The AD Knowledge Portal is a platform for accessing data, analyses, and tools that the National Institute on Aging’s (NIA) Alzheimer's Disease Translational Research Program generates through several initiatives. The program encourages open-science collaborations that share resources early in the research life cycle. The AD Knowledge Portal initially hosted data from the Accelerating Medicines Partnership in Alzheimer’s Disease (AMP-AD) Target Discovery and Preclinical Validation Project. The AD Knowledge Portal now includes “omics” data from human samples and experimental model systems, as well as bioinformatic analyses from research teams and cross-consortium working groups. Please note that, while the data are publicly searchable, a login is required to download data sets.