Therapeutic Structural Antibody Database
Names
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Therapeutic Structural Antibody Database
metasource: Fairsharing.org
version: FAIRsharing.org: Thera-SAbDab; Therapeutic Structural Antibody Database; DOI: https://doi.org/10.25504/FAIRsharing.UiP2kL; Last edited: Jan. 21, 2020, 11:02 a.m.; Last accessed: Jan 03 2022 7:06 p.m.
Thera-SAbDab
metasource: Fairsharing.org
version: FAIRsharing.org: Thera-SAbDab; Therapeutic Structural Antibody Database; DOI: https://doi.org/10.25504/FAIRsharing.UiP2kL; Last edited: Jan. 21, 2020, 11:02 a.m.; Last accessed: Jan 03 2022 7:06 p.m.
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:23.250611
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:23.250611
Names
More detailed information about this field from each metasource.
Therapeutic Structural Antibody Database
metasource: Fairsharing.orgversion: FAIRsharing.org: Thera-SAbDab; Therapeutic Structural Antibody Database; DOI: https://doi.org/10.25504/FAIRsharing.UiP2kL; Last edited: Jan. 21, 2020, 11:02 a.m.; Last accessed: Jan 03 2022 7:06 p.m.
Thera-SAbDab
metasource: Fairsharing.orgversion: FAIRsharing.org: Thera-SAbDab; Therapeutic Structural Antibody Database; DOI: https://doi.org/10.25504/FAIRsharing.UiP2kL; Last edited: Jan. 21, 2020, 11:02 a.m.; Last accessed: Jan 03 2022 7:06 p.m.
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:23.250611
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:23.250611
Names
More detailed information about this field from each metasource.
Therapeutic Structural Antibody Database
metasource: Fairsharing.orgversion: FAIRsharing.org: Thera-SAbDab; Therapeutic Structural Antibody Database; DOI: https://doi.org/10.25504/FAIRsharing.UiP2kL; Last edited: Jan. 21, 2020, 11:02 a.m.; Last accessed: Jan 03 2022 7:06 p.m.
Thera-SAbDab
metasource: Fairsharing.orgversion: FAIRsharing.org: Thera-SAbDab; Therapeutic Structural Antibody Database; DOI: https://doi.org/10.25504/FAIRsharing.UiP2kL; Last edited: Jan. 21, 2020, 11:02 a.m.; Last accessed: Jan 03 2022 7:06 p.m.
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:23.250611
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:23.250611
The Therapeutic Structural Antibody Database tracks all antibody- and nanobody-related therapeutics recognized by the World Health Organisation (WHO), and identifies any corresponding structures in the Structural Antibody Database (SAbDab) with near-exact or exact variable domain sequence matches. Thera-SAbDab is synchronized with SAbDab to update weekly, reflecting new Protein Data Bank entries and the availability of new sequence data published by the WHO. Each therapeutic summary page lists structural coverage (with links to the appropriate SAbDab entries), alignments showing where any near-matches deviate in sequence, and accompanying metadata, such as intended target and investigated conditions. Thera-SAbDab can be queried by therapeutic name, by a combination of metadata, or by variable domain sequence - returning all therapeutics that are within a specified sequence identity over a specified region of the query. The sequences of all therapeutics listed in Thera-SAbDab are downloadable as a single file with accompanying metadata.
Description
More detailed information about this field from each metasource.
The Therapeutic Structural Antibody Database tracks all antibody- and nanobody-related therapeutics recognized by the World Health Organisation (WHO), and identifies any corresponding structures in the Structural Antibody Database (SAbDab) with near-exact or exact variable domain sequence matches. Thera-SAbDab is synchronized with SAbDab to update weekly, reflecting new Protein Data Bank entries and the availability of new sequence data published by the WHO. Each therapeutic summary page lists structural coverage (with links to the appropriate SAbDab entries), alignments showing where any near-matches deviate in sequence, and accompanying metadata, such as intended target and investigated conditions. Thera-SAbDab can be queried by therapeutic name, by a combination of metadata, or by variable domain sequence - returning all therapeutics that are within a specified sequence identity over a specified region of the query. The sequences of all therapeutics listed in Thera-SAbDab are downloadable as a single file with accompanying metadata.
metasource: Fairsharing.orgversion: FAIRsharing.org: Thera-SAbDab; Therapeutic Structural Antibody Database; DOI: https://doi.org/10.25504/FAIRsharing.UiP2kL; Last edited: Jan. 21, 2020, 11:02 a.m.; Last accessed: Jan 03 2022 7:06 p.m.
the Therapeutic Structural Antibody Database | The Structural Antibody Database | (Therapeutic Structural Antibody Database) | Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link] | SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:29:23.250611
Webpage:
http://opig.stats.ox.ac.uk/webapps/newsabdab/therasabdabWebpage
More detailed information about this field from each metasource.
http://opig.stats.ox.ac.uk/webapps/newsabdab/therasabdab
metasource: Fairsharing.orgversion: FAIRsharing.org: Thera-SAbDab; Therapeutic Structural Antibody Database; DOI: https://doi.org/10.25504/FAIRsharing.UiP2kL; Last edited: Jan. 21, 2020, 11:02 a.m.; Last accessed: Jan 03 2022 7:06 p.m.
http://opig.stats.ox.ac.uk/webapps/therasabdab
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:29:23.250611
Publications:
Publications
More detailed information about this field from each metasource.
