysis of Animal Studies Testing Intra-Arterial Chilled Infusates After Ischemic Stroke. PMID:33488495
Neuronal Responses to Short Wavelength Light Deficiency in the Rat Subcortical Visual System. PMID:33488355
A novel lymphatic pattern promotes metastasis of cervical cancer in a hypoxic tumour-associated macrophage-dependent manner. PMID:33484377
Facing the urgency of therapies for progressive MS - a Progressive MS Alliance proposal. PMID:33483719
Hyperglycemia-induced VEGF and ROS production in retinal cells is inhibited by the mTOR inhibitor, rapamycin. PMID:33479328
Compartmentation of β2 -adrenoceptor stimulated cAMP responses by phosphodiesterase types 2 and 3 in cardiac ventricular myocytes. PMID:33475150
Accelerating functional gene discovery in osteoarthritis. PMID:33473114
Effects of Immunization With the Soil-Derived Bacterium Mycobacterium vaccae on Stress Coping Behaviors and Cognitive Performance in a "Two Hit" Stressor Model. PMID:33469429
Continuous chest compressions with asynchronous ventilations increase carotid blood flow in the perinatal asphyxiated lamb model. PMID:33469187
Formulation and Optimization of Nanospanlastics for Improving the Bioavailability of Green Tea Epigallocatechin Gallate. PMID:33467631
Various aspects of sex and gender bias in biomedical research. PMID:33464920
Translational animal models for Alzheimer's disease: An Alzheimer's Association Business Consortium Think Tank. PMID:33457489
JUNB-FBXO21-ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy. PMID:33450132
Percutaneous ultrasound guided PEG-coated gold nanoparticles enhanced radiofrequency ablation in liver. PMID:33446793
NT-PGC-1α deficiency attenuates high-fat diet-induced obesity by modulating food intake, fecal fat excretion and intestinal fat absorption. PMID:33446719
Aberrant spinal mechanical loading stress triggers intervertebral disc degeneration by inducing pyroptosis and nerve ingrowth. PMID:33437038
Galanin receptor 3 attenuates inflammation and influences the gut microbiota in an experimental murine colitis model. PMID:33436730
Targeting the RHOA pathway improves learning and memory in adult Kctd13 and 16p11.2 deletion mouse models. PMID:33436060
Gynura procumbens Root Extract Ameliorates Ischemia-Induced Neuronal Damage in the Hippocampal CA1 Region by Reducing Neuroinflammation. PMID:33435613
Effects of Iron and Zinc Biofortified Foods on Gut Microbiota In Vivo (Gallus gallus): A Systematic Review. PMID:33435398
Altered mRNA Levels of Stress-Related Peptides in Mouse Hippocampus and Caudate-Putamen in Withdrawal after Long-Term Intermittent Exposure to Tobacco Smoke or Electronic Cigarette Vapour. PMID:33435320
Developmental Profile of Brain Neprilysin Expression Correlates with Olfactory Behaviour of Rats. PMID:33433852
Histone deacetylase 2 regulates ULK1 mediated pyroptosis during acute liver failure by the K68 acetylation site. PMID:33431796
Asphyxiated Female and Male Newborn Piglets Have Similar Outcomes With Different Cardiopulmonary Resuscitation Interventions. PMID:33425814
Combination of platelet-rich plasma and stromal vascular fraction on the level of transforming growth factor-β in rat subjects experiencing deep dermal burn injury. PMID:33425344
Fluoroless intravascular ultrasound image-guided liver navigation in porcine models. PMID:33422010
Adenosine Signaling and Clathrin-Mediated Endocytosis of Glutamate AMPA Receptors in Delayed Hypoxic Injury in Rat Hippocampus: Role of Casein Kinase 2. PMID:33415682
Metastatic colorectal cancer cells maintain the TGFβ program and use TGFBI to fuel angiogenesis. PMID:33408771
Immune responses to azacytidine in animal models of inflammatory disorders: a systematic review. PMID:33407530
Anti-inflammatory Activity of Caspian Cobra (Naja naja oxiana) Snake Venom on the Serum Level of Interleukin-27 and Histopathological Changes in Myelin Oligodendrocyte Glycoprotein-experimental Autoimmune Encephalomyelitisinduced Mice. PMID:33403844
Endothelin B receptor dysfunction mediates elevated myogenic tone in cerebral arteries from aged male Fischer 344 rats. PMID:33403617
Osteoinduction in Novel Micropores of Partially Dissolved and Precipitated Hydroxyapatite Block in Scalp of Young Rats. PMID:33401628
Inadequate awareness of adherence to ARRIVE guidelines, regarding reporting quality of hernia models repaired with meshes: a systematic review. PMID:33394255
Prenatal Hypoxia Induces Premature Aging Accompanied by Impaired Function of the Glutamatergic System in Rat Hippocampus. PMID:33389385
Antitumour activity of Annona muricata L. leaf methanol extracts against Ehrlich Ascites Carcinoma and Dalton's Lymphoma Ascites mediated tumours in Swiss albino mice. PMID:33380281
Effect of pharmacological agents on relapse following orthodontic tooth movement. PMID:33378496
Biomimetic Mineralization on 3D Printed PLA Scaffolds: On the Response of Human Primary Osteoblasts Spheroids and In Vivo Implantation. PMID:33375451
Stem Cells as Therapy for Necrotizing Enterocolitis: A Systematic Review and Meta-Analysis of Preclinical Studies. PMID:33363060
L-PGDS deficiency accelerated the development of naturally occurring age-related osteoarthritis. PMID:33361529
Treatment with an Angiopoietin-1 mimetic peptide promotes neurological recovery after stroke in diabetic rats. PMID:33346402
Macrophage phenotypes and monocyte subsets after destabilization of the medial meniscus in mice. PMID:33336820
Threshold for copulation-induced analgesia varies according to the ejaculatory endophenotypes in rats. PMID:33328617
An update to the Monro-Kellie doctrine to reflect tissue compliance after severe ischemic and hemorrhagic stroke. PMID:33328490
Characterisation of microvessel blood velocity and segment length in the brain using multi-diffusion-time diffusion-weighted MRI. PMID:33325766
Experimental diffuse brain injury and a model of Alzheimer's disease exhibit disease-specific changes in sleep and incongruous peripheral inflammation. PMID:33319441
Effect of Tank Size on Zebrafish Behavior and Physiology. PMID:33317187
Changes in the brain transcriptome after DNA Aβ42 trimer immunization in a 3xTg-AD mouse model. PMID:33316368
Changes in left ventricular electromechanical relations during targeted hypothermia. PMID:33315166
Revitalizing the common peroneal function index for assessing functional recovery following nerve injury. PMID:33314721
CircCDKN2B-AS1 interacts with IMP3 to stabilize hexokinase 2 mRNA and facilitate cervical squamous cell carcinoma aerobic glycolysis progression. PMID:33308298
Local Tranexamic Acid for Local Hemostasis in an Animal Liver Injury Model. PMID:33304069
The effect of deferoxamine injection on composite graft survival in rabbits. PMID:33299559
Can harmonisation of outcomes bridge the translation gap for pre-clinical research? A systematic review of outcomes measured in mouse models of type 2 diabetes. PMID:33298112
Pre-Clinical Common Data Elements for Traumatic Brain Injury Research: Progress and Use Cases. PMID:33297844
Comparing quality of reporting between preprints and peer-reviewed articles in the biomedical literature. PMID:33292815
An imbalanced ratio between PC(16:0/16:0) and LPC(16:0) revealed by lipidomics supports the role of the Lands cycle in ischemic brain injury. PMID:33288676
Collagenated Synthetic Bone Substitute Material for Sinus Floor Elevation at Sites with a Perforated Schneiderian Membrane. PMID:33266417
Hematology and Blood Chemistry Reference Values of Captive Adult Black-Faced Ibis (Theristicus melanopis melanopis). PMID:33261073
Topical delivery of a small molecule RUNX1 transcription factor inhibitor for the treatment of proliferative vitreoretinopathy. PMID:33257736
Role of endothelial nitric oxide synthase for early brain injury after subarachnoid hemorrhage in mice. PMID:33256507
Maxillary sinus lift response to platelet-rich plasma associated with autogenous bone, ceramic biphasic HA/β-TCP (70:30), or deproteinized bovine bone. PMID:33251558
Impact of Genetic and Pharmacologic Inhibition of Myostatin in a Murine Model of Osteogenesis Imperfecta. PMID:33249643
Xenon treatment after severe traumatic brain injury improves locomotor outcome, reduces acute neuronal loss and enhances early beneficial neuroinflammation: a randomized, blinded, controlled animal study. PMID:33246487
Influence of oxidative stress on vascular calcification in the setting of coexisting chronic kidney disease and diabetes mellitus. PMID:33244056
Daily inhalation of hydrogen gas has a blood pressure-lowering effect in a rat model of hypertension. PMID:33244027
Quality of interventional animal experiments in Chinese journals: compliance with ARRIVE guidelines. PMID:33243206
Altered skeletal muscle glucose-fatty acid flux in amyotrophic lateral sclerosis. PMID:33241210
No Effect of Long-Term Risedronate Use on Cartilage and Subchondral Bone in an Experimental Rabbit Model of Osteoarthritis. PMID:33240955
Lumbar Epidural: Anatomical and Clinical Study in Dogs Submitted to Ovariohysterectomy. PMID:33240944
The Spinal Control of Backward Locomotion. PMID:33239399
Using the concept of "deserved trust" to strengthen the value and integrity of biomedical research. PMID:33233949
Experimental Models to Study Autism Spectrum Disorders: hiPSCs, Rodents and Zebrafish. PMID:33233737
Manganese Ferrite Nanoparticles (MnFe2O4): Size Dependence for Hyperthermia and Negative/Positive Contrast Enhancement in MRI. PMID:33233590
Effects and Safe Inclusion of Narbonne Vetch (Vicia narbonensis) in Rainbow Trout (Oncorhynchus mykiss) Diets: Towards a More Sustainable Aquaculture. PMID:33233435
In vitro and in vivo pharmacological activity of minor cannabinoids isolated from Cannabis sativa. PMID:33230154
The in vitro and in vivo wound-healing effects of royal jelly derived from Apis mellifera L. during blossom seasons of Castanea mollissima Bl. and Brassica napus L. in South China exhibited distinct patterns. PMID:33225942
Botanical from the medicinal spice, Piper capense is safe as demonstrated by oral acute and subchronic toxicity investigations. PMID:33225095
Internal consistency and compatibility of the 3Rs and 3Vs principles for project evaluation of animal research. PMID:33215575
Postweaning Grouping as a Strategy to Reduce Singly Housed Male Mice. PMID:33212955
Cell-specific activation of RIPK1 and MLKL after intracerebral hemorrhage in mice. PMID:33210566
Rats with congenital hydronephrosis show increased susceptibility to renal ischemia-reperfusion injury. PMID:33207081
The Influence of Nanostructured Hydroxyapatite Surface in the Early Stages of Osseointegration: A Multiparameter Animal Study in Low-Density Bone. PMID:33204089
Neuraminidase inhibitors rewire neutrophil function in vivo in murine sepsis and ex vivo in COVID-19. PMID:33200130
The Rigor and Transparency Index Quality Metric for Assessing Biological and Medical Science Methods. PMID:33196023
Adipose-derived stromal vascular fraction prevent bone bridge formation on growth plate injury in rat (in vivo studies) an experimental research. PMID:33194176
Increased Immunosignals of Collagen IV and Fibronectin Indicate Ischemic Consequences for the Neurovascular Matrix Adhesion Zone in Various Animal Models and Human Stroke Tissue. PMID:33192578
Systematic Review: Anaesthetic Protocols and Management as Confounders in Rodent Blood Oxygen Level Dependent Functional Magnetic Resonance Imaging (BOLD fMRI)-Part A: Effects of Changes in Physiological Parameters. PMID:33192261
Comparing distress of mouse models for liver damage. PMID:33188220
Differences in the progression of experimental peri-implantitis depending on the implant to abutment connection. PMID:33179178
On the Organization of the Locomotor CPG: Insights From Split-Belt Locomotion and Mathematical Modeling. PMID:33177987
Similar cognitive deficits in mice and humans in the chronic phase post-stroke identified using the touchscreen-based paired-associate learning task. PMID:33177588
Recovering from depression with repetitive transcranial magnetic stimulation (rTMS): a systematic review and meta-analysis of preclinical studies. PMID:33173042
EP300 knockdown reduces cancer stem cell phenotype, tumor growth and metastasis in triple negative breast cancer. PMID:33167919
Imbalance of Endocannabinoid/Lysophosphatidylinositol Receptors Marks the Severity of Alzheimer's Disease in a Preclinical Model: A Therapeutic Opportunity. PMID:33167441
A role for phosphodiesterase type 5 inhibitors in remodelling the urinary bladder after radiation exposure. PMID:33166368
Comparison of nonparametric and parametric methods for time-frequency heart rate variability analysis in a rodent model of cardiovascular disease. PMID:33166366
SMARCB1 Promotes Ubiquitination and Degradation of NR4A3 via Direct Interaction Driven by ROS in Vascular Endothelial Cell Injury. PMID:33163142
Antinociceptive and neurochemical effects of a single dose of IB-MECA in chronic pain rat models. PMID:33161497
CXCL13/CXCR5 signalling is pivotal to preserve motor neurons in amyotrophic lateral sclerosis. PMID:33161233
Preconceptional diet manipulation and fetus number can influence placenta endocrine function in sheep. PMID:33160155
Lysophospholipids Contribute to Oxaliplatin-Induced Acute Peripheral Pain. PMID:33158961
Impaired Hand Dexterity Function in a Non-human Primate Model with Chronic Parkinson's Disease. PMID:33154199
Are Turkeys (Meleagris gallopavo) Motivated to Avoid Excreta-Soiled Substrate? PMID:33147707
Regenerative effect of mesenteric fat stem cells on ccl4-induced liver cirrhosis, an experimental study. PMID:33145022
The effect of different suturing materials for abdominal fascia wound closure on the collagen I/III expression ratio in rats. PMID:33145017
Identification of New Ocellatin Antimicrobial Peptides by cDNA Precursor Cloning in the Frame of This Family of Intriguing Peptides. PMID:33138046
Developmental Roles of FUSE Binding Protein 1 (Fubp1) in Tooth Morphogenesis. PMID:33138041
Reviewing the animal literature: how to describe and choose between different types of literature reviews. PMID:33135562
Mir363-3p Treatment Attenuates Long-Term Cognitive Deficits Precipitated by an Ischemic Stroke in Middle-Aged Female Rats. PMID:33132904
Early local neutralization of CC16 in sepsis‑induced ALI following blunt chest trauma leads to delayed mortality without benefitting overall survival. PMID:33125155
Identifying and understanding factors that affect the translation of therapies from the laboratory to patients: a study protocol. PMID:33123348
Systemic Effects Induced by Hyperoxia in a Preclinical Model of Intra-abdominal Sepsis. PMID:33122967
Comparison of Four Beddings for Ammonia Control in Individually Ventilated Mouse Cages. PMID:33121563
Ethyl Pyruvate Reduces Systemic Leukocyte Activation via Caspase-1 and NF-κB After Blunt Chest Trauma and Haemorrhagic Shock. PMID:33117829
Dexamethasone-Loaded Thermosensitive Hydrogel Suppresses Inflammation and Pain in Collagen-Induced Arthritis Rats. PMID:33116399
Simvastatin Posttreatment Controls Inflammation and Improves Bacterial Clearance in Experimental Sepsis. PMID:33110395
Ferroptosis Mediates Cuprizone-Induced Loss of Oligodendrocytes and Demyelination. PMID:33106352
Dissociable contributions of mediodorsal and anterior thalamic nuclei in visual attentional performance: A comparison using nicotinic and muscarinic cholinergic receptor antagonists. PMID:33103560
The long noncoding RNA LUCAT1 promotes colorectal cancer cell proliferation by antagonizing Nucleolin to regulate MYC expression. PMID:33097685
An Anglocentric History of Anaesthetics and Analgesics in the Refinement of Animal Experiments. PMID:33096686
High-throughput genotyping of high-homology mutant mouse strains by next-generation sequencing. PMID:33096238
Principal component analysis, a useful tool to study cyclin-dependent kinase-inhibitor's effect on cerebral ischaemia. PMID:33094284
Cell Tracking Profiler - a user-driven analysis framework for evaluating 4D live-cell imaging data. PMID:33093241
Predicting experimental success: a retrospective case-control study using the rat intraluminal thread model of stroke. PMID:33093066
Novel oxygen saturation imaging endoscopy to assess anastomotic integrity in a porcine ischemia model. PMID:33092548
Nutritional profile of rodent diets impacts experimental reproducibility in microbiome preclinical research. PMID:33082369
Change in jaw occlusive power by paralysis of masseter muscle with a neuromuscular blocker: Sion's masseter muscle paralysis. PMID:33078734
A Semiquantitative Non-invasive Measurement of PcomA Patency in C57BL/6 Mice Explains Variance in Ischemic Brain Damage in Filament MCAo. PMID:33071747
Neural Transplants From Human Induced Pluripotent Stem Cells Rescue the Pathology and Behavioral Defects in a Rodent Model of Huntington's Disease. PMID:33071737
Effects of Quercetin on Cardiac Function in Pressure Overload and Postischemic Cardiac Injury in Rodents: a Systematic Review and Meta-Analysis. PMID:33064235
Improving quality of preclinical academic research through auditing: A feasibility study. PMID:33057427
Evidence of early vasogenic edema following minor head impact that can be reduced with a vasopressin V1a receptor antagonist. PMID:33053434
Productive and Physiological Response of Male Rabbits to Dietary Supplementation with Thyme Essential Oil. PMID:33050468
Preventing neuronal edema increases network excitability after traumatic brain injury. PMID:33044227
The Pupillary Response of the Common Octopus (Octopus vulgaris). PMID:33041848
Epilepsy miRNA Profile Depends on the Age of Onset in Humans and Rats. PMID:33041753
Dental stem cells: The role of biomaterials and scaffolds in developing novel therapeutic strategies. PMID:33033554
Low-Flow Nasal Cannula Hydrogen Therapy. PMID:33029275
Description of the unusual digestive tract of Platax orbicularis and the potential impact of Tenacibaculum maritimum infection. PMID:33024633
Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research. PMID:33017053
Motor Cortex and Hippocampus Display Decreased Heme Oxygenase Activity 2 Weeks After Ventricular Fibrillation Cardiac Arrest in Rats. PMID:33015090
Iso-Oncotic Albumin Mitigates Brain and Kidney Injury in Experimental Focal Ischemic Stroke. PMID:33013661
Regional Differences in Penetration of the Protein Stabilizer Trimethoprim (TMP) in the Rat Central Nervous System. PMID:33013318
Comparing the effects of two different strains of mycobacteria, Mycobacterium vaccae NCTC 11659 and M. vaccae ATCC 15483, on stress-resilient behaviors and lipid-immune signaling in rats. PMID:33011306
Methylmercury-Induced Toxicopathologic Findings in Salivary Glands of Offspring Rats After Gestational and Lactational Exposure. PMID:33009984
CD163 deficiency facilitates lipopolysaccharide-induced inflammatory responses and endotoxin shock in mice. PMID:33005412
Argon treatment after experimental subarachnoid hemorrhage: evaluation of microglial activation and neuronal survival as a subanalysis of a randomized controlled animal trial. PMID:33004706
Suaeda vermiculata Aqueous-Ethanolic Extract-Based Mitigation of CCl4-Induced Hepatotoxicity in Rats, and HepG-2 and HepG-2/ADR Cell-Lines-Based Cytotoxicity Evaluations. PMID:33003604
A defucosylated anti‑CD44 monoclonal antibody 5‑mG2a‑f exerts antitumor effects in mouse xenograft models of oral squamous cell carcinoma. PMID:33000243
Early-life exposure to bisphenol A and reproductive-related outcomes in rodent models: a systematic review and meta-analysis. PMID:32996894
The effect of addition of dexamethasone into normal saline irrigation solution on Prevention of Intraperitoneal Adhesion Post Laparotomy in wistar rats (Rattus norvegicus). PMID:32994984
Continuing surgical education of non-technical skills. PMID:32994981
Assessment of antidiabetic potential and phytochemical profiling of Rhazya stricta root extracts. PMID:32993632
Preoperative endoscopic marking of the gastrointestinal tract using fluorescence imaging: submucosal indocyanine green tattooing versus a novel fluorescent over-the-scope clip in a survival experimental study. PMID:32989536
Effect of intraperitoneally administered propentofylline in a rat model of postoperative pain. PMID:32989197
The Phytochemical Constituents and Pharmacological Activities of Annona atemoya: A Systematic Review. PMID:32987818
Does expression of a human complement-regulatory protein on xenograft cells protect them from systemic complement activation? PMID:32987208
Genetic Loss of LCK Kinase Leads to Acceleration of Chronic Lymphocytic Leukemia. PMID:32983140
Formulation of Nanospanlastics as a Promising Approach for Improving the Topical Delivery of a Natural Leukotriene Inhibitor (3-Acetyl-11-Keto-β-Boswellic Acid): Statistical Optimization, in vitro Characterization, and ex vivo Permeation Study. PMID:32982176
TRPV4-Mediated Regulation of the Blood Brain Barrier Is Abolished During Inflammation. PMID:32974355
Serum-deprivation leads to activation-like changes in primary microglia and BV-2 cells but not astrocytes. PMID:32974017
Cathelicidin and Calprotectin Are Disparately Altered in Murine Models of Inflammatory Arthritis and Airway Inflammation. PMID:32973796
Pulmonary Deposition of Radionucleotide-Labeled Palivizumab: Proof-of-Concept Study. PMID:32973520
Agonist-induced functional analysis and cell sorting associated with single-cell transcriptomics characterizes cell subtypes in normal and pathological brain. PMID:32973039
Peripheral blood-derived monocytes show neuronal properties and integration in immune-deficient rd1 mouse model upon phenotypic differentiation and induction with retinal growth factors. PMID:32967734
Laparoscopic procedures impact on mast cell mediators, extracellular matrix and adhesion scoring system in rats. PMID:32963775
Maternal exercise conveys protection against NAFLD in the offspring via hepatic metabolic programming. PMID:32963289
The potential protective role of folic acid against acetaminophen-induced hepatotoxicity and nephrotoxicity in rats. PMID:32963203
Harnessing the Secretome of Mesenchymal Stromal Cells for Traumatic Spinal Cord Injury: Multicell Comparison and Assessment of In Vivo Efficacy. PMID:32962528
Obinutuzumab-Induced B Cell Depletion Reduces Spinal Cord Pathology in a CD20 Double Transgenic Mouse Model of Multiple Sclerosis. PMID:32962135
Glucagon-like peptide-1 receptor agonists as neuroprotective agents for ischemic stroke: a systematic scoping review. PMID:32954901
Characterization of kindled VGAT-Cre mice as a new animal model of temporal lobe epilepsy. PMID:32954490
Cardiorespiratory physiological perturbations after acute smoke-induced lung injury and during extracorporeal membrane oxygenation support in sheep. PMID:32953091
Perinatal exposure to FireMaster® 550 (FM550), brominated or organophosphate flame retardants produces sex and compound specific effects on adult Wistar rat socioemotional behavior. PMID:32949556
Intranasal administration of Cytoglobin modifies human umbilical cord‑derived mesenchymal stem cells and improves hypoxic‑ischemia brain damage in neonatal rats by modulating p38 MAPK signaling‑mediated apoptosis. PMID:32945464
Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis. PMID:32938936
Only Hyperuricemia with Crystalluria, but not Asymptomatic Hyperuricemia, Drives Progression of Chronic Kidney Disease. PMID:32938648
Adenosine A2a Receptor Stimulation Attenuates Ischemia-Reperfusion Injury and Improves Survival in A Porcine Model of DCD Liver Transplantation. PMID:32938013
Protein Stability Buffers the Cost of Translation Attenuation following eIF2α Phosphorylation. PMID:32937139
Subarachnoid hemorrhage leads to early and persistent functional connectivity and behavioral changes in mice. PMID:32936728
New Psychoactive Substance 5-MeO-MiPT In vivo Acute Toxicity and Hystotoxicological Study. PMID:32936075
Formulation of Sodium Valproate Nanospanlastics as a Promising Approach for Drug Repurposing in the Treatment of Androgenic Alopecia. PMID:32933001
TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses. PMID:32929069
Morphine and Fentanyl Repeated Administration Induces Different Levels of NLRP3-Dependent Pyroptosis in the Dorsal Raphe Nucleus of Male Rats via Cell-Specific Activation of TLR4 and Opioid Receptors. PMID:32926257
A Translational Porcine Model for Human Cell-Based Therapies in the Treatment of Posttraumatic Osteoarthritis After Anterior Cruciate Ligament Injury. PMID:32924528
Precision and practical usefulness of intraoral scanners in implant dentistry: A systematic literature review. PMID:32913577
A botanical from the antiproliferative Cameroonian spice, Imperata cylindrica is safe at lower doses, as demonstrated by oral acute and sub-chronic toxicity screenings. PMID:32912178
Study logistics that can impact medical countermeasure efficacy testing in mouse models of radiation injury. PMID:32909878
Treatment with Hyaluronic Acid and Collagen-Polyvinylpyrrolidone Improves Extracellular Matrix Assembly for Scarring after Tracheal Resection. PMID:32908887
Extracts or Active Components from Acorus gramineus Aiton for Cognitive Function Impairment: Preclinical Evidence and Possible Mechanisms. PMID:32908635
Photoisomerization Neutralizes Vasoconstrictive Activity of a Heme Degradation Product. PMID:32905283
A standardized social preference protocol for measuring social deficits in mouse models of autism. PMID:32895524
Alterations of peripheral nerve excitability in an experimental autoimmune encephalomyelitis mouse model for multiple sclerosis. PMID:32894170
MUC4 is overexpressed in idiopathic pulmonary fibrosis and collaborates with transforming growth factor β inducing fibrotic responses. PMID:32887938
Effects of caffeic acid phenethyl ester in reducing cerebral edema in rat subjects experiencing brain injury: An in vivo study. PMID:32874565
Survey on Sheep Usage in Biomedical Research. PMID:32872575
A Mouse Brain-based Multi-omics Integrative Approach Reveals Potential Blood Biomarkers for Ischemic Stroke. PMID:32868372
Does Training Innate Immunity Confer Broad-spectrum Protection Against Bone and Joint Infection in a Mouse Model? PMID:32858720
Protective effect and mechanism of mesenchymal stem cells on heat stroke induced intestinal injury. PMID:32855671
A Systematic Approach to Review of in vitro Methods in Brain Tumour Research (SAToRI-BTR): Development of a Preliminary Checklist for Evaluating Quality and Human Relevance. PMID:32850761
Secreted Osteoclastogenic Factor of Activated T Cells (SOFAT) Is Associated With Rheumatoid Arthritis and Joint Pain: Initial Evidences of a New Pathway. PMID:32849501
Fructose Consumption During Pregnancy Influences Milk Lipid Composition and Offspring Lipid Profiles in Guinea Pigs. PMID:32849314
Differential Role of Anterior Cingulate Cortical Glutamatergic Neurons in Pain-Related Aversion Learning and Nociceptive Behaviors in Male and Female Rats. PMID:32848657
Starch composition, glycemic indices, antioxidant properties and carbohydrate hydrolyzing enzymes activities of African star apple fruit parts. PMID:32843013
Draft for internal testing Scientific Committee guidance on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments. PMID:32831946
Skeletal Muscle Interleukin-6 Contributes to the Innate Immune Response in Septic Mice. PMID:32826815
Transient Receptor Potential Melastatin 2 (TRPM2) Inhibition by Antioxidant, N-Acetyl-l-Cysteine, Reduces Global Cerebral Ischemia-Induced Neuronal Death. PMID:32825703
Magnetic resonance imaging in multiple sclerosis animal models: A systematic review, meta-analysis, and white paper. PMID:32818883
An analysis of preclinical efficacy testing of antivenoms for sub-Saharan Africa: Inadequate independent scrutiny and poor-quality reporting are barriers to improving snakebite treatment and management. PMID:32817682
Altered mastication adversely impacts morpho-functional features of the hippocampus: A systematic review on animal studies in three different experimental conditions involving the masticatory function. PMID:32817680
Longitudinal neuroanatomical and behavioral analyses show phenotypic drift and variability in the Ts65Dn mouse model of Down syndrome. PMID:32817053
Modelling gluteus medius tendon degeneration and repair in a large animal model. PMID:32813126
Effect of Co-Administration of Panax ginseng and Brassica oleracea on Postmenopausal Osteoporosis in Ovariectomized Mice. PMID:32806557
Hydrogen Gas Inhalation Attenuates Endothelial Glycocalyx Damage and Stabilizes Hemodynamics in a Rat Hemorrhagic Shock Model. PMID:32804466
Murine cathelicidin: as a host defensive response against Leishmania major infection. PMID:32801517
The study of microtubule dynamics and stability at the postsynaptic density in a rat pilocarpine model of temporal lobe epilepsy. PMID:32793707
Welfare Impact of Carbon Dioxide Euthanasia on Laboratory Mice and Rats: A Systematic Review. PMID:32793645
Systematic Interrogation of Angiogenesis in the Ischemic Mouse Hind Limb: Vulnerabilities and Quality Assurance. PMID:32787524
Behavioral Phenotyping for Down Syndrome in Mice. PMID:32780566
The Effects of Palm Oil on Plasma and Serum Lipid Parameters: A Systematic Review on Animal Intervention Studies. PMID:32775343
Biomechanical, histologic, and molecular characteristics of graft-tunnel healing in a murine modified ACL reconstruction model. PMID:32775202
Federation of European Laboratory Animal Science Associations recommendations of best practices for the health management of ruminants and pigs used for scientific and educational purposes. PMID:32772790
Editor's Spotlight/Take 5: Are the Lives of Animals Well-spent in Laboratory Science Research? A Study of Orthopaedic Animal Studies in Turkey. PMID:32769546
Effects of an alpha-1d adrenoreceptor antagonist (naftopidil) on bladder dysfunction after radiotherapy in female rats. PMID:32761376
Heart Failure With Reduced Ejection Fraction Is Characterized by Systemic NEP Downregulation. PMID:32760858
The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis. PMID:32758418
Consumption of Wild Rice (Zizania latifolia) Prevents Metabolic Associated Fatty Liver Disease through the Modulation of the Gut Microbiota in Mice Model. PMID:32751062
Modification of the Marmarou model in developing countries. PMID:32742649
Neural defects caused by total and Wnt1-Cre mediated ablation of p120ctn in mice. PMID:32741376
Liquid biopsy by NGS: Differential presence of exons (DPE) is related to metastatic potential in a colon-cancer model in the rat. PMID:32736333
Peripheral soluble epoxide hydrolase inhibition reduces hypernociception and inflammation in albumin-induced arthritis in temporomandibular joint of rats. PMID:32736189
Heart rate sensor validation and seasonal and diurnal variation of body temperature and heart rate in domestic sheep. PMID:32734092
Generation of Gene-Knockout Mongolian Gerbils via CRISPR/Cas9 System. PMID:32733872
The design and implementation of restraint devices for the injection of pathogenic microorganisms into Galleria mellonella. PMID:32730254
Importance of Systematic Reviews and Meta-analyses of Animal Studies: Challenges for Animal-to-Human Translation. PMID:32727637
Influence of Hypoxic and Hyperoxic Preconditioning on Endothelial Function in a Model of Myocardial Ischemia-Reperfusion Injury with Cardiopulmonary Bypass (Experimental Study). PMID:32727110
Repeated administration of a flavonoid-based formulated extract from citrus peels significantly reduces peripheral inflammation-induced pain in the rat. PMID:32724582
Stem cell therapy: a potential for the perils of pancreatitis. PMID:32721912
Improving transparency and scientific rigor in academic publishing. PMID:32721132
The Stage of the Estrus Cycle Is Critical for Interpretation of Female Mouse Social Interaction Behavior. PMID:32714163
Complex Microbiota in Laboratory Rodents: Management Considerations. PMID:32706377
High-altitude rodents have abundant collaterals that protect against tissue injury after cerebral, coronary and peripheral artery occlusion. PMID:32703056
The impact of bone cancer on the peripheral encoding of mechanical pressure stimuli. PMID:32701848
Micturition defects and altered bladder function in the klotho mutant mouse model of aging. PMID:32699807
Nicotine increases alcohol self-administration in male rats via a μ-opioid mechanism within the mesolimbic pathway. PMID:32697329
Intranasal delivery of Thyroid hormones in MCT8 deficiency. PMID:32687511
Levelling the Translational Gap for Animal to Human Efficacy Data. PMID:32679706
Perinatal Opioid Exposure Primes the Peripheral Immune System Toward Hyperreactivity. PMID:32670993
G-protein coupled receptor 88 knockdown in the associative striatum reduces psychiatric symptoms in a translational male rat model of Parkinson disease. PMID:32667145
Simulated model of RAPID concept: highlighting innate inflammation and liver regeneration. PMID:32666716
The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. PMID:32666574
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. PMID:32666546
Guidelines for planning and conducting high-quality research and testing on animals. PMID:32665911
Uncoupling sodium channel dimers restores the phenotype of a pain-linked Nav 1.7 channel mutation. PMID:32663327
Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0. PMID:32663221
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. PMID:32663219
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. PMID:32663096
ARRIVE 2.0 and the British Journal of Pharmacology: Updated guidance for 2020. PMID:32662875
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. PMID:32662519
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. PMID:32660541
Inhibition of African Swine Fever Virus Replication by Porcine Type I and Type II Interferons. PMID:32655518
E Pluribus Octo - Building Consensus on Standards of Care and Experimentation in Cephalopod Research; a Historical Outlook. PMID:32655409
Optogenetic Activation of Dopamine Receptor D1 and D2 Neurons in Anterior Cingulate Cortex Differentially Modulates Trigeminal Neuropathic Pain. PMID:32654077
D-Pinitol from Ceratonia siliqua Is an Orally Active Natural Inositol That Reduces Pancreas Insulin Secretion and Increases Circulating Ghrelin Levels in Wistar Rats. PMID:32650579
Rethinking animal models of sepsis - working towards improved clinical translation whilst integrating the 3Rs. PMID:32648582
Efficacy of phage cocktail AB-SA01 therapy in diabetic mouse wound infections caused by multidrug-resistant Staphylococcus aureus. PMID:32646376
Social enrichment by separated pair housing of male C57BL/6JRj mice. PMID:32636413
Development of insulin resistance preceded major changes in iron homeostasis in mice fed a high-fat diet. PMID:32629238
Oxidative stress evaluation of skeletal muscle in ischemia-reperfusion injury using enhanced magnetic resonance imaging. PMID:32616815
