Signaling Pathway Integrated Knowledge Engine
Names
More detailed information about this field from each metasource.
Signaling Pathway Integrated Knowledge Engine
metasource: Fairsharing.org
version: FAIRsharing.org: SPIKE; Signaling Pathway Integrated Knowledge Engine; DOI: https://doi.org/10.25504/FAIRsharing.scsnja; Last edited: April 26, 2021, 3:19 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
SPIKE
metasource: Fairsharing.org
version: FAIRsharing.org: SPIKE; Signaling Pathway Integrated Knowledge Engine; DOI: https://doi.org/10.25504/FAIRsharing.scsnja; Last edited: April 26, 2021, 3:19 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
metasource: bio.tools
version: extracted_at: 2022-11-04T11:26:36.844554
spike
metasource: bio.tools
version: extracted_at: 2022-11-04T11:26:36.844554
Names
More detailed information about this field from each metasource.
Signaling Pathway Integrated Knowledge Engine
metasource: Fairsharing.orgversion: FAIRsharing.org: SPIKE; Signaling Pathway Integrated Knowledge Engine; DOI: https://doi.org/10.25504/FAIRsharing.scsnja; Last edited: April 26, 2021, 3:19 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
SPIKE
metasource: Fairsharing.orgversion: FAIRsharing.org: SPIKE; Signaling Pathway Integrated Knowledge Engine; DOI: https://doi.org/10.25504/FAIRsharing.scsnja; Last edited: April 26, 2021, 3:19 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
metasource: bio.tools
version: extracted_at: 2022-11-04T11:26:36.844554
spike
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:26:36.844554
Names
More detailed information about this field from each metasource.
Signaling Pathway Integrated Knowledge Engine
metasource: Fairsharing.orgversion: FAIRsharing.org: SPIKE; Signaling Pathway Integrated Knowledge Engine; DOI: https://doi.org/10.25504/FAIRsharing.scsnja; Last edited: April 26, 2021, 3:19 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
SPIKE
metasource: Fairsharing.orgversion: FAIRsharing.org: SPIKE; Signaling Pathway Integrated Knowledge Engine; DOI: https://doi.org/10.25504/FAIRsharing.scsnja; Last edited: April 26, 2021, 3:19 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
metasource: bio.tools
version: extracted_at: 2022-11-04T11:26:36.844554
spike
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:26:36.844554
SPIKE (Signaling Pathway Integrated Knowledge Engine) is an interactive software environment that graphically displays biological signaling networks, allows dynamic layout and navigation through these networks, and enables the superposition of DNA microarray and other functional genomics data on interaction maps.
Description
More detailed information about this field from each metasource.
SPIKE (Signaling Pathway Integrated Knowledge Engine) is an interactive software environment that graphically displays biological signaling networks, allows dynamic layout and navigation through these networks, and enables the superposition of DNA microarray and other functional genomics data on interaction maps.
metasource: Fairsharing.orgversion: FAIRsharing.org: SPIKE; Signaling Pathway Integrated Knowledge Engine; DOI: https://doi.org/10.25504/FAIRsharing.scsnja; Last edited: April 26, 2021, 3:19 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
Signaling Pathways Integrated Knowledge Engine
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
Database for highly curated interactions for particular human pathways, along with literature-referenced information on the nature of each interaction. Pathways are laid out as maps that reflect the curator's understanding and make the utilization of the pathways easy. The database currently focuses primarily on pathways describing DNA damage response, cell cycle, programmed cell death and hearing related pathways.
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:26:36.844554
Webpage:
http://www.cs.tau.ac.il/~spike/Webpage
More detailed information about this field from each metasource.
http://www.cs.tau.ac.il/~spike/
metasource: Fairsharing.orgversion: FAIRsharing.org: SPIKE; Signaling Pathway Integrated Knowledge Engine; DOI: https://doi.org/10.25504/FAIRsharing.scsnja; Last edited: April 26, 2021, 3:19 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
metasource: bio.tools
version: extracted_at: 2022-11-04T11:26:36.844554
Publications:
Publications
More detailed information about this field from each metasource.
