SigMol
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SigMol is a specialized repository of quorom sensing signaling molecules (QSSMs) in prokaryotes. SigMol harbors information on QSSMs pertaining to different quorum sensing signaling systems namely acylated homoserine lactones (AHLs), diketopiperazines (DKPs), 4- hydroxy-2-alkylquinolines (HAQs), diffusible signal factors (DSFs), autoinducer-2 (AI-2) and others. The database includes biological as well as chemical aspects of signaling molecules. Biological information includes genes, preliminary bioassays, identification assays and applications, while chemical detail comprises of IUPAC name, SMILES and structure.
Description
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SigMol is a specialized repository of quorom sensing signaling molecules (QSSMs) in prokaryotes. SigMol harbors information on QSSMs pertaining to different quorum sensing signaling systems namely acylated homoserine lactones (AHLs), diketopiperazines (DKPs), 4- hydroxy-2-alkylquinolines (HAQs), diffusible signal factors (DSFs), autoinducer-2 (AI-2) and others. The database includes biological as well as chemical aspects of signaling molecules. Biological information includes genes, preliminary bioassays, identification assays and applications, while chemical detail comprises of IUPAC name, SMILES and structure.
metasource: Fairsharing.orgversion: FAIRsharing.org: SigMol; SigMol; DOI: https://doi.org/10.25504/FAIRsharing.p7ev6e; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
Quorum sensing is a widespread phenomenon in prokaryotes that helps them to communicate among themselves and with eukaryotes. It is driven through quorum sensing signaling molecules (QSSMs) in a density dependent manner that assists in numerous biological functions like biofilm formation, virulence factors secretion, swarming motility, bioluminescence, etc. Despite immense implications, dedicated resources of QSSMs are lacking. Therefore, we have developed SigMol (http://bioinfo.imtech.res.in/manojk/sigmol), a specialized repository of these molecules in prokaryotes. SigMol harbors information on QSSMs pertaining to different quorum sensing signaling systems namely acylated homoserine lactones (AHLs), diketopiperazines (DKPs), 4-hydroxy-2-alkylquinolines (HAQs), diffusible signal factors (DSFs), autoinducer-2 (AI-2) and others. Database contains 1382 entries of 182 unique signaling molecules from 215 organisms. It encompasses biological as well as chemical aspects of signaling molecules. Biological information includes genes, preliminary bioassays, identification assays and applications, while chemical detail comprises of IUPAC name, SMILES and structure. We have provided user-friendly browsing and searching facilities for easy data retrieval and comparison. We have gleaned information of diverse QSSMs reported in literature at a single platform 'SigMol'. This comprehensive resource will assist the scientific community in understanding intraspecies, interspecies or interkingdom networking and further help to unfold different facets of quorum sensing and related therapeutics.
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
Webpage:
http://bioinfo.imtech.res.in/manojk/sigmol/Webpage
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http://bioinfo.imtech.res.in/manojk/sigmol/
metasource: Fairsharing.orgversion: FAIRsharing.org: SigMol; SigMol; DOI: https://doi.org/10.25504/FAIRsharing.p7ev6e; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
http://bioinfo.imtech.res.in/manojk/sigmol
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
Publications:
Publications
More detailed information about this field from each metasource.
SigMol: repertoire of quorum sensing signaling molecules in prokaryotes
PMID: 26490957
metasource: Fairsharing.org
version: FAIRsharing.org: SigMol; SigMol; DOI: https://doi.org/10.25504/FAIRsharing.p7ev6e; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
http://dx.doi.org/10.1093/nar/gkv1076
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Publications
More detailed information about this field from each metasource.
SigMol: repertoire of quorum sensing signaling molecules in prokaryotes
PMID: 26490957
metasource: Fairsharing.org
version: FAIRsharing.org: SigMol; SigMol; DOI: https://doi.org/10.25504/FAIRsharing.p7ev6e; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
http://dx.doi.org/10.1093/nar/gkv1076
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
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SigMol: repertoire of quorum sensing signaling molecules in prokaryotes
PubMed citations: 35.