Graphene Oxide Improves in vitro Fertilization in Mice With No Impact on Embryo Development and Preserves the Membrane Microdomains Architecture. PMID:32612987
Acid bone lysates reduce bone regeneration in rat calvaria defects. PMID:32608132
Long Noncoding RNA SNHG12 Indicates the Prognosis and Accelerates Tumorigenesis of Diffuse Large B-Cell Lymphoma Through Sponging microR-195. PMID:32606771
Injected human umbilical cord-derived mesenchymal stromal cells do not appear to elicit an inflammatory response in a murine model of osteoarthritis. PMID:32596691
Identification of Novel miRNAs Involved in Cardiac Repair Following Infarction in Fetal and Adolescent Sheep Hearts. PMID:32587529
Efficacy of Intravenous, Endotracheal, or Nasal Adrenaline Administration During Resuscitation of Near-Term Asphyxiated Lambs. PMID:32582589
A chalcone derivative, 1m-6, exhibits atheroprotective effects by increasing cholesterol efflux and reducing inflammation-induced endothelial dysfunction. PMID:32579243
MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma. PMID:32577161
Comparison of differential accessibility analysis strategies for ATAC-seq data. PMID:32576878
Quality and validity of large animal experiments in stroke: A systematic review. PMID:32576074
Effects of sustained inflation pressure during neonatal cardiopulmonary resuscitation of asphyxiated piglets. PMID:32574159
A Drug Holiday Reduces the Frequency and Severity of Medication-Related Osteonecrosis of the Jaw in a Minipig Model. PMID:32568416
Broiler Chicks' Motivation for Different Wood Beddings and Amounts of Soiling. PMID:32560113
Pharmacokinetics of a single inhalation of hydrogen gas in pigs. PMID:32559239
A semi-structured questionnaire survey of laboratory animal rehoming practice across 41 UK animal research facilities. PMID:32559221
A potent antagonist antibody targeting connexin hemichannels alleviates Clouston syndrome symptoms in mutant mice. PMID:32553574
Improving preclinical to clinical translation in Alzheimer's disease research. PMID:32548237
Antinociceptive Activity of Chemical Components of Essential Oils That Involves Docking Studies: A Review. PMID:32547391
AMPA/kainate glutamate receptor antagonists prevent posttraumatic osteoarthritis. PMID:32544091
How STRANGE are your study animals? PMID:32541916
Rhythmic light flicker rescues hippocampal low gamma and protects ischemic neurons by enhancing presynaptic plasticity. PMID:32541656
Therapeutic Efficacy of Novel Antimicrobial Peptide AA139-Nanomedicines in a Multidrug-Resistant Klebsiella pneumoniae Pneumonia-Septicemia Model in Rats. PMID:32540976
Do we really know how many clinical trials are conducted ethically? Why research ethics committee review practices need to be strengthened and initial steps we could take to strengthen them. PMID:32532827
Neurobehavioral effects of uremic toxin-indoxyl sulfate in the rat model. PMID:32528183
Automated Analysis of Stroke Mouse Trajectory Data With Traja. PMID:32523509
A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities. PMID:32523045
Duration of immunity against heterologous porcine parvovirus 1 challenge in gilts immunized with a novel subunit vaccine based on the viral protein 2. PMID:32517691
The Impact of Common Recovery Blood Sampling Methods, in Mice (Mus Musculus), on Well-Being and Sample Quality: A Systematic Review. PMID:32517144
Biological and health-related effects of weak static magnetic fields (≤ 1 mT) in humans and vertebrates: A systematic review. PMID:32516313
Oral intake of lipopolysaccharide regulates toll-like receptor 4-dependent granulopoiesis. PMID:32515223
Multinucleated giant cells within the in vivo implantation bed of a collagen-based biomaterial determine its degradation pattern. PMID:32514904
Heart-derived fibroblasts express LYPD-1 and negatively regulate angiogenesis in rat. PMID:32514414
Δ9 -Tetrahydrocannabinolic acid alleviates collagen-induced arthritis: Role of PPARγ and CB1 receptors. PMID:32510591
Evaluation of the effective dose of amygdalin for the improvement of antioxidant gene expression and suppression of oxidative damage in mice. PMID:32509470
Translational Intracerebral Hemorrhage Research: Has Current Neuroprotection Research ARRIVEd at a Standard for Experimental Design and Reporting? PMID:32504197
Statistical analysis of longitudinal data on tumour growth in mice experiments. PMID:32499558
Neutrophil Gelatinase-Associated Lipocalin Protects from ANCA-Induced GN by Inhibiting TH17 Immunity. PMID:32487561
Defining immune correlates during latent and active chlamydial infection in sheep. PMID:32487248
Improving translational research in sex-specific effects of comorbidities and risk factors in ischaemic heart disease and cardioprotection: position paper and recommendations of the ESC Working Group on Cellular Biology of the Heart. PMID:32484892
PTH(1-34) treatment and/or mechanical loading have different osteogenic effects on the trabecular and cortical bone in the ovariectomized C57BL/6 mouse. PMID:32483372
Are the Lives of Animals Well-spent in Laboratory Science Research? A Study of Orthopaedic Animal Studies in Turkey. PMID:32467410
Infusion of Cold Saline into the Carotid Artery Does Not Affect Outcome After Intrastriatal Hemorrhage. PMID:32456561
Mouse model systems of autism spectrum disorder: Replicability and informatics signature. PMID:32445272
Antidepressant-Like Effect of Terpineol in an Inflammatory Model of Depression: Involvement of the Cannabinoid System and D2 Dopamine Receptor. PMID:32443870
Characterisation of mexiletine's translational therapeutic index for suppression of ischaemia-induced ventricular fibrillation in the rat isolated heart. PMID:32439959
Spiny lobster sounds can be detectable over kilometres underwater. PMID:32439882
Optimized lactoferrin as a highly promising treatment for intracerebral hemorrhage: Pre-clinical experience. PMID:32438861
Temporal dissociation of phencyclidine: Induced locomotor and social alterations in rats using an automated homecage monitoring system - implications for the 3Rs and preclinical drug discovery. PMID:32438848
Statistical differences resulting from selection of stable reference genes after hypoxia and hypothermia in the neonatal rat brain. PMID:32437382
Ethanol consumption and sedation are altered in mice lacking the glycine receptor α2 subunit. PMID:32436225
Metabolite Profile Changes in Different Regions of Rat Brain Affected by Ephedra sinica. PMID:32419830
Safety and immunogenicity of a recombinant vaccine against Trypanosoma cruzi in Rhesus macaques. PMID:32417142
Serelaxin activates eNOS, suppresses inflammation, attenuates developmental delay and improves cognitive functions of neonatal rats after germinal matrix hemorrhage. PMID:32415164
Prophylactic effects of biogenic selenium nanoparticles on acute toxoplasmosis: An in vivo study. PMID:32405413
Magnetic Resonance Elastography reveals effects of anti-angiogenic glioblastoma treatment on tumor stiffness and captures progression in an orthotopic mouse model. PMID:32398076
A Novel Zinc Chelator, 1H10, Ameliorates Experimental Autoimmune Encephalomyelitis by Modulating Zinc Toxicity and AMPK Activation. PMID:32397660
Lower oxygen consumption and Complex I activity in mitochondria isolated from skeletal muscle of fetal sheep with intrauterine growth restriction. PMID:32396498
miRNA-21 deficiency impairs alveolar socket healing in mice. PMID:32396233
Heterogeneity of proteome dynamics between connective tissue phases of adult tendon. PMID:32393437
Characterization of Amphetamine, Methylphenidate, Nicotine, and Atomoxetine on Measures of Attention, Impulsive Action, and Motivation in the Rat: Implications for Translational Research. PMID:32390829
Automated Home-Cage Testing as a Tool to Improve Reproducibility of Behavioral Research? PMID:32390795
Short time guided bone regeneration using beta-tricalcium phosphate with and without fibronectin - An experimental study in rats. PMID:32388521
Rodent models of post-traumatic stress disorder: behavioral assessment. PMID:32376819
Administration of mulberry leaves maintains pancreatic β-cell mass in obese/type 2 diabetes mellitus mouse model. PMID:32375753
In Defense of P Values. PMID:32373778
Antibiotics: A Bibliometric Analysis of Top 100 Classics. PMID:32365471
Characterization of a porcine model of atrial arrhythmogenicity in the context of ischaemic heart failure. PMID:32365085
The hyperpolarization-activated cyclic nucleotide-gated 4 channel as a potential anti-seizure drug target. PMID:32364262
What are innovations in peer review and editorial assessment for? PMID:32362286
Zinc transporter 3 modulates cell proliferation and neuronal differentiation in the adult hippocampus. PMID:32346941
Haemoglobin causes neuronal damage in vivo which is preventable by haptoglobin. PMID:32346673
The Effect of Size, Maturation, Global Asphyxia, Cerebral Ischemia, and Therapeutic Hypothermia on the Pharmacokinetics of High-Dose Recombinant Erythropoietin in Fetal Sheep. PMID:32344930
Effect of High-Dose Topical Minoxidil on Erythrocyte Quality in SKH1 Hairless Mice. PMID:32340110
Semi-mechanistic modelling platform to assess cardiac contractility and haemodynamics in preclinical cardiovascular safety profiling of new molecular entities. PMID:32335903
The transverse aortic constriction heart failure animal model: a systematic review and meta-analysis. PMID:32335789
Calcium Phosphate Ceramics Can Prevent Bisphosphonate-Related Osteonecrosis of the Jaw. PMID:32331240
Effects of delayed intraventricular TLR7 agonist administration on long-term neurological outcome following asphyxia in the preterm fetal sheep. PMID:32327682
Characterisation of the static offset in the travelling wave in the cochlear basal turn. PMID:32318797
Acquired Immunity Is Not Essential for Radiation-Induced Heart Dysfunction but Exerts a Complex Impact on Injury. PMID:32316187
Increased expression of microRNA-155-5p by alveolar type II cells contributes to development of lethal ARDS in H1N1 influenza A virus-infected mice. PMID:32308197
Cotinine Enhances Fear Extinction and Astrocyte Survival by Mechanisms Involving the Nicotinic Acetylcholine Receptors Signaling. PMID:32300297
Novel airway smooth muscle-mast cell interactions and a role for the TRPV4-ATP axis in non-atopic asthma. PMID:32299856
The role of C-afferents in mediating neurogenic vasodilatation in plantar skin after acute sciatic nerve injury in rats. PMID:32299361
A practical staging atlas to study embryonic development of Octopus vulgaris under controlled laboratory conditions. PMID:32299349
Galectin-3 Identifies a Subset of Macrophages With a Potential Beneficial Role in Atherosclerosis. PMID:32295421
Application of Zebrafish Model in the Suppression of Drug-Induced Cardiac Hypertrophy by Traditional Indian Medicine Yogendra Ras. PMID:32295034
Supplemental taurine during adolescence and early adulthood has sex-specific effects on cognition, behavior and neurotransmitter levels in C57BL/6J mice dependent on exposure window. PMID:32289445
Compression-induced senescence of nucleus pulposus cells by promoting mitophagy activation via the PINK1/PARKIN pathway. PMID:32281308
Acute phase response to exertional heat stroke in mice. PMID:32281170
Neuroprotective and anti-inflammatory activity of DAT inhibitor R-phenylpiracetam in experimental models of inflammation in male mice. PMID:32279140
Transgenerational epigenetic and transcriptomic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure in rat. PMID:32277265
Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells. PMID:32270040
Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis. PMID:32264897
Sex-specific effects of developmental exposure to polychlorinated biphenyls on neuroimmune and dopaminergic endpoints in adolescent rats. PMID:32259577
Heat shock protein 70 increases cell proliferation, neuroblast differentiation, and the phosphorylation of CREB in the hippocampus. PMID:32257909
Aged mice show an increased mortality after anesthesia with a standard dose of ketamine/xylazine. PMID:32257896
Total Glycosides of Cistanche deserticola Promote Neurological Function Recovery by Inducing Neurovascular Regeneration via Nrf-2/Keap-1 Pathway in MCAO/R Rats. PMID:32256351
Effects of Prenatal Exposure to a Mixture of Organophosphate Flame Retardants on Placental Gene Expression and Serotonergic Innervation in the Fetal Rat Brain. PMID:32243540
Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes. PMID:32238360
Video laryngoscopic oral intubation in rats: a simple and effective method. PMID:32233786
Differential Responses of LINE-1 in the Dentate Gyrus, Striatum and Prefrontal Cortex to Chronic Neurotoxic Methamphetamine: A Study in Rat Brain. PMID:32231019
Low-Dose Phosphodiesterase III Inhibitor Reduces the Vascular Amyloid Burden in Amyloid-β Protein Precursor Transgenic Mice. PMID:32225099
The human milk oligosaccharides 2'-fucosyllactose and 6'-sialyllactose protect against the development of necrotizing enterocolitis by inhibiting toll-like receptor 4 signaling. PMID:32221473
Applying univariate vs. multivariate statistics to investigate therapeutic efficacy in (pre)clinical trials: A Monte Carlo simulation study on the example of a controlled preclinical neurotrauma trial. PMID:32214370
Blood carboxyhemoglobin elimination curve, half-lifetime, and arterial-venous differences in acute phase of carbon monoxide poisoning in ovine smoke inhalation injury model. PMID:32199614
Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic Inflammation. PMID:32194553
Artificial microbiome heterogeneity spurs six practical action themes and examples to increase study power-driven reproducibility. PMID:32193395
Metabarcoding reveals that a non-nutritive sweetener and sucrose yield similar gut microbiota patterns in Wistar rats. PMID:32191789
Podocyte-specific deletion of tubular sclerosis complex 2 promotes focal segmental glomerulosclerosis and progressive renal failure. PMID:32191726
Ridge Alterations following Socket Preservation Using a Collagen Membrane in Dogs. PMID:32190649
Biological Activities and Proteomic Profile of the Venom of Vipera ursinii ssp., a very Rare Karst Viper from Croatia. PMID:32188060
Effects of Sodium-Glucose Co-transporter 2 Inhibition with Empaglifozin on Renal Structure and Function in Non-diabetic Rats with Left Ventricular Dysfunction After Myocardial Infarction. PMID:32185580
Size of portally deprived liver lobe after portal vein ligation and additional partial hepatectomy: Result of balancing proliferation and apoptosis. PMID:32184404
Poultry Coccidiosis: Design and Interpretation of Vaccine Studies. PMID:32175341
Exploring the Comparative Efficacy of Metformin and Resveratrol in the Management of Diabetes-associated Complications: A Systematic Review of Preclinical Studies. PMID:32168855
Effect of Chronic Administration of Aqueous Leaves Extract of Moringa Stenopetala on Blood Parameters and Histology of Liver and Kidney in Rats. PMID:32165816
A comparison of respiratory function in pigs anaesthetised by propofol or alfaxalone in combination with dexmedetomidine and ketamine. PMID:32164761
Proposed Definition of Experimental Secondary Ischemia for Mouse Subarachnoid Hemorrhage. PMID:32152960
UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: Questionnaire and workshop proceedings. PMID:32151228
Reversible Thiol Oxidation Inhibits the Mitochondrial ATP Synthase in Xenopus Laevis Oocytes. PMID:32150908
Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care: NHLBI Working Group Report. PMID:32150460
Adverse Effects of Autoclaved Diets on the Progression of Chronic Kidney Disease and Chronic Kidney Disease-Mineral Bone Disorder in Rats. PMID:32146472
Standards for preclinical research and publications in developmental anaesthetic neurotoxicity: expert opinion statement from the SmartTots preclinical working group. PMID:32145876
Direct inhibition of the TLR4/MyD88 pathway by geniposide suppresses HIF-1α-independent VEGF expression and angiogenesis in hepatocellular carcinoma. PMID:32144747
Cutaneous optical coherence tomography for longitudinal volumetric assessment of intradermal volumes in a mouse model. PMID:32144359
Liraglutide Protects Against Brain Amyloid-β1-42 Accumulation in Female Mice with Early Alzheimer's Disease-Like Pathology by Partially Rescuing Oxidative/Nitrosative Stress and Inflammation. PMID:32143329
Successful High-Dosage Monotherapy of Tigecycline in a Multidrug-Resistant Klebsiella pneumoniae Pneumonia-Septicemia Model in Rats. PMID:32138210
Alterations of estrous cycle, 3β hydroxysteroid dehydrogenase activity and progesterone synthesis in female rats after exposure to hypobaric hypoxia. PMID:32103034
IL-4 induces M2 macrophages to produce sustained analgesia via opioids. PMID:32102987
Murine genetic models of obesity: type I error rates and the power of commonly used analyses as assessed by plasmode-based simulation. PMID:32099106
The ESAS-score: A histological severity grading system of subarachnoid hemorrhage using the modified double hemorrhage model in rats. PMID:32097426
Sex as a biological variable in the rat model of diisopropylfluorophosphate-induced long-term neurotoxicity. PMID:32090337
Doppler Ultrasound for Heart Rate Assessment in a Porcine Model of Neonatal Asphyxia. PMID:32083045
Airway Hyperresponsiveness, Inflammation, and Pulmonary Emphysema in Rodent Models Designed to Mimic Exposure to Fuel Oil-Derived Volatile Organic Compounds Encountered during an Experimental Oil Spill. PMID:32074461
MicroRNA 27a Is a Key Modulator of Cholesterol Biosynthesis. PMID:32071155
Sex bias and omission in neuroscience research is influenced by research model and journal, but not reported NIH funding. PMID:32070715
In Vitro and In Vivo Preclinical Testing of Pericyte-Engineered Grafts for the Correction of Congenital Heart Defects. PMID:32067581
A diet high in fat and fructose adversely affects osseointegration of titanium implants in rats. PMID:32067396
Diffusion model comparison identifies distinct tumor sub-regions and tracks treatment response. PMID:32057115
Magnesium and vitamin C supplementation attenuates steroid-associated osteonecrosis in a rat model. PMID:32045781
Phage Lytic Protein LysRODI Prevents Staphylococcal Mastitis in Mice. PMID:32038593
Diapocynin, an NADPH oxidase inhibitor, counteracts diisopropylfluorophosphate-induced long-term neurotoxicity in the rat model. PMID:32037612
Gut microbiota alterations affect glioma growth and innate immune cells involved in tumor immunosurveillance in mice. PMID:32034922
Endovascular procedures cause transient endothelial injury but do not disrupt mature neointima in Drug Eluting Stents. PMID:32034227
Cerebellar Ataxia Caused by Type II Unipolar Brush Cell Dysfunction in the Asic5 Knockout Mouse. PMID:32034189
Bone regeneration of minipig mandibular defect by adipose derived mesenchymal stem cells seeded tri-calcium phosphate- poly(D,L-lactide-co-glycolide) scaffolds. PMID:32029875
Fetal cardiovascular response to acute hypoxia during maternal anesthesia. PMID:32026576
Improving Post-Operative Outcomes in Aged and Diabetic Obese Mice. PMID:32025533
Acute and sub-acute toxicity of Echinops kebericho decoction in rats. PMID:32020865
Checkpoint inhibitor therapy in preclinical sepsis models: a systematic review and meta-analysis. PMID:32020483
Horses Failed to Learn from Humans by Observation. PMID:32013218
Considerations in selecting postoperative analgesia for pregnant sheep following fetal instrumentation surgery. PMID:32002263
Ezetimibe Attenuates Oxidative Stress and Neuroinflammation via the AMPK/Nrf2/TXNIP Pathway after MCAO in Rats. PMID:31998437
Primary pulmonary arterial hypertension: Protocol to assess comprehensively in the rat the response to pharmacologic treatments. PMID:31993338
Trauma Severity and Its Impact on Local Inflammation in Extremity Injury-Insights From a Combined Trauma Model in Pigs. PMID:31993054
Epitranscriptomic profiling of N6-methyladenosine-related RNA methylation in rat cerebral cortex following traumatic brain injury. PMID:31992337
Sex as a Biological Variable: A 5-Year Progress Report and Call to Action. PMID:31971851
Senescence and the Impact on Biodistribution of Different Nanosystems: the Discrepancy on Tissue Deposition of Graphene Quantum Dots, Polycaprolactone Nanoparticle and Magnetic Mesoporous Silica Nanoparticles in Young and Elder Animals. PMID:31970499
Antihypertensive Effects of Virgin Olive Oil (Unfiltered) Low Molecular Weight Peptides with ACE Inhibitory Activity in Spontaneously Hypertensive Rats. PMID:31968696
Gastrointestinal Tracking and Gastric Emptying of Coated Capsules in Rats with or without Sedation Using CT imaging. PMID:31963818
Alpha-Lactalbumin Enriched Whey Protein Concentrate to Improve Gut, Immunity and Brain Development in Preterm Pigs. PMID:31963562
Differential gene responses 3 days following infarction in the fetal and adolescent sheep heart. PMID:31961761
Chronic vagal nerve stimulation has no effect on tachycardia-induced heart failure progression or excitation-contraction coupling. PMID:31961064
Calpain-1 ablation partially rescues disease-associated hallmarks in models of Machado-Joseph disease. PMID:31960910
Intrauterine exposure to chronic hypoxia in the rat leads to progressive diastolic function and increased aortic stiffness from early postnatal developmental stages. PMID:31960611
Improving Delineation of True Tumor Volume With Multimodal MRI in a Rat Model of Brain Metastasis. PMID:31959544
The Tentacular Strike Behavior in Squid: Functional Interdependency of Morphology and Predatory Behaviors During Ontogeny. PMID:31956313
Dietary Fat and Sugar Differentially Affect β-Adrenergic Stimulation of Cardiac ERK and AKT Pathways in C57BL/6 Male Mice Subjected to High-Calorie Feeding. PMID:31950177
Distinctive effect of anesthetics on the effect of limb remote ischemic postconditioning following ischemic stroke. PMID:31945776
Mangosteen pericarp components alleviate progression of prostatic hyperplasia and mitochondrial dysfunction in rats. PMID:31941927
Acupuncture Targeting SIRT1 in the Hypothalamic Arcuate Nucleus Can Improve Obesity in High-Fat-Diet-Induced Rats with Insulin Resistance via an Anorectic Effect. PMID:31935731
Improved detection of molecularly targeted iron oxide particles in mouse brain using B0 field stabilised high resolution MRI. PMID:31935444
Targeting Antigen to the Surface of EVs Improves the In Vivo Immunogenicity of Human and Non-human Adenoviral Vaccines in Mice. PMID:31934599
Does a high-fat diet affect the development and progression of osteoarthritis in mice?: A systematic review. PMID:31934329
Inflammation-induced IgE promotes epithelial hyperplasia and tumour growth. PMID:31931959
Neuroimmune/Hematopoietic Axis with Distinct Regulation by the High-Mobility Group Box 1 in Association with Tachykinin Peptides. PMID:31924647
Decreases in Circulating Concentrations of Long-Chain Acylcarnitines and Free Fatty Acids During the Glucose Tolerance Test Represent Tissue-Specific Insulin Sensitivity. PMID:31920980
Adaptation of wild boar (Sus scrofa) activity in a human-dominated landscape. PMID:31918698
Practical considerations in the use of a porcine model (Sus scrofa domesticus) to assess prevention of postoperative peritubal adhesions. PMID:31918436
Effects of Azelnidipine-Carboxymethylcellulose Gel on Healing of Full-Thickness Skin Wounds in Streptozotocin Induced Diabetic Rats. PMID:31908995
MTF2 Induces Epithelial-Mesenchymal Transition and Progression of Hepatocellular Carcinoma by Transcriptionally Activating Snail. PMID:31908487
Convection-enhanced delivery of temozolomide and whole cell tumor immunizations in GL261 and KR158 experimental mouse gliomas. PMID:31900109
Effect of Repeated Exposure to Isoflurane on Nest Building and Burrowing in Mice. PMID:31896393
CIBER-CLAP (CIBERCV Cardioprotection Large Animal Platform): A multicenter preclinical network for testing reproducibility in cardiovascular interventions. PMID:31889088
Plant Extracts in the Bone Repair Process: A Systematic Review. PMID:31885494
ERK Activation Modulates Cancer Stemness and Motility of a Novel Mouse Oral Squamous Cell Carcinoma Cell Line. PMID:31878324
VGF: a biomarker and potential target for the treatment of neuropathic pain? PMID:31875189
Antidiabetic and Hypolipidemic Effects of 5,7-Dimethoxyflavone in Streptozotocin-Induced Diabetic Rats. PMID:31869828
Modeling Cardiac Dysfunction Following Traumatic Hemorrhage Injury: Impact on Myocardial Integrity. PMID:31866998
Stroke Induces Prolonged Changes in Lipid Metabolism, the Liver and Body Composition in Mice. PMID:31865538
Pharmacological HIF1 Inhibition Eliminates Downregulation of the Pentose Phosphate Pathway and Prevents Neuronal Apoptosis in Rat Hippocampus Caused by Severe Hypoxia. PMID:31865524
Biphasic Calcium Phosphate Sphere Graft Combined with a Double-Layer Non-Crosslinked Collagen Membrane Technique for Ridge Preservation: A Randomized Controlled Animal Study. PMID:31861493
How Can Systematic Reviews Teach Us More about the Implementation of the 3Rs and Animal Welfare? PMID:31861205
Companion Animals as Models for Inhibition of STAT3 and STAT5. PMID:31861073
Power to the People: Power, Negative Results and Sample Size. PMID:31852563
Azithromycin Affords Neuroprotection in Rat Undergone Transient Focal Cerebral Ischemia. PMID:31849581
Rethinking research into metastasis. PMID:31845646
Neuroprotectants attenuate hypobaric hypoxia-induced brain injuries in cynomolgus monkeys. PMID:31840949
Transient versus Permanent MCA Occlusion in Mice Genetically Modified to Have Good versus Poor Collaterals. PMID:31840083
Psychological Stress Phenocopies Brain Mitochondrial Dysfunction and Motor Deficits as Observed in a Parkinsonian Rat Model. PMID:31836946
Perioperative Neurocognitive Disorder: State of the Preclinical Science. PMID:31834869
Effect of oxygen-producing suture material on hypoxic colonic anastomoses in an experimental model. PMID:31832595
The recovery of standing and locomotion after spinal cord injury does not require task-specific training. PMID:31825306
The Effects of Positive End-Expiratory Pressure on Transpulmonary Pressure and Recruitment-Derecruitment During Neurally Adjusted Ventilator Assist: A Continuous Computed Tomography Study in an Animal Model of Acute Respiratory Distress Syndrome. PMID:31824326
Combined Treatment with Low-Dose Ionizing Radiation and Ketamine Induces Adverse Changes in CA1 Neuronal Structure in Male Murine Hippocampi. PMID:31817026
Detection of live M. bovis BCG in tissues and IFN-γ responses in European badgers (Meles meles) vaccinated by oropharyngeal instillation or directly in the ileum. PMID:31810466
Mechanical Ventilation Redistributes Blood to Poorly Ventilated Areas in Experimental Lung Injury. PMID:31809278
Antenatal sildenafil citrate treatment increases offspring blood pressure in the placental-specific Igf2 knockout mouse model of FGR. PMID:31809211
Effects of Propolis Extract and Propolis-Derived Compounds on Obesity and Diabetes: Knowledge from Cellular and Animal Models. PMID:31805752
Short-term treatment with a peroxisome proliferator-activated receptor α agonist influences plasma one-carbon metabolites and B-vitamin status in rats. PMID:31805132
Esmolol for cardioprotection during resuscitation with adrenaline in an ischaemic porcine cardiac arrest model. PMID:31802327
Emergency myelopoiesis contributes to immune cell exhaustion and pulmonary vascular remodelling. PMID:31793661
The wmN1 Enhancer Region of the Mouse Myelin Proteolipid Protein Gene (mPlp1) is Indispensable for Expression of an mPlp1-lacZ Transgene in Both the CNS and PNS. PMID:31782102
Dose Articulation in Preclinical and Clinical Stroke Recovery: Refining a Discovery Research Pipeline and Presenting a Scoping Review Protocol. PMID:31781018
A Pilot Study of Postoperative Animal Welfare as a Guidance Tool in the Development of a Kidney Autotransplantation Model With Extended Warm Ischemia. PMID:31773049
Faecal neutrophil elastase-antiprotease balance reflects colitis severity. PMID:31772324
The Effectiveness of Dog Population Management: A Systematic Review. PMID:31766746
Multi-Organ NMR Metabolomics to Assess In Vivo Overall Metabolic Impact of Cisplatin in Mice. PMID:31766161
Sex and gender in health research: updating policy to reflect evidence. PMID:31760662
Endothelial Cell-Specific Transcriptome Reveals Signature of Chronic Stress Related to Worse Outcome After Mild Transient Brain Ischemia in Mice. PMID:31758402
The World Cancer Research Fund/American Institute for Cancer Research Third Expert Report on Diet, Nutrition, Physical Activity, and Cancer: Impact and Future Directions. PMID:31758189
Application of Fluorine- and Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators. PMID:31756109
Effects of high glucose conditions on the expansion and differentiation capabilities of mesenchymal stromal cells derived from rat endosteal niche. PMID:31752674
Evaluation of a Tap-Based Smartphone App for Heart Rate Assessment During Asphyxia in a Porcine Model of Neonatal Resuscitation. PMID:31750281
Stress-induced changes in group behaviour. PMID:31748696
The History of the WHHL Rabbit, an Animal Model of Familial Hypercholesterolemia (II) - Contribution to the Development and Validation of the Therapeutics for Hypercholesterolemia and Atherosclerosis. PMID:31748470
Iridoid glycosides from Radix Scrophulariae attenuates focal cerebral ischemia‑reperfusion injury via inhibiting endoplasmic reticulum stress‑mediated neuronal apoptosis in rats. PMID:31746404
The Role of the Three Rs in Improving the Planning and Reproducibility of Animal Experiments. PMID:31739641
Didelphis albiventris: an overview of unprecedented transcriptome sequencing of the white-eared opossum. PMID:31730444
Gadoxetate-enhanced dynamic contrast-enhanced MRI for evaluation of liver function and liver fibrosis in preclinical trials. PMID:31729971
The nociceptin/orphanin FQ receptor system as a target to alleviate cancer-induced bone pain in rats: Model validation and pharmacological evaluation. PMID:31724155
Specification of Subject Sex in Oncology-Related Animal Studies. PMID:31723882
Orexin A as a modulator of dorsal lateral geniculate neuronal activity: a comprehensive electrophysiological study on adult rats. PMID:31723155
The novel antipsychotic cariprazine stabilizes gamma oscillations in rat hippocampal slices. PMID:31722437
Journal Initiatives to Enhance Preclinical Research: Analyses of Stroke, Nature Medicine, Science Translational Medicine. PMID:31718504
Quality of Adherence to the ARRIVE Guidelines in the Material and Methods Section in Studies Where Swine Were Used as Surgical Biomodels: A Systematic Review (2013-2018). PMID:31717897
Prey and Venom Efficacy of Male and Female Wandering Spider, Phoneutria boliviensis (Araneae: Ctenidae). PMID:31717836
Lentinus edodes Exposure before and after Fetus Implantation: Materno-Fetal Development in Rats with Gestational Diabetes Mellitus. PMID:31717560
Early embryonic exposure of freshwater gastropods to pharmaceutical 5-alpha-reductase inhibitors results in a surprising open-coiled "banana-shaped" shell. PMID:31712739
The Role of IACUCs in Responsible Animal Research. PMID:31711237
Finite element analysis of the rotator cuff: A systematic review. PMID:31707188
Gut Microbiota Influences Experimental Outcomes in Mouse Models of Colorectal Cancer. PMID:31703321
In vivo biocompatibility and immunogenicity of metal-phenolic gelation. PMID:31700596
Volume incompliance and transfusion are essential for transfusion-associated circulatory overload: a novel animal model. PMID:31697425
HDAC4 and HDAC5 form a complex with DREAM that epigenetically down-regulates NCX3 gene and its pharmacological inhibition reduces neuronal stroke damage. PMID:31696766
Neuroanatomical correlates of the inhibition of tremulous jaw movements in rats by a combination of memantine and Δ9 -tetrahydrocannabinol. PMID:31696510
Genetic deletion of S6k1 does not rescue the phenotypic deficits observed in the R6/2 mouse model of Huntington's disease. PMID:31695068
Effects of 1,25-dihydroxyvitamin D3 on experimental periodontitis and AhR/NF-κB/NLRP3 inflammasome pathway in a mouse model. PMID:31691738
Reproducibility and Rigor in Animal-Based Research. PMID:31687758
Anaesthetic and Perioperative Management of 14 Male New Zealand White Rabbits for Calvarial Bone Surgery. PMID:31683852
Cultures of care? Animals and science in Britain. PMID:31682001
Indomethacin Enhances Type 1 Cannabinoid Receptor Signaling. PMID:31680861
Dynamic single-slice CT estimates whole-lung dual-energy CT variables in pigs with and without experimental lung injury. PMID:31676929
Reduction of Fmr1 mRNA Levels Rescues Pathological Features in Cortical Neurons in a Model of FXTAS. PMID:31671347
CD147 as a key mediator of the spleen inflammatory response in mice after focal cerebral ischemia. PMID:31666088
Comparing the Osteogenic Potentials and Bone Regeneration Capacities of Bone Marrow and Dental Pulp Mesenchymal Stem Cells in a Rabbit Calvarial Bone Defect Model. PMID:31658685
Sex-specific behavioural deficits induced at early life by prenatal exposure to the cannabinoid receptor agonist WIN55, 212-2 depend on mGlu5 receptor signalling. PMID:31658362
Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation. PMID:31653858
Kaempferol promotes bone formation in part via the mTOR signaling pathway. PMID:31638215
Comparison between two- and three-dimensional scoring of zebrafish response to psychoactive drugs: identifying when three-dimensional analysis is needed. PMID:31637136
Ablation of Immunoproteasome β5i Subunit Suppresses Hypertensive Retinopathy by Blocking ATRAP Degradation in Mice. PMID:31636038
Endogenous Uteroglobin as Intrinsic Anti-inflammatory Signal Modulates Monocyte and Macrophage Subsets Distribution Upon Sepsis Induced Lung Injury. PMID:31632392
Use of Zebrafish in Drug Discovery Toxicology. PMID:31625720
Antibiotic efficacy varies based on the infection model and treatment regimen for Pseudomonas aeruginosa. PMID:31624114
Refining animal research: The Animal Study Registry. PMID:31613875
Goal-Directed Fluid Therapy Does Not Improve Early Glomerular Filtration Rate in a Porcine Renal Transplantation Model. PMID:31609257
New tracheal stainless steel stent pilot study: twelve month follow-up in a rabbit model. PMID:31608174
Impact of Chronic Risperidone Use on Behavior and Survival of 3xTg-AD Mice Model of Alzheimer's Disease and Mice With Normal Aging. PMID:31607916
Macronutrient Supplements in Preterm and Small-for-Gestational-Age Animals: A Systematic Review and Meta-analysis. PMID:31605011
Isoflurane mediated neuropathological and cognitive impairments in the triple transgenic Alzheimer's mouse model are associated with hippocampal synaptic deficits in an age-dependent manner. PMID:31600350