SPIKE: a database of highly curated human signaling pathways
PMID: 21097778
metasource: Fairsharing.org
version: FAIRsharing.org: SPIKE; Signaling Pathway Integrated Knowledge Engine; DOI: https://doi.org/10.25504/FAIRsharing.scsnja; Last edited: April 26, 2021, 3:19 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
metasource: bio.tools
version: extracted_at: 2022-11-04T11:26:36.844554
http://nar.oxfordjournals.org/content/39/suppl_1/D793
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Publications
More detailed information about this field from each metasource.
SPIKE: a database of highly curated human signaling pathways
PMID: 21097778
metasource: Fairsharing.org
version: FAIRsharing.org: SPIKE; Signaling Pathway Integrated Knowledge Engine; DOI: https://doi.org/10.25504/FAIRsharing.scsnja; Last edited: April 26, 2021, 3:19 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
metasource: bio.tools
version: extracted_at: 2022-11-04T11:26:36.844554
http://nar.oxfordjournals.org/content/39/suppl_1/D793
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
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SPIKE: a database of highly curated human signaling pathways
PubMed citations: 34.
34 articles citing: SPIKE: a database of highly curated human signaling pathways
ConsensusPathDB 2022: molecular interactions update as a resource for network biology. PMID:34850110
Assembling Disease Networks From Causal Interaction Resources. PMID:34178043
The status of causality in biological databases: data resources and data retrieval possibilities to support logical modeling. PMID:33378765
In vitro dexamethasone treatment does not induce alternative ATM transcripts in cells from Ataxia-Telangiectasia patients. PMID:33214630
Ataxia-telangiectasia complicated with Hodgkin's lymphoma: A case report. PMID:32548172
Integrating protein localization with automated signaling pathway reconstruction. PMID:31787091
pathDIP 4: an extended pathway annotations and enrichment analysis resource for human, model organisms and domesticated species. PMID:31733064
Phosphoproteomics-Based Profiling of Kinase Activities in Cancer Cells. PMID:29344887
An individualized gene expression signature for prediction of lung adenocarcinoma metastases. PMID:28922552
Pathways on demand: automated reconstruction of human signaling networks. PMID:28725467
Endothelium-Independent Primitive Myxoid Vascularization Creates Invertebrate-Like Channels to Maintain Blood Supply in Optic Gliomas. PMID:28606795
NaviCom: a web application to create interactive molecular network portraits using multi-level omics data. PMID:28415074
Ataxia telangiectasia: a review. PMID:27884168
Exon-centric regulation of ATM expression is population-dependent and amenable to antisense modification by pseudoexon targeting. PMID:26732650
Identifying communities from multiplex biological networks. PMID:26713261
A method for developing regulatory gene set networks to characterize complex biological systems. PMID:26576648
ESEA: Discovering the Dysregulated Pathways based on Edge Set Enrichment Analysis. PMID:26267116
MyProteinNet: build up-to-date protein interaction networks for organisms, tissues and user-defined contexts. PMID:25990735
Systematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations. PMID:25887147
Comparison of human cell signaling pathway databases--evolution, drawbacks and challenges. PMID:25632107
Pathway mapping and development of disease-specific biomarkers: protein-based network biomarkers. PMID:25560835
Signaling hypergraphs. PMID:24857424
R-based software for the integration of pathway data into bioinformatic algorithms. PMID:24833336
Navigating the multilayered organization of eukaryotic signaling: a new trend in data integration. PMID:24550716
Pattern search in BioPAX models. PMID:24045775
A context-sensitive framework for the analysis of human signalling pathways in molecular interaction networks. PMID:23812986
ResponseNet2.0: Revealing signaling and regulatory pathways connecting your proteins and genes--now with human data. PMID:23761447
Interferon-beta induces distinct gene expression response patterns in human monocytes versus T cells. PMID:23626809
