MycoBrowser tuberculosis
Mycobrowser is a resource that provides both in silico generated and manually reviewed information within databases dedicated to the complete genomes of Mycobacterium tuberculosis, Mycobacterium leprae, Mycobacterium marinum and Mycobacterium smegmatis. This collection references Mycobacteria tuberculosis information.
Description
More detailed information about this field from each metasource.
Mycobrowser is a resource that provides both in silico generated and manually reviewed information within databases dedicated to the complete genomes of Mycobacterium tuberculosis, Mycobacterium leprae, Mycobacterium marinum and Mycobacterium smegmatis. This collection references Mycobacteria tuberculosis information.
metasource: Fairsharing.orgversion: FAIRsharing.org: MycoBrowser tuberculosis; MycoBrowser tuberculosis; DOI: https://doi.org/10.25504/FAIRsharing.6s44n0; Last edited: April 26, 2021, 9:31 a.m.; Last accessed: Jan 03 2022 7:06 p.m.
Webpage:
http://tuberculist.epfl.ch/Webpage
More detailed information about this field from each metasource.
http://tuberculist.epfl.ch/
metasource: Fairsharing.orgversion: FAIRsharing.org: MycoBrowser tuberculosis; MycoBrowser tuberculosis; DOI: https://doi.org/10.25504/FAIRsharing.6s44n0; Last edited: April 26, 2021, 9:31 a.m.; Last accessed: Jan 03 2022 7:06 p.m.
Publications:
Publications
More detailed information about this field from each metasource.
The MycoBrowser portal: a comprehensive and manually annotated resource for mycobacterial genomes
PMID: 20980200
metasource: Fairsharing.org
version: FAIRsharing.org: MycoBrowser tuberculosis; MycoBrowser tuberculosis; DOI: https://doi.org/10.25504/FAIRsharing.6s44n0; Last edited: April 26, 2021, 9:31 a.m.; Last accessed: Jan 03 2022 7:06 p.m.
Publications
More detailed information about this field from each metasource.
The MycoBrowser portal: a comprehensive and manually annotated resource for mycobacterial genomes
PMID: 20980200
metasource: Fairsharing.org
version: FAIRsharing.org: MycoBrowser tuberculosis; MycoBrowser tuberculosis; DOI: https://doi.org/10.25504/FAIRsharing.6s44n0; Last edited: April 26, 2021, 9:31 a.m.; Last accessed: Jan 03 2022 7:06 p.m.
-
The MycoBrowser portal: a comprehensive and manually annotated resource for mycobacterial genomes
PubMed citations: 145.
145 articles citing: The MycoBrowser portal: a comprehensive and manually annotated resource for mycobacterial genomes
Potential Efficacy of β-Amyrin Targeting Mycobacterial Universal Stress Protein by In Vitro and In Silico Approach. PMID:35889451
In silico Analysis of Peptide-Based Biomarkers for the Diagnosis and Prevention of Latent Tuberculosis Infection. PMID:35836423
Immunogenicity of Mycobacterial Extracellular Vesicles Isolated From Host-Related Conditions Informs About Tuberculosis Disease Status. PMID:35814710
High clustering rate and genotypic drug-susceptibility screening for the newly recommended anti-tuberculosis drugs among global extensively drug-resistant Mycobacterium tuberculosis isolates. PMID:35792049
A convolutional neural network highlights mutations relevant to antimicrobial resistance in Mycobacterium tuberculosis. PMID:35780211
Proteo-genetic analysis reveals clear hierarchy of ESX-1 secretion in Mycobacterium marinum. PMID:35671426
Listeria-Vectored Multiantigenic Tuberculosis Vaccine Enhances Protective Immunity against Aerosol Challenge with Virulent Mycobacterium tuberculosis in BCG-Immunized C57BL/6 and BALB/c Mice. PMID:35642945
A tRNA-Acetylating Toxin and Detoxifying Enzyme in Mycobacterium tuberculosis. PMID:35638832
In silico and in vitro study of Mycobacterium tuberculosis H37Rv uncharacterized protein (RipD): an insight on tuberculosis therapeutics. PMID:35624324
Reverse vaccinology approach to design a multi-epitope vaccine construct based on the Mycobacterium tuberculosis biomarker PE_PGRS17. PMID:35554858
Distribution of Common and Rare Genetic Markers of Second-Line-Injectable-Drug Resistance in Mycobacterium tuberculosis Revealed by a Genome-Wide Association Study. PMID:35532237