Bexarotene therapy ameliorates behavioral deficits and induces functional and molecular changes in very-old Triple Transgenic Mice model of Alzheimer´s disease. PMID:31596896
Dl-3-n-butylphthalide Reduces Neurovascular Inflammation and Ischemic Brain Injury in Mice. PMID:31595195
Bardet-Biedl Syndrome in rhesus macaques: A nonhuman primate model of retinitis pigmentosa. PMID:31589838
The effect of angiopoietin-1 upregulation on the outcome of acute ischaemic stroke in rodent models: A meta-analysis. PMID:31581897
The 3Rs and Humane Experimental Technique: Implementing Change. PMID:31575048
Maternal Obesity Alters Neurotrophin-Associated MAPK Signaling in the Hypothalamus of Male Mouse Offspring. PMID:31572115
Animal models used to study direct peripheral nerve repair: a systematic review. PMID:31571661
Lung Purinoceptor Activation Triggers Ventilator-Induced Brain Injury. PMID:31567350
A Dual Protective Effect of Intestinal Remote Ischemic Conditioning in a Rat Model of Total Hepatic Ischemia. PMID:31561505
Sex-specific hippocampal metabolic signatures at the onset of systemic inflammation with lipopolysaccharide in the APPswe/PS1dE9 mouse model of Alzheimer's disease. PMID:31560941
Carbon monoxide attenuates vasospasm and improves neurobehavioral function after subarachnoid hemorrhage. PMID:31560866
Extrahypothalamic GABAergic nociceptin-expressing neurons regulate AgRP neuron activity to control feeding behavior. PMID:31557134
Gene expression signatures of site-specificity in cancer metastases. PMID:31555944
How Early Life Stress Impact Maternal Care: A Systematic Review of Rodent Studies. PMID:31555106
Bruton's Tyrosine Kinase Inhibition Attenuates the Cardiac Dysfunction Caused by Cecal Ligation and Puncture in Mice. PMID:31552054
Central Application of Aliskiren, a Renin Inhibitor, Improves Outcome After Experimental Stroke Independent of Its Blood Pressure Lowering Effect. PMID:31551909
α-Hispanolol Induces Apoptosis and Suppresses Migration and Invasion of Glioblastoma Cells Likely via Downregulation of MMP-2/9 Expression and p38MAPK Attenuation. PMID:31551765
Value of contrast-enhanced ultrasound for detection of synovial vascularity in experimental rheumatoid arthritis: an exploratory study. PMID:31547746
Effects of Lidocaine and Src Inhibition on Metastasis in a Murine Model of Breast Cancer Surgery. PMID:31546727
Will the real Dahl S rat please stand up? PMID:31545925
Myc-dependent endothelial proliferation is controlled by phosphotyrosine 1212 in VEGF receptor-2. PMID:31545012
Proteins mimicking epitope of HIV-1 virus neutralizing antibody induce virus-neutralizing sera in mice. PMID:31544770
Sex-specific behavioral effects following developmental exposure to tetrabromobisphenol A (TBBPA) in Wistar rats. PMID:31541695
Photopheresis efficacy in the treatment of rheumatoid arthritis: a pre-clinical proof of concept. PMID:31533744
Mesenchymal Stromal Cells Are More Effective Than Their Extracellular Vesicles at Reducing Lung Injury Regardless of Acute Respiratory Distress Syndrome Etiology. PMID:31531026
Pre-arrest hypothermia improved cardiac function of rats by ameliorating the myocardial mitochondrial injury after cardiac arrest. PMID:31530020
DBBM shows no signs of resorption under inflammatory conditions. An experimental study in the mouse calvaria. PMID:31529644
Ultrasound remission can predict future good structural outcome in collagen-induced arthritis rats. PMID:31527701
The Application of Statins in the Regeneration of Bone Defects. Systematic Review and Meta-Analysis. PMID:31527399
Adenosine Kinase Inhibition Augments Conducted Vasodilation and Prevents Left Ventricle Diastolic Dysfunction in Heart Failure With Preserved Ejection Fraction. PMID:31525084
Comparative assessment of the effects of meso-2,3-dimercaptosuccinic acid and salinomycin on spleen function of cadmium-exposed mice. PMID:31520384
Minocycline alters behavior, microglia and the gut microbiome in a trait-anxiety-dependent manner. PMID:31519869
Spinal Cord Injury Results in Chronic Mechanical Stiffening. PMID:31516087
The Potential of Biomaterial-Based Approaches as Therapies for Ischemic Stroke: A Systematic Review and Meta-Analysis of Pre-clinical Studies. PMID:31507524
Differences in blastomere totipotency in 2-cell mouse embryos are a maternal trait mediated by asymmetric mRNA distribution. PMID:31504820
High-density lipoprotein remodelled in hypercholesterolaemic blood induce epigenetically driven down-regulation of endothelial HIF-1α expression in a preclinical animal model. PMID:31504272
PKI-587 enhances chemosensitivity of oxaliplatin in hepatocellular carcinoma through suppressing DNA damage repair pathway (NHEJ and HR) and PI3K/AKT/mTOR pathway. PMID:31497229
Adaptation to chronic acidic extracellular pH elicits a sustained increase in lung cancer cell invasion and metastasis. PMID:31489536
The period circadian clock 2 gene responds to glucocorticoids and regulates osteogenic capacity. PMID:31489343
Skeletal muscle amino acid uptake is lower and alanine production is greater in late gestation intrauterine growth-restricted fetal sheep hindlimb. PMID:31483682
Virus Shedding of Avian Influenza in Poultry: A Systematic Review and Meta-Analysis. PMID:31480744
Imaging of translocator protein upregulation is selective for pro-inflammatory polarized astrocytes and microglia. PMID:31479168
Experimental Aneurysmal Subarachnoid Hemorrhage: Tiding Over. PMID:31478128
A circRNA signature predicts postoperative recurrence in stage II/III colon cancer. PMID:31475771
Contamination of hybrid hernia meshes compared to bioresorbable Phasix™ Mesh in a rabbit subcutaneous implant inoculation model. PMID:31467674
A systematic summary and comparison of animal models for chemotherapy induced (peripheral) neuropathy (CIPN). PMID:31461480
The impact of the systemic inflammatory response on hepatic bacterial elimination in experimental abdominal sepsis. PMID:31456116
The pain trajectory of juvenile idiopathic arthritis (JIA): translating from adolescent patient report to behavioural sensitivity in a juvenile animal model. PMID:31455369
Resveratrol suppresses the myofibroblastic phenotype and fibrosis formation in kidneys via proliferation-related signalling pathways. PMID:31454852
Comparative anti-osteoporotic properties of the leaves and roots of Marantodes pumilum var. alata in postmenopausal rat model. PMID:31453136
Modulation of Cardiovascular Function in Primary Hypertension in Rat by SKA-31, an Activator of KCa2.x and KCa3.1 Channels. PMID:31450834
Evidence for central antispastic effect of botulinum toxin type A. PMID:31444910
Ischemia and reperfusion injury following cardioplegic arrest is attenuated by age and testosterone deficiency in male but not female mice. PMID:31443710
Changes in Oral Microbial Ecology of C57BL/6 Mice at Different Ages Associated with Sampling Methodology. PMID:31443509
Hop2 Interacts with ATF4 to Promote Osteoblast Differentiation. PMID:31433867
Melatonin ameliorates cuprizone-induced reduction of hippocampal neurogenesis, brain-derived neurotrophic factor, and phosphorylation of cyclic AMP response element-binding protein in the mouse dentate gyrus. PMID:31429533
A systematic review of studies utilizing hair glucocorticoids as a measure of stress suggests the marker is more appropriate for quantifying short-term stressors. PMID:31427664
Mechanical Ventilation Strategies Targeting Different Magnitudes of Collapse and Tidal Recruitment in Porcine Acid Aspiration-Induced Lung Injury. PMID:31426607
A Classic Herbal Formula Guizhi Fuling Wan for Menopausal Hot Flushes: From Experimental Findings to Clinical Applications. PMID:31426588
Pharmacological exposures may precipitate craniosynostosis through targeted stem cell depletion. PMID:31415959
Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival. PMID:31413318
Sex-Specific Differences in Fat Storage, Development of Non-Alcoholic Fatty Liver Disease and Brain Structure in Juvenile HFD-Induced Obese Ldlr-/-.Leiden Mice. PMID:31405127
Reporting and analysis of repeated measurements in preclinical animals experiments. PMID:31404099
Evidence of adaptation of maternofetal transport of glutamine relative to placental size in normal mice, and in those with fetal growth restriction. PMID:31400764
Re-thinking the Etiological Framework of Neurodegeneration. PMID:31396030
Osteostatin Inhibits Collagen-Induced Arthritis by Regulation of Immune Activation, Pro-Inflammatory Cytokines, and Osteoclastogenesis. PMID:31394717
Sex Differences Between Female and Male Newborn Piglets During Asphyxia, Resuscitation, and Recovery. PMID:31380324
Effect of protracted dexamethasone exposure and its withdrawal on rocuronium-induced neuromuscular blockade and sugammadex reversal: an ex vivo rat study. PMID:31375743
The effects on the mandibular condyle of Botox injection into the masseter are not transient. PMID:31375229
Improved efficacy of naproxen-loaded NLC for temporomandibular joint administration. PMID:31371737
Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer's disease tau. PMID:31370885
β-Caryophyllene Mitigates Collagen Antibody Induced Arthritis (CAIA) in Mice Through a Cross-Talk between CB2 and PPAR-γ Receptors. PMID:31370242
Blood Flow Deficits and Cerebrovascular Changes in a Dietary Model of Hyperhomocysteinemia. PMID:31362539
Whole genome sequence and de novo assembly revealed genomic architecture of Indian Mithun (Bos frontalis). PMID:31357931
Cell-specific role of histone deacetylase 6 in chemotherapy-induced mechanical allodynia and loss of intraepidermal nerve fibers. PMID:31356453
Effects of the FGF receptor-1 inhibitor, infigratinib, with or without sildenafil, in experimental pulmonary arterial hypertension. PMID:31351013
A Protocol for the Ethical Assessment of Wild Animal-Visitor Interactions (AVIP) Evaluating Animal Welfare, Education, and Conservation Outcomes. PMID:31349726
Remote computer-assisted analysis of ICG fluorescence signal for evaluation of small intestinal anastomotic perfusion: a blinded, randomized, experimental trial. PMID:31332565
Inflammation up-regulates cochlear expression of TRPV1 to potentiate drug-induced hearing loss. PMID:31328162
Neuroinvasion and cognitive impairment in comorbid alcohol dependence and chronic viral infection: An initial investigation. PMID:31325774
CD8+ T-cells negatively regulate inflammation post-myocardial infarction. PMID:31322426
Rhesus Brain Transcriptomic Landscape in an ex vivo Model of the Interaction of Live Borrelia Burgdorferi With Frontal Cortex Tissue Explants. PMID:31316336
Effects of crystalloid, hyper-oncotic albumin, and iso-oncotic albumin on lung and kidney damage in experimental acute lung injury. PMID:31311539
Abnormal Mitochondria in a Non-human Primate Model of MPTP-induced Parkinson's Disease: Drp1 and CDK5/p25 Signaling. PMID:31308800
Animal to human translation: a systematic scoping review of reported concordance rates. PMID:31307492
Assessing the Completeness of Reporting in Preclinical Oncolytic Virus Therapy Studies. PMID:31276026
Effects of Obesity on Pulmonary Inflammation and Remodeling in Experimental Moderate Acute Lung Injury. PMID:31275296
Irreversible electroporation for catheter-based cardiac ablation: a systematic review of the preclinical experience. PMID:31270656
Effects of Air Pollution on Lung Innate Lymphoid Cells: Review of In Vitro and In Vivo Experimental Studies. PMID:31269777
Protective effects of delayed intraventricular TLR7 agonist administration on cerebral white and gray matter following asphyxia in the preterm fetal sheep. PMID:31267031
Low-level cyclic tibial compression attenuates early osteoarthritis progression after joint injury in mice. PMID:31265883
Aerosol immunization by alginate coated mycobacterium (BCG/MIP) particles provide enhanced immune response and protective efficacy than aerosol of plain mycobacterium against M.tb. H37Rv infection in mice. PMID:31262260
Lazaroid U-74389G in liver ischemia-reperfusion injury: A swine model. PMID:31258658
Characterization of Sigma 1 Receptor Antagonist CM-304 and Its Analog, AZ-66: Novel Therapeutics Against Allodynia and Induced Pain. PMID:31258480
Perinatal bisphenol A (BPA) exposure alters brain oxytocin receptor (OTR) expression in a sex- and region- specific manner: A CLARITY-BPA consortium follow-up study. PMID:31251963
Validation of the Fetal Lamb Model of Spina Bifida. PMID:31249378
Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes. PMID:31241172
Impact of acute handling stress, anaesthesia, and euthanasia on fish plasma biochemistry: implications for veterinary screening and metabolomic sampling. PMID:31240506
Inhibition of the Receptor for Advanced Glycation End-Products in Acute Respiratory Distress Syndrome: A Randomised Laboratory Trial in Piglets. PMID:31239497
Assessment of simplified methods for quantification of [18F]-DPA-714 using 3D whole-brain TSPO immunohistochemistry in a non-human primate. PMID:31238764
Early Local Inhibition of Club Cell Protein 16 Following Chest Trauma Reduces Late Sepsis-Induced Acute Lung Injury. PMID:31234556
Regional Behavior of Airspaces During Positive Pressure Reduction Assessed by Synchrotron Radiation Computed Tomography. PMID:31231245
Inducible knockout of CHUK/IKKα in adult chondrocytes reduces progression of cartilage degradation in a surgical model of osteoarthritis. PMID:31222033
Correlation of miRNA expression with intensity of neuropathic pain in man. PMID:31218919
Validation of MRI for Volumetric Quantification of Atelectasis in the Perioperative Period: An Experimental Study in Swine. PMID:31214052
A new mouse model to study the role of ectopic Nanos3 expression in cancer. PMID:31208373
Neutrophil extracellular trap-microparticle complexes trigger neutrophil recruitment via high-mobility group protein 1 (HMGB1)-toll-like receptors(TLR2)/TLR4 signalling. PMID:31206609
A randomised controlled trial of an Intervention to Improve Compliance with the ARRIVE guidelines (IICARus). PMID:31205756
Incomplete reporting of experimental studies and items associated with risk of bias in veterinary research. PMID:31205725
Productive performance and reproductive characteristics of Morada Nova male lambs fed with high-energy diet. PMID:31197722
Immune Relevant and Immune Deficient Mice: Options and Opportunities in Translational Research. PMID:31197363
Effects of nicotine exposure on murine mandibular development. PMID:31194840
A standardised framework to identify optimal animal models for efficacy assessment in drug development. PMID:31194784
Endotoxin-Induced Emphysema Exacerbation: A Novel Model of Chronic Obstructive Pulmonary Disease Exacerbations Causing Cardiopulmonary Impairment and Diaphragm Dysfunction. PMID:31191356
Effects of glycyrrhizin on lipopolysaccharide-induced acute lung injury in a mouse model. PMID:31179071
Outcome heterogeneity and bias in acute experimental spinal cord injury: A meta-analysis. PMID:31175207
Influence of different isoflurane anesthesia protocols on murine cerebral hemodynamics measured with pseudo-continuous arterial spin labeling. PMID:31172591
Derivation and maintenance of mouse haploid embryonic stem cells. PMID:31160788
Heterogenising study samples across testing time improves reproducibility of behavioural data. PMID:31160667
Dual PPARα/γ agonist aleglitazar confers stroke protection in a model of mild focal brain ischemia in mice. PMID:31147725
Suppression of NLRP3 inflammasome improves alveolar bone defect healing in diabetic rats. PMID:31146750
Toward a Standardized Test of Fearful Temperament in Primates: A Sensitive Alternative to the Human Intruder Task for Laboratory-Housed Rhesus Macaques (Macaca mulatta). PMID:31139115
Deficient Skeletal Muscle Regeneration after Injury Induced by a Clostridium perfringens Strain Associated with Gas Gangrene. PMID:31138614
Differential Effects of a Full and Biased Ghrelin Receptor Agonist in a Mouse Kindling Model. PMID:31137460
The Relationship Between Heart Rate and Left Ventricular Isovolumic Relaxation During Normoxia and Hypoxia-Asphyxia in Newborn Piglets. PMID:31133873
AT1 Receptor Mediated Hypertensive Response to Ang II in the Nucleus Tractus Solitarii of Normotensive Rats Involves NO Dependent Local GABA Release. PMID:31130861
Xenon improves long-term cognitive function, reduces neuronal loss and chronic neuroinflammation, and improves survival after traumatic brain injury in mice. PMID:31122738
Reporting preclinical anesthesia study (REPEAT): Evaluating the quality of reporting in the preclinical anesthesiology literature. PMID:31120888
In Utero Transplantation of Expanded Autologous Amniotic Fluid Stem Cells Results in Long-Term Hematopoietic Engraftment. PMID:31116895
Regeneration of periodontal bone defects with dental pulp stem cells grafting: Systematic Review. PMID:31110618
Animal models of chemotherapy-induced peripheral neuropathy: A machine-assisted systematic review and meta-analysis. PMID:31107871
An Animal Model of Acute and Chronic Chagas Disease With the Reticulotropic Y Strain of Trypanosoma cruzi That Depicts the Multifunctionality and Dysfunctionality of T Cells. PMID:31105709
Imaging of nano-hydroxyapatite/chitosan scaffolds using a cone beam computed tomography device on rat calvarial defects with histological verification. PMID:31104110
Effect of Ground Transportation on Adrenocortical Activity in Prepuberal Female Mice from Five Different Genetic Backgrounds. PMID:31096568
Stem cell therapy for preventing neonatal diseases in the 21st century: Current understanding and challenges. PMID:31086355
Marine-Steroid Derivative 5α-Androst-3β, 5α, 6β-triol Protects Retinal Ganglion Cells from Ischemia⁻Reperfusion Injury by Activating Nrf2 Pathway. PMID:31060323
The α9α10 Nicotinic Acetylcholine Receptor Antagonist αO-Conotoxin GeXIVA[1,2] Alleviates and Reverses Chemotherapy-Induced Neuropathic Pain. PMID:31060282
Hypothyroidism-related zinc deficiency leads to suppression of T lymphocyte activity. PMID:31056723
Laser speckle contrast imaging and quantitative fluorescence angiography for perfusion assessment. PMID:31055638
Pathology Principles and Practices for Analysis of Animal Models. PMID:31053847
Effect of Perioperative Lidocaine, Propofol and Steroids on Pulmonary Metastasis in a Murine Model of Breast Cancer Surgery. PMID:31052479
Leaf extracts from Dendropanax morbifera Léveille mitigate mercury-induced reduction of spatial memory, as well as cell proliferation, and neuroblast differentiation in rat dentate gyrus. PMID:31046739
Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2. PMID:31045582
Effects of ajmaline on contraction patterns of isolated rat gastric antrum and portal vein smooth muscle strips and on neurogenic relaxations of gastric fundus. PMID:31044280
Phosphodiesterase 5 inhibition improves contractile function and restores transverse tubule loss and catecholamine responsiveness in heart failure. PMID:31043634
The effects of aging on hydromorphone-induced thermal antinociception in healthy female cats. PMID:31041422
The transcriptomic response to irinotecan in colon carcinoma bearing mice preconditioned by fasting. PMID:31040913
Can Resveratrol Treatment Control the Progression of Induced Periodontal Disease? A Systematic Review and Meta-Analysis of Preclinical Studies. PMID:31035477
The reporting quality of acupuncture for neurogenesis in experimental ischemic stroke study. PMID:31032278
A study to assess the methodological quality of in vivo animal experiments published in Indian journal of pharmacology: A retrospective, cross-sectional, observational study. PMID:31031462
Protein kinase C-mediated insulin receptor phosphorylation in diabetic rat retina. PMID:31025213
Continuous cuprizone intoxication allows active experimental autoimmune encephalomyelitis induction in C57BL/6 mice. PMID:31016368
The problem with unadjusted multiple and sequential statistical testing. PMID:31015469
Prevention of Lung Bacterial Colonization With a Leak-Proof Endotracheal Tube Cuff: An Experimental Animal Study. PMID:31015390
Structural and diffusion weighted MRI demonstrates responses to ibrutinib in a mouse model of follicular helper (Tfh) T-cell lymphoma. PMID:31013298
"Stem cell therapy to promote limb function recovery in peripheral nerve damage in a rat model" - Experimental research. PMID:31011420
Regulation of Neprilysin Activity and Cognitive Functions in Rats After Prenatal Hypoxia. PMID:31006092
Acute canagliflozin treatment protects against in vivo myocardial ischemia-reperfusion injury in non-diabetic male rats and enhances endothelium-dependent vasorelaxation. PMID:30992077
The Proton Pump Inhibitor Lansoprazole Has Hepatoprotective Effects in In Vitro and In Vivo Rat Models of Acute Liver Injury. PMID:30989463
Preclinical Testing in Translational Animal Models of Prader-Willi Syndrome: Overview and Gap Analysis. PMID:30989085
Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells. PMID:30975914
Publication reform to safeguard wildlife from researcher harm. PMID:30973871
Attenuation of Acute Renal Injury After the Post-resuscitation Administration of Doxycycline in Surviving Newborn Piglets With Severe Hypoxia-Reoxygenation. PMID:30968002
The "Gastrocnemius-Achilles Tendon-Calcaneus Complex": Different Responses after Percutaneous versus Vulpius Achilles Tendon Lengthening in New Zealand White Rabbits. PMID:30967705
Sustained hypoxemia in late gestation potentiates hepatic gluconeogenic gene expression but does not activate glucose production in the ovine fetus. PMID:30964701
Radiosensitization of orthotopic GIC-driven glioblastoma by doxycycline causes skin damage. PMID:30961616
Non-perfusing cardiac rhythms in asphyxiated newborn piglets. PMID:30947278
Bradykinin increases BP in endotoxemic rat: functional and biochemical evidence of angiotensin II AT1 /bradykinin B2 receptor heterodimerization. PMID:30945263
Intestinal Epithelial Cells and the Microbiome Undergo Swift Reprogramming at the Inception of Colonic Citrobacter rodentium Infection. PMID:30940698
Positive allosteric modulation of the type 1 cannabinoid receptor reduces the signs and symptoms of Huntington's disease in the R6/2 mouse model. PMID:30940536
Inducible nitric oxide synthase inhibitor, 1400W, mitigates DFP-induced long-term neurotoxicity in the rat model. PMID:30940499
Contributing factors in the development of acute lung injury in a murine double hit model. PMID:30937460
γδ T Cells Modulate Myeloid Cell Recruitment but Not Pain During Peripheral Inflammation. PMID:30936874
Bioactivity of Bioceramic Materials Used in the Dentin-Pulp Complex Therapy: A Systematic Review. PMID:30934746
Chorioamnionitis in Rats Precipitates Extended Postnatal Inflammatory Lymphocyte Hyperreactivity. PMID:30921800
Extracorporeal membrane oxygenation (ECMO) and the acute respiratory distress syndrome (ARDS): a systematic review of pre-clinical models. PMID:30911932
Experimental pharmacokinetics evaluation of chemotherapy delivery by PIPAC for colon cancer: first evidence for efficacy. PMID:30911638
Identifying stroke therapeutics from preclinical models: A protocol for a novel application of network meta-analysis. PMID:30906535
Unidirectional opioid-cannabinoid cross-tolerance in the modulation of social play behavior in rats. PMID:30903212
Laparoscopic fluorescence image-guided photothermal therapy enhances cancer diagnosis and treatment. PMID:30899637
Evolving data analysis of an Oral Lipid Tolerance Test toward the standard for the Oral Glucose Tolerance Test: Cross species modeling effects of AZD7687 on plasma triacylglycerol. PMID:30899516
Transcriptomic Impact of IMA-08401, a Novel AHR Agonist Resembling Laquinimod, on Rat Liver. PMID:30893768
Vibration in mice: A review of comparative effects and use in translational research. PMID:30891556
The role of the gut microbiota on animal model reproducibility. PMID:30891555
Differential Response to Injury in Fetal and Adolescent Sheep Hearts in the Immediate Post-myocardial Infarction Period. PMID:30890961
MRI Imaging of the Hemodynamic Vasculature of Neuroblastoma Predicts Response to Antiangiogenic Treatment. PMID:30877107
Pharmacokinetic and pharmacodynamic actions of clozapine-N-oxide, clozapine, and compound 21 in DREADD-based chemogenetics in mice. PMID:30872749
Monotrauma is associated with enhanced remote inflammatory response and organ damage, while polytrauma intensifies both in porcine trauma model. PMID:30864051
In vitro/vivo Mechanism of Action of MP1102 With Low/Nonresistance Against Streptococcus suis Type 2 Strain CVCC 3928. PMID:30863725
Targeting the thioredoxin system as a novel strategy against B-cell acute lymphoblastic leukemia. PMID:30861284
Licochalcone A Protects the Blood-Milk Barrier Integrity and Relieves the Inflammatory Response in LPS-Induced Mastitis. PMID:30858849
Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice. PMID:30855565
Ischemic postconditioning decreases iNOS gene expression but ischemic preconditioning ameliorates histological injury in a swine model of extended liver resection. PMID:30854492
Housing mice in the individually ventilated or open cages-Does it matter for behavioral phenotype? PMID:30848040
Bone healing dynamics associated with 3 implants with different surfaces: histologic and histomorphometric analyses in dogs. PMID:30847254
Direct Effects of Nicotine Exposure on Murine Calvaria and Calvarial Cells. PMID:30846819
Reporting guidelines for health research: protocol for a cross-sectional analysis of the EQUATOR Network Library. PMID:30837245
Generating Robust and Informative Nonclinical In Vitro and In Vivo Bacterial Infection Model Efficacy Data To Support Translation to Humans. PMID:30833428
ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer. PMID:30833304
Evaluation of endoscopic visible light spectroscopy: comparison with microvascular oxygen tension measurements in a porcine model. PMID:30819196
Jaw osteosarcoma models in mice: first description. PMID:30813941
Evaluation of synthetic reticular hybrid meshes designed for intraperitoneal abdominal wall repair: Preclinical and in vitro behavior. PMID:30811503
Sub-clinical dose of bone morphogenetic protein-2 does not precipitate rampant, sustained inflammatory response in bone wound healing. PMID:30805987
Nonviral ultrasound-mediated gene delivery in small and large animal models. PMID:30804568
Extent of Inflammation and Foreign Body Reaction to Porous Polyethylene In Vitro and In Vivo. PMID:30804110
Priming of Adult Incision Response by Early-Life Injury: Neonatal Microglial Inhibition Has Persistent But Sexually Dimorphic Effects in Adult Rats. PMID:30796159
CRISPR-cas gene-editing as plausible treatment of neuromuscular and nucleotide-repeat-expansion diseases: A systematic review. PMID:30794581
Therapeutic Effects of HIF-1α on Bone Formation around Implants in Diabetic Mice Using Cell-Penetrating DNA-Binding Protein. PMID:30791543
Myoinositol CEST signal in animals with increased Iba-1 levels in response to an inflammatory challenge-Preliminary findings. PMID:30789943
Muscle weakness in a S. pneumoniae sepsis mouse model. PMID:30788356
The impact of anxiety on chronic musculoskeletal pain and the role of astrocyte activation. PMID:30779717
Smart bone plates can monitor fracture healing. PMID:30765721
Connexin-43-dependent ATP release mediates macrophage activation during sepsis. PMID:30735126
The impact of bipedal mechanical loading history on longitudinal long bone growth. PMID:30730948
Renal Na+ excretion consequent to pharmacogenetic activation of Gq-DREADD in principal cells. PMID:30724104
Dynamic, Not Isometric Resistance Training Improves Muscle Inflammation, Oxidative Stress and Hypertrophy in Rats. PMID:30723416
Circulating heparan sulfate fragments mediate septic cognitive dysfunction. PMID:30720464
Long-Lasting, Antinociceptive Effects of pH-Sensitive Niosomes Loaded with Ibuprofen in Acute and Chronic Models of Pain. PMID:30717144
Fundamental Concepts for Semiquantitative Tissue Scoring in Translational Research. PMID:30715381
A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension. PMID:30710493
All-trans retinoic acid inhibits lipopolysaccharide-induced inflammatory responses in bovine adipocytes via TGFβ1/Smad3 signaling pathway. PMID:30709353
Analgesic effects of the cathepsin K inhibitor L-006235 in the monosodium iodoacetate model of osteoarthritis pain. PMID:30706033
Identification and characterization of synthetic chondroitin-4-sulfate binding peptides in neuronal functions. PMID:30705359
Complete Genome Sequence of Humibacter aquilariae BT305, Isolated from the Small Intestine of Castrated Beef Cattle. PMID:30701243
Remyelination promoting therapies in multiple sclerosis animal models: a systematic review and meta-analysis. PMID:30696832
Immunological Homeostasis at the Ovine Placenta May Reflect the Degree of Maternal Fetal Interaction. PMID:30687304
Tidal changes in PaO2 and their relationship to cyclical lung recruitment/derecruitment in a porcine lung injury model. PMID:30686314
Efficacy and safety of culture-expanded, mesenchymal stem/stromal cells for the treatment of knee osteoarthritis: a systematic review protocol. PMID:30683159
Pharmacological impact of antiretroviral therapy on platelet function to investigate human immunodeficiency virus-associated cardiovascular risk. PMID:30681136
Delayed Cerebral Ischemia After Subarachnoid Hemorrhage: Experimental-Clinical Disconnect and the Unmet Need. PMID:30671784
Bacopa monnieri extract improves novel object recognition, cell proliferation, neuroblast differentiation, brain-derived neurotrophic factor, and phosphorylation of cAMP response element-binding protein in the dentate gyrus. PMID:30671111
Changes of myelin basic protein in the hippocampus of an animal model of type 2 diabetes. PMID:30671103
Ceruloplasmin Plays a Neuroprotective Role in Cerebral Ischemia. PMID:30670944
Reduction of Serum Uric Acid Associated with Attenuation of Renal Injury, Inflammation and Macrophages M1/M2 Ratio in Hyperuricemic Mice Model. PMID:30666040
Sost Haploinsufficiency Provokes Peracute Lethal Cardiac Tamponade without Rescuing the Osteopenia in a Mouse Model of Excess Glucocorticoids. PMID:30664862
Non‑canonical Wnt signaling contributes to ventilator‑induced lung injury through upregulation of WISP1 expression. PMID:30664165
The broiler chicken as a signal of a human reconfigured biosphere. PMID:30662712
Transcriptional Alterations by Ischaemic Postconditioning in a Pig Infarction Model: Impact on Microvascular Protection. PMID:30650650
Maternal obesity in pregnancy impacts offspring cardiometabolic health: Systematic review and meta-analysis of animal studies. PMID:30633422
Application of Autologous Platelet-Rich Plasma on Tooth Extraction Site Prevents Occurence of Medication-Related Osteonecrosis of the Jaws in Rats. PMID:30631095
Brain-derived and circulating vesicle profiles indicate neurovascular unit dysfunction in early Alzheimer's disease. PMID:30629763
Small airway hyperresponsiveness in COPD: relationship between structure and function in lung slices. PMID:30628486
Generating mouse models for biomedical research: technological advances. PMID:30626588
A Review of Oxygen Use During Chest Compressions in Newborns-A Meta-Analysis of Animal Data. PMID:30619794
Focal Malonate Injection Into the Internal Capsule of Rats as a Model of Lacunar Stroke. PMID:30619036
Peripheral nerve transfers change target muscle structure and function. PMID:30613770
Zn-alloy provides a novel platform for mechanically stable bioresorbable vascular stents. PMID:30601854
T-2 Toxin Induces Epiphyseal Plate Lesions via Decreased SECISBP2-Mediated Selenoprotein Expression in DA Rats, Exacerbated by Selenium Deficiency. PMID:30596260
Pre-stroke surgery is not beneficial to normotensive rats undergoing sixty minutes of transient focal cerebral ischemia. PMID:30592760
Kctd13-deficient mice display short-term memory impairment and sex-dependent genetic interactions. PMID:30590535
Toxicokinetics of bisphenol A, bisphenol S, and bisphenol F in a pregnancy sheep model. PMID:30583211
The dependence of brain mitochondria reactive oxygen species production on oxygen level is linear, except when inhibited by antimycin A. PMID:30582748
Alteration of tumor suppressor BMP5 in sporadic colorectal cancer: a genomic and transcriptomic profiling based study. PMID:30572883
Oxidative stress, autophagy and pyroptosis in the neovascularization of oxygen‑induced retinopathy in mice. PMID:30569132
Description of a Novel Phosphodiesterase (PDE)-3 Inhibitor Protecting Mice From Ischemic Stroke Independent From Platelet Function. PMID:30566040
Disc degeneration promotes regional inhomogeneity in the trabecular morphology of loaded rat tail vertebrae. PMID:30564552
Advances in Achieving Opioid Analgesia Without Side Effects. PMID:30555325
Deletion of myeloid IRS2 enhances adipose tissue sympathetic nerve function and limits obesity. PMID:30553769
Quantity and Reporting Quality of Kidney Research. PMID:30545982
ProvCaRe: Characterizing scientific reproducibility of biomedical research studies using semantic provenance metadata. PMID:30545485
The FAK inhibitor BI 853520 inhibits spheroid formation and orthotopic tumor growth in malignant pleural mesothelioma. PMID:30539198
Electrocardiography vs. Auscultation to Assess Heart Rate During Cardiac Arrest With Pulseless Electrical Activity in Newborn Infants. PMID:30538976
Sensitivity of Multiphase Pseudocontinuous Arterial Spin Labelling (MP pCASL) Magnetic Resonance Imaging for Measuring Brain and Tumour Blood Flow in Mice. PMID:30532663
Increased Vulnerability to Atrial Fibrillation Is Associated With Increased Susceptibility to Alternans in Old Sheep. PMID:30520673
Stroke: The past, present and future. PMID:30519643
Murine MPDZ-linked hydrocephalus is caused by hyperpermeability of the choroid plexus. PMID:30518636
Mechanisms Underpinning Adaptations in Placental Calcium Transport in Normal Mice and Those With Fetal Growth Restriction. PMID:30515131
Improving transparency and scientific rigor in academic publishing. PMID:30506879
Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6+ cancer cell and macrophage polarization. PMID:30504836
Fluid administration rate for uncontrolled intraabdominal hemorrhage in swine. PMID:30496239
Survival Curves and Behavioral Profiles of Female 3xTg-AD Mice Surviving to 18-Months of Age as Compared to Mice with Normal Aging. PMID:30480229
Increasing FIM2/3 antigen-content improves efficacy of Bordetella pertussis vaccines in mice in vivo without altering vaccine-induced human reactogenicity biomarkers in vitro. PMID:30478007
Adult-onset hypothyroidism increases ethanol consumption. PMID:30470859
Differential effects of hypothermia on neurovascular unit determine protective or toxic results: Toward optimized therapeutic hypothermia. PMID:30461327
