Strategies to access biosynthetic novelty in bacterial genomes for drug discovery.
PMID:35296832
Halovirs I-K, antibacterial and cytotoxic lipopeptaibols from the plant pathogenic fungus Paramyrothecium roridum NRRL 2183.
PMID:35288678
Metabolomics on the study of marine organisms.
PMID:35235054
NP Analyst: An Open Online Platform for Compound Activity Mapping.
PMID:35233454
Rare actinobacteria isolated from the hypersaline Ojo de Liebre Lagoon as a source of novel bioactive compounds with biotechnological potential.
PMID:35213299
Biosynthetic Potential of the Endophytic Fungus Helotiales sp. BL73 Revealed via Compound Identification and Genome Mining.
PMID:35108081
Aulosirazoles B and C from the Cyanobacterium Nostoc sp. UIC 10771: Analogues of an Isothiazolonaphthoquinone Scaffold that Activate Nuclear Transcription Factor FOXO3a in Ovarian Cancer Cells.
PMID:35100504
Induction of Isochromanones by Co-Cultivation of the Marine Fungus Cosmospora sp. and the Phytopathogen Magnaporthe oryzae.
PMID:35054969
New Deoxyenhygrolides from Plesiocystis pacifica Provide Insights into Butenolide Core Biosynthesis.
PMID:35049927
Potential Anti-Obesity, Anti-Steatosis, and Anti-Inflammatory Properties of Extracts from the Microalgae Chlorella vulgaris and Chlorococcum amblystomatis under Different Growth Conditions.
PMID:35049863
An isotopic labeling approach linking natural products with biosynthetic gene clusters.
PMID:34969972
Genome-Guided Discovery of the First Myxobacterial Biarylitide Myxarylin Reveals Distinct C-N Biaryl Crosslinking in RiPP Biosynthesis.
PMID:34946566
Structure-Function Characteristics of SARS-CoV-2 Proteases and Their Potential Inhibitors from Microbial Sources.
PMID:34946083
Potential Antagonistic Bacteria against Verticillium dahliae Isolated from Artificially Infested Nursery.
PMID:34944096
Metabolomics Tools Assisting Classic Screening Methods in Discovering New Antibiotics from Mangrove Actinomycetia in Leizhou Peninsula.
PMID:34940687
Probing the Therapeutic Potential of Marine Phyla by SPE Extraction.
PMID:34822511
Advances in decomposing complex metabolite mixtures using substructure- and network-based computational metabolomics approaches.
PMID:34821250
Genome-Guided Discovery of Natural Products through Multiplexed Low-Coverage Whole-Genome Sequencing of Soil Actinomycetes on Oxford Nanopore Flongle.
PMID:34812649
NP-MRD: the Natural Products Magnetic Resonance Database.
PMID:34791429
Benefiting from big data in natural products: importance of preserving foundational skills and prioritizing data quality.
PMID:34734219
The Natural Products Atlas 2.0: a database of microbially-derived natural products.
PMID:34718710
Biogeography of Bacterial Communities and Specialized Metabolism in Human Aerodigestive Tract Microbiomes.
PMID:34704787
Marine Biodiscovery in a Changing World.
PMID:34698944
Contemporary Approaches to the Discovery and Development of Broad-Spectrum Natural Product Prototypes for the Control of Coronaviruses.
PMID:34677966
Nerpa: A Tool for Discovering Biosynthetic Gene Clusters of Bacterial Nonribosomal Peptides.
PMID:34677408
Classifying natural products from plants, fungi or bacteria using the COCONUT database and machine learning.
PMID:34663470
NPClassifier: A Deep Neural Network-Based Structural Classification Tool for Natural Products.
PMID:34662515
"Microbial Wars" in a Stirred Tank Bioreactor: Investigating the Co-Cultures of Streptomyces rimosus and Aspergillus terreus, Filamentous Microorganisms Equipped With a Rich Arsenal of Secondary Metabolites.
PMID:34660550
Discovery and characterisation of an amidine-containing ribosomally-synthesised peptide that is widely distributed in nature.
PMID:34659714
Advancements in capturing and mining mass spectrometry data are transforming natural products research.
PMID:34612288
Orally Administered Natural Lipid Nanoparticle-Loaded 6-Shogaol Shapes the Anti-Inflammatory Microbiota and Metabolome.
PMID:34575431
Mass spectrometry-based metabolomics in microbiome investigations.
PMID:34552265
An overview of potential inhibitors targeting non-structural proteins 3 (PLpro and Mac1) and 5 (3CLpro/Mpro) of SARS-CoV-2.
PMID:34457214
Facilitating Imaging Mass Spectrometry of Microbial Specialized Metabolites with METASPACE.
PMID:34436418
Comprehensive Large-Scale Integrative Analysis of Omics Data To Accelerate Specialized Metabolite Discovery.
PMID:34427506
Towards the sustainable discovery and development of new antibiotics.
PMID:34426795
Dereplication, Annotation, and Characterization of 74 Potential Antimicrobial Metabolites from Penicillium Sclerotiorum Using t-SNE Molecular Networks.
PMID:34357338
Phormidepistatin from the Cyanobacterium UIC 10484: Assessing the Phylogenetic Distribution of the Statine Pharmacophore.
PMID:34314586
Characterization of the Exometabolome of Nitrosopumilus maritimus SCM1 by Liquid Chromatography-Ion Mobility Mass Spectrometry.