35 articles citing: SigMol: repertoire of quorum sensing signaling molecules in prokaryotes
The role of eugenol and ferulic acid as the competitive inhibitors of transcriptional regulator RhlR in P. aeruginosa. PMID:35800985
Mechanisms of Inhibition of Quorum Sensing as an Alternative for the Control of E. coli and Salmonella. PMID:35630329
Bacterial Quorum-Sensing Molecules as Promising Natural Inhibitors of Candida albicans Virulence Dimorphism: An In Silico and In Vitro Study. PMID:34926324
QSDB-a graphical Quorum Sensing Database. PMID:34559210
A covariation analysis reveals elements of selectivity in quorum sensing systems. PMID:34180398
Recent trends in biocatalysis. PMID:34142684
Metagenomic Insights Into the Microbial Assemblage Capable of Quorum Sensing and Quorum Quenching in Particulate Organic Matter in the Yellow Sea. PMID:33519743
Pangenome Analytics Reveal Two-Component Systems as Conserved Targets in ESKAPEE Pathogens. PMID:33500331
DrugRepV: a compendium of repurposed drugs and chemicals targeting epidemic and pandemic viruses. PMID:33480398
Rich Repertoire of Quorum Sensing Protein Coding Sequences in CPR and DPANN Associated with Interspecies and Interkingdom Communication. PMID:33051376
Detection of Diverse N-Acyl Homoserine Lactone Signalling Molecules Among Bacteria Associated with Rice Rhizosphere. PMID:32918570
Engineering acyl-homoserine lactone-interfering enzymes toward bacterial control. PMID:32690609
Bacterial RNA as a signal to eukaryotic cells as part of the infection process. PMID:32309589
Can rumen bacteria communicate to each other? PMID:32085816
Inhibitory Effect of Two Traditional Chinese Medicine Monomers, Berberine and Matrine, on the Quorum Sensing System of Antimicrobial-Resistant Escherichia coli. PMID:31798551
AidB, a Novel Thermostable N-Acylhomoserine Lactonase from the Bacterium Bosea sp. PMID:31604771
Burst statistics in an early biofilm quorum sensing model: the role of spatial colony-growth heterogeneity. PMID:31427659
A neural network model predicts community-level signaling states in a diverse microbial community. PMID:31233492
Elucidating the Hot Spot Residues of Quorum Sensing Peptidic Autoinducer PapR by Multiple Amino Acid Replacements. PMID:31231335
Comparative genomic analysis of Pectobacterium carotovorum subsp. brasiliense SX309 provides novel insights into its genetic and phenotypic features. PMID:31195968
Bacterial Bioluminescence: Light Emission in Photobacterium phosphoreum Is Not Under Quorum-Sensing Control. PMID:30886606
Quorum Sensing Signal Selectivity and the Potential for Interspecies Cross Talk. PMID:30837333
Quorum sensing intervened bacterial signaling: Pursuit of its cognizance and repression. PMID:30733731
Quorum Sensing System of Ruegeria mobilis Rm01 Controls Lipase and Biofilm Formation. PMID:30687283
A dataset of small molecules triggering transcriptional and translational cellular responses. PMID:29556520
aBiofilm: a resource of anti-biofilm agents and their potential implications in targeting antibiotic drug resistance. PMID:29156005
Quantifying the strength of quorum sensing crosstalk within microbial communities. PMID:29049387
In silico analyses of conservational, functional and phylogenetic distribution of the LuxI and LuxR homologs in Gram-positive bacteria. PMID:28765541
Strategies for Biofilm Inhibition and Virulence Attenuation of Foodborne Pathogen-Escherichia coli O157:H7. PMID:28744570
Computational Exploration of Putative LuxR Solos in Archaea and Their Functional Implications in Quorum Sensing. PMID:28515720
Molecular Mechanism of Quorum-Sensing in Enterococcus faecalis: Its Role in Virulence and Therapeutic Approaches. PMID:28467378
Cross- species communication in bacterial world. PMID:28220296
A diketopiperazine factor from Rheinheimera aquimaris QSI02 exhibits anti-quorum sensing activity. PMID:28000767
Diverse Profiles of AI-1 Type Quorum Sensing Molecules in Cultivable Bacteria from the Mangrove (Kandelia obovata) Rhizosphere Environment. PMID:27994584
ZikaVR: An Integrated Zika Virus Resource for Genomics, Proteomics, Phylogenetic and Therapeutic Analysis. PMID:27633273 - http://dx.doi.org/10.1093/nar/gkv1076
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assay
metasource: Fairsharing.org
version: FAIRsharing.org: SigMol; SigMol; DOI: https://doi.org/10.25504/FAIRsharing.p7ev6e; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
gene
metasource: Fairsharing.org
version: FAIRsharing.org: SigMol; SigMol; DOI: https://doi.org/10.25504/FAIRsharing.p7ev6e; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
signaling
metasource: Fairsharing.org
version: FAIRsharing.org: SigMol; SigMol; DOI: https://doi.org/10.25504/FAIRsharing.p7ev6e; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
structure
metasource: Fairsharing.org
version: FAIRsharing.org: SigMol; SigMol; DOI: https://doi.org/10.25504/FAIRsharing.p7ev6e; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
metabolic and signaling pathways
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
signalling pathways
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
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assay
metasource: Fairsharing.orgversion: FAIRsharing.org: SigMol; SigMol; DOI: https://doi.org/10.25504/FAIRsharing.p7ev6e; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
gene
metasource: Fairsharing.orgversion: FAIRsharing.org: SigMol; SigMol; DOI: https://doi.org/10.25504/FAIRsharing.p7ev6e; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
signaling
metasource: Fairsharing.orgversion: FAIRsharing.org: SigMol; SigMol; DOI: https://doi.org/10.25504/FAIRsharing.p7ev6e; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
structure
metasource: Fairsharing.orgversion: FAIRsharing.org: SigMol; SigMol; DOI: https://doi.org/10.25504/FAIRsharing.p7ev6e; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
metabolic and signaling pathways
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
signalling pathways
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
assay gene signaling structure metabolic and signaling pathways signalling pathways
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