Phosphoglycerate Mutase 1 Promotes Cell Proliferation and Neuroblast Differentiation in the Dentate Gyrus by Facilitating the Phosphorylation of cAMP Response Element-Binding Protein. PMID:30460638
Effects of Rodent Thermoregulation on Animal Models in the Research Environment. PMID:30458902
MUC1 deficiency mediates corticosteroid resistance in chronic obstructive pulmonary disease. PMID:30458870
Active full-length DNA Aβ42 immunization in 3xTg-AD mice reduces not only amyloid deposition but also tau pathology. PMID:30454039
Bioavailability of a novel form of silicon supplement. PMID:30451899
A companion to the preclinical common data elements on neurobehavioral comorbidities of epilepsy: a report of the TASK3 behavior working group of the ILAE/AES Joint Translational Task Force. PMID:30450484
Neuroprotective Mechanism of Hypoxic Post-conditioning Involves HIF1-Associated Regulation of the Pentose Phosphate Pathway in Rat Brain. PMID:30448928
The Acute Phase of Experimental Subarachnoid Hemorrhage: Intracranial Pressure Dynamics and Their Effect on Cerebral Blood Flow and Autoregulation. PMID:30443885
Prenatal metformin exposure or organic cation transporter 3 knock-out curbs social interaction preference in male mice. PMID:30423430
Sex bias in preclinical research and an exploration of how to change the status quo. PMID:30418665
Proteomic Analysis of Baboon Cerebral Artery Reveals Potential Pathways of Damage by Prenatal Alcohol Exposure. PMID:30413562
The Reporting Items for Patent Landscapes statement. PMID:30412195
Alcohol Binge Reduces Systemic Leukocyte Activation and Pulmonary PMN Infiltration After Blunt Chest Trauma and Hemorrhagic Shock. PMID:30411212
Pre-clinical assay of the tissue integration and mechanical adhesion of several types of cyanoacrylate adhesives in the fixation of lightweight polypropylene meshes for abdominal hernia repair. PMID:30388135
Validating Rat Model of Empathy for Pain: Effects of Pain Expressions in Social Partners. PMID:30386220
Building a framework to optimize animal models of maternal immune activation: Like your ongoing home improvements, it's a work in progress. PMID:30385273
GFP tagging of Brucella melitensis Rev1 allows the identification of vaccinated sheep. PMID:30375177
A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive-compulsive disorder: Mapping the way forward. PMID:30361863
Polybrominated diphenyl ether (PBDE) neurotoxicity: a systematic review and meta-analysis of animal evidence. PMID:30352012
LGI1 antibodies alter Kv1.1 and AMPA receptors changing synaptic excitability, plasticity and memory. PMID:30346486
Quantitative perfusion assessment of intestinal anastomoses in pigs treated with glucagon-like peptide 2. PMID:30338374
Spinal control of muscle synergies for adult mammalian locomotion. PMID:30334575
Visualizing pregnenolone sulfate-like modulators of NMDA receptor function reveals intracellular and plasma-membrane localization. PMID:30332607
Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury. PMID:30332405
Cofilin-actin rod formation in neuronal processes after brain ischemia. PMID:30325927
Bovine Milk Oligosaccharides with Sialyllactose for Preterm Piglets. PMID:30322051
Extended Combined Neonatal Treatment With Erythropoietin Plus Melatonin Prevents Posthemorrhagic Hydrocephalus of Prematurity in Rats. PMID:30319361
New Insights Into the Role of Cav2 Protein Family in Calcium Flux Deregulation in Fmr1-KO Neurons. PMID:30319351
Does the medical literature remain inadequately described despite having reporting guidelines for 21 years? - A systematic review of reviews: an update. PMID:30310289
Overaugmentation to compensate for postextraction ridge atrophy using a putty-type porcine bone substitute material with recombinant bone morphogenetic protein-2: 4 weeks of healing in a canine model. PMID:30306336
Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons. PMID:30304668
Combined inhibition of receptor tyrosine and p21-activated kinases as a therapeutic strategy in childhood ALL. PMID:30301811
The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review. PMID:30298361
Aging alters glucose uptake in the naïve and injured rodent spinal cord. PMID:30296507
Simultaneous Cryosectioning of Multiple Rodent Brains. PMID:30295667
Replication Study: Intestinal inflammation targets cancer-inducing activity of the microbiota. PMID:30295289
Visualization of the auditory pathway in rats with 18F-FDG PET activation studies based on different auditory stimuli and reference conditions including cochlea ablation. PMID:30278068
Cisplatin-Induced Rodent Model of Kidney Injury: Characteristics and Challenges. PMID:30276200
Reported use of reporting guidelines among JNCI: Journal of the National Cancer Institute authors, editorial outcomes, and reviewer ratings related to adherence to guidelines and clarity of presentation. PMID:30275983
Complete genome sequence of Kocuria rhizophila BT304, isolated from the small intestine of castrated beef cattle. PMID:30275909
The histone deacetylase inhibitor nicotinamide exacerbates neurodegeneration in the lactacystin rat model of Parkinson's disease. PMID:30269333
The Role of CD38 on the Function of Regulatory B Cells in a Murine Model of Lupus. PMID:30257456
Effects of probiotics, prebiotics or synbiotics on jawbone in obese-insulin resistant rats. PMID:30251017
Pharmacokinetics of intramuscular alfaxalone and its echocardiographic, cardiopulmonary and sedative effects in healthy dogs. PMID:30248146
Selenium-sensitive miRNA-181a-5p targeting SBP2 regulates selenoproteins expression in cartilage. PMID:30247797
Faithful animal modelling of human glioma by using primary initiating cells and its implications for radiosensitization therapy [ARRIVE 1]. PMID:30242200
The Shared Ethical Responsibility of Medically and Non-medically Qualified Experts in Human Drug Development Teams. PMID:30233356
Metallic crown-induced occlusal trauma as a protocol to evaluate inflammatory response in temporomandibular joint and periodontal tissues of rats. PMID:30232624
Systematic Review of In Vivo Animal Models of Subarachnoid Hemorrhage: Species, Standard Parameters, and Outcomes. PMID:30209798
In vitro studies on space-conforming self-assembling silk hydrogels as a mesenchymal stem cell-support matrix suitable for minimally invasive brain application. PMID:30209255
Assessing the feasibility of intranasal radiotracer administration for in brain PET imaging. PMID:30208358
Sex-dependent effects of in utero cannabinoid exposure on cortical function. PMID:30201092
Variability in PolyIC induced immune response: Implications for preclinical maternal immune activation models. PMID:30196839
Translating SOD1 Gene Silencing toward the Clinic: A Highly Efficacious, Off-Target-free, and Biomarker-Supported Strategy for fALS. PMID:30195799
Characterization of a Listeria monocytogenes meningitis mouse model. PMID:30193592
Combined aerobic and resistance exercise training attenuates cardiac dysfunctions in a model of diabetes and menopause. PMID:30192778
Minimum information reporting in bio-nano experimental literature. PMID:30190620
Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin. PMID:30182051
A Context-Based Analgesia Model in Rats: Involvement of Prefrontal Cortex. PMID:30178433
Fat composition in infant formula contributes to the severity of necrotising enterocolitis. PMID:30176959
A histomorphometric classification system for normal and inflamed mouse duodenum-Quali-quantitative approach. PMID:30175413
Comparative effects of meso-2,3- dimercaptosuccinic acid, monensin, and salinomycin on cadmium-induced brain dysfunction in cadmium-intoxicated mice. PMID:30174534
Selective serotonin re-uptake inhibitor sertraline inhibits bone healing in a calvarial defect model. PMID:30174329
Preclinical Evidence Supporting Early Initiation of Citalopram Treatment in Machado-Joseph Disease. PMID:30173407
A critical review of the in vitro and in vivo models for the evaluation of anti-infective meshes. PMID:30168006
Local release of tacrolimus from hydrogel-based drug delivery system is controlled by inflammatory enzymes in vivo and can be monitored non-invasively using in vivo imaging. PMID:30161258
Applicability of Plant Extracts in Preclinical Studies of Melanoma: A Systematic Review. PMID:30147443
Tanshinone IIA attenuates nerve structural and functional damage induced by nerve crush injury in rats. PMID:30138344
Assessment of HIF-1α expression and release following endothelial injury in-vitro and in-vivo. PMID:30134815
BET Inhibition-Induced GSK3β Feedback Enhances Lymphoma Vulnerability to PI3K Inhibitors. PMID:30134175
LXR/RXR signaling and neutrophil phenotype following myocardial infarction classify sex differences in remodeling. PMID:30132266
Heart rate elevations during early sepsis predict death in fluid-resuscitated rats with fecal peritonitis. PMID:30128907
The polyphenol resveratrol promotes skeletal growth in mice through a sirtuin 1-bone morphogenic protein 2 longevity axis. PMID:30125963
Content validation of a Critical Appraisal Tool for Reviewing Analgesia Studies (CATRAS) involving subjects incapable of self-reporting pain. PMID:30123860
Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection. PMID:30120595
Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A. PMID:30115750
Translational Sepsis Research: Spanning the Divide. PMID:30113370
Evaluation of Amino-Functional Polyester Dendrimers Based on Bis-MPA as Nonviral Vectors for siRNA Delivery. PMID:30110914
Metabolism of a synthetic compared with a natural therapeutic pulmonary surfactant in adult mice. PMID:30108154
Part I: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Study Design and Humane Modeling Endpoints. PMID:30106874
RAS modulation prevents progressive cognitive impairment after experimental stroke: a randomized, blinded preclinical trial. PMID:30103772
The Barnes Maze Task Reveals Specific Impairment of Spatial Learning Strategy in the Intrahippocampal Kainic Acid Model for Temporal Lobe Epilepsy. PMID:30097883
Induction of a transmissible tau pathology by traumatic brain injury. PMID:30084913
Evaluating Imaging Biomarkers of Acquired Resistance to Targeted EGFR Therapy in Xenograft Models of Human Head and Neck Squamous Cell Carcinoma. PMID:30083516
Development of Swimming Abilities in Squid Paralarvae: Behavioral and Ecological Implications for Dispersal. PMID:30083106
Experimental study of diclofenac and its biliary metabolites on anastomotic healing. PMID:30079391
Leukemia Inhibitory Factor-Receptor is Dispensable for Prenatal Testis Development but is Required in Sertoli cells for Normal Spermatogenesis in Mice. PMID:30068994
Changes in Plasma Protein Expression Indicative of Early Diet-induced Metabolic Disease in Male Pigs (Sus scrofa). PMID:30064550
Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B. PMID:30057111
Involvement of calvarial stem cells in healing: A regional analysis of large cranial defects. PMID:30054956
Body temperature and mouse scoring systems as surrogate markers of death in cecal ligation and puncture sepsis. PMID:30054760
Analysis of anti-osteoporosis function of chlorogenic acid by gene microarray profiling in ovariectomy rat model. PMID:30054432
Attenuation of oxidative damage by targeting mitochondrial complex I in neonatal hypoxic-ischemic brain injury. PMID:30037775
BRD4 amplification facilitates an oncogenic gene expression program in high-grade serous ovarian cancer and confers sensitivity to BET inhibitors. PMID:30036377
Toxicological assessment of multi-walled carbon nanotubes combined with nonylphenol in male mice. PMID:30028835
Statistical considerations in reporting cardiovascular research. PMID:30028200
A Preclinical Systematic Review and Meta-Analysis of Astragaloside IV for Myocardial Ischemia/Reperfusion Injury. PMID:30018562
Epithelial damage and tissue γδ T cells promote a unique tumor-protective IgE response. PMID:30013146
Reframing the Biological Basis of Neuroprotection Using Functional Genomics: Differentially Weighted, Time-Dependent Multifactor Pathogenesis of Human Ischemic Brain Damage. PMID:29997569
Analgesic effects of a novel pH-dependent μ-opioid receptor agonist in models of neuropathic and abdominal pain. PMID:29994988
Pharmacological and toxicological activity of RSD921, a novel sodium channel blocker. PMID:29990839
Pancreatic Compression during Lymph Node Dissection in Laparoscopic Gastrectomy: Possible Cause of Pancreatic Leakage. PMID:29984063
Ca2+-activated K+ channels modulate microglia affecting motor neuron survival in hSOD1G93A mice. PMID:29981425
Common marmoset (Callithrix jacchus) personality, subjective well-being, hair cortisol level and AVPR1a, OPRM1, and DAT genotypes. PMID:29980755
Validation of Pressure Reactivity and Pulse Amplitude Indices against the Lower Limit of Autoregulation, Part I: Experimental Intracranial Hypertension. PMID:29978744
Transcriptome analysis reveals candidate genes involved in splay leg syndrome in piglets. PMID:29978277
Animal experimental research design in critical care. PMID:29976162
Left ventricular hypertrophy in experimental chronic kidney disease is associated with reduced expression of cardiac Kruppel-like factor 15. PMID:29970016
Impaired Neurofilament Integrity and Neuronal Morphology in Different Models of Focal Cerebral Ischemia and Human Stroke Tissue. PMID:29967576
l-Phenylalanine Restores Vascular Function in Spontaneously Hypertensive Rats Through Activation of the GCH1-GFRP Complex. PMID:29963647
The adiponectin promoter activator NP-1 induces high levels of circulating TNFα and weight loss in obese (fa/fa) Zucker rats. PMID:29959379
Experimental evaluation of liver regeneration patterns and liver function following ALPPS. PMID:29951610
The G protein-coupled estrogen receptor agonist, G-1, attenuates BK channel activation in cerebral arterial smooth muscle cells. PMID:29938113
Differential Role of Prefrontal and Parietal Cortices in Controlling Level of Consciousness. PMID:29937348
Opioid analgesia and the somatosensory memory of neonatal surgical injury in the adult rat. PMID:29935586
siRNA Library Screening Identifies a Druggable Immune-Signature Driving Esophageal Adenocarcinoma Cell Growth. PMID:29930979
Rho-kinase inhibitors do not expand hematoma volume in acute experimental intracerebral hemorrhage. PMID:29928660
Murine models of Pneumocystis infection recapitulate human primary immune disorders. PMID:29925696
Improving the standardization of mRNA measurement by RT-qPCR. PMID:29922589
Inhibition of the CD36 receptor reduces visceral fat accumulation and improves insulin resistance in obese mice carrying the BDNF-Val66Met variant. PMID:29914985
Efficacy and Pharmacokinetics Evaluation of a Single Oral Dose of Afoxolaner against Sarcoptes scabiei in the Porcine Scabies Model for Human Infestation. PMID:29914951
Opening the debate on deep brain stimulation for Alzheimer disease - a critical evaluation of rationale, shortcomings, and ethical justification. PMID:29886845
A guideline for reporting experimental protocols in life sciences. PMID:29868256
Combination therapy with protein kinase inhibitor H89 and Tetrandrine elicits enhanced synergistic antitumor efficacy. PMID:29866132
Exposure of laboratory animals to small air ions: a systematic review of biological and behavioral studies. PMID:29866122
Evaluation of small intestinal damage in a rat model of 6 Minutes cardiac arrest. PMID:29866034
The influence of suturectomy on age-related changes in cerebral blood flow in rabbits with familial bicoronal suture craniosynostosis: A quantitative analysis. PMID:29856748
P2X7 ionotropic receptor is functionally expressed in rabbit articular chondrocytes and mediates extracellular ATP cytotoxicity. PMID:29845461
Sparstolonin B improves neurological outcomes following intracerebral hemorrhage in mice. PMID:29844805
ARRIVE has not ARRIVEd: Support for the ARRIVE (Animal Research: Reporting of in vivo Experiments) guidelines does not improve the reporting quality of papers in animal welfare, analgesia or anesthesia. PMID:29795636
Novel TNF receptor-1 inhibitors identified as potential therapeutic candidates for traumatic brain injury. PMID:29789012
Feasibility and effectiveness of laparoscopic transgastric stapler-assisted circumferential esophageal mucosectomy and simultaneous fundoplication in a pig model. PMID:29788275
Five traditional Nigerian Polyherbal remedies protect against high fructose fed, Streptozotocin-induced type 2 diabetes in male Wistar rats. PMID:29769061
Mice exposed to bisphenol A exhibit depressive-like behavior with neurotransmitter and neuroactive steroid dysfunction. PMID:29763587
P values in display items are ubiquitous and almost invariably significant: A survey of top science journals. PMID:29763472
Lactoferricin B reverses cisplatin resistance in head and neck squamous cell carcinoma cells through targeting PD-L1. PMID:29761938
The Yin and Yang of Tyrosine Kinase Inhibition During Experimental Polymicrobial Sepsis. PMID:29760707
Time-Restricted Feeding Prevents Ablation of Diurnal Rhythms in Gastric Vagal Afferent Mechanosensitivity Observed in High-Fat Diet-Induced Obese Mice. PMID:29760179
Hyperuricemia Induces Wnt5a/Ror2 Gene Expression, Epithelial-Mesenchymal Transition, and Kidney Tubular Injury in Mice. PMID:29749985
Rivaroxaban does not influence hemorrhagic transformation in a diabetes ischemic stroke and endovascular thrombectomy model. PMID:29743683
Thermoregulatory responses and reproductive traits in composite beef bulls raised in a tropical climate. PMID:29732473
Targeting the dopamine D1 receptor or its downstream signalling by inhibiting phosphodiesterase-1 improves cognitive performance. PMID:29726015
EAAC1 gene deletion reduces adult hippocampal neurogenesis after transient cerebral ischemia. PMID:29720605
Automatic recognition of self-acknowledged limitations in clinical research literature. PMID:29718377
Animal Models in Forensic Science Research: Justified Use or Ethical Exploitation? PMID:29717465
Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology. PMID:29712883
Huntington's disease pattern of transcriptional dysregulation in the absence of mutant huntingtin is produced by knockout of neuronal GLT-1. PMID:29709465
Fibronectin EDA forms the chronic fibrotic scar after contusive spinal cord injury. PMID:29705186
Effect size and statistical power in the rodent fear conditioning literature - A systematic review. PMID:29698451
Identification of a novel small-molecule Keap1-Nrf2 PPI inhibitor with cytoprotective effects on LPS-induced cardiomyopathy. PMID:29693453
A comparative in vivo study of strontium-functionalized and SLActive™ implant surfaces in early bone healing. PMID:29692613
Elf3 Contributes to Cartilage Degradation in vivo in a Surgical Model of Post-Traumatic Osteoarthritis. PMID:29691435
Chronic calcitriol supplementation improves the inflammatory profiles of circulating monocytes and the associated intestinal/adipose tissue alteration in a diet-induced steatohepatitis rat model. PMID:29684027
The wmN1 enhancer region in intron 1 is required for expression of human PLP1. PMID:29683207
Impact of Different Tidal Volume Levels at Low Mechanical Power on Ventilator-Induced Lung Injury in Rats. PMID:29670537
Steroid-associated osteonecrosis animal model in rats. PMID:29662787
Myocardial Infarct Size Reduction Provided by Local and Remote Ischaemic Preconditioning: References Values from the Hatter Cardiovascular Institute. PMID:29656359
Salicytamide: a New Anti-inflammatory Designed Drug Candidate. PMID:29654432
Inhibition of the NLRP3-inflammasome as a potential approach for neuroprotection after stroke. PMID:29654318
A review of the pharmaceutical exposome in aquatic fauna. PMID:29653304
3D artificial round section micro-vessels to investigate endothelial cells under physiological flow conditions. PMID:29651108
Critical Role of Flavin and Glutathione in Complex I-Mediated Bioenergetic Failure in Brain Ischemia/Reperfusion Injury. PMID:29643256
Electrical dynamics of isolated cerebral and skeletal muscle endothelial tubes: Differential roles of G-protein-coupled receptors and K+ channels. PMID:29636977
Broad-Spectrum Regulation of Nonreceptor Tyrosine Kinases by the Bacterial ADP-Ribosyltransferase EspJ. PMID:29636436
A practical blueprint to systematically study life-long health consequences of novel medically assisted reproductive treatments. PMID:29635479
Systematic Assessment of Well-Being in Mice for Procedures Using General Anesthesia. PMID:29630060
Ensuring reproducibility and ethics in animal experiments reporting in Korea using the ARRIVE guideline. PMID:29628972
Meniscal extrusion and degeneration during the course of osteoarthritis in the Murine collagenase-induced osteoarthritis model. PMID:29624738
Cannabidiol regulates behavioural alterations and gene expression changes induced by spontaneous cannabinoid withdrawal. PMID:29624642
Preclinical efficacy studies in investigator brochures: Do they enable risk-benefit assessment? PMID:29621228
Superparamagnetic iron oxide nanoparticles modified with polyethylenimine and galactose for siRNA targeted delivery in hepatocellular carcinoma therapy. PMID:29618926
S100A12 concentrations and myeloperoxidase activities are increased in the intestinal mucosa of dogs with chronic enteropathies. PMID:29618371
Mast Cells Are Activated by Streptococcus pneumoniae In Vitro but Dispensable for the Host Defense Against Pneumococcal Central Nervous System Infection In Vivo. PMID:29616039
Adenosine A2A Receptors Control Glutamatergic Synaptic Plasticity in Fast Spiking Interneurons of the Prefrontal Cortex. PMID:29615897
Complexes of myo-inositol-hexakisphosphate (InsP6) with zinc or lanthanum to enhance excretion of radioactive strontium from the body. PMID:29614122
Maternal environment and craniofacial growth: geometric morphometric analysis of mandibular shape changes with in utero thyroxine overexposure in mice. PMID:29611183
Ozanimod (RPC1063), a selective S1PR1 and S1PR5 modulator, reduces chronic inflammation and alleviates kidney pathology in murine systemic lupus erythematosus. PMID:29608575
Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice. PMID:29604337
Comparative Analysis of the Regulatory T Cells Dynamics in Peripheral Blood in Human and Porcine Polytrauma. PMID:29593715
Retrospective harm benefit analysis of pre-clinical animal research for six treatment interventions. PMID:29590200
Why Epilepsia Open? PMID:29588923
A Novel Role for Lymphotactin (XCL1) Signaling in the Nervous System: XCL1 Acts via its Receptor XCR1 to Increase Trigeminal Neuronal Excitability. PMID:29588250
Correspondence: Challenging a proposed role for TRPC5 in aortic baroreceptor pressure-sensing. PMID:29572499
Effect of Obesity or Metabolic Syndrome and Diabetes on Osseointegration of Dental Implants in a Miniature Swine Model: A Pilot Study. PMID:29572133
The effect of FASN inhibition on the growth and metabolism of a cisplatin-resistant ovarian carcinoma model. PMID:29569717
The age of heterozygous telomerase mutant parents influences the adult phenotype of their offspring irrespective of genotype in zebrafish. PMID:29568807
Contribution of the Breadth and Depth of IACUC Membership to Experimental Design as a Factor in Research Reproducibility. PMID:29554998
Protectin DX Exhibits Protective Effects in Mouse Model of Lipopolysaccharide-Induced Acute Lung Injury. PMID:29553051
Gestational bisphenol S impairs placental endocrine function and the fusogenic trophoblast signaling pathway. PMID:29550860
The acute diuretic effect of an ethanolic fraction of Phyllanthus amarus (Euphorbiaceae) in rats involves prostaglandins. PMID:29544490
Optically Guided Single Cell Mass Spectrometry of Rat Dorsal Root Ganglia to Profile Lipids, Peptides and Proteins. PMID:29544029
Dose-response, therapeutic time-window and tPA-combinatorial efficacy of compound 21: A randomized, blinded preclinical trial in a rat model of thromboembolic stroke. PMID:29537907
Asymmetric expression level of clock genes in left vs. right nasal mucosa in humans with and without allergies and in rats: Circadian characteristics and possible contribution to nasal cycle. PMID:29534090
Misrepresentation and distortion of research in biomedical literature. PMID:29531025
Evaluation of different drug classes on transient sciatic nerve injury-depressed marble burying in mice. PMID:29528965
Glutathione S-Transferase Pi Prevents Sepsis-Related High Mobility Group Box-1 Protein Translocation and Release. PMID:29520271
Assisted delivery of antisense therapeutics in animal models of heritable neurodegenerative and neuromuscular disorders: a systematic review and meta-analysis. PMID:29520012
Abstinence to chronic methamphetamine switches connectivity between striatal, hippocampal and sensorimotor regions and increases cerebral blood volume response. PMID:29518566
Neuroanatomical characterization of imidazoline I2 receptor agonist-induced antinociception. PMID:29514408
Host and Environmental Factors Affecting the Intestinal Microbiota in Chickens. PMID:29503637
The immunoproteasome subunit LMP10 mediates angiotensin II-induced retinopathy in mice. PMID:29499566
Quantitative blood flow measurement in rat brain with multiphase arterial spin labelling magnetic resonance imaging. PMID:29498562
Protocol for a Systematic Review of Effect Sizes and Statistical Power in the Rodent Fear Conditioning Literature. PMID:29497557
Long-term Treatment with Low-Dose Caffeine Worsens BPSD-Like Profile in 3xTg-AD Mice Model of Alzheimer's Disease and Affects Mice with Normal Aging. PMID:29497377
Tegumentary leishmaniasis and coinfections other than HIV. PMID:29494584
The case for introducing pre-registered confirmatory pharmacological pre-clinical studies. PMID:29480040
Body temperature measurement in mice during acute illness: implantable temperature transponder versus surface infrared thermometry. PMID:29476115
Patient-derived organoids model treatment response of metastatic gastrointestinal cancers. PMID:29472484
CD38 promotes pristane-induced chronic inflammation and increases susceptibility to experimental lupus by an apoptosis-driven and TRPM2-dependent mechanism. PMID:29463868
Dihydrodiosgenin protects against experimental acute pancreatitis and associated lung injury through mitochondrial protection and PI3Kγ/Akt inhibition. PMID:29457828
Inflammatory and degenerative phases resulting from anterior cruciate rupture in a non-invasive murine model of post-traumatic osteoarthritis. PMID:29453795
Sex and Gender Equity in Research: rationale for the SAGER guidelines and recommended use. PMID:29451543
Simple decision-tree tool to facilitate author identification of reporting guidelines during submission: a before-after study. PMID:29451534
Endogenous Sex Steroids Dampen Neuroinflammation and Improve Outcome of Traumatic Brain Injury in Mice. PMID:29450697
The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity. PMID:29449530
Doxycycline inhibits experimental cerebral malaria by reducing inflammatory immune reactions and tissue-degrading mediators. PMID:29438386
Sex as an important biological variable in biomedical research. PMID:29429452
Ethyl pyruvate ameliorates hepatic injury following blunt chest trauma and hemorrhagic shock by reducing local inflammation, NF-kappaB activation and HMGB1 release. PMID:29420582
Effect of bupivacaine and adjuvant drugs for regional anesthesia on nerve tissue oximetry and nerve blood flow. PMID:29416372
Ultrafine Particulate Matter Combined With Ozone Exacerbates Lung Injury in Mature Adult Rats With Cardiovascular Disease. PMID:29394414
Bench-to-Bedside: A Translational Perspective on Murine Models of Sepsis. PMID:29394153
Distinct Roles of Protein Phosphatase 1 Bound on Neurabin and Spinophilin and Its Regulation in AMPA Receptor Trafficking and LTD Induction. PMID:29383693
A Fragment of Adhesion Molecule L1 Binds to Nuclear Receptors to Regulate Synaptic Plasticity and Motor Coordination. PMID:29383692
Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology. PMID:29382817
Biological response to self-etch adhesive after partial caries removal in rats. PMID:29380132
(Mesenchymal) Stem Cell-Based Therapy in Cisplatin-Induced Acute Kidney Injury Animal Model: Risk of Immunogenicity and Tumorigenicity. PMID:29379525
Effect of hyperbaric oxygen therapy (HBO) on implant-associated osteitis in a femur fracture model in mice. PMID:29377928
The common use of improper control diets in diet-induced metabolic disease research confounds data interpretation: the fiber factor. PMID:29371873
Temporary carriage of bovine coronavirus and bovine respiratory syncytial virus by fomites and human nasal mucosa after exposure to infected calves. PMID:29357935
Guidelines for experimental models of myocardial ischemia and infarction. PMID:29351451
Impact of valve-less vs. standard insufflation on pneumoperitoneum volume, inflammation, and peritoneal physiology in a laparoscopic sigmoid resection experimental model. PMID:29330589
Facilitating healthcare decisions by assessing the certainty in the evidence from preclinical animal studies. PMID:29324741
Influence of Thrombolysis on the Safety and Efficacy of Blocking Platelet Adhesion or Secretory Activity in Acute Ischemic Stroke in Mice. PMID:29322481
Safety evaluation of Bon-santé cleanser® polyherbal in male Wistar rats: Further investigations on androgenic and toxicological profile. PMID:29322011
Unit of analysis issues in laboratory-based research. PMID:29319501
Osteopontin regulates dentin and alveolar bone development and mineralization. PMID:29313816
High-intensity resistance training alone or combined with aerobic training improves strength, heart function and collagen in rats with heart failure. PMID:29312495
Adaptations in Maternofetal Calcium Transport in Relation to Placental Size and Fetal Sex in Mice. PMID:29311979
Palmitoylethanolamide Supplementation during Sensitization Prevents Airway Allergic Symptoms in the Mouse. PMID:29311913
Genoprotective, antioxidant, antifungal and anti-inflammatory evaluation of hydroalcoholic extract of wild-growing Juniperus communis L. (Cupressaceae) native to Romanian southern sub-Carpathian hills. PMID:29301523
A call for action: Improve reporting of research studies to increase the scientific basis for regulatory decision-making. PMID:29297199
Liver X Receptor Agonist GW3965 Regulates Synaptic Function upon Amyloid Beta Exposure in Hippocampal Neurons. PMID:29297151
Systematic heterogenization for better reproducibility in animal experimentation. PMID:29296016
Serial quantitative neuroimaging of iron in the intracerebral hemorrhage pig model. PMID:29292651
Effect of implant placement depth on the peri-implant bone defect configurations in ligature-induced peri-implantitis: An experimental study in dogs. PMID:29274159
Functional shift with maintained regenerative potential following portal vein ligation. PMID:29273725
Repeated social defeat induces transient glial activation and brain hypometabolism: A positron emission tomography imaging study. PMID:29271288
Modulation of SF1 Neuron Activity Coordinately Regulates Both Feeding Behavior and Associated Emotional States. PMID:29262334
Citrobacter rodentium Relies on Commensals for Colonization of the Colonic Mucosa. PMID:29262319
Induction of the cell survival kinase Sgk1: A possible novel mechanism for α-phenyl-N-tert-butyl nitrone in experimental stroke. PMID:29260627
Evaluations of the uptake and impact of the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) Statement and extensions: a scoping review. PMID:29258593
A core program of gene expression characterizes cancer metastases. PMID:29254233
Nonhuman Primates and Translational Research: Progress, Opportunities, and Challenges. PMID:29253273
Berberine attenuated pro-inflammatory factors and protect against neuronal damage via triggering oligodendrocyte autophagy in spinal cord injury. PMID:29228691
Hyper-response to Novelty Increases c-Fos Expression in the Hippocampus and Prefrontal Cortex in a Rat Model of Schizophrenia. PMID:29214513
Validation of a new experimental model of extrusive luxation on maxillary molars of rats: a histological study. PMID:29214377
From a mouse: systematic analysis reveals limitations of experiments testing interventions in Alzheimer's disease mouse models. PMID:29214041
Refinement of Mouse Protocols for the Study of Platelet Thromboembolic Responses In Vivo. PMID:29212116
In vivo evaluation of antipyretic effects of some homeopathic ultra-high dilutions on Baker's yeast-induced fever on Similia principle. PMID:29203352
Resolvins suppress tumor growth and enhance cancer therapy. PMID:29191914
Arthritic role of Porphyromonas gingivalis in collagen-induced arthritis mice. PMID:29190705
Promoting and improving three Rs practice: the Korean guidelines. PMID:29187280
The Weak Spots in Contemporary Science (and How to Fix Them). PMID:29186879
To Group or Not to Group? Good Practice for Housing Male Laboratory Mice. PMID:29186765
Mocetinostat combined with gemcitabine for the treatment of leiomyosarcoma: Preclinical correlates. PMID:29186204
Toxicological investigation of acute and chronic treatment with Gnidia stenophylla Gilg root extract on some blood parameters and histopathology of spleen, liver and kidney in mice. PMID:29183389
A Murine Orthotopic Allograft to Model Prostate Cancer Growth and Metastasis. PMID:29177185
Autologous Cell Seeding in Tracheal Tissue Engineering. PMID:29177132
NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy. PMID:29175372
Stall in Canonical Autophagy-Lysosome Pathways Prompts Nucleophagy-Based Nuclear Breakdown in Neurodegeneration. PMID:29174892
Quantitative analysis of motor evoked potentials in the neonatal lamb. PMID:29170524
α7 Nicotinic Agonist AR-R17779 Protects Mice against 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis in a Spleen-Dependent Way. PMID:29167641
Elevated Levels of Peripheral Kynurenine Decrease Bone Strength in Rats with Chronic Kidney Disease. PMID:29163188
Quantifying the relationship between inhibition of VEGF receptor 2, drug-induced blood pressure elevation and hypertension. PMID:29161763
Oral administration of a novel lipophilic PPARδ agonist is not neuroprotective after rodent cerebral ischemia. PMID:29160120
Protective effect of dehydroandrographolide on obstructive cholestasis in bile duct-ligated mice. PMID:29152129
Guidelines for the use of flow cytometry. PMID:29148621
Depot-specific inflammation with decreased expression of ATM2 in white adipose tissues induced by high-margarine/lard intake. PMID:29141038
Defective synaptic transmission causes disease signs in a mouse model of juvenile neuronal ceroid lipofuscinosis. PMID:29135436
PTEN loss and activation of K-RAS and β-catenin cooperate to accelerate prostate tumourigenesis. PMID:29134654