RNase E and HupB dynamics foster mycobacterial cell homeostasis and fitness. PMID:35521527
Mycobacterium tuberculosis requires SufT for Fe-S cluster maturation, metabolism, and survival in vivo. PMID:35427399
Glby, Encoded by MAB_3167c, Is Required for In Vivo Growth of Mycobacteroides abscessus and Exhibits Mild β-Lactamase Activity. PMID:35380462
Mycobacterium tuberculosis EspK Has Active but Distinct Roles in the Secretion of EsxA and EspB. PMID:35315684
First-line drug resistance profiling of Mycobacterium tuberculosis: a machine learning approach. PMID:35309001
Machine Learning of All Mycobacterium tuberculosis H37Rv RNA-seq Data Reveals a Structured Interplay between Metabolism, Stress Response, and Infection. PMID:35306876
Mycobacterium tuberculosis Rv0309 Dampens the Inflammatory Response and Enhances Mycobacterial Survival. PMID:35281073
Multi-Omics Profiling Specifies Involvement of Alternative Ribosomal Proteins in Response to Zinc Limitation in Mycobacterium smegmatis. PMID:35222334
Peptide-Based Vaccines for Tuberculosis. PMID:35173740
Prophage Gene Rv2650c Enhances Intracellular Survival of Mycobacterium smegmatis. PMID:35111145
A modified decision tree approach to improve the prediction and mutation discovery for drug resistance in Mycobacterium tuberculosis. PMID:35016609
Drug Discovery for Mycobacterium tuberculosis Using Structure-Based Computer-Aided Drug Design Approach. PMID:34948055
Genomic signatures of pre-resistance in Mycobacterium tuberculosis. PMID:34911948
An evolutionary functional genomics approach identifies novel candidate regions involved in isoniazid resistance in Mycobacterium tuberculosis. PMID:34819627
The whole-genome sequencing in predicting Mycobacterium tuberculosis drug susceptibility and resistance in Papua, Indonesia. PMID:34802420
Comparison of carbohydrate ABC importers from Mycobacterium tuberculosis. PMID:34798821
Characterisation of a putative M23-domain containing protein in Mycobacterium tuberculosis. PMID:34784363
In silico comparisons of lipid-related genes between Mycobacterium tuberculosis and BCG vaccine strains. PMID:34699585
Leprosy in wild chimpanzees. PMID:34646009
Regulation of Ribosomal Protein Synthesis in Mycobacteria: The Autogenous Control of rpsO. PMID:34575857
Targeted RNA-Seq Reveals the M. tuberculosis Transcriptome from an In Vivo Infection Model. PMID:34571725
Phosphopantetheinyl transferase binding and inhibition by amidino-urea and hydroxypyrimidinethione compounds. PMID:34508141
A Murine Model of Mycobacterium kansasii Infection Reproducing Necrotic Lung Pathology Reveals Considerable Heterogeneity in Virulence of Clinical Isolates. PMID:34504483
A genome epidemiological study of mycobacterium tuberculosis in subpopulations with high and low incidence rate in Guangxi, South China. PMID:34412585
Biochemical and phenotypic characterisation of the Mycobacterium smegmatis transporter UspABC. PMID:34296047
Mycobacterium tuberculosis complex lineage 5 exhibits high levels of within-lineage genomic diversity and differing gene content compared to the type strain H37Rv. PMID:34241588
Shotgun EM of mycobacterial protein complexes during stationary phase stress. PMID:34235480
AC2P20 selectively kills Mycobacterium tuberculosis at acidic pH by depleting free thiols. PMID:34168865
Increased whiB7 expression and antibiotic resistance in Mycobacterium chelonae carrying two prophages. PMID:34107872
Metabolic bifunctionality of Rv0812 couples folate and peptidoglycan biosynthesis in Mycobacterium tuberculosis. PMID:33950161
Solution and Membrane Interaction Dynamics of Mycobacterium tuberculosis Fatty Acyl-CoA Synthetase FadD13. PMID:33913324
De novo histidine biosynthesis protects Mycobacterium tuberculosis from host IFN-γ mediated histidine starvation. PMID:33767335
Mapping Gene-by-Gene Single-Nucleotide Variation in 8,535 Mycobacterium tuberculosis Genomes: a Resource To Support Potential Vaccine and Drug Development. PMID