PMID:34276593
MassSpecBlocks: a web-based tool to create building blocks and sequences of nonribosomal peptides and polyketides for tandem mass spectra analysis.
PMID:34233741
MolDiscovery: learning mass spectrometry fragmentation of small molecules.
PMID:34140479
Mining genomes to illuminate the specialized chemistry of life.
PMID:34083778
Aspergillus Metabolome Database for Mass Spectrometry Metabolomics.
PMID:34063531
MetFish: a Metabolomics Pipeline for Studying Microbial Communities in Chemically Extreme Environments.
PMID:34061574
Synthetic biology approaches to actinomycete strain improvement.
PMID:34057181
Applications of Virtual Screening in Bioprospecting: Facts, Shifts, and Perspectives to Explore the Chemo-Structural Diversity of Natural Products.
PMID:33996755
Synergizing the potential of bacterial genomics and metabolomics to find novel antibiotics.
PMID:33995996
Phylogenetic analysis of the salinipostin γ-butyrolactone gene cluster uncovers new potential for bacterial signalling-molecule diversity.
PMID:33979276
An interpreted atlas of biosynthetic gene clusters from 1,000 fungal genomes.
PMID:33941694
Heterologous production of cyanobacterial compounds.
PMID:33928376
Bioprospecting of Soil-Derived Actinobacteria Along the Alar-Hotan Desert Highway in the Taklamakan Desert.
PMID:33790875
Development of an NMR-Based Platform for the Direct Structural Annotation of Complex Natural Products Mixtures.
PMID:33750122
Blocks in the pseudouridimycin pathway unlock hidden metabolites in the Streptomyces producer strain.
PMID:33712632
PSC-db: A Structured and Searchable 3D-Database for Plant Secondary Compounds.
PMID:33672700
A community resource for paired genomic and metabolomic data mining.
PMID:33589842
Intense bitterness of molecules: Machine learning for expediting drug discovery.
PMID:33510862
Planomonospora: A Metabolomics Perspective on an Underexplored Actinobacteria Genus.
PMID:33496580
The Landscape of Recombination Events That Create Nonribosomal Peptide Diversity.
PMID:33480992
Diverse Taxonomies for Diverse Chemistries: Enhanced Representation of Natural Product Metabolism in UniProtKB.
PMID:33445429
COCONUT online: Collection of Open Natural Products database.
PMID:33423696
Can natural products stop the SARS-CoV-2 virus? A docking and molecular dynamics study of a natural product database.
PMID:33415989
Geometrically Diverse Lariat Peptide Scaffolds Reveal an Untapped Chemical Space of High Membrane Permeability.
PMID:33381960
Diversity, Bioactivity Profiling and Untargeted Metabolomics of the Cultivable Gut Microbiota of Ciona intestinalis.
PMID:33374243
Recent developments of tools for genome and metabolome studies in basidiomycete fungi and their application to natural product research.
PMID:33268478
Comprehensive prediction of secondary metabolite structure and biological activity from microbial genome sequences.
PMID:33247171
Bacterial terpenome.
PMID:33169126
Culture-Dependent Microbiome of the Ciona intestinalis Tunic: Isolation, Bioactivity Profiling and Untargeted Metabolomics.
PMID:33167375
Diversity and Bioactive Potential of Actinobacteria Isolated from a Coastal Marine Sediment in Northern Portugal.
PMID:33143202
Screening Fungal Endophytes Derived from Under-Explored Egyptian Marine Habitats for Antimicrobial and Antioxidant Properties in Factionalised Textiles.
PMID:33096635
Cryptic or Silent? The Known Unknowns, Unknown Knowns, and Unknown Unknowns of Secondary Metabolism.
PMID:33082252
StreptomeDB 3.0: an updated compendium of streptomycetes natural products.
PMID:33051671
BiG-FAM: the biosynthetic gene cluster families database.
PMID:33010170
Assigning the Origin of Microbial Natural Products by Chemical Space Map and Machine Learning.
PMID:32998475
Microbial natural product databases: moving forward in the multi-omics era.
PMID:32856641
From Ocean to Medicine: Pharmaceutical Applications of Metabolites from Marine Bacteria.
PMID:32731464
Cheminformatics in Natural Product-based Drug Discovery.
PMID:32725781
The need to innovate sample collection and library generation in microbial drug discovery: a focus on academia.
PMID:32706349
Microbial Natural Products as Potential Inhibitors of SARS-CoV-2 Main Protease (Mpro).
PMID:32610445
Mass Spectrometry: A Rosetta Stone to Learn How Fungi Interact and Talk.
PMID:32575729
Advances in the study of drug metabolism - symposium report of the 12th Meeting of the International Society for the Study of Xenobiotics (ISSX).
PMID:32456484
ARTS 2.0: feature updates and expansion of the Antibiotic Resistant Target Seeker for comparative genome mining.
PMID:32427317
Nematode-Trapping Fungi Produce Diverse Metabolites during Predator-Prey Interaction.
PMID:32245081
Targeted Isolation of Indole Alkaloids from Streptomyces sp. CT37.
PMID:32131464
Functional group and diversity analysis of BIOFACQUIM: A Mexican natural product database.
PMID:32047598
A Convolutional Neural Network-Based Approach for the Rapid Annotation of Molecularly Diverse Natural Products.
PMID:32045230
Signalling and Bioactive Metabolites from Streptomyces sp. RK44.
PMID:31979050