Problems and Progress regarding Sex Bias and Omission in Neuroscience Research. PMID:29134192
Dispersion of TiO2 nanoparticles improves burn wound healing and tissue regeneration through specific interaction with blood serum proteins. PMID:29133853
Using semantics for representing experimental protocols. PMID:29132408
Early decreased TLR2 expression on monocytes is associated with their reduced phagocytic activity and impaired maturation in a porcine polytrauma model. PMID:29125848
A prototype small-bore ventilation catheter with a cuff: cuff inflation optimizes ventilation with the Ventrain. PMID:29119549
N-acetyl cysteine reverses bio-behavioural changes induced by prenatal inflammation, adolescent methamphetamine exposure and combined challenges. PMID:29116368
The Academic-Industrial Complexity: Failure to Launch. PMID:29111229
Common data elements for preclinical epilepsy research: Standards for data collection and reporting. A TASK3 report of the AES/ILAE Translational Task Force of the ILAE. PMID:29105074
Garcinia mangostana Linn displays antidepressant-like and pro-cognitive effects in a genetic animal model of depression: a bio-behavioral study in the Flinders Sensitive Line rat. PMID:29101602
Ghrelin therapy improves lung and cardiovascular function in experimental emphysema. PMID:29100513
Contribution of GABAa, GABAc and glycine receptors to rat dark-adapted oscillatory potentials in the time and frequency domain. PMID:29100418
Improved identification and quantitation of mature endogenous peptides in the rodent hypothalamus using a rapid conductive sample heating system. PMID:29098220
Reduced Expression of VAMP8 in Lacrimal Gland Affected by Chronic Graft-versus-Host Disease. PMID:29098081
Augmented cartilage regeneration by implantation of cellular versus acellular implants after bone marrow stimulation: a systematic review and meta-analysis of animal studies. PMID:29093996
PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models. PMID:29092942
Reproducibility of science: Fraud, impact factors and carelessness. PMID:29079076
Preclinical mouse solid tumour models: status quo, challenges and perspectives. PMID:29077691
A New Method for Targeted and Sustained Induction of Type 2 Diabetes in Rodents. PMID:29075006
Ultra-low Doses of Follicle Stimulating Hormone and Progesterone Attenuate the Severity of Polycystic Ovary Syndrome Features in a Hyperandrogenized Mouse Model. PMID:29062793
Murine genotype impacts pancreatitis severity and systemic inflammation: An experimental study. PMID:29062479
Reliability of transcardiopulmonary thermodilution cardiac output measurement in experimental aortic valve insufficiency. PMID:29049339
ZnT3 Gene Deletion Reduces Colchicine-Induced Dentate Granule Cell Degeneration. PMID:29048371
The role of PI3Kα isoform in cardioprotection. PMID:29043508
Characterisation of fibrosis in chemically-induced rat mammary carcinomas using multi-modal endogenous contrast MRI on a 1.5T clinical platform. PMID:29038934
Risk of bias reporting in the recent animal focal cerebral ischaemia literature. PMID:29026002
Stroke-induced chronic systolic dysfunction driven by sympathetic overactivity. PMID:29023958
The Mechanical Properties and Biometrical Effect of 3D Preformed Titanium Membrane for Guided Bone Regeneration on Alveolar Bone Defect. PMID:29018818
Experimental Models of Maternal Obesity and Neuroendocrine Programming of Metabolic Disorders in Offspring. PMID:28993758
Citrobacter rodentium Subverts ATP Flux and Cholesterol Homeostasis in Intestinal Epithelial Cells In Vivo. PMID:28988824
Determination of stable reference genes for RT-qPCR expression data in mechanistic pain studies on pig dorsal root ganglia and spinal cord. PMID:28987956
ATP catabolism by tissue nonspecific alkaline phosphatase contributes to development of ARDS in influenza-infected mice. PMID:28982733
Systematic Review and Meta-Analysis of Early-Life Exposure to Bisphenol A and Obesity-Related Outcomes in Rodents. PMID:28982642
The Locus Coeruleus-Norepinephrine System Mediates Empathy for Pain through Selective Up-Regulation of P2X3 Receptor in Dorsal Root Ganglia in Rats. PMID:28979194
Intrinsic remote conditioning of the myocardium as a comprehensive cardiac response to ischemia and reperfusion. PMID:28978029
Mesenchymal stromal cell therapy reduces lung inflammation and vascular remodeling and improves hemodynamics in experimental pulmonary arterial hypertension. PMID:28974252
Tacrolimus rescues the signaling and gene expression signature of endothelial ALK1 loss-of-function and improves HHT vascular pathology. PMID:28973643
Alternative technique or mitigating strategy for sevoflurane-induced neurodegeneration: a randomized controlled dose-escalation study of dexmedetomidine in neonatal rats. PMID:28969315
Establishing a Rodent Model of Ventricular Fibrillation Cardiac Arrest With Graded Histologic and Neurologic Damage With Different Cardiac Arrest Durations. PMID:28968287
Arctic ground squirrel resist peroxynitrite-mediated cell death in response to oxygen glucose deprivation. PMID:28962873
The Experimental Design Assistant. PMID:28960183
Cellular and Molecular Mechanisms of REM Sleep Homeostatic Drive: A Plausible Component for Behavioral Plasticity. PMID:28959190
Enhancing Scientific Foundations to Ensure Reproducibility: A New Paradigm. PMID:28958817
Xiphoid Surface Temperature Predicts Mortality in a Murine Model of Septic Shock. PMID:28957876
The Experimental Design Assistant. PMID:28957312
Oxytocin as an Indicator of Psychological and Social Well-Being in Domesticated Animals: A Critical Review. PMID:28955264
Comparative Medicine: An Inclusive Crossover Discipline. PMID:28955187
Sex-Specific Modulation of Fetal Adipogenesis by Gestational Bisphenol A and Bisphenol S Exposure. PMID:28938450
Periodontal-induced chronic inflammation triggers macrophage secretion of Ccl12 to inhibit fibroblast-mediated cardiac wound healing. PMID:28931761
Inhibition of IL-1β Signaling Normalizes NMDA-Dependent Neurotransmission and Reduces Seizure Susceptibility in a Mouse Model of Creutzfeldt-Jakob Disease. PMID:28924012
Adult hippocampal neurogenesis poststroke: More new granule cells but aberrant morphology and impaired spatial memory. PMID:28910298
A checklist is associated with increased quality of reporting preclinical biomedical research: A systematic review. PMID:28902887
Aged blood factors decrease cellular responses associated with delayed gingival wound repair. PMID:28898261
Nerve-specific, xenogeneic extracellular matrix hydrogel promotes recovery following peripheral nerve injury. PMID:28891122
Computer modeling defines the system driving a constant current crucial for homeostasis in the mammalian cochlea by integrating unique ion transports. PMID:28861279
A Systematic Review of the Quality of IV Fluid Therapy in Veterinary Medicine. PMID:28856137
Novel Influences of IL-10 on CNS Inflammation Revealed by Integrated Analyses of Cytokine Networks and Microglial Morphology. PMID:28855862
Beneficial Effects of Delayed P7C3-A20 Treatment After Transient MCAO in Rats. PMID:28842830
Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase. PMID:28839250
The Purine Salvage Pathway and the Restoration of Cerebral ATP: Implications for Brain Slice Physiology and Brain Injury. PMID:28836168
Melatonin limits paclitaxel-induced mitochondrial dysfunction in vitro and protects against paclitaxel-induced neuropathic pain in the rat. PMID:28833461
Diet-induced vitamin D deficiency has no effect on acute post-stroke outcomes in young male mice. PMID:28832249
Recovery of hippocampal functions and modulation of muscarinic response by electroacupuncture in young diabetic rats. PMID:28831054
Atlas registration for edema-corrected MRI lesion volume in mouse stroke models. PMID:28829217
Intravenous immune-modifying nanoparticles as a therapy for spinal cord injury in mice. PMID:28823935
Age exacerbates microglial activation, oxidative stress, inflammatory and NOX2 gene expression, and delays functional recovery in a middle-aged rodent model of spinal cord injury. PMID:28821269
Performance, biochemical and haematological responses, and relative organ weights of laying hens fed diets supplemented with prebiotic, probiotic and synbiotic. PMID:28814309
Approaches to Evaluate Lung Inflammation in Translational Research. PMID:28812529
Chitosan in viscosupplementation: in vivo effect on rabbit subchondral bone. PMID:28810851
The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments). PMID:28797196
Different behavior of myeloperoxidase in two rodent amoebic liver abscess models. PMID:28796788
Chemoprotective effects of butanol fraction of Buchholzia coriacea (Capparidaceae) against type 2 diabetes and oxidative stress in male Wistar rats. PMID:28790167
Pre-clinical imaging of transgenic mouse models of neuroblastoma using a dedicated 3-element solenoid coil on a clinical 3T platform. PMID:28787429
Neuroprotection of Catalpol for Experimental Acute Focal Ischemic Stroke: Preclinical Evidence and Possible Mechanisms of Antioxidation, Anti-Inflammation, and Antiapoptosis. PMID:28785376
Evaluation of the Response of Intracranial Xenografts to VEGF Signaling Inhibition Using Multiparametric MRI. PMID:28780387
Deoxyarbutin displays antitumour activity against melanoma in vitro and in vivo through a p38-mediated mitochondria associated apoptotic pathway. PMID:28775302
Advances in nonhuman primate models of autism: Integrating neuroscience and behavior. PMID:28774750
PREPARE: guidelines for planning animal research and testing. PMID:28771074
Massive Accumulation of Myofibroblasts in the Critical Isthmus Is Associated With Ventricular Tachycardia Inducibility in Post-Infarct Swine Heart. PMID:28770255
Effects of date palm pollen on fertility: research proposal for a systematic review. PMID:28764804
Effects of individualized electrical impedance tomography and image reconstruction settings upon the assessment of regional ventilation distribution: Comparison to 4-dimensional computed tomography in a porcine model. PMID:28763474
A novel preventive therapy for paclitaxel-induced cognitive deficits: preclinical evidence from C57BL/6 mice. PMID:28763058
Differential effects of late gestation maternal overnutrition on the regulation of surfactant maturation in fetal and postnatal life. PMID:28759122
Reducing Animal Use with a Biotelemetry-Enhanced Murine Model of Sepsis. PMID:28747734
Sleep-Dependent Oscillatory Synchronization: A Role in Fear Memory Consolidation. PMID:28729826
Selective matrix metalloproteinase inhibition increases breaking strength and reduces anastomotic leakage in experimentally obstructed colon. PMID:28717842
Vitamin A Affects Flatfish Development in a Thyroid Hormone Signaling and Metamorphic Stage Dependent Manner. PMID:28713287
Mouse models of 17q21.31 microdeletion and microduplication syndromes highlight the importance of Kansl1 for cognition. PMID:28704368
Quality of reporting of otorhinolaryngology articles using animal models with the ARRIVE statement. PMID:28696159
qMotor, a set of rules for sensitive, robust and quantitative measurement of motor performance in mice. PMID:28686587
Butyrate Reduces HFD-Induced Adipocyte Hypertrophy and Metabolic Risk Factors in Obese LDLr-/-.Leiden Mice. PMID:28686216
Publication bias in animal research presented at the 2008 Society of Critical Care Medicine Conference. PMID:28683761
Post-stroke angiotensin II type 2 receptor activation provides long-term neuroprotection in aged rats. PMID:28671997
Considerations for Infectious Disease Research Studies Using Animals. PMID:28662751
Propofol, Sevoflurane, and Ketamine Induce a Reversible Increase in Delta-Gamma and Theta-Gamma Phase-Amplitude Coupling in Frontal Cortex of Rat. PMID:28659769
Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells. PMID:28659575
Effects of Low-Dose Developmental Bisphenol A Exposure on Metabolic Parameters and Gene Expression in Male and Female Fischer 344 Rat Offspring. PMID:28657538
Tail-Cuff Technique and Its Influence on Central Blood Pressure in the Mouse. PMID:28655735
Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium. PMID:28650483
Next-generation mammalian genetics toward organism-level systems biology. PMID:28649442
Pretreatment with Sodium Phenylbutyrate Alleviates Cerebral Ischemia/Reperfusion Injury by Upregulating DJ-1 Protein. PMID:28649223
Human germline hedgehog pathway mutations predispose to fatty liver. PMID:28645738
Lack of adaptation during prolonged split-belt locomotion in the intact and spinal cat. PMID:28643899
Biomedical text mining for research rigor and integrity: tasks, challenges, directions. PMID:28633401
Sex differences in prostaglandin biosynthesis in neutrophils during acute inflammation. PMID:28630405
A robust methodology for the quantitative assessment of the rat jawbone microstructure. PMID:28621323
PTH [1-34] induced differentiation and mineralization of mandibular condylar cartilage. PMID:28607469
Th1/Th2 Balance and Th17/Treg-Mediated Immunity in relation to Murine Resistance to Dextran Sulfate-Induced Colitis. PMID:28584821
Accelerating Biomedical Discoveries through Rigor and Transparency. PMID:28575443
Global position paper on cardiovascular regenerative medicine. PMID:28575280
Differences in inflammation and acute phase response but similar genotoxicity in mice following pulmonary exposure to graphene oxide and reduced graphene oxide. PMID:28570647
Chemically induced mouse models of acute and chronic intestinal inflammation. PMID:28569761
Monitoring the Vascular Response and Resistance to Sunitinib in Renal Cell Carcinoma In Vivo with Susceptibility Contrast MRI. PMID:28566330
Chronic treatment with paeonol improves endothelial function in mice through inhibition of endoplasmic reticulum stress-mediated oxidative stress. PMID:28562691
A systematic review of the asymmetric inheritance of cellular organelles in eukaryotes: A critique of basic science validity and imprecision. PMID:28562636
Extracorporeal Life Support Increases Survival After Prolonged Ventricular Fibrillation Cardiac Arrest in the Rat. PMID:28562481
MiR-650 represses high-risk non-metastatic colorectal cancer progression via inhibition of AKT2/GSK3β/E-cadherin pathway. PMID:28548936
Ageing is associated with brown adipose tissue remodelling and loss of white fat browning in female C57BL/6 mice. PMID:28543963
Evaluation of connectivity map-discovered celastrol as a radiosensitizing agent in a murine lung carcinoma model: Feasibility study of diffusion-weighted magnetic resonance imaging. PMID:28542649
Biofilm microenvironment induces a widespread adaptive amino-acid fermentation pathway conferring strong fitness advantage in Escherichia coli. PMID:28542503
Circulating Heparan Sulfate Fragments Attenuate Histone-Induced Lung Injury Independently of Histone Binding. PMID:28538085
In vivo effect of Commiphora swynnertonii ethanolic extracts on Trypanosoma congolense and selected immunological components in mice. PMID:28535783
Mechanistic link between diesel exhaust particles and respiratory reflexes. PMID:28532657
Postepizootic Persistence of Asymptomatic Mycoplasma conjunctivae Infection in Iberian Ibex. PMID:28526790
Metabolomics of Therapy Response in Preclinical Glioblastoma: A Multi-Slice MRSI-Based Volumetric Analysis for Noninvasive Assessment of Temozolomide Treatment. PMID:28524099
Effect of a high-fat diet and alcohol on cutaneous repair: A systematic review of murine experimental models. PMID:28493875
Delineating morbillivirus entry, dissemination and airborne transmission by studying in vivo competition of multicolor canine distemper viruses in ferrets. PMID:28481926
Anti-Onchocerca and Anti-Caenorhabditis Activity of a Hydro-Alcoholic Extract from the Fruits of Acacia nilotica and Some Proanthocyanidin Derivatives. PMID:28481237
Preclinical transgenic and patient-derived xenograft models recapitulate the radiological features of human adamantinomatous craniopharyngioma. PMID:28481062
Review of surgical implant procedures for male incontinence after radical prostatectomy according to IDEAL framework. PMID:28478521
Effect of solvents extraction on phytochemical components and biological activities of Tunisian date seeds (var. Korkobbi and Arechti). PMID:28472941
Repeated-dose toxicity of common ragweed on rats. PMID:28472131
Mechanisms responsible for the inhibitory effects of epothilone B on scar formation after spinal cord injury. PMID:28469665
The Antinociceptive Effect of Light-Emitting Diode Irradiation on Incised Wounds Is Correlated with Changes in Cyclooxygenase 2 Activity, Prostaglandin E2, and Proinflammatory Cytokines. PMID:28469528
The effect of dexmedetomidine on cerebral perfusion and oxygenation in healthy piglets with normal and lowered blood pressure anaesthetized with propofol-remifentanil total intravenous anaesthesia. PMID:28468670
Critical overview of all available animal models for abdominal wall hernia research. PMID:28466188
Augmented Serum Amyloid A1/2 Mediated by TNF-induced NF-κB in Human Serous Ovarian Epithelial Tumors. PMID:28458624
Effect of Oral Administration of Gnidia Stenophylla Gilg Aqueous Root Extract on Food Intake and Histology of Gastrointestinal Tract in Mice. PMID:28458489
Assessing mouse behaviour throughout the light/dark cycle using automated in-cage analysis tools. PMID:28456660
Age-associated changes in the blood-brain barrier: comparative studies in human and mouse. PMID:28453876
Allogeneic pASC transplantation in humanized pigs attenuates cardiac remodeling post-myocardial infarction. PMID:28448588
Pharmacokinetic and pharmacodynamic modelling after subcutaneous, intravenous and buccal administration of a high-concentration formulation of buprenorphine in conscious cats. PMID:28445495
Ribonucleotide Reductase Catalytic Subunit M1 (RRM1) as a Novel Therapeutic Target in Multiple Myeloma. PMID:28442502
A link between central kynurenine metabolism and bone strength in rats with chronic kidney disease. PMID:28439468
Acute inflammation reveals GABAA receptor-mediated nociception in mouse dorsal root ganglion neurons via PGE2 receptor 4 signaling. PMID:28438981
Hypertension, cerebrovascular impairment, and cognitive decline in aged AβPP/PS1 mice. PMID:28435465
A systematic review of discomfort due to toe or ear clipping in laboratory rodents. PMID:28429644
Intra-arterial verapamil post-thrombectomy is feasible, safe, and neuroprotective in stroke. PMID:28429604
Design, analysis and reporting of tumor models. PMID:28422097
Meloxicam ameliorates the cartilage and subchondral bone deterioration in monoiodoacetate-induced rat osteoarthritis. PMID:28413731
Analgesic efficacy of tramadol in cats with naturally occurring osteoarthritis. PMID:28403198
The effect of L-PRF membranes on bone healing in rabbit tibiae bone defects: micro-CT and biomarker results. PMID:28401929
Thyroxine Exposure Effects on the Cranial Base. PMID:28391432
Enhancing the toolbox to study IL-17A in cattle and sheep. PMID:28388924
Cdh13 and AdipoQ gene knockout alter instrumental and Pavlovian drug conditioning. PMID:28387990
Antenatal dexamethasone before asphyxia promotes cystic neural injury in preterm fetal sheep by inducing hyperglycemia. PMID:28387144
The Interplay of Ethics, Animal Welfare, and IACUC Oversight on the Reproducibility of Animal Studies. PMID:28381309
Survey of basic medical researchers on the awareness of animal experimental designs and reporting standards in China. PMID:28380050
Translational Modeling of Drug-Induced Myelosuppression and Effect of Pretreatment Myelosuppression for AZD5153, a Selective BRD4 Inhibitor. PMID:28378926
Methodological Rigor in Preclinical Cardiovascular Studies: Targets to Enhance Reproducibility and Promote Research Translation. PMID:28373349
In vivo MRI and ex vivo histological assessment of the cardioprotection induced by ischemic preconditioning, postconditioning and remote conditioning in a closed-chest porcine model of reperfused acute myocardial infarction: importance of microvasculature. PMID:28364777
Contributions of space-clamp errors to apparent time-dependent loss of Mg2+ block induced by NMDA. PMID:28356471
Reducing Caloric Intake Prevents Ischemic Injury and Myocardial Dysfunction and Affects Anesthetic Cardioprotection in Type 2 Diabetic Rats. PMID:28349068
24S-hydroxycholesterol and 25-hydroxycholesterol differentially impact hippocampal neuronal survival following oxygen-glucose deprivation. PMID:28346482
Microbiota and reproducibility of rodent models. PMID:28328896
Introducing Therioepistemology: the study of how knowledge is gained from animal research. PMID:28328885
The role of the IACUC in ensuring research reproducibility. PMID:28328872
Implication of VEGF and aquaporin 4 mediating Müller cell swelling to diabetic retinal edema. PMID:28303331
Oesophageal heat exchangers with a diameter of 11mm or 14.7mm are equally effective and safe for targeted temperature management. PMID:28291783
Killing of Staphylococcus aureus and Salmonella enteritidis and neutralization of lipopolysaccharide by 17-residue bovine lactoferricins: improved activity of Trp/Ala-containing molecules. PMID:28287172
Data Standardization and Quality Management. PMID:28283966
Allogenic adipose-derived stem cell therapy overcomes ischemia-induced microvessel rarefaction in the myocardium: systems biology study. PMID:28279225
Neurotoxic Doses of Chronic Methamphetamine Trigger Retrotransposition of the Identifier Element in Rat Dorsal Dentate Gyrus. PMID:28272323
A specific dietary intervention to restore brain structure and function after ischemic stroke. PMID:28255345
Can Quality Improvement Tools Overcome the Translational Roadblock-the Vital Influence of the Researcher. PMID:28236151
Improved Social Interaction, Recognition and Working Memory with Cannabidiol Treatment in a Prenatal Infection (poly I:C) Rat Model. PMID:28230072
Reconsideration of Serial Visual Reversal Learning in Octopus (Octopus vulgaris) from a Methodological Perspective. PMID:28223940
Arctic ground squirrel hippocampus tolerates oxygen glucose deprivation independent of hibernation season even when not hibernating and after ATP depletion, acidosis, and glutamate efflux. PMID:28222226
Butyrate restores HFD-induced adaptations in brain function and metabolism in mid-adult obese mice. PMID:28220041
Automated Ischemic Lesion Segmentation in MRI Mouse Brain Data after Transient Middle Cerebral Artery Occlusion. PMID:28197090
Establishment and characterization of a novel highly aggressive gallbladder cancer cell line, TJ-GBC2. PMID:28194091
Triggering Cell Stress and Death Using Conventional UV Laser Confocal Microscopy. PMID:28190072
[Direct oral anticoagulants and acute stroke : Insights into translational research studies]. PMID:28188404
Evolution of ischemic damage and behavioural deficit over 6 months after MCAo in the rat: Selecting the optimal outcomes and statistical power for multi-centre preclinical trials. PMID:28182727
The Effect of Oral Vaccination with Mycobacterium bovis BCG on the Development of Tuberculosis in Captive European Badgers (Meles meles). PMID:28174695
Characterization of murine polyspecific monoamine transporters. PMID:28174689
Heavy Chain-Hyaluronan/Pentraxin 3 from Amniotic Membrane Suppresses Inflammation and Scarring in Murine Lacrimal Gland and Conjunctiva of Chronic Graft-versus-Host Disease. PMID:28165063
Novel Treatment of Chronic Graft-Versus-Host Disease in Mice Using the ER Stress Reducer 4-Phenylbutyric Acid. PMID:28165054
Inhibition of neutrophil elastase contributes to attenuation of lipopolysaccharide-induced acute lung injury during neutropenia recovery in mice. PMID:28144780
A Systematic and Meta-Analysis of Mortality in Experimental Mouse Models Analyzing Delayed Cerebral Ischemia After Subarachnoid Hemorrhage. PMID:28138916
Maternal Immune Activation and Autism Spectrum Disorder: From Rodents to Nonhuman and Human Primates. PMID:28137374
Influence of uncontrolled diabetes mellitus on periodontal tissues during orthodontic tooth movement: a systematic review of animal studies. PMID:28133716
Impact of Stroke Therapy Academic Industry Roundtable (STAIR) Guidelines on Peri-Anesthesia Care for Rat Models of Stroke: A Meta-Analysis Comparing the Years 2005 and 2015. PMID:28122007
Histamine Increases Neuronal Excitability and Sensitivity of the Lateral Vestibular Nucleus and Promotes Motor Behaviors via HCN Channel Coupled to H2 Receptor. PMID:28119568
Translational models for vascular cognitive impairment: a review including larger species. PMID:28118831
Recent advances in understanding neuropathic pain: glia, sex differences, and epigenetics. PMID:28105313
A signature of renal stress resistance induced by short-term dietary restriction, fasting, and protein restriction. PMID:28102354
21st Century Cell Culture for 21st Century Toxicology. PMID:28092941
Time-Dependent Lactate Production and Amino Acid Utilization in Cultured Astrocytes Under High Glucose Exposure. PMID:28092089
Molecular Mechanisms of Increased Heart Rate in Shenxianshengmai-treated Bradycardia Rabbits. PMID:28091410
Absence of system xc- on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis. PMID:28086920
Compendium of TCDD-mediated transcriptomic response datasets in mammalian model systems. PMID:28086803
Effect of ginseng extract on the TGF-β1 signaling pathway in CCl4-induced liver fibrosis in rats. PMID:28086769
Dose- and time-dependent effects of clodronate on orthodontic tooth movement. PMID:28086064
Hypothermia revisited: Impact of ischaemic duration and between experiment variability. PMID:28084873
The Sharing Experimental Animal Resources, Coordinating Holdings (SEARCH) Framework: Encouraging Reduction, Replacement, and Refinement in Animal Research. PMID:28081116
Genome-wide transposon screening and quantitative insertion site sequencing for cancer gene discovery in mice. PMID:28079877
Effect of tualang honey against KA-induced oxidative stress and neurodegeneration in the cortex of rats. PMID:28068984
Inhibition of Connexin43 Hemichannels Impairs Spatial Short-Term Memory without Affecting Spatial Working Memory. PMID:28066184
Ischemic stroke: experimental models and reality. PMID:28064357
Antiinflammatory actions of inorganic nitrate stabilize the atherosclerotic plaque. PMID:28057862
Genome-wide in vivo screen identifies novel host regulators of metastatic colonization. PMID:28052056
Preclinical Applications of 3'-Deoxy-3'-[18F]Fluorothymidine in Oncology - A Systematic Review. PMID:28042315
Chlorogenic Acid Prevents Osteoporosis by Shp2/PI3K/Akt Pathway in Ovariectomized Rats. PMID:28033335
E2-25K SUMOylation inhibits proteasome for cell death during cerebral ischemia/reperfusion. PMID:28032866
Intra-arterial nitroglycerin as directed acute treatment in experimental ischemic stroke. PMID:28031354
Activation of brain-derived neurotrophic factor-tropomyosin receptor kinase B signaling in the pedunculopontine tegmental nucleus: a novel mechanism for the homeostatic regulation of rapid eye movement sleep. PMID:28027399
Micronucleated Erythrocytes in Peripheral Blood from Neonate Rats Exposed by Breastfeeding to Cyclophosphamide, Colchicine, or Cytosine-Arabinoside. PMID:28018917
Characterization of blunt chest trauma in a long-term porcine model of severe multiple trauma. PMID:28000769
Does therapeutic hypothermia during extracorporeal cardiopulmonary resuscitation preserve cardiac function? PMID:27998282
Quantitative data describing the impact of the flavonol rutin on in-vivo blood-glucose and fluid-intake profiles, and survival of human-amylin transgenic mice. PMID:27995166
Astrocyte-derived interleukin-15 exacerbates ischemic brain injury via propagation of cellular immunity. PMID:27994144
Effects of In Utero Thyroxine Exposure on Murine Cranial Suture Growth. PMID:27959899
Systemic review and meta-analysis of diagnostic imaging technologies. PMID:27942483
ACLAM Position Statement on Reproducibility. PMID:27931326
High-Speed Mouse Backcrossing Through the Female Germ Line. PMID:27926922
The Researchers' View of Scientific Rigor-Survey on the Conduct and Reporting of In Vivo Research. PMID:27911901
Authorization of Animal Experiments Is Based on Confidence Rather than Evidence of Scientific Rigor. PMID:27911892
A Laboratory Critical Incident and Error Reporting System for Experimental Biomedicine. PMID:27906976
Methodological Considerations for Optimizing and Validating Behavioral Assays. PMID:27906464
Examining potential side effects of therapeutic hypothermia in experimental intracerebral hemorrhage. PMID:27899766
Lovastatin fails to improve motor performance and survival in methyl-CpG-binding protein2-null mice. PMID:27892851
Evaluating mesenchymal stem cell therapy for sepsis with preclinical meta-analyses prior to initiating a first-in-human trial. PMID:27870924
Preclinical randomized controlled multicenter trials in translational stroke research. PMID:27868026
Reparative effects of interleukin-1 receptor antagonist in young and aged/co-morbid rodents after cerebral ischemia. PMID:27856349
The Devil Is in the Details: Incomplete Reporting in Preclinical Animal Research. PMID:27855228
Machine perfusion versus cold storage of livers: a meta-analysis. PMID:27837413
Effect of Topical Administration of Fractions and Isolated Molecules from Plant Extracts on Skin Wound Healing: A Systematic Review of Murine Experimental Models. PMID:27829707
Vasculogenic mimicry in small cell lung cancer. PMID:27827359
Inhibition of citrate cotransporter Slc13a5/mINDY by RNAi improves hepatic insulin sensitivity and prevents diet-induced non-alcoholic fatty liver disease in mice. PMID:27818933
Spatio-temporal profile, phenotypic diversity, and fate of recruited monocytes into the post-ischemic brain. PMID:27814740
Use of non-invasive imaging to monitor response to aflibercept treatment in murine models of colorectal cancer liver metastases. PMID:27812769
Deregulated expression of HDAC9 in B cells promotes development of lymphoproliferative disease and lymphoma in mice. PMID:27799148
Health evaluation of African penguins (<i>Spheniscus demersus</i>) in southern Africa. PMID:27796116
One compound of saponins from Disocorea zingiberensis protected against experimental acute pancreatitis by preventing mitochondria-mediated necrosis. PMID:27779235
Myoferlin regulates cellular lipid metabolism and promotes metastases in triple-negative breast cancer. PMID:27775075
Investigating the Vascular Phenotype of Subcutaneously and Orthotopically Propagated PC3 Prostate Cancer Xenografts Using Combined Carbogen Ultrasmall Superparamagnetic Iron Oxide MRI. PMID:27748709
Radiologic and histological observations in experimental T1-T12 dorsal arthrodesis: A qualitative description of T1-T12 segment and other body parts involved, between prepubertal age and skeletal maturityxs. PMID:27746501
Purification of functional human ES and iPSC-derived midbrain dopaminergic progenitors using LRTM1. PMID:27739432
Preclinical Study of Single-Dose Moxidectin, a New Oral Treatment for Scabies: Efficacy, Safety, and Pharmacokinetics Compared to Two-Dose Ivermectin in a Porcine Model. PMID:27732588
Cellular and Matrix Response of the Mandibular Condylar Cartilage to Botulinum Toxin. PMID:27723812
NF-κB-Mediated CCL20 Reigns Dominantly in CXCR2-Driven Ovarian Cancer Progression. PMID:27723802
Adoptive transfer of M2 macrophages reduces neuropathic pain via opioid peptides. PMID:27717401
Modulation of renal oxygenation and perfusion in rat kidney monitored by quantitative diffusion and blood oxygen level dependent magnetic resonance imaging on a clinical 1.5T platform. PMID:27716094
Pharmacological mechanisms underlying the cardiovascular effects of the "bath salt" constituent 3,4-methylenedioxypyrovalerone (MDPV). PMID:27714779
Effects of voluntary exercise on structure and function of cortical microvasculature. PMID:27683451
Investigating intracranial tumour growth patterns with multiparametric MRI incorporating Gd-DTPA and USPIO-enhanced imaging. PMID:27671990
A systematic review and meta-analysis of gene therapy in animal models of cerebral glioma: why did promise not translate to human therapy? PMID:27668084
The EP1/EP3 receptor agonist 17-pt-PGE2 acts as an EP4 receptor agonist on endothelial barrier function and in a model of LPS-induced pulmonary inflammation. PMID:27664754
Efficient genome engineering approaches for the short-lived African turquoise killifish. PMID:27658015
Deptor transcriptionally regulates endoplasmic reticulum homeostasis in multiple myeloma cells. PMID:27655709
The effect of perioperative insulin treatment on cardiodepression in mild adiposity in mice. PMID:27651131
Thrombomodulin blocks calcineurin inhibitor-induced vascular permeability via inhibition of Src/VE-cadherin axis. PMID:27643869
Cross-centre replication of suppressed burrowing behaviour as an ethologically relevant pain outcome measure in the rat: a prospective multicentre study. PMID:27643836
Metformin protects against infection-induced myocardial dysfunction. PMID:27621180
Genetic Background Limits Generalizability of Genotype-Phenotype Relationships. PMID:27618673
Effects of 21-day d-amphetamine and risperidone treatment on cocaine vs food choice and extended-access cocaine intake in male rhesus monkeys. PMID:27615401
Citrobacter rodentium mouse model of bacterial infection. PMID:27606775
Distinct roles of exogenous opioid agonists and endogenous opioid peptides in the peripheral control of neuropathy-triggered heat pain. PMID:27605249
Colony stimulating factor 1 receptor inhibition eliminates microglia and attenuates brain injury after intracerebral hemorrhage. PMID:27596835
Angiotensin II, hypertension and angiotensin II receptor antagonism: Roles in the behavioural and brain pathology of a mouse model of Alzheimer's disease. PMID:27596834
Efficacy of Polyvalent Human Immunoglobulins in an Animal Model of Neuromyelitis Optica Evoked by Intrathecal Anti-Aquaporin 4 Antibodies. PMID:27571069
Molecular Mechanisms of Anesthetic Neurotoxicity: A Review of the Current Literature. PMID:27564556
A Good Death? Report of the Second Newcastle Meeting on Laboratory Animal Euthanasia. PMID:27563926
Heterogeneous incidence and propagation of spreading depolarizations. PMID:27562866
Shrinkage-mediated imaging of entire organs and organisms using uDISCO. PMID:27548807
Partial loss of VE-cadherin improves long-term outcome and cerebral blood flow after transient brain ischemia in mice. PMID:27538712
Acute tumour response to a bispecific Ang-2-VEGF-A antibody: insights from multiparametric MRI and gene expression profiling. PMID:27529514
Systematic Review and Meta-Analysis of the Efficacy of Interleukin-1 Receptor Antagonist in Animal Models of Stroke: an Update. PMID:27526101
Capsaicin-Sensitive Sensory Nerves Mediate the Cellular and Microvascular Effects of H2S via TRPA1 Receptor Activation and Neuropeptide Release. PMID:27525636