Thera-SAbDab: the Therapeutic Structural Antibody Database
PMID: 31555805
metasource: Fairsharing.org
version: FAIRsharing.org: Thera-SAbDab; Therapeutic Structural Antibody Database; DOI: https://doi.org/10.25504/FAIRsharing.UiP2kL; Last edited: Jan. 21, 2020, 11:02 a.m.; Last accessed: Jan 03 2022 7:06 p.m.
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:23.250611
Publications
More detailed information about this field from each metasource.
Thera-SAbDab: the Therapeutic Structural Antibody Database
PMID: 31555805
metasource: Fairsharing.org
version: FAIRsharing.org: Thera-SAbDab; Therapeutic Structural Antibody Database; DOI: https://doi.org/10.25504/FAIRsharing.UiP2kL; Last edited: Jan. 21, 2020, 11:02 a.m.; Last accessed: Jan 03 2022 7:06 p.m.
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:23.250611
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Thera-SAbDab: the Therapeutic Structural Antibody Database
PubMed citations: 23.
23 articles citing: Thera-SAbDab: the Therapeutic Structural Antibody Database
Separating clinical antibodies from repertoire antibodies, a path to in silico developability assessment. PMID:35771588
A perspective toward mass spectrometry-based de novo sequencing of endogenous antibodies. PMID:35699511
Progress and challenges for the machine learning-based design of fit-for-purpose monoclonal antibodies. PMID:35293269
BioPhi: A platform for antibody design, humanization, and humanness evaluation based on natural antibody repertoires and deep learning. PMID:35133949
Current advances in biopharmaceutical informatics: guidelines, impact and challenges in the computational developability assessment of antibody therapeutics. PMID:35104168
Designing of a bispecific antibody against SARS-CoV-2 spike glycoprotein targeting human entry receptors DPP4 and ACE2. PMID:35042653
SAbDab in the age of biotherapeutics: updates including SAbDab-nano, the nanobody structure tracker. PMID:34986602
IgG1-b12-HIV-gp120 Interface in Solution: A Computational Study. PMID:34971312
Unravelling the molecular interactions between the SARS-CoV-2 RBD spike protein and various specific monoclonal antibodies. PMID:34710552
Single-domain antibody screening by isPLA-seq. PMID:34675071
SYNBIP: synthetic binding proteins for research, diagnosis and therapy. PMID:34664670
Structure-based charge calculations for predicting isoelectric point, viscosity, clearance, and profiling antibody therapeutics. PMID:34632944
RAPID: A Rep-Seq Dataset Analysis Platform With an Integrated Antibody Database. PMID:34484220
Therapeutic Antibodies: An Overview. PMID:34478129
Identifying biophysical assays and in silico properties that enrich for slow clearance in clinical-stage therapeutic antibodies. PMID:34116620
Humanization of antibodies using a machine learning approach on large-scale repertoire data. PMID:34110413
Exploring antibody repurposing for COVID-19: beyond presumed roles of therapeutic antibodies. PMID:33986382
IsAb: a computational protocol for antibody design. PMID:33876197
Data mining patented antibody sequences. PMID:33722161
Public Baseline and shared response structures support the theory of antibody repertoire functional commonality. PMID:33647011
A computational method for immune repertoire mining that identifies novel binders from different clonotypes, demonstrated by identifying anti-pertussis toxoid antibodies. PMID:33427589
How repertoire data are changing antibody science. PMID:32409582
The 27th annual Nucleic Acids Research database issue and molecular biology database collection. PMID:31906604
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antibody
metasource: Fairsharing.org
version: FAIRsharing.org: Thera-SAbDab; Therapeutic Structural Antibody Database; DOI: https://doi.org/10.25504/FAIRsharing.UiP2kL; Last edited: Jan. 21, 2020, 11:02 a.m.; Last accessed: Jan 03 2022 7:06 p.m.
nucleic acid structure analysis
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:23.250611
structure prediction
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:23.250611
small molecules
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:23.250611
Tags
More detailed information about this field from each metasource.
antibody
metasource: Fairsharing.orgversion: FAIRsharing.org: Thera-SAbDab; Therapeutic Structural Antibody Database; DOI: https://doi.org/10.25504/FAIRsharing.UiP2kL; Last edited: Jan. 21, 2020, 11:02 a.m.; Last accessed: Jan 03 2022 7:06 p.m.
nucleic acid structure analysis
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:29:23.250611
structure prediction
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:29:23.250611
small molecules
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:29:23.250611
antibody nucleic acid structure analysis structure prediction small molecule
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