p53 induces transcriptional and translational programs to suppress cell proliferation and growth. PMID:23594524
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. PMID:23486281
Altered transcriptome signature of phenotypically normal skin fibroblasts heterozygous for CDKN2A in familial melanoma: relevance to early intervention. PMID:23371019
SignaLink 2 - a signaling pathway resource with multi-layered regulatory networks. PMID:23331499
Constructing a robust protein-protein interaction network by integrating multiple public databases. PMID:22165958
Transcriptional modulation induced by ionizing radiation: p53 remains a central player. PMID:21795128 - http://nar.oxfordjournals.org/content/39/suppl_1/D793
Tags:
Tags
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deoxyribonucleic acid
metasource: Fairsharing.org
version: FAIRsharing.org: SPIKE; Signaling Pathway Integrated Knowledge Engine; DOI: https://doi.org/10.25504/FAIRsharing.scsnja; Last edited: April 26, 2021, 3:19 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
gene expression data
metasource: Fairsharing.org
version: FAIRsharing.org: SPIKE; Signaling Pathway Integrated Knowledge Engine; DOI: https://doi.org/10.25504/FAIRsharing.scsnja; Last edited: April 26, 2021, 3:19 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
network model
metasource: Fairsharing.org
version: FAIRsharing.org: SPIKE; Signaling Pathway Integrated Knowledge Engine; DOI: https://doi.org/10.25504/FAIRsharing.scsnja; Last edited: April 26, 2021, 3:19 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
signaling
metasource: Fairsharing.org
version: FAIRsharing.org: SPIKE; Signaling Pathway Integrated Knowledge Engine; DOI: https://doi.org/10.25504/FAIRsharing.scsnja; Last edited: April 26, 2021, 3:19 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
metabolic and signaling pathways
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
signalling pathways
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
molecular interactions, pathways and networks
metasource: bio.tools
version: extracted_at: 2022-11-04T11:26:36.844554
human biology
metasource: bio.tools
version: extracted_at: 2022-11-04T11:26:36.844554
mapping
metasource: bio.tools
version: extracted_at: 2022-11-04T11:26:36.844554
data submission, annotation and curation
metasource: bio.tools
version: extracted_at: 2022-11-04T11:26:36.844554
Tags
More detailed information about this field from each metasource.
deoxyribonucleic acid
metasource: Fairsharing.orgversion: FAIRsharing.org: SPIKE; Signaling Pathway Integrated Knowledge Engine; DOI: https://doi.org/10.25504/FAIRsharing.scsnja; Last edited: April 26, 2021, 3:19 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
gene expression data
metasource: Fairsharing.orgversion: FAIRsharing.org: SPIKE; Signaling Pathway Integrated Knowledge Engine; DOI: https://doi.org/10.25504/FAIRsharing.scsnja; Last edited: April 26, 2021, 3:19 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
network model
metasource: Fairsharing.orgversion: FAIRsharing.org: SPIKE; Signaling Pathway Integrated Knowledge Engine; DOI: https://doi.org/10.25504/FAIRsharing.scsnja; Last edited: April 26, 2021, 3:19 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
signaling
metasource: Fairsharing.orgversion: FAIRsharing.org: SPIKE; Signaling Pathway Integrated Knowledge Engine; DOI: https://doi.org/10.25504/FAIRsharing.scsnja; Last edited: April 26, 2021, 3:19 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
metabolic and signaling pathways
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
signalling pathways
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
molecular interactions, pathways and networks
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:26:36.844554
human biology
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:26:36.844554
mapping
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:26:36.844554
data submission, annotation and curation
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:26:36.844554
dna gene expression network model signaling metabolic and signaling pathways signalling pathways molecular interactions, pathways and networks human mapping data submission, annotation and curation
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