Deficiency and Also Transgenic Overexpression of Timp-3 Both Lead to Compromised Bone Mass and Architecture In Vivo. PMID:27519049
Efficacy of Soiled Bedding Transfer for Transmission of Mouse and Rat Infections to Sentinels: A Systematic Review. PMID:27518654
Patient-derived xenograft models of colorectal cancer in pre-clinical research: a systematic review. PMID:27517155
Dissociable effects of the prodrug phendimetrazine and its metabolite phenmetrazine at dopamine transporters. PMID:27514281
Mechanistic characterization of nitrite-mediated neuroprotection after experimental cardiac arrest. PMID:27507435
Soluble Urokinase Receptors in Focal Segmental Glomerulosclerosis: A Review on the Scientific Point of View. PMID:27504461
Carbogen-induced increases in tumor oxygenation depend on the vascular status of the tumor: A multiparametric MRI study in two rat glioblastoma models. PMID:27496553
Superselective intra-arterial hepatic injection of indocyanine green (ICG) for fluorescence image-guided segmental positive staining: experimental proof of the concept. PMID:27495341
Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life. PMID:27489884
Interaction of ARC and Daxx: A Novel Endogenous Target to Preserve Motor Function and Cell Loss after Focal Brain Ischemia in Mice. PMID:27488634
Show and tell: disclosure and data sharing in experimental pathology. PMID:27483498
Statistical Rigor and the Perils of Chance. PMID:27482537
Optimized design and analysis of preclinical intervention studies in vivo. PMID:27480578
Physical Activity Counteracts Tumor Cell Growth in Colon Carcinoma C26-Injected Muscles: An Interim Report. PMID:27478560
The effects of two-stage carotid occlusion on spatial memory and pro-inflammatory markers in the hippocampus of rats. PMID:27470129
PIK3CA dependence and sensitivity to therapeutic targeting in urothelial carcinoma. PMID:27465249
The Efficacy of Trastuzumab in Animal Models of Breast Cancer: A Systematic Review and Meta-Analysis. PMID:27463246
Sarcoptic mange in the Scandinavian wolf Canis lupus population. PMID:27459965
Inadequate food and water intake determine mortality following stroke in mice. PMID:27449604
Steroid Androgen Exposure during Development Has No Effect on Reproductive Physiology of Biomphalaria glabrata. PMID:27448327
Effects of thyroxine exposure on the Twist 1 +/- phenotype: A test of gene-environment interaction modeling for craniosynostosis. PMID:27435288
A Porcine Animal Model for Early Meniscal Degeneration - Analysis of Histology, Gene Expression and Magnetic Resonance Imaging Six Months after Resection of the Anterior Cruciate Ligament. PMID:27434644
Genetic ablation of the p66Shc adaptor protein reverses cognitive deficits and improves mitochondrial function in an APP transgenic mouse model of Alzheimer's disease. PMID:27431297
Functional Rescue of Dopaminergic Neuron Loss in Parkinson's Disease Mice After Transplantation of Hematopoietic Stem and Progenitor Cells. PMID:27428421
Developing a Collaborative Agenda for Humanities and Social Scientific Research on Laboratory Animal Science and Welfare. PMID:27428071
Left-right coordination from simple to extreme conditions during split-belt locomotion in the chronic spinal adult cat. PMID:27426732
The oxidative stress theory of disease: levels of evidence and epistemological aspects. PMID:27425643
Synergistic impacts by an invasive amphipod and an invasive fish explain native gammarid extinction. PMID:27417858
Microbiota Dysbiosis Controls the Neuroinflammatory Response after Stroke. PMID:27413153
Computed Tomography Perfusion, Magnetic Resonance Imaging, and Histopathological Findings After Laparoscopic Renal Cryoablation: An In Vivo Pig Model. PMID:27402631
Rubus occidentalis alleviates hyperalgesia induced by repeated intramuscular injection of acidic saline in rats. PMID:27400712
Protocol for a retrospective, controlled cohort study of the impact of a change in Nature journals' editorial policy for life sciences research on the completeness of reporting study design and execution. PMID:27390387
Safety evaluation of Bon-santé cleanser® polyherbal in male Wistar rats. PMID:27387026
Melatonin Alters the Mechanical and Thermal Hyperalgesia Induced by Orofacial Pain Model in Rats. PMID:27378529
Transparent reporting for reproducible science. PMID:27377972
Host-Imposed Copper Poisoning Impacts Fungal Micronutrient Acquisition during Systemic Candida albicans Infections. PMID:27362522
Consomic mouse strain selection based on effect size measurement, statistical significance testing and integrated behavioral z-scoring: focus on anxiety-related behavior and locomotion. PMID:27357390
IL-13 from intraepithelial lymphocytes regulates tissue homeostasis and protects against carcinogenesis in the skin. PMID:27357235
Ibudilast attenuates expression of behavioral sensitization to cocaine in male and female rats. PMID:27343385
Effect of benazepril, robenacoxib and their combination on glomerular filtration rate in cats. PMID:27338786
Exogenous Administration of Recombinant MIF at Physiological Concentrations Failed to Attenuate Infarct Size in a Langendorff Perfused Isolated Mouse Heart Model. PMID:27335054
Precision real-time evaluation of bowel perfusion: accuracy of confocal endomicroscopy assessment of stoma in a controlled hemorrhagic shock model. PMID:27324327
Cytotoxicity of Cyanoacrylate-Based Tissue Adhesives and Short-Term Preclinical In Vivo Biocompatibility in Abdominal Hernia Repair. PMID:27322731
Magnesium sulfate reduces EEG activity but is not neuroprotective after asphyxia in preterm fetal sheep. PMID:27317658
Extended therapeutic window of a novel peptide inhibitor of TRPM2 channels following focal cerebral ischemia. PMID:27317297
PAR2-dependent activation of GSK3β regulates the survival of colon stem/progenitor cells. PMID:27313176
Does age matter? The impact of rodent age on study outcomes. PMID:27307423
Return of spontaneous Circulation Is Not Affected by Different Chest Compression Rates Superimposed with Sustained Inflations during Cardiopulmonary Resuscitation in Newborn Piglets. PMID:27304210
Histopathological Characterization of Tail Injury and Traumatic Neuroma Development after Tail Docking in Piglets. PMID:27302763
Isolation, culture and characterization of primary mouse RPE cells. PMID:27281648
Phase 4 Studies in Heart Failure - What is Done and What is Needed? PMID:27280303
Characterisation of the Novel Mixed Mu-NOP Peptide Ligand Dermorphin-N/OFQ (DeNo). PMID:27272042
Alcohol intake alters immune responses and promotes CNS viral persistence in mice. PMID:27269869
RetroDISCO: Clearing technique to improve quantification of retrograde labeled motor neurons of intact mouse spinal cords. PMID:27268155
Design and Reporting of Targeted Anticancer Preclinical Studies: A Meta-Analysis of Animal Studies Investigating Sorafenib Antitumor Efficacy. PMID:27261504
Identification of key metabolic changes in renal interstitial fibrosis rats using metabonomics and pharmacology. PMID:27256510
The Road to Reproducibility in Animal Research. PMID:27255286
Chronic spinal cord injury attenuates influenza virus-specific antiviral immunity. PMID:27245318
Olfactory Ensheathing Cell Transplantation in Experimental Spinal Cord Injury: Effect size and Reporting Bias of 62 Experimental Treatments: A Systematic Review and Meta-Analysis. PMID:27244556
Costs and Benefits to Pregnant Male Pipefish Caring for Broods of Different Sizes. PMID:27243937
Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor. PMID:27237957
Animal Models of Rheumatoid Arthritis (I): Pristane-Induced Arthritis in the Rat. PMID:27227821
A Systematic Review of the Modifying Effect of Anaesthetic Drugs on Metastasis in Animal Models for Cancer. PMID:27227779
Efficacy and safety of regenerative cell therapy for pulmonary arterial hypertension in animal models: a preclinical systematic review protocol. PMID:27225668
Neuroprotective effect of Cerebralcare Granule after cerebral ischemia/reperfusion injury. PMID:27212924
Partial white and grey matter protection with prolonged infusion of recombinant human erythropoietin after asphyxia in preterm fetal sheep. PMID:27207167
Risk of long-term anticoagulation under sustained severe arterial hypertension: A translational study comparing warfarin and the new oral anticoagulant apixaban. PMID:27189904
BioSharing: curated and crowd-sourced metadata standards, databases and data policies in the life sciences. PMID:27189610
Adherence to ARRIVE Guidelines in Chinese Journal Reports on Neoplasms in Animals. PMID:27182788
Data in support of the bone analysis of NOD-SCID mice treated with zoledronic acid and prednisolone. PMID:27182545
Pain and Laboratory Animals: Publication Practices for Better Data Reproducibility and Better Animal Welfare. PMID:27171143
Short-term effect of acute and repeated urinary bladder inflammation on thigmotactic behaviour in the laboratory rat. PMID:27158443
PABPN1-Dependent mRNA Processing Induces Muscle Wasting. PMID:27152426
2,3,7,8 Tetrachlorodibenzo-p-dioxin-induced RNA abundance changes identify Ackr3, Col18a1, Cyb5a and Glud1 as candidate mediators of toxicity. PMID:27136898
Neuron-immune mechanisms contribute to pain in early stages of arthritis. PMID:27130316
Effects of Early Post-Ischemic Reperfusion and tPA on Cerebrovascular Function and Nitrosative Stress in Female Rats. PMID:27125535
Precise Characterization of the Penumbra Revealed by MRI: A Modified Photothrombotic Stroke Model Study. PMID:27093556
CD8(+) T-cell Immune Evasion Enables Oncolytic Virus Immunotherapy. PMID:27077112
Berberine alleviates the cerebrovascular contractility in streptozotocin-induced diabetic rats through modulation of intracellular Ca²⁺ handling in smooth muscle cells. PMID:27067643
The Effects of Dietary Iron and Capsaicin on Hemoglobin, Blood Glucose, Insulin Tolerance, Cholesterol, and Triglycerides, in Healthy and Diabetic Wistar Rats. PMID:27064411
Cocaine-like discriminative stimulus effects of alpha-pyrrolidinovalerophenone, methcathinone and their 3,4-methylenedioxy or 4-methyl analogs in rhesus monkeys. PMID:27060605
Planar cell polarity gene expression correlates with tumor cell viability and prognostic outcome in neuroblastoma. PMID:27036398
Spontaneous Physical Activity Downregulates Pax7 in Cancer Cachexia. PMID:27034684
Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury. PMID:27033551
Enhanced c-Fos expression in the central amygdala correlates with increased thigmotaxis in rats with peripheral nerve injury. PMID:27030378
Cerebral haemodynamics during experimental intracranial hypertension. PMID:26994043
A Pharmacogenetic Discovery: Cystamine Protects Against Haloperidol-Induced Toxicity and Ischemic Brain Injury. PMID:26993135
The Effects of Granulocyte-Colony Stimulating Factor on Regeneration in Nerve Crush Injuries in Rats. PMID:26980007
Social Suppressive Behavior Is Organized by the Spatiotemporal Integration of Multiple Cortical Regions in the Japanese Macaque. PMID:26963915
Western diet enhances benzo(a)pyrene-induced colon tumorigenesis in a polyposis in rat coli (PIRC) rat model of colon cancer. PMID:26959117
Evidence-based review of oral traditional Chinese medicine compound recipe administration for treating weight drop-induced experimental traumatic brain injury. PMID:26956181
Bias in the reporting of sex and age in biomedical research on mouse models. PMID:26939790
Forelimb Kinematics of Rats Using XROMM, with Implications for Small Eutherians and Their Fossil Relatives. PMID:26933950
Effects of salinity on nest-building behaviour in a marine fish. PMID:26928449
Alcoholic vs non-alcoholic fatty liver in rats: distinct differences in endocytosis and vesicle trafficking despite similar pathology. PMID:26924554
Hyperglycemia-Induced Hypovolemia Is Involved in Early Cardiac Magnetic Resonance Alterations in Streptozotocin-Induced Diabetic Mice: A Comparison with Furosemide-Induced Hypovolemia. PMID:26901278
The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis. PMID:26899380
The effect of surgery (Ovariohysterectomy) on the plasma disposition of meloxicam following intravenous administration in dogs. PMID:26896943
Comparison of minilaparoscopy and single-incision intragastric surgery for gastric submucosal tumor resection in a porcine model. PMID:26895907
Study of in vivo catheter biofilm infections using pediatric central venous catheter implanted in rat. PMID:26890680
Long Noncoding RNA LOC100129973 Suppresses Apoptosis by Targeting miR-4707-5p and miR-4767 in Vascular Endothelial Cells. PMID:26887505
The Formation of Microthrombi in Parenchymal Microvessels after Traumatic Brain Injury Is Independent of Coagulation Factor XI. PMID:26886854
Thermal plasticity in farmed, wild and hybrid Atlantic salmon during early development: has domestication caused divergence in low temperature tolerance? PMID:26883947
Therapeutic potential of targeting microRNA-10b in established intracranial glioblastoma: first steps toward the clinic. PMID:26881967
Minimally Invasive Techniques to Accelerate the Orthodontic Tooth Movement: A Systematic Review of Animal Studies. PMID:26881201
A history of the evolution of guidelines for reporting medical research: the long road to the EQUATOR Network. PMID:26880653
Reciprocal Effects on Neurocognitive and Metabolic Phenotypes in Mouse Models of 16p11.2 Deletion and Duplication Syndromes. PMID:26872257
Toward Good Read-Across Practice (GRAP) guidance. PMID:26863606
HDAC7 inhibition resets STAT3 tumorigenic activity in human glioblastoma independently of EGFR and PTEN: new opportunities for selected targeted therapies. PMID:26853466
Development of a Rapid Insulin Assay by Homogenous Time-Resolved Fluorescence. PMID:26849707
Immunity Elicited by an Experimental Vaccine Based on Recombinant Flagellin-Porcine Circovirus Type 2 Cap Fusion Protein in Piglets. PMID:26848967
Laboratory rhesus macaque social housing and social changes: Implications for research. PMID:26848542
Using systematic reviews for hazard and risk assessment of endocrine disrupting chemicals. PMID:26847432
Reporting of Preclinical Research in Anesthesiology: Transparency and Enforcement. PMID:26845144
Using the mouse to model human disease: increasing validity and reproducibility. PMID:26839397
Effects of high and low 17β-estradiol doses on focal cerebral ischemia in rats. PMID:26839007
Deficiencies of effectiveness of intervention studies in veterinary medicine: a cross-sectional survey of ten leading veterinary and medical journals. PMID:26835187
Corticotropin releasing factor excites neurons of posterior hypothalamic nucleus to produce tachycardia in rats. PMID:26831220
Myocardial Perfusion and Function Are Distinctly Altered by Sevoflurane Anesthesia in Diet-Induced Prediabetic Rats. PMID:26824042
Pulse pressure-dependent cerebrovascular eNOS regulation in mice. PMID:26823473
Common swine models of cardiovascular disease for research and training. PMID:26814353
Magnetic Resonance Spectroscopy discriminates the response to microglial stimulation of wild type and Alzheimer's disease models. PMID:26813748
MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model. PMID:26809474
The Vital Role of Pathology in Improving Reproducibility and Translational Relevance of Aging Studies in Rodents. PMID:26792843
Transient receptor potential cation channel, subfamily V, member 4 and airway sensory afferent activation: Role of adenosine triphosphate. PMID:26792207
Oxidative Stress and the Use of Antioxidants in Stroke. PMID:26785066
Daily morphine administration increases impulsivity in rats responding under a 5-choice serial reaction time task. PMID:26776751
Identification of Proteins Implicated in the Increased Heart Rate in ShenSongYangXin-Treated Bradycardia Rabbits by iTRAQ-Based Quantitative Proteomics. PMID:26770253
Exhaled CO2 Parameters as a Tool to Assess Ventilation-Perfusion Mismatching during Neonatal Resuscitation in a Swine Model of Neonatal Asphyxia. PMID:26766424
Early Cellular Changes in the Ascending Aorta and Myocardium in a Swine Model of Metabolic Syndrome. PMID:26766185
Spinal cord injury-induced immune deficiency syndrome enhances infection susceptibility dependent on lesion level. PMID:26754788
Testing flow diversion in animal models: a systematic review. PMID:26747181
Maternal high-fat diet influences outcomes after neonatal hypoxic-ischemic brain injury in rodents. PMID:26738750
In Vitro Analysis of Fibronectin-Modified Titanium Surfaces. PMID:26731536
Where Have All the Rodents Gone? The Effects of Attrition in Experimental Research on Cancer and Stroke. PMID:26726833
Role of Liver X Receptor in AD Pathophysiology. PMID:26720273
Drug delivery systems for ovarian cancer treatment: a systematic review and meta-analysis of animal studies. PMID:26713240
Temporal Development of Autonomic Dysfunction in Heart Failure: Effects of Age in an Ovine Rapid-pacing Model. PMID:26707382
Natural killer (NK) cells inhibit systemic metastasis of glioblastoma cells and have therapeutic effects against glioblastomas in the brain. PMID:26704632
The relationship between study sponsorship, risks of bias, and research outcomes in atrazine exposure studies conducted in non-human animals: Systematic review and meta-analysis. PMID:26694022
Potential variables affecting the quality of animal studies regarding pathophysiology of traumatic spinal cord injuries. PMID:26690856
Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations. PMID:26683237
Bidirectional crosstalk via IL-6, PGE2 and PGD2 between murine myofibroblasts and alternatively activated macrophages enhances anti-inflammatory phenotype in both cells. PMID:26676587
The Murine Lung Microbiome Changes During Lung Inflammation and Intranasal Vancomycin Treatment. PMID:26668669
Drug therapy: Preclinical oncology - reporting transparency needed. PMID:26667971
Comparative Medicine in the Twenty-First Century: Where are We Now and Where Do We Go from Here? PMID:26664931
Characterization of the Affective Component of Acute Postoperative Pain Associated with a Novel Rat Model of Inguinal Hernia Repair Pain. PMID:26663888
Efficacy of the PSD95 inhibitor Tat-NR2B9c in mice requires dose translation between species. PMID:26661213
Neuronal NCX1 overexpression induces stroke resistance while knockout induces vulnerability via Akt. PMID:26661211
Stroke neuroprotection revisited: Intra-arterial verapamil is profoundly neuroprotective in experimental acute ischemic stroke. PMID:26661189
A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke. PMID:26661169
Optogenetic fMRI in the mouse hippocampus: Hemodynamic response to brief glutamatergic stimuli. PMID:26661158
CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation. PMID:26661156
Oxygen-Enhanced MRI Accurately Identifies, Quantifies, and Maps Tumor Hypoxia in Preclinical Cancer Models. PMID:26659574
Lyophilized allografts without pre-treatment with glutaraldehyde are more suitable than cryopreserved allografts for pulmonary artery reconstruction. PMID:26648092
Extracellular matrix-blood composite injection reduces post-traumatic osteoarthritis after anterior cruciate ligament injury in the rat. PMID:26629963
Sorafenib suppresses the epithelial-mesenchymal transition of hepatocellular carcinoma cells after insufficient radiofrequency ablation. PMID:26620566
PAR1 inhibition suppresses the self-renewal and growth of A2B5-defined glioma progenitor cells and their derived gliomas in vivo. PMID:26616854
Effect of proximal versus distal 50% enterectomy on nutritional parameters in rats preconditioned with a high-fat diet or regular chow. PMID:26612764
Longitudinal trends and subgroup analysis in publication patterns for preclinical data of newly approved drugs. PMID:26612506
Standard of reporting animal-based experimental research in Indian Journal of Pharmacology. PMID:26600640
Quality of Reporting and Adherence to ARRIVE Guidelines in Animal Studies for Chagas Disease Preclinical Drug Research: A Systematic Review. PMID:26587586
Preliminary application of a single-port access technique for laparoscopic ovariohysterectomy in dogs. PMID:26568831
The thyroid status reprograms T cell lymphoma growth and modulates immune cell frequencies. PMID:26564151
Differential myofiber-type transduction preference of adeno-associated virus serotypes 6 and 9. PMID:26561520
Preclinical Bioassay of a Polypropylene Mesh for Hernia Repair Pretreated with Antibacterial Solutions of Chlorhexidine and Allicin: An In Vivo Study. PMID:26556805
Liver X Receptor Agonist Modifies the DNA Methylation Profile of Synapse and Neurogenesis-Related Genes in the Triple Transgenic Mouse Model of Alzheimer's Disease. PMID:26553261
Glucose and fatty acid metabolism in infarcted heart from streptozotocin-induced diabetic rats after 2 weeks of tissue remodeling. PMID:26553117
Single-cell Hi-C for genome-wide detection of chromatin interactions that occur simultaneously in a single cell. PMID:26540590
Endothelial CD36 Contributes to Postischemic Brain Injury by Promoting Neutrophil Activation via CSF3. PMID:26538649
Bridging Translation by Improving Preclinical Study Design in AKI. PMID:26538634
BLOCKADE OF ENDOTHELIAL GROWTH FACTOR, ANGIOPOIETIN-2, REDUCES INDICES OF ARDS AND MORTALITY IN MICE RESULTING FROM THE DUAL-INSULTS OF HEMORRHAGIC SHOCK AND SEPSIS. PMID:26529660
Near-infrared cholecysto-cholangiography with indocyanine green may secure cholecystectomy in difficult clinical situations: proof of the concept in a porcine model. PMID:26511116
Keeper-Animal Interactions: Differences between the Behaviour of Zoo Animals Affect Stockmanship. PMID:26509670
Mesenchymal Stromal Cells in Animal Bleomycin Pulmonary Fibrosis Models: A Systematic Review. PMID:26494779
Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass, and Bone Strength of Intact Bones in Adult Male Rats. PMID:26494536
Activity of botulinum toxin type A in cranial dura: implications for treatment of migraine and other headaches. PMID:26493010
Impact of guidance documents on translational large animal studies of cartilage repair. PMID:26491080
Novel laparoscopic narrow band imaging for real-time detection of bile leak during hepatectomy: proof of the concept in a porcine model. PMID:26487207
Pain Management for Animals Used in Science: Views of Scientists and Veterinarians in Canada. PMID:26480320
A Critical Look at Biomedical Journals' Policies on Animal Research by Use of a Novel Tool: The EXEMPLAR Scale. PMID:26479237
Platelets modulate the immune response following trauma by interaction with CD4+ T regulatory cells in a mouse model. PMID:26471021
Neurotoxic Methamphetamine Doses Increase LINE-1 Expression in the Neurogenic Zones of the Adult Rat Brain. PMID:26463126
Risk of Bias in Reports of In Vivo Research: A Focus for Improvement. PMID:26460723
A meta-analysis of threats to valid clinical inference in preclinical research of sunitinib. PMID:26460544
HMBOX1 interacts with MT2A to regulate autophagy and apoptosis in vascular endothelial cells. PMID:26456220
Short-term follow-up of exercise training program and beta-blocker treatment on quality of life in dogs with naturally acquired chronic mitral valve disease. PMID:26445331
The Effects of GH Transgenic Goats on the Microflora of the Intestine, Feces and Surrounding Soil. PMID:26445136
Improving translational studies: lessons from rare neuromuscular diseases. PMID:26438690
Role of Opioid Receptors Signaling in Remote Electrostimulation--Induced Protection against Ischemia/Reperfusion Injury in Rat Hearts. PMID:26430750
Transcriptomic Analysis of Ovaries from Pigs with High And Low Litter Size. PMID:26426260
Associations between proteasomal activator PA28γ and outcome of oral squamous cell carcinoma: Evidence from cohort studies and functional analyses. PMID:26425691
Reducing the stress of drug administration: implications for the 3Rs. PMID:26395864
Metabolic Effects of CX3CR1 Deficiency in Diet-Induced Obese Mice. PMID:26393344
A comprehensive study on different modelling approaches to predict platelet deposition rates in a perfusion chamber. PMID:26391513
Targeted therapies in bladder cancer: an overview of in vivo research. PMID:26390971
Male Investments in High Quality Sperm Improve Fertilization Success, but May Have Negative Impact on Offspring Fitness in Whitefish. PMID:26389594
Image-derived arterial input function for quantitative fluorescence imaging of receptor-drug binding in vivo. PMID:26349671
Aquaporin-1 Deficiency Protects Against Myocardial Infarction by Reducing Both Edema and Apoptosis in Mice. PMID:26348407
A porcine polytrauma model with two different degrees of hemorrhagic shock: outcome related to trauma within the first 48 h. PMID:26338818
Successful ECMO-cardiopulmonary resuscitation with the associated post-arrest cardiac dysfunction as demonstrated by MRI. PMID:26335546
Asporin Is a Fibroblast-Derived TGF-β1 Inhibitor and a Tumor Suppressor Associated with Good Prognosis in Breast Cancer. PMID:26327350
Manipulating the Gut Microbiota: Methods and Challenges. PMID:26323630
Bioreactor-Based Online Recovery of Human Progenitor Cells with Uncompromised Regenerative Potential: A Bone Tissue Engineering Perspective. PMID:26313143
Bedside-to-Bench Translational Research for Chronic Heart Failure: Creating an Agenda for Clients Who Do Not Meet Trial Enrollment Criteria. PMID:26309418
The Prostaglandin E2 Receptor EP4 Regulates Obesity-Related Inflammation and Insulin Sensitivity. PMID:26308623
Oral Application of T4 Phage Induces Weak Antibody Production in the Gut and in the Blood. PMID:26308042
Anesthesia and Monitoring in Small Laboratory Mammals Used in Anesthesiology, Respiratory and Critical Care Research: A Systematic Review on the Current Reporting in Top-10 Impact Factor Ranked Journals. PMID:26305700
Butorphanol with oxygen insufflation improves cardiorespiratory function in field-immobilised white rhinoceros (Ceratotherium simum). PMID:26304140
Cordycepin induced MA-10 mouse Leydig tumor cell apoptosis by regulating p38 MAPKs and PI3K/AKT signaling pathways. PMID:26303320
Response of biochemical biomarkers in the aquatic crustacean Daphnia magna exposed to silver nanoparticles. PMID:26296504
Interleukin-18 Down-Regulates Multidrug Resistance-Associated Protein 2 Expression through Farnesoid X Receptor Associated with Nuclear Factor Kappa B and Yin Yang 1 in Human Hepatoma HepG2 Cells. PMID:26292095
Male and female mice show significant differences in hepatic transcriptomic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. PMID:26290441
An orthotopic xenograft model with survival hindlimb amputation allows investigation of the effect of tumor microenvironment on sarcoma metastasis. PMID:26278104
Real-time fluorescence angiography by intra-arterial indocyanine green injection to identify obscure gastrointestinal bleeding territory: proof of concept in the porcine model. PMID:26275550
A 1,000-Year-Old Antimicrobial Remedy with Antistaphylococcal Activity. PMID:26265721
Correlation of lung collapse and gas exchange - a computer tomographic study in sheep and pigs with atelectasis in otherwise normal lungs. PMID:26258686
Helping to drive the robustness of preclinical research - the assay capability tool. PMID:26236488
Macrolides increase the expression of 11β-hydroxysteroid dehydrogenase 1 in human sinonasal epithelium, contributing to glucocorticoid activation in sinonasal mucosa. PMID:26228509
Endotoxemia-mediated inflammation potentiates aminoglycoside-induced ototoxicity. PMID:26223301
α7 nicotinic ACh receptor-deficient mice exhibit sustained attention impairments that are reversed by β2 nicotinic ACh receptor activation. PMID:26222090
The temporary and accumulated effects of transcranial direct current stimulation for the treatment of advanced Parkinson's disease monkeys. PMID:26220760
Why do they die? Comparison of selected aspects of organ injury and dysfunction in mice surviving and dying in acute abdominal sepsis. PMID:26215812
Can animal data translate to innovations necessary for a new era of patient-centred and individualised healthcare? Bias in preclinical animal research. PMID:26215508
Cyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent Neuroblastoma. PMID:26202950
Chronic Rho-kinase inhibition improves left ventricular contractile dysfunction in early type-1 diabetes by increasing myosin cross-bridge extension. PMID:26194354
A Direct Comparison of Three Clinically Relevant Treatments in a Rat Model of Cervical Spinal Cord Injury. PMID:26192071
A potential small-molecule synthetic antilymphangiogenic agent norcantharidin inhibits tumor growth and lymphangiogenesis of human colonic adenocarcinomas through blocking VEGF-A,-C,-D/VEGFR-2,-3 "multi-points priming" mechanisms in vitro and in vivo. PMID:26187792
Rutin administration attenuates myocardial dysfunction in diabetic rats. PMID:26185015
A systematic review and meta-analysis of the ability of analgesic drugs to reduce metastasis in experimental cancer models. PMID:26181303
Applying refinement to the use of mice and rats in rheumatoid arthritis research. PMID:26168847
Effects of stem cell transplantation on cognitive decline in animal models of Alzheimer's disease: A systematic review and meta-analysis. PMID:26159750
In vitro and in vivo generation and characterization of Pseudomonas aeruginosa biofilm-dispersed cells via c-di-GMP manipulation. PMID:26158442
Mechanism of brain targeting by dexibuprofen prodrugs modified with ethanolamine-related structures. PMID:26154870
Lung Transcriptomics during Protective Ventilatory Support in Sepsis-Induced Acute Lung Injury. PMID:26147972
PhenStat: A Tool Kit for Standardized Analysis of High Throughput Phenotypic Data. PMID:26147094
A Model of Post-Infection Fatigue Is Associated with Increased TNF and 5-HT2A Receptor Expression in Mice. PMID:26147001
Detecting microvascular changes in the mouse spleen using optical computed tomography. PMID:26142118
The novel PAR2 ligand C391 blocks multiple PAR2 signalling pathways in vitro and in vivo. PMID:26140338
Co-Expression of Ezrin-CLIC5-Podocalyxin Is Associated with Migration and Invasiveness in Hepatocellular Carcinoma. PMID:26135398
Experimental design and analysis and their reporting: new guidance for publication in BJP. PMID:26114403
Improving standards for reporting studies involving humans and experimental animals in the British Journal of Nutrition and in the Journal of Nutritional Science. PMID:26101588
Cardioprotective Signature of Short-Term Caloric Restriction. PMID:26098549
GeneWeaver: finding consilience in heterogeneous cross-species functional genomics data. PMID:26092690
N-acetylcysteine Plus Deferoxamine Improves Cardiac Function in Wistar Rats After Non-reperfused Acute Myocardial Infarction. PMID:26085187
Recombinant Flagellin-Porcine Circovirus Type 2 Cap Fusion Protein Promotes Protective Immune Responses in Mice. PMID:26070075
Reproducibility: use mouse biobanks or lose them. PMID:26062496
Vascular replacement using a layered elastin-collagen vascular graft in a porcine model: one week patency versus one month occlusion. PMID:26060888
Resveratrol Upregulates Cardiac SDF-1 in Mice with Acute Myocardial Infarction through the Deacetylation of Cardiac p53. PMID:26053177
Preclinical Pharmacokinetic Studies of the Tritium Labelled D-Enantiomeric Peptide D3 Developed for the Treatment of Alzheimer´s Disease. PMID:26046986
Neurorestoration induced by the HDAC inhibitor sodium valproate in the lactacystin model of Parkinson's is associated with histone acetylation and up-regulation of neurotrophic factors. PMID:26040297
Overexpression of PLAP-1 in bone marrow stromal cells inhibits the rat critical-size skull defect repair. PMID:26031659
The Challenging Road towards a Unified Animal Research Network in Europe. PMID:26018997
Inhibition of NADPH oxidase activation reduces EAE-induced white matter damage in mice. PMID:26017142
Assessment of intensive care unit-acquired weakness in young and old mice: An E. coli septic peritonitis model. PMID:26015329
1-Methyl-4-phenylpyridinium stereotactic infusion completely and specifically ablated the nigrostriatal dopaminergic pathway in rhesus macaque. PMID:26010745
Anti-Tumor Action, Clinical Biochemistry Profile and Phytochemical Constituents of a Pharmacologically Active Fraction of S. crispus in NMU-Induced Rat Mammary Tumour Model. PMID:26000968
Applying the ARRIVE Guidelines to an In Vivo Database. PMID:25992600
Quality of methods reporting in animal models of colitis. PMID:25989337
Prolyl hydroxylase inhibition corrects functional iron deficiency and inflammation-induced anaemia in rats. PMID:25988595
Comparative clinico-haematological analysis in young Zebu cattle experimentally infected with Trypanosoma vivax isolates from tsetse infested and non-tsetse infested areas of Northwest Ethiopia. PMID:25986858
Rethinking Meta-Analysis: Applications for Air Pollution Data and Beyond. PMID:25969128
Humanized thymidine kinase-NOG mice can be used to identify drugs that cause animal-specific hepatotoxicity: a case study with furosemide. PMID:25962391
Expectations for methodology and translation of animal research: a survey of health care workers. PMID:25947255
Methylophiopogonanone A Protects against Cerebral Ischemia/Reperfusion Injury and Attenuates Blood-Brain Barrier Disruption In Vitro. PMID:25897666
Systematic review and meta-analysis of efficacy of mesenchymal stem cells on locomotor recovery in animal models of traumatic brain injury. PMID:25881229
Pentoxifylline Attenuates Proteinuria in Anti-Thy1 Glomerulonephritis via Downregulation of Nuclear Factor-κB and Smad2/3 Signaling. PMID:25879629
Nigral proteasome inhibition in mice leads to motor and non-motor deficits and increased expression of Ser129 phosphorylated α-synuclein. PMID:25873870
Tryptase is involved in the development of early ventilator-induced pulmonary fibrosis in sepsis-induced lung injury. PMID:25871971
Wound models for periodontal and bone regeneration: the role of biologic research. PMID:25867976
Targeting p38 Mitogen-activated Protein Kinase to Reduce the Impact of Neonatal Microglial Priming on Incision-induced Hyperalgesia in the Adult Rat. PMID:25859904
ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy. PMID:25851535
Pioneering better science through the 3Rs: an introduction to the national centre for the replacement, refinement, and reduction of animals in research (NC3Rs). PMID:25836967
The evolution of animal welfare and the 3Rs in Brazil, China, and India. PMID:25836965
Roles of the International Council for Laboratory Animal Science (ICLAS) and International Association of Colleges of Laboratory Animal Medicine (IACLAM) in the Global Organization and Support of 3Rs Advances in Laboratory Animal Science. PMID:25836964
The use of systematic reviews and reporting guidelines to advance the implementation of the 3Rs. PMID:25836961
Optical measurement of mouse strain differences in cerebral blood flow using indocyanine green. PMID:25833343
Anti-arthritic activity of Fu-Fang-Lu-Jiao-Shuang on collagen-induced arthritis in Balb/c mice and its underlying mechanisms. PMID:25829761
The multifactorial role of the 3Rs in shifting the harm-benefit analysis in animal models of disease. PMID:25823812
Copolymer-1 promotes neurogenesis and improves functional recovery after acute ischemic stroke in rats. PMID:25821957
Tumor cells switch to mitochondrial oxidative phosphorylation under radiation via mTOR-mediated hexokinase II inhibition--a Warburg-reversing effect. PMID:25807077
Deficient copper concentrations in dried-defatted hepatic tissue from ob/ob mice: A potential model for study of defective copper regulation in metabolic liver disease. PMID:25797622
The National Institutes of Health and guidance for reporting preclinical research. PMID:25775278
Characterisation of pain responses in the high fat diet/streptozotocin model of diabetes and the analgesic effects of antidiabetic treatments. PMID:25759824
CD47 agonist peptides induce programmed cell death in refractory chronic lymphocytic leukemia B cells via PLCγ1 activation: evidence from mice and humans. PMID:25734483
A rapid and convenient method for fluorescence analysis of in vitro cultivated metacestode vesicles from Echinococcus multilocularis. PMID:25705880
Chemical composition and biological activities of trans-Himalayan alga Spirogyra porticalis (Muell.) Cleve. PMID:25693168
Tractography of the spider monkey (Ateles geoffroyi) corpus callosum using diffusion tensor magnetic resonance imaging. PMID:25693078
Revision of instructions to authors for pharmacology research and perspectives: enhancing the quality and transparency of published work. PMID:25692028
Exploring the biomechanical properties of brain malignancies and their pathologic determinants in vivo with magnetic resonance elastography. PMID:25672978
Micheliolide derivative DMAMCL inhibits glioma cell growth in vitro and in vivo. PMID:25658946
Treatment of irradiated mice with high-dose ascorbic acid reduced lethality. PMID:25651298
AALAS/FELASA Working Group on Health Monitoring of rodents for animal transfer. PMID:25650968
The role of Abcb5 alleles in susceptibility to haloperidol-induced toxicity in mice and humans. PMID:25647612
The Relationship between Risk of Bias Criteria, Research Outcomes, and Study Sponsorship in a Cohort of Preclinical Thiazolidinedione Animal Studies: A Meta-Analysis. PMID:25642330
High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers. PMID:25612230
Guidelines for translational research in heart failure. PMID:25604959
The neuromuscular junction: measuring synapse size, fragmentation and changes in synaptic protein density using confocal fluorescence microscopy. PMID:25590231
DAMP signaling is a key pathway inducing immune modulation after brain injury. PMID:25589753
Heritability of periodontal bone loss in mice. PMID:25581386
Effects of the kappa opioid receptor antagonist nor-binaltorphimine (nor-BNI) on cocaine versus food choice and extended-access cocaine intake in rhesus monkeys. PMID:25581305
A high-throughput in vivo micronucleus assay for genome instability screening in mice. PMID:25551665
Berberine protects against neuronal damage via suppression of glia-mediated inflammation in traumatic brain injury. PMID:25546475
Dissemination bias in systematic reviews of animal research: a systematic review. PMID:25541734
The significance of meaning: why do over 90% of behavioral neuroscience results fail to translate to humans, and what can we do to fix it? PMID:25541546
Granulocyte colony-stimulating factor (G-CSF) treatment in combination with transplantation of bone marrow cells is not superior to G-CSF treatment alone after cortical stroke in spontaneously hypertensive rats. PMID:25538562
Gene expression profile of increased heart rate in shensongyangxin-treated bradycardia rabbits. PMID:25525447
Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells. PMID:25522369
Inactivated Sendai virus strain Tianjin induces apoptosis in breast cancer MCF-7 cells by promoting caspase activation and Fas/FasL expression. PMID:25517620
A common control group - optimising the experiment design to maximise sensitivity. PMID:25504147
TALEN-mediated targeting of HPV oncogenes ameliorates HPV-related cervical malignancy. PMID:25500889
Refinement of analgesia following thoracotomy and experimental myocardial infarction using the Mouse Grimace Scale. PMID:25480160
Changes in expression of aquaporin-4 and aquaporin-9 in optic nerve after crushing in rats. PMID:25479407
Cross-species transcriptomic analysis elucidates constitutive aryl hydrocarbon receptor activity. PMID:25467400
Loss of TLR3 aggravates CHIKV replication and pathology due to an altered virus-specific neutralizing antibody response. PMID:25452586
Metformin inhibits ovarian cancer growth and increases sensitivity to paclitaxel in mouse models. PMID:25446664
Hatching time and alevin growth prior to the onset of exogenous feeding in farmed, wild and hybrid Norwegian Atlantic salmon. PMID:25438050
From in vitro to in vivo Models of Bacterial Biofilm-Related Infections. PMID:25437038
Chimeric TK-NOG mice: a predictive model for cholestatic human liver toxicity. PMID:25424997
Transcriptional profiling of the spleen in progressive visceral leishmaniasis reveals mixed expression of type 1 and type 2 cytokine-responsive genes. PMID:25424735
Ridge preservation using a new 3D collagen matrix: a preclinical study. PMID:25418353
Human glial chimeric mice reveal astrocytic dependence of JC virus infection. PMID:25401469
Using pancreas tissue slices for in situ studies of islet of Langerhans and acinar cell biology. PMID:25393778
Immunization with advanced glycation end products modified low density lipoprotein inhibits atherosclerosis progression in diabetic apoE and LDLR null mice. PMID:25391642
ESC working group cellular biology of the heart: position paper: improving the preclinical assessment of novel cardioprotective therapies. PMID:25344369
Early activation of pro-fibrotic WNT5A in sepsis-induced acute lung injury. PMID:25331176
Identification of reference proteins for Western blot analyses in mouse model systems of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxicity. PMID:25329058
Viral pre-challenge increases central nervous system inflammation after intracranial interleukin-1β injection. PMID:25323767
Diabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in rats. PMID:25301475
Protective effects of n-6 fatty acids-enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4 and its receptor. PMID:25296998
Treatment for calcium channel blocker poisoning: a systematic review. PMID:25283255
Viewing systematic reviews and meta-analysis in social research through different lenses. PMID:25279303
Polyethylene glycol formulations show different soft tissue remodeling and angiogenesis features. PMID:25275669
Early detection of motor dysfunction in the SOD1G93A mouse model of Amyotrophic Lateral Sclerosis (ALS) using home cage running wheels. PMID:25268710
Development of a fatal noncompressible truncal hemorrhage model with combined hepatic and portal venous injury in normothermic normovolemic swine. PMID:25251401
EUS assisted transmural cholecystogastrostomy fistula creation as a bridge for endoscopic internal gallbladder therapy using a novel fully covered metal stent. PMID:25249425
Allopregnanolone and its precursor progesterone do not reduce injury after experimental stroke in hypertensive rats - role of postoperative temperature regulation? PMID:25248155
Surgical delivery of drug releasing poly(lactic-co-glycolic acid)/poly(ethylene glycol) paste with in vivo effects against glioblastoma. PMID:25245726
Improving standards for reporting studies involving humans and experimental animals in the British Journal of Nutrition and in the Journal of Nutritional Science. PMID:25216108
Scientific rigor and the art of motorcycle maintenance. PMID:25203032
Exendin-4 ameliorates cardiac ischemia/reperfusion injury via caveolae and caveolins-3. PMID:25194961
The structural and functional organization of the podocyte filtration slits is regulated by Tjp1/ZO-1. PMID:25184792
In vitro anti-Onchocerca ochengi activities of extracts and chromatographic fractions of Craterispermum laurinum and Morinda lucida. PMID:25179014
Introduction to mammalian genome special issue: metabolism. PMID:25178883
Development of a closed-artery catheter-based myocardial infarction in pigs using sponge and lidocaine hydrochloride infusion to prevent irreversible ventricular fibrillation. PMID:25168871
A preclinical physiological assay to test modulation of knee joint pain in the spinal cord: effects of oxycodone and naproxen. PMID:25157947
Progesterone receptor expression declines in the guinea pig uterus during functional progesterone withdrawal and in response to prostaglandins. PMID:25157946
Impact of statins on cognitive deficits in adult male rodents after traumatic brain injury: a systematic review. PMID:25157352
Establishment of a rat model of portal vein ligation combined with in situ splitting. PMID:25144490
The challenge and promise of anti-epileptic therapy development in animal models. PMID:25127174
Phenotypic modulation of corpus cavernosum smooth muscle cells in a rat model of cavernous neurectomy. PMID:25127037
The methodological quality of animal research in critical care: the public face of science. PMID:25114829
Structured evaluation of rodent behavioral tests used in drug discovery research. PMID:25100962
A novel 11β-hydroxysteroid dehydrogenase type1 inhibitor CNX-010-49 improves hyperglycemia, lipid profile and reduces body weight in diet induced obese C57B6/J mice with a potential to provide cardio protective benefits. PMID:25098735
Antagonistic effect of TNF-alpha and insulin on uncoupling protein 2 (UCP-2) expression and vascular damage. PMID:25077985
Respiratory mechanics and plasma levels of tumor necrosis factor alpha and interleukin 6 are affected by gas humidification during mechanical ventilation in dogs. PMID:25036811
Phagocyte NADPH oxidase restrains the inflammasome in ANCA-induced GN. PMID:25012177
Carbohydrate-Free Peach (Prunus persica) and Plum (Prunus salicina) [corrected] Juice Affects Fecal Microbial Ecology in an Obese Animal Model. PMID:25007331
Independent evaluation of the anatomical and behavioral effects of Taxol in rat models of spinal cord injury. PMID:24999028
Activation and measurement of free whisking in the lightly anesthetized rodent. PMID:24992095
Intersection of systematic review methodology with the NIH reproducibility initiative. PMID:24984224
Research wranglers: initiatives to improve reproducibility of study findings. PMID:24984077
An activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E⁻/⁻ mice. PMID:24980430
Micronucleated erythrocytes in newborn rats exposed to raltegravir placental transfer. PMID:24977162
Traditional formula, modern application: chinese medicine formula sini tang improves early ventricular remodeling and cardiac function after myocardial infarction in rats. PMID:24971143
Relation of completeness of reporting of health research to journals' endorsement of reporting guidelines: systematic review. PMID:24965222
Tissue engineering in animal models for urinary diversion: a systematic review. PMID:24964011
Gender dimorphism of the cardiac dysfunction in murine sepsis: signalling mechanisms and age-dependency. PMID:24945834
Cloning, expression and characterization of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) from Wolbachia endosymbiont of human lymphatic filarial parasite Brugia malayi. PMID:24941309
Memantine enhances recovery from stroke. PMID:24938836
Diabetic cardiomyopathy is associated with defective myocellular copper regulation and both defects are rectified by divalent copper chelation. PMID:24927960
The effect of regular exercise on antioxidant enzyme activities and lipid peroxidation levels in both hippocampi after occluding one carotid in rat. PMID:24923383
Reproducibility of results in preclinical studies: a perspective from the bone field. PMID:24916175
Preserved regulation of renal perfusion pressure by small and intermediate conductance KCa channels in hypertensive mice with or without renal failure. PMID:24903240
The multicopper ferroxidase hephaestin enhances intestinal iron absorption in mice. PMID:24896847
Of (stressed) mice and men. PMID:24874574
Minimum information about a spinal cord injury experiment: a proposed reporting standard for spinal cord injury experiments. PMID:24870067
Evoked temporal summation in cats to highlight central sensitization related to osteoarthritis-associated chronic pain: a preliminary study. PMID:24859251
Inhibition of tumor vasculogenic mimicry and prolongation of host survival in highly aggressive gallbladder cancers by norcantharidin via blocking the ephrin type a receptor 2/focal adhesion kinase/paxillin signaling pathway. PMID:24811250
In-depth metabolic phenotyping of genetically engineered mouse models in obesity and diabetes. PMID:24792749
Differences in the phagocytic response of microglia and peripheral macrophages after spinal cord injury and its effects on cell death. PMID:24790202
Neuroprotective effects of guanosine administration on behavioral, brain activity, neurochemical and redox parameters in a rat model of chronic hepatic encephalopathy. PMID:24788896
Evaluation of antiviral efficacy of ribavirin, arbidol, and T-705 (favipiravir) in a mouse model for Crimean-Congo hemorrhagic fever. PMID:24786461
Optimal management of the critically ill: anaesthesia, monitoring, data capture, and point-of-care technological practices in ovine models of critical care. PMID:24783206
Defective Wound-healing in Aging Gingival Tissue. PMID:24776985
Effects of glucosamine and risedronate alone or in combination in an experimental rabbit model of osteoarthritis. PMID:24766775
Evidence of Rift Valley fever seroprevalence in the Sahrawi semi-nomadic pastoralist system, Western Sahara. PMID:24758592
Rat experimental model of myocardial ischemia/reperfusion injury: an ethical approach to set up the analgesic management of acute post-surgical pain. PMID:24756074
Histone acetylation and CREB binding protein are required for neuronal resistance against ischemic injury. PMID:24748101
Effect of thoracic arthrodesis in prepubertal New Zealand white rabbits on cardio-pulmonary function. PMID:24741141
Fialuridine induces acute liver failure in chimeric TK-NOG mice: a model for detecting hepatic drug toxicity prior to human testing. PMID:24736310
Peripheral calcitonin gene-related peptide receptor activation and mechanical sensitization of the joint in rat models of osteoarthritis pain. PMID:24719311
Systematic reviews of animal studies; missing link in translational research? PMID:24670965
SYRCLE's risk of bias tool for animal studies. PMID:24667063
Microglial Cx3cr1 knockout reduces prion disease incubation time in mice. PMID:24655482
Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene. PMID:24642684
Fibroblast growth factor 9 activates akt and MAPK pathways to stimulate steroidogenesis in mouse leydig cells. PMID:24603862
A mushroom extract Piwep from Phellinus igniarius ameliorates experimental autoimmune encephalomyelitis by inhibiting immune cell infiltration in the spinal cord. PMID:24592383
Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically. PMID:24549183
Improving the translation of analgesic drugs to the clinic: animal models of neuropathic pain. PMID:24527763
Optimized axolotl (Ambystoma mexicanum) husbandry, breeding, metamorphosis, transgenesis and tamoxifen-mediated recombination. PMID:24504478
Qualichem in vivo: a tool for assessing the quality of in vivo studies and its application for bisphenol A. PMID:24489958
Surgical manipulation compromises leukocyte mobilization responses and inflammation after experimental cerebral ischemia in mice. PMID:24478617
Assessment of regional ventilation distribution: comparison of vibration response imaging (VRI) with electrical impedance tomography (EIT). PMID:24475160
Selective ROCK2 Inhibition In Focal Cerebral Ischemia. PMID:24466563
Some salt with your statin, professor? PMID:24465176
A review of experimental infections with bluetongue virus in the mammalian host. PMID:24462840
CNX-012-570, a direct AMPK activator provides strong glycemic and lipid control along with significant reduction in body weight; studies from both diet-induced obese mice and db/db mice models. PMID:24460834
Metformin induces PGC-1α expression and selectively affects hepatic PGC-1α functions. PMID:24428821
The ethical dimension in published animal research in critical care: the public face of science. PMID:24423201
Increasing value and reducing waste in research design, conduct, and analysis. PMID:24411645
A survey of the awareness, knowledge, policies and views of veterinary journal Editors-in-Chief on reporting guidelines for publication of research. PMID:24410882
Open science and reporting animal studies: who's accountable? PMID:24409097
Two years later: journals are not yet enforcing the ARRIVE guidelines on reporting standards for pre-clinical animal studies. PMID:24409096
Using body temperature, food and water consumption as biomarkers of disease progression in mice with Eμ-myc lymphoma. PMID:24407190
Role of SOX2 in the etiology of embryonal carcinoma, based on analysis of the NCCIT and NT2 cell lines. PMID:24404135
Effect of dorsal and ventral hippocampal lesions on contextual fear conditioning and unconditioned defensive behavior induced by electrical stimulation of the dorsal periaqueductal gray. PMID:24404134
Cephalopods in neuroscience: regulations, research and the 3Rs. PMID:24385049
Ubiquitin B in cervical cancer: critical for the maintenance of cancer stem-like cell characters. PMID:24367661
Stem cell transplantation in traumatic spinal cord injury: a systematic review and meta-analysis of animal studies. PMID:24358022
Bedside to bench: a look at experimental research with a clinical trial checklist. PMID:24357016
A novel phenylcyclohex-1-enecarbothioamide derivative inhibits CXCL8-mediated chemotaxis through selective regulation of CXCR2-mediated signalling. PMID:24354854
Aneurysmal remodeling in the circle of Willis after carotid occlusion in an experimental model. PMID:24326393
Immune cell infiltration in malignant middle cerebral artery infarction: comparison with transient cerebral ischemia. PMID:24326388
Transgene delivery to endothelial cultures derived from porcine carotid artery ex vivo. PMID:24323377
In Support of EHP's Proposal to Adopt the ARRIVE Guidelines. PMID:24284027
Reporting of results from animal studies. PMID:24284018
Experimental liver fibrosis research: update on animal models, legal issues and translational aspects. PMID:24274743
Bringing rigour to translational medicine. PMID:24247324
Behaviour of a new composite mesh for the repair of full-thickness abdominal wall defects in a rabbit model. PMID:24236192
Nanoparticle toxicity by the gastrointestinal route: evidence and knowledge gaps. PMID:24228068
Gene transfer of human neuregulin-1 attenuates ventricular remodeling in diabetic cardiomyopathy rats. PMID:24223630
Catheter-based renal sympathetic denervation significantly inhibits atrial fibrillation induced by electrical stimulation of the left stellate ganglion and rapid atrial pacing. PMID:24223140
Do major roads reduce gene flow in urban bird populations? PMID:24204724
Steroid-associated hip joint collapse in bipedal emus. PMID:24204675
13C-isotope-based protocol for prenyl lipid metabolic analysis in zebrafish embryos. PMID:24177291
Factors influencing arthrodesis rates in a rabbit posterolateral spine model with iliac crest autograft. PMID:24166021
Growth reaction norms of domesticated, wild and hybrid Atlantic salmon families in response to differing social and physical environments. PMID:24165438
Ulinastatin attenuates oxidation, inflammation and neural apoptosis in the cerebral cortex of adult rats with ventricular fibrillation after cardiopulmonary resuscitation. PMID:24141840
Wild-type but not mutant SOD1 transgenic astrocytes promote the efficient generation of motor neuron progenitors from mouse embryonic stem cells. PMID:24134124
Synaptic activity bidirectionally regulates a novel sequence-specific S-Q phosphoproteome in neurons. PMID:24117848
KIBRA (KIdney/BRAin protein) regulates learning and memory and stabilizes Protein kinase Mζ. PMID:24117625
Plasma proteome profiles associated with diet-induced metabolic syndrome and the early onset of metabolic syndrome in a pig model. PMID:24086269
Desorption electrospray ionization mass spectrometry reveals lipid metabolism of individual oocytes and embryos. PMID:24073231
Human umbilical cord blood mononuclear cells in a double-hit model of bronchopulmonary dysplasia in neonatal mice. PMID:24069341
Multimodal exercises simultaneously stimulating cortical and brainstem pathways after unilateral corticospinal lesion. PMID:24055330
MiR-499 regulates cell proliferation and apoptosis during late-stage cardiac differentiation via Sox6 and cyclin D1. PMID:24040263
Effect of different suprahepatic vena cava reconstruction methods on the hemodynamics of rats after liver transplantation. PMID:24023763
Better reporting of scientific studies: why it matters. PMID:24013839
Infection of type I interferon receptor-deficient mice with various old world arenaviruses: a model for studying virulence and host species barriers. PMID:23991083
Protection of the heart by treatment with a divalent-copper-selective chelator reveals a novel mechanism underlying cardiomyopathy in diabetic rats. PMID:23981320
Single-molecule mRNA detection and counting in mammalian tissue. PMID:23949380
Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments. PMID:23935460
Issues related to symptomatic and disease-modifying treatments affecting cognitive and neuropsychiatric comorbidities of epilepsy. PMID:23909853
Issues related to development of antiepileptogenic therapies. PMID:23909852
Epilepsy therapy development: technical and methodologic issues in studies with animal models. PMID:23909850
Morphological and molecular characterization of dietary-induced pseudo-albinism during post-embryonic development of Solea senegalensis (Kaup, 1858). PMID:23874785
Evaluation of excess significance bias in animal studies of neurological diseases. PMID:23874156
Low-density lipoprotein receptor-related protein 1 (LRP1)-dependent cell signaling promotes axonal regeneration. PMID:23867460
Look back in anger - what clinical studies tell us about preclinical work. PMID:23861075
Decreased in vitro mitochondrial function is associated with enhanced brain metabolism, blood flow, and memory in Surf1-deficient mice. PMID:23838831
Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's disease. PMID:23801246
Instruments for assessing risk of bias and other methodological criteria of published animal studies: a systematic review. PMID:23771496
Atorvastatin enhance efficacy of mesenchymal stem cells treatment for swine myocardial infarction via activation of nitric oxide synthase. PMID:23741509
Time course of the development of nonalcoholic Fatty liver disease in the Otsuka long-evans Tokushima Fatty rat. PMID:23737763
Feasibility of targeting ischaemia-related ventricular arrhythmias by mimicry of endogenous protection by endocannabinoids. PMID:23713981
High-fat feeding rapidly induces obesity and lipid derangements in C57BL/6N mice. PMID:23712496
Coordinated regulation of chromatophore differentiation and melanogenesis during the ontogeny of skin pigmentation of Solea senegalensis (Kaup, 1858). PMID:23671650
Characterization of periodontal structures of enamelin-null mice. PMID:23646854
Mismatch responses in the awake rat: evidence from epidural recordings of auditory cortical fields. PMID:23646197
Combined antiapoptotic and antioxidant approach to acute neuroprotection for stroke in hypertensive rats. PMID:23632970
High concentrations of L-ascorbic acid specifically inhibit the growth of human leukemic cells via downregulation of HIF-1α transcription. PMID:23626851
Recommendations for the investigation of animal models of Prader-Willi syndrome. PMID:23609791
Proteolytically inactive insulin-degrading enzyme inhibits amyloid formation yielding non-neurotoxic aβ peptide aggregates. PMID:23593132
Power failure: why small sample size undermines the reliability of neuroscience. PMID:23571845
Multi frequency phase fluorimetry (MFPF) for oxygen partial pressure measurement: ex vivo validation by polarographic clark-type electrode. PMID:23565259
Metabolic disturbances and worsening of atherosclerotic lesions in ApoE-/- mice after cola beverages drinking. PMID:23547749
Qualitative and quantitative metabolomic investigation of single neurons by capillary electrophoresis electrospray ionization mass spectrometry. PMID:23538882
Preserved endothelium-dependent dilatation of the coronary microvasculature at the early phase of diabetes mellitus despite the increased oxidative stress and depressed cardiac mechanical function ex vivo. PMID:23530768
Improving basic and translational science by accounting for litter-to-litter variation in animal models. PMID:23522086
Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice. PMID:23503654
Early cardiac changes in a rat model of prediabetes: brain natriuretic peptide overexpression seems to be the best marker. PMID:23497124
Enhancing the reporting and transparency of rheumatology research: a guide to reporting guidelines. PMID:23448311
Whole animal experiments should be more like human randomized controlled trials. PMID:23424284
Therapeutics targeting Nogo-A hold promise for stroke restoration. PMID:23394537
Ischemic post-conditioning and vasodilator therapy during standard cardiopulmonary resuscitation to reduce cardiac and brain injury after prolonged untreated ventricular fibrillation. PMID:23376583
Effects by silodosin on the partially obstructed rat ureter in vivo and on human and rat isolated ureters. PMID:23373675
Systematic reviews of animal models: methodology versus epistemology. PMID:23372426
Treatment with a copper-selective chelator causes substantive improvement in cardiac function of diabetic rats with left-ventricular impairment. PMID:23368770
Intranasal delivery of cell-penetrating anti-NF-κB peptides (Tat-NBD) alleviates infection-sensitized hypoxic-ischemic brain injury. PMID:23353638
Sod1 deficiency reduces incubation time in mouse models of prion disease. PMID:23349894
Patient-derived breast tumor xenografts facilitating personalized cancer therapy. PMID:23339383
P2Y1R-initiated, IP3R-dependent stimulation of astrocyte mitochondrial metabolism reduces and partially reverses ischemic neuronal damage in mouse. PMID:23321785
Hands-on defibrillation has the potential to improve the quality of cardiopulmonary resuscitation and is safe for rescuers-a preclinical study. PMID:23316286
Thoracic cage plasticity in prepubertal New Zealand white rabbits submitted to T1-T12 dorsal arthrodesis: computed tomography evaluation, echocardiographic assessment and cardio-pulmonary measurements. PMID:23307193
Vitamin e and the healing of bone fracture: the current state of evidence. PMID:23304211
The stress-response gene redd1 regulates dorsoventral patterning by antagonizing Wnt/β-catenin activity in zebrafish. PMID:23300740
Robust and sensitive analysis of mouse knockout phenotypes. PMID:23300663
Reproducibility: Research-reporting standards fall short. PMID:23222599
Inhaled nitric oxide reduces secondary brain damage after traumatic brain injury in mice. PMID:23188422
Targeted deletion of the antisilencer/enhancer (ASE) element from intron 1 of the myelin proteolipid protein gene (Plp1) in mouse reveals that the element is dispensable for Plp1 expression in brain during development and remyelination. PMID:23157328
Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease. PMID:23121022
Do stroke models model stroke? PMID:23115201
Animal welfare in studies on murine tuberculosis: assessing progress over a 12-year period and the need for further improvement. PMID:23110093
Gait analysis in rats with single joint inflammation: influence of experimental factors. PMID:23071540
A call for transparent reporting to optimize the predictive value of preclinical research. PMID:23060188
Effects of the sigma-1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)-piperazine dihydro-chloride on inflammation after stroke. PMID:23028794
Disruption of subcellular Arc/Arg 3.1 mRNA expression in striatal efferent neurons following partial monoamine loss induced by methamphetamine. PMID:22978492
Erythropoietin attenuates cardiac dysfunction by increasing myocardial angiogenesis and inhibiting interstitial fibrosis in diabetic rats. PMID:22954171
No influence of dabigatran anticoagulation on hemorrhagic transformation in an experimental model of ischemic stroke. PMID:22911709
Join the dialogue. PMID:22902961
Surface functionalization of barium titanate SHG nanoprobes for in vivo imaging in zebrafish. PMID:22899331
Reporting of preclinical tumor-graft cancer therapeutic studies. PMID:22895077
Far infra-red therapy promotes ischemia-induced angiogenesis in diabetic mice and restores high glucose-suppressed endothelial progenitor cell functions. PMID:22894755
Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice. PMID:22869728
Recurrent/moderate hypoglycemia induces hippocampal dendritic injury, microglial activation, and cognitive impairment in diabetic rats. PMID:22830525
The fallacy of ratio correction to address confounding factors. PMID:22829707
Wound healing activities of different extracts of Centella asiatica in incision and burn wound models: an experimental animal study. PMID:22817824
Pain management standards in the eighth edition of the Guide for the Care and Use of Laboratory Animals. PMID:22776189
Analgesic effects of noninvasive brain stimulation in rodent animal models: a systematic review of translational findings. PMID:22759345
Sensitive detection of chromatin coassociations using enhanced chromosome conformation capture on chip. PMID:22722369
High fat diet-induced glucose intolerance impairs myocardial function, but not myocardial perfusion during hyperaemia: a pilot study. PMID:22716959
Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity. PMID:22642416
The '3Is' of animal experimentation. PMID:22641201
International, multicenter randomized preclinical trials in translational stroke research: it's time to act. PMID:22510602
Development of a unique small molecule modulator of CXCR4. PMID:22485156
Collapsin response mediator protein-2 phosphorylation promotes the reversible retraction of oligodendrocyte processes in response to non-lethal oxidative stress. PMID:22443207
Ischemic preconditioning in the animal kidney, a systematic review and meta-analysis. PMID:22389693
Inclusion of policies on ethical standards in animal experiments in biomedical science journals. PMID:22330784
Maximising the output of osteoarthritis research: the ARRIVE guidelines. PMID:22321718
Short small-interfering RNAs produce interferon-α-mediated analgesia. PMID:22307241
Quantitative MRI establishes the efficacy of PI3K inhibitor (GDC-0941) multi-treatments in PTEN-deficient mice lymphoma. PMID:22287727
Platelet hyperaggregability in high-fat fed rats: a role for intraplatelet reactive-oxygen species production. PMID:22248260
Genetically-engineered pig-to-baboon liver xenotransplantation: histopathology of xenografts and native organs. PMID:22247784
Effects of granulocyte-colony stimulating factor (G-CSF) on diabetic cardiomyopathy in Otsuka Long-Evans Tokushima fatty rats. PMID:21999467
Why animal research needs to improve. PMID:21956292
Evaluation of social and physical enrichment in modulation of behavioural phenotype in C57BL/6J female mice. PMID:21931844
Designing phenotyping studies for genetically engineered mice. PMID:21930803
Predicting the emetic liability of novel chemical entities: a comparative study. PMID:21913900
A search filter for increasing the retrieval of animal studies in Embase. PMID:21890653
Optimised and rapid pre-clinical screening in the SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS). PMID:21876739
Experimental intracerebral hemorrhage: avoiding pitfalls in translational research. PMID:21863040
Therapeutic effects of neuregulin-1 in diabetic cardiomyopathy rats. PMID:21798071
Reporting of method of animal sacrifice in articles published in Indian journals. PMID:21772779
Quality of reporting statistics in two Indian pharmacology journals. PMID:21772766
Dietary saturated fat/cholesterol, but not unsaturated fat or starch, induces C-reactive protein associated early atherosclerosis and ectopic fat deposition in diabetic pigs. PMID:21756316
Effect of silibinin on endothelial dysfunction and ADMA levels in obese diabetic mice. PMID:21756303
Will stem cell therapies be safe and effective for treating spinal cord injuries? PMID:21586446
Improving the reporting of animal research: when will we ARRIVE? PMID:21555328
Changes in cardiac heparan sulfate proteoglycan expression and streptozotocin-induced diastolic dysfunction in rats. PMID:21518435
Hyperglycemia can delay left ventricular dysfunction but not autonomic damage after myocardial infarction in rodents. PMID:21470409
Preclinical stroke research--advantages and disadvantages of the most common rodent models of focal ischaemia. PMID:21457227
Predicting harms and benefits in translational trials: ethics, evidence, and uncertainty. PMID:21423344
Predictive validity of behavioural animal models for chronic pain. PMID:21371010
[Original scientific articles: conception, accomplishment and publication]. PMID:21243326
Animal research: reporting in vivo experiments--the ARRIVE guidelines. PMID:21206507
Improving the quality of biomedical research: guidelines for reporting experiments involving animals. PMID:21206506
Systematic survey of the design, statistical analysis, and reporting of studies published in the 2008 volume of the Journal of Cerebral Blood Flow and Metabolism. PMID:21157472
The Gold Standard Publication Checklist (GSPC) for improved design, reporting and scientific quality of animal studies GSPC versus ARRIVE guidelines. PMID:21088032
Benefits of histone deacetylase inhibitors for acute brain injury: a systematic review of animal studies. PMID:20831615
Animal research: reporting in vivo experiments: the ARRIVE guidelines. PMID:20649561
Guidelines for reporting experiments involving animals: the ARRIVE guidelines. PMID:20649560
Animal research: reporting in vivo experiments: the ARRIVE guidelines. PMID:20634180
Reporting animal studies: good science and a duty of care. PMID:20613860
Survey of the quality of experimental design, statistical analysis and reporting of research using animals PubMed citations: 272.

272 articles citing: Survey of the quality of experimental design, statistical analysis and reporting of research using animals

What has preclinical systematic review ever done for us? PMID:35360370
Red-Fleshed Apples Rich in Anthocyanins and White-Fleshed Apples Modulate the Aorta and Heart Proteome in Hypercholesterolaemic Rats: The AppleCOR Study. PMID:35268023
Role of Environment and Experimenter in Reproducibility of Behavioral Studies With Laboratory Mice. PMID:35250504
Between two stools: preclinical research, reproducibility, and statistical design of experiments. PMID:35189946
Using Mice to Model Human Disease: Understanding the Roles of Baseline Housing-Induced and Experimentally Imposed Stresses in Animal Welfare and Experimental Reproducibility. PMID:35158694
Vidarabine, an anti-herpes agent, prevents occlusal-disharmony-induced cardiac dysfunction in mice. PMID:35148678
Administration of meloxicam to improve the welfare of mice in research: a systematic review (2000 - 2020). PMID:34988874
Yeast Beta-Glucans Ingestion Does Not Influence Body Weight: A Systematic Review and Meta-Analysis of Pre-Clinical Studies. PMID:34959802
Translational science: a survey of US biomedical researchers' perspectives and practices. PMID:34949847
Regulatory considerations for animal studies of biomaterial products. PMID:34938912
Combining Animal Welfare With Experimental Rigor to Improve Reproducibility in Behavioral Neuroscience. PMID:34916915
Challenges for assessing replicability in preclinical cancer biology. PMID:34874008
Safety and Efficacy of the East Coast Fever Muguga Cocktail Vaccine: A Systematic Review. PMID:34835249
Beyond t test and ANOVA: applications of mixed-effects models for more rigorous statistical analysis in neuroscience research. PMID:34784504
The laboratory rat: Age and body weight matter. PMID:34737685
Development of an aerogenous Escherichia coli infection model in adult broiler breeders. PMID:34599201
Improving rigor and reproducibility in nonhuman primate research. PMID:34541703
Errors in the implementation, analysis, and reporting of randomization within obesity and nutrition research: a guide to their avoidance. PMID:34326476
The Mutant Mouse Resource and Research Center (MMRRC): the NIH-supported National Public Repository and Distribution Archive of Mutant Mouse Models in the USA. PMID:34313795
The rodent object-in-context task: A systematic review and meta-analysis of important variables. PMID:34270575
Non-steroidal anti-inflammatory drugs and bone healing in animal models-a systematic review and meta-analysis. PMID:34238360
Signaling Targets Related to Antiobesity Effects of Capsaicin: A Scoping Review. PMID:34171094
The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. PMID:34095516
Enteral Feeding Interventions in the Prevention of Necrotizing Enterocolitis: A Systematic Review of Experimental and Clinical Studies. PMID:34069699
The Embryonic Chick Femur Organotypic Model as a Tool to Analyze the Angiotensin II Axis on Bone Tissue. PMID:34065702
Systematic Review and Methodological Considerations for the Use of Single Prolonged Stress and Fear Extinction Retention in Rodents. PMID:34054443
A Handful of Details to Ensure the Experimental Reproducibility on the FORCED Running Wheel in Rodents: A Systematic Review. PMID:34040580
Recent developments in in vitro and in vivo models for improved translation of preclinical pharmacokinetics and pharmacodynamics data. PMID:33989099
A manifesto for reproducible science. PMID:33954258
Systematic Review and Quality Evaluation Using ARRIVE 2.0 Guidelines on Animal Models Used for Periosteal Distraction Osteogenesis. PMID:33923253
Statistical analysis of comparative tumor growth repeated measures experiments in the ovarian cancer patient derived xenograft (PDX) setting. PMID:33850213
Ethics of primate use. PMID:33841745
Online resources for improving the care and use of non-human primates in research. PMID:33778154
Applying the 3Rs to non-human primate research: Barriers and solutions. PMID:33777153
Assessing Scientific Soundness and Translational Value of Animal Studies on DPP4 Inhibitors for Treating Type 2 Diabetes Mellitus. PMID:33669354
Bisphosphonates as disease-modifying drugs in osteoarthritis preclinical studies: a systematic review from 2000 to 2020. PMID:33618776
Open Transparent Communication about Animals in Laboratories: Dialog for Multiple Voices and Multiple Audiences. PMID:33540590
Stem Cells as Therapy for Necrotizing Enterocolitis: A Systematic Review and Meta-Analysis of Preclinical Studies. PMID:33363060
Effects of Cyclocarya paliurus Aqueous and Ethanol Extracts on Glucolipid Metabolism and the Underlying Mechanisms: A Meta-Analysis and Systematic Review. PMID:33335910
Menoci: lightweight extensible web portal enhancing data management for biomedical research projects. PMID:33334310
Quantifying and addressing the prevalence and bias of study designs in the environmental and social sciences. PMID:33311448
Quality of interventional animal experiments in Chinese journals: compliance with ARRIVE guidelines. PMID:33243206
Anticonvulsant Effectiveness and Neurotoxicity Profile of 4-butyl-5-[(4-chloro-2-methylphenoxy)methyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione (TPL-16) in Mice. PMID:33206316
The Rigor and Transparency Index Quality Metric for Assessing Biological and Medical Science Methods. PMID:33196023
Evolving applications of the egg: chorioallantoic membrane assay and ex vivo organotypic culture of materials for bone tissue engineering. PMID:33194169
An Anglocentric History of Anaesthetics and Analgesics in the Refinement of Animal Experiments. PMID:33096686
Novel bifunctional hybrid compounds designed to enhance the effects of opioids and antagonize the pronociceptive effects of nonopioid peptides as potent analgesics in a rat model of neuropathic pain. PMID:32826750
Implantable Osmotic Transport Device Can Reduce Edema After Severe Contusion Spinal Cord Injury. PMID:32754586
Importance of Systematic Reviews and Meta-analyses of Animal Studies: Challenges for Animal-to-Human Translation. PMID:32727637
Improving transparency and scientific rigor in academic publishing. PMID:32721132
Effects of occlusal disharmony on cardiac fibrosis, myocyte apoptosis and myocyte oxidative DNA damage in mice. PMID:32716920
Effect of Sodium-Glucose Cotransporter-2 Inhibitors on Endothelial Function: A Systematic Review of Preclinical Studies. PMID:32715425
European Society for Sexual Medicine Consensus Statement on the Use of the Cavernous Nerve Injury Rodent Model to Study Postradical Prostatectomy Erectile Dysfunction. PMID:32674971
The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. PMID:32666574
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. PMID:32666546
Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0. PMID:32663221
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. PMID:32663219
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. PMID:32663096
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. PMID:32662519
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. PMID:32660541
Detrimental effects of the 'bath salt' methylenedioxypyrovalerone on social play behavior in male rats. PMID:32506112
Statistical analysis of longitudinal data on tumour growth in mice experiments. PMID:32499558
Are the Lives of Animals Well-spent in Laboratory Science Research? A Study of Orthopaedic Animal Studies in Turkey. PMID:32467410
Heart failure supported by veno-arterial extracorporeal membrane oxygenation (ECMO): a systematic review of pre-clinical models. PMID:32451698
Characterization of Amphetamine, Methylphenidate, Nicotine, and Atomoxetine on Measures of Attention, Impulsive Action, and Motivation in the Rat: Implications for Translational Research. PMID:32390829
Evaluation of Preclinical and Clinical Studies Published in Medical Journals of Bosnia and Herzegovina: Methodology Issues. PMID:32210508
Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care: NHLBI Working Group Report. PMID:32150460
Experimental replications in animal trials. PMID:32138592
Comprehensive survey among statistical members of medical ethics committees in Germany on their personal impression of completeness and correctness of biostatistical aspects of submitted study protocols. PMID:32024788
In Vitro Research Reproducibility: Keeping Up High Standards. PMID:31920667
Astragaloside IV Exerts Cardioprotection in Animal Models of Viral Myocarditis: A Preclinical Systematic Review and Meta-Analysis. PMID:31849654
Menagerie: A text-mining tool to support animal-human translation in neurodegeneration research. PMID:31846471
Evaluation of Published Preclinical Experimental Studies in Medicine: Methodology Issues. PMID:31819300
The effect of analgesics on stimulus evoked pain-like behaviour in animal models for chemotherapy induced peripheral neuropathy- a meta-analysis. PMID:31772391
The World Cancer Research Fund/American Institute for Cancer Research Third Expert Report on Diet, Nutrition, Physical Activity, and Cancer: Impact and Future Directions. PMID:31758189
Journal Initiatives to Enhance Preclinical Research: Analyses of Stroke, Nature Medicine, Science Translational Medicine. PMID:31718504
Pharmacological Blockade of Spinal CXCL3/CXCR2 Signaling by NVP CXCR2 20, a Selective CXCR2 Antagonist, Reduces Neuropathic Pain Following Peripheral Nerve Injury. PMID:31616413
Doxorubicin-induced skeletal muscle atrophy: Elucidating the underlying molecular pathways. PMID:31600860
Reporting and analysis of repeated measurements in preclinical animals experiments. PMID:31404099
Assessing the Completeness of Reporting in Preclinical Oncolytic Virus Therapy Studies. PMID:31276026
The dark side of technological advances in analysis of microbial ecosystems. PMID:31236270
A randomised controlled trial of an Intervention to Improve Compliance with the ARRIVE guidelines (IICARus). PMID:31205756
Incomplete reporting of experimental studies and items associated with risk of bias in veterinary research. PMID:31205725
Adaptation of the Systematic Review Framework to the Assessment of Toxicological Test Methods: Challenges and Lessons Learned with the Zebrafish Embryotoxicity Test. PMID:31192353
Reporting preclinical anesthesia study (REPEAT): Evaluating the quality of reporting in the preclinical anesthesiology literature. PMID:31120888
Dependence of Neuroprosthetic Stimulation on the Sensory Modality of the Trigeminal Neurons Following Nerve Injury. Implications in the Design of Future Sensory Neuroprostheses for Correct Perception and Modulation of Neuropathic Pain. PMID:31118880
A study to assess the methodological quality of in vivo animal experiments published in Indian journal of pharmacology: A retrospective, cross-sectional, observational study. PMID:31031462
How to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation. PMID:30931172
Housing mice in the individually ventilated or open cages-Does it matter for behavioral phenotype? PMID:30848040
The Brazilian Reproducibility Initiative. PMID:30720433
The antidepressant impact of minocycline in rodents: A systematic review and meta-analysis. PMID:30670723
Efficacy of Biophysical Energies on Healing of Diabetic Skin Wounds in Cell Studies and Animal Experimental Models: A Systematic Review. PMID:30654555
Inclusion of females does not increase variability in rodent research studies. PMID:30560152
Quantity and Reporting Quality of Kidney Research. PMID:30545982
Improving transparency and scientific rigor in academic publishing. PMID:30506879
Sex bias in preclinical research and an exploration of how to change the status quo. PMID:30418665
The Reporting Items for Patent Landscapes statement. PMID:30412195
Model-based serial blood sampling protocol for minimal mortality and better recovery in small to medium sized tilapia. PMID:30305283
Efficient two-stage designs and proper inference for animal studies. PMID:30294384
Preclinical efficacy in therapeutic area guidelines from the U.S. Food and Drug Administration and the European Medicines Agency: a cross-sectional study. PMID:30153701
Part I: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Study Design and Humane Modeling Endpoints. PMID:30106874
Preclinical therapies to prevent or treat fracture non-union: A systematic review. PMID:30067783
- Editorial - Guidelines for experimental design and statistical analyses in animal studies submitted for publication in the Asian-Australasian Journal of Animal Sciences. PMID:30056648
Systematic literature review of Rift Valley fever virus seroprevalence in livestock, wildlife and humans in Africa from 1968 to 2016. PMID:30036382
Animal experimental research design in critical care. PMID:29976162
Getting personal with the "reproducibility crisis": interviews in the animal research community. PMID:29942056
A guideline for reporting experimental protocols in life sciences. PMID:29868256
Disbiome database: linking the microbiome to disease. PMID:29866037
Effects of Panax ginseng on Obesity in Animal Models: A Systematic Review and Meta-Analysis. PMID:29861768
Repurposing Dantrolene for Long-Term Combination Therapy to Potentiate Antisense-Mediated DMD Exon Skipping in the mdx Mouse. PMID:29858053
ARRIVE has not ARRIVEd: Support for the ARRIVE (Animal Research: Reporting of in vivo Experiments) guidelines does not improve the reporting quality of papers in animal welfare, analgesia or anesthesia. PMID:29795636
Nitric Oxide Synthase Inhibition as a Neuroprotective Strategy Following Hypoxic-Ischemic Encephalopathy: Evidence From Animal Studies. PMID:29725319
Repetitive Neonatal Erythropoietin and Melatonin Combinatorial Treatment Provides Sustained Repair of Functional Deficits in a Rat Model of Cerebral Palsy. PMID:29706928
Effect size and statistical power in the rodent fear conditioning literature - A systematic review. PMID:29698451
Ensuring reproducibility and ethics in animal experiments reporting in Korea using the ARRIVE guideline. PMID:29628972
Preclinical efficacy studies in investigator brochures: Do they enable risk-benefit assessment? PMID:29621228
What exactly is 'N' in cell culture and animal experiments? PMID:29617358
Scientific productivity: An exploratory study of metrics and incentives. PMID:29614101
Retrospective harm benefit analysis of pre-clinical animal research for six treatment interventions. PMID:29590200
PLK1 has tumor-suppressive potential in APC-truncated colon cancer cells. PMID:29549256
Protocol for a Systematic Review of Effect Sizes and Statistical Power in the Rodent Fear Conditioning Literature. PMID:29497557
Simple decision-tree tool to facilitate author identification of reporting guidelines during submission: a before-after study. PMID:29451534
A Guerilla Guide to Common Problems in 'Neurostatistics': Essential Statistical Topics in Neuroscience. PMID:29371855
Facilitating healthcare decisions by assessing the certainty in the evidence from preclinical animal studies. PMID:29324741
Unit of analysis issues in laboratory-based research. PMID:29319501
Promoting and improving three Rs practice: the Korean guidelines. PMID:29187280
The Weak Spots in Contemporary Science (and How to Fix Them). PMID:29186879
Mesenchymal Stromal Cell Therapy in Bronchopulmonary Dysplasia: Systematic Review and Meta-Analysis of Preclinical Studies. PMID:29045045
Enhancing Scientific Foundations to Ensure Reproducibility: A New Paradigm. PMID:28958817
The Experimental Design Assistant. PMID:28957312
PREPARE: guidelines for planning animal research and testing. PMID:28771074
The Association between High Fat Diet around Gestation and Metabolic Syndrome-related Phenotypes in Rats: A Systematic Review and Meta-Analysis. PMID:28698653
Quality of reporting of otorhinolaryngology articles using animal models with the ARRIVE statement. PMID:28696159
Publication bias in animal research presented at the 2008 Society of Critical Care Medicine Conference. PMID:28683761
Microfluidic on-chip biomimicry for 3D cell culture: a fit-for-purpose investigation from the end user standpoint. PMID:28670465
Preclinical progenitor cell therapy in traumatic brain injury: a meta-analysis. PMID:28624058
Current Advancements and Strategies in Tissue Engineering for Wound Healing: A Comprehensive Review. PMID:28616360
Assessing the utility of an institutional publications officer: a pilot assessment. PMID:28584700
Accelerating Biomedical Discoveries through Rigor and Transparency. PMID:28575443
Kinoscope: An Open-Source Computer Program for Behavioral Pharmacologists. PMID:28553211
Impact of different analgesic depths and abdominal trauma of different severities on stress and recovery of rats undergoing total intravenous anesthesia. PMID:28553135
Design, analysis and reporting of tumor models. PMID:28422097
Survey of basic medical researchers on the awareness of animal experimental designs and reporting standards in China. PMID:28380050
Methodological Rigor in Preclinical Cardiovascular Studies: Targets to Enhance Reproducibility and Promote Research Translation. PMID:28373349
Animal models of maternal high fat diet exposure and effects on metabolism in offspring: a meta-regression analysis. PMID:28371083
Introducing Therioepistemology: the study of how knowledge is gained from animal research. PMID:28328885
The role of the IACUC in ensuring research reproducibility. PMID:28328872
Increasing efficiency of preclinical research by group sequential designs. PMID:28282371
Established patterns of animal study design undermine translation of disease-modifying therapies for Parkinson's disease. PMID:28182759
Study Design Rigor in Animal-Experimental Research Published in Anesthesia Journals. PMID:28181936
The Researchers' View of Scientific Rigor-Survey on the Conduct and Reporting of In Vivo Research. PMID:27911901
Authorization of Animal Experiments Is Based on Confidence Rather than Evidence of Scientific Rigor. PMID:27911892
Methodological Considerations for Optimizing and Validating Behavioral Assays. PMID:27906464
The reproducibility of biomedical research: Sleepers awake! PMID:27896142
The Devil Is in the Details: Incomplete Reporting in Preclinical Animal Research. PMID:27855228
Reproducibility and Research Integrity. PMID:27820655
Impact of Chronic Stress Protocols in Learning and Memory in Rodents: Systematic Review and Meta-Analysis. PMID:27662580
The Role of Animal Models in the Study of Hematopoietic Stem Cell Transplantation and GvHD: A Historical Overview. PMID:27625651
Quality of reporting randomized controlled trials (RCTs) in diabetes in Iran; a systematic review. PMID:27610356
Efficacy of Soiled Bedding Transfer for Transmission of Mouse and Rat Infections to Sentinels: A Systematic Review. PMID:27518654
Show and tell: disclosure and data sharing in experimental pathology. PMID:27483498
Developing a Collaborative Agenda for Humanities and Social Scientific Research on Laboratory Animal Science and Welfare. PMID:27428071
A Bayesian multi-stage cost-effectiveness design for animal studies in stroke research. PMID:27405325
Report on a pilot project to introduce a publications officer. PMID:27325134
Phase 4 Studies in Heart Failure - What is Done and What is Needed? PMID:27280303
Ibogaine and addiction in the animal model, a systematic review and meta-analysis. PMID:27244235
A Systematic Review of the Modifying Effect of Anaesthetic Drugs on Metastasis in Animal Models for Cancer. PMID:27227779
Adherence to ARRIVE Guidelines in Chinese Journal Reports on Neoplasms in Animals. PMID:27182788
The Advantages of Structural Equation Modeling to Address the Complexity of Spatial Reference Learning. PMID:26955327
Bias in the reporting of sex and age in biomedical research on mouse models. PMID:26939790
Editorial: Reporting guidelines for psychopharmacology. PMID:26915651
How do researchers decide early clinical trials? PMID:26833467
Mixed-strain housing for female C57BL/6, DBA/2, and BALB/c mice: validating a split-plot design that promotes refinement and reduction. PMID:26817696
Testing flow diversion in animal models: a systematic review. PMID:26747181
Toward more predictive genetic mouse models of Alzheimer's disease. PMID:26708939
Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations. PMID:26683237
Standard of reporting animal-based experimental research in Indian Journal of Pharmacology. PMID:26600640
Quality of Reporting and Adherence to ARRIVE Guidelines in Animal Studies for Chagas Disease Preclinical Drug Research: A Systematic Review. PMID:26587586
Determinants of the Efficacy of Cardiac Ischemic Preconditioning: A Systematic Review and Meta-Analysis of Animal Studies. PMID:26580958
Refining Housing, Husbandry and Care for Animals Used in Studies Involving Biotelemetry. PMID:26480045
A Critical Look at Biomedical Journals' Policies on Animal Research by Use of a Novel Tool: The EXEMPLAR Scale. PMID:26479237
Risk of Bias in Reports of In Vivo Research: A Focus for Improvement. PMID:26460723
A meta-analysis of threats to valid clinical inference in preclinical research of sunitinib. PMID:26460544
Quantitative volumetric imaging of normal, neoplastic and hyperplastic mouse prostate using ultrasound. PMID:26391476
Factors influencing preclinical in vivo evaluation of mumps vaccine strain immunogenicity. PMID:26376015
Effects of MVA85A vaccine on tuberculosis challenge in animals: systematic review. PMID:26351306
A Systematic Review of Rhubarb (a Traditional Chinese Medicine) Used for the Treatment of Experimental Sepsis. PMID:26339264
A combined pre-clinical meta-analysis and randomized confirmatory trial approach to improve data validity for therapeutic target validation. PMID:26310318
Bedside-to-Bench Translational Research for Chronic Heart Failure: Creating an Agenda for Clients Who Do Not Meet Trial Enrollment Criteria. PMID:26309418
A systematic review and meta-analysis of the ability of analgesic drugs to reduce metastasis in experimental cancer models. PMID:26181303
Applying refinement to the use of mice and rats in rheumatoid arthritis research. PMID:26168847
Evidence of Experimental Bias in the Life Sciences: Why We Need Blind Data Recording. PMID:26154287
Do bells affect behaviour and heart rate variability in grazing dairy cows? PMID:26110277
Osteogenic Potential of Dental Mesenchymal Stem Cells in Preclinical Studies: A Systematic Review Using Modified ARRIVE and CONSORT Guidelines. PMID:26106427
Principles and standards for reporting animal experiments in The Journal of Physiology and Experimental Physiology. PMID:26095019
Applying the ARRIVE Guidelines to an In Vivo Database. PMID:25992600
Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP. PMID:25964986
Expectations for methodology and translation of animal research: a survey of health care workers. PMID:25947255
Practical murine hematopathology: a comparative review and implications for research. PMID:25926395
Wound models for periodontal and bone regeneration: the role of biologic research. PMID:25867976
The use of systematic reviews and reporting guidelines to advance the implementation of the 3Rs. PMID:25836961
The multifactorial role of the 3Rs in shifting the harm-benefit analysis in animal models of disease. PMID:25823812
The National Institutes of Health and guidance for reporting preclinical research. PMID:25775278
Statistical considerations for preclinical studies. PMID:25725352
Editorial: preclinical data reproducibility for R&D - the challenge for neuroscience. PMID:25674489
Preclinical data reproducibility for R&D--the challenge for neuroscience. PMID:25585680
The significance of meaning: why do over 90% of behavioral neuroscience results fail to translate to humans, and what can we do to fix it? PMID:25541546
The usefulness of systematic reviews of animal experiments for the design of preclinical and clinical studies. PMID:25541545
Meta-analyses of animal studies: an introduction of a valuable instrument to further improve healthcare. PMID:25541544
A common control group - optimising the experiment design to maximise sensitivity. PMID:25504147
Improving the predictive value of interventional animal models data. PMID:25448761
Quantifying the behavioural relevance of hippocampal neurogenesis. PMID:25426717
The importance of early life in childhood obesity and related diseases: a report from the 2014 Gravida Strategic Summit. PMID:25308169
The methodological quality of animal research in critical care: the public face of science. PMID:25114829
Individually specific call feature is not used to neighbour-stranger discrimination: the corncrake case. PMID:25090457
Reproducibility of results in preclinical studies: a perspective from the bone field. PMID:24916175
Negative animal studies published in Indian Medical Journal: Are they methodologically strong enough to conclude what they are concluding? PMID:24741285
Systematic reviews of animal studies; missing link in translational research? PMID:24670965
SYRCLE's risk of bias tool for animal studies. PMID:24667063
Improving the translation of analgesic drugs to the clinic: animal models of neuropathic pain. PMID:24527763
Scientific Rigor Recommendations for Optimizing the Clinical Applicability of Translational Research. PMID:24490120
The ethical dimension in published animal research in critical care: the public face of science. PMID:24423201
Open science and reporting animal studies: who's accountable? PMID:24409097
Two years later: journals are not yet enforcing the ARRIVE guidelines on reporting standards for pre-clinical animal studies. PMID:24409096
Standard operating procedures for maintaining cleanliness in a novel compact facility for breeding SPF mice. PMID:24351759
Reporting of results from animal studies. PMID:24284018
On the reproducibility of science: unique identification of research resources in the biomedical literature. PMID:24032093
Better reporting of scientific studies: why it matters. PMID:24013839
Ethical reproducibility: towards transparent reporting in biomedical research. PMID:23985730
Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments. PMID:23935460
Declaration of transparency for each research article. PMID:23924655
Progress in using systematic reviews of animal studies to improve translational research. PMID:23874162
RIGOR guidelines: escalating STAIR and STEPS for effective translational research. PMID:23658596
Improving basic and translational science by accounting for litter-to-litter variation in animal models. PMID:23522086
Whole animal experiments should be more like human randomized controlled trials. PMID:23424284
Therapeutics targeting Nogo-A hold promise for stroke restoration. PMID:23394537
Robust and sensitive analysis of mouse knockout phenotypes. PMID:23300663
The effects of probiotic supplementation on experimental acute pancreatitis: a systematic review and meta-analysis. PMID:23152810
Development of a clinically relevant animal model for the talar osteonecrosis in sheep. PMID:23136546
Animal welfare in studies on murine tuberculosis: assessing progress over a 12-year period and the need for further improvement. PMID:23110093
Gait analysis in rats with single joint inflammation: influence of experimental factors. PMID:23071540
A call for transparent reporting to optimize the predictive value of preclinical research. PMID:23060188
Reporting of preclinical tumor-graft cancer therapeutic studies. PMID:22895077
The fallacy of ratio correction to address confounding factors. PMID:22829707
An evaluation of the quality of statistical design and analysis of published medical research: results from a systematic survey of general orthopaedic journals. PMID:22533688
A systematic review of exercise training to promote locomotor recovery in animal models of spinal cord injury. PMID:22401139
Inclusion of policies on ethical standards in animal experiments in biomedical science journals. PMID:22330784
Environmental enrichment of laboratory rodents: the answer depends on the question. PMID:22330246
Maximising the output of osteoarthritis research: the ARRIVE guidelines. PMID:22321718
Systematic review and meta-analysis of pre-clinical research: the need for reporting guidelines. PMID:22066146
Why animal research needs to improve. PMID:21956292
Evaluation of social and physical enrichment in modulation of behavioural phenotype in C57BL/6J female mice. PMID:21931844
Designing phenotyping studies for genetically engineered mice. PMID:21930803
Survey of Canadian animal-based researchers' views on the Three Rs: replacement, reduction and refinement. PMID:21857928
Reporting of method of animal sacrifice in articles published in Indian journals. PMID:21772779
Will stem cell therapies be safe and effective for treating spinal cord injuries? PMID:21586446
Improving the reporting of animal research: when will we ARRIVE? PMID:21555328
Predicting harms and benefits in translational trials: ethics, evidence, and uncertainty. PMID:21423344
Predictive validity of behavioural animal models for chronic pain. PMID:21371010
Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research. PMID:21350617
Animal rights and wrongs. PMID:21350441
Improving the quality of biomedical research: guidelines for reporting experiments involving animals. PMID:21206506
Systematic survey of the design, statistical analysis, and reporting of studies published in the 2008 volume of the Journal of Cerebral Blood Flow and Metabolism. PMID:21157472
Improving planning, design, reporting and scientific quality of animal experiments by using the Gold Standard Publication Checklist, in addition to the ARRIVE guidelines. PMID:21091655
The Gold Standard Publication Checklist (GSPC) for improved design, reporting and scientific quality of animal studies GSPC versus ARRIVE guidelines. PMID:21088032
Benefits of histone deacetylase inhibitors for acute brain injury: a systematic review of animal studies. PMID:20831615
Optimising experimental design for high-throughput phenotyping in mice: a case study. PMID:20799038
Guidelines for reporting experiments involving animals: the ARRIVE guidelines. PMID:20649560
Reporting animal studies: good science and a duty of care. PMID:20613860
Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PMID:20613859
Statistics in experimental cerebrovascular research: comparison of more than two groups with a continuous outcome variable. PMID:20571520
The problem of pseudoreplication in neuroscientific studies: is it affecting your analysis? PMID:20074371

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animal research
metasource: Fairsharing.org
version: FAIRsharing.org: ARRIVE; Animals in Research: Reporting In Vivo Experiments; DOI: https://doi.org/10.25504/FAIRsharing.t58zhj; Last edited: Jan. 8, 2019, 1:31 p.m.; Last accessed: Jan 03 2022 7:12 p.m.

in vivo design
metasource: Fairsharing.org
version: FAIRsharing.org: ARRIVE; Animals in Research: Reporting In Vivo Experiments; DOI: https://doi.org/10.25504/FAIRsharing.t58zhj; Last edited: Jan. 8, 2019, 1:31 p.m.; Last accessed: Jan 03 2022 7:12 p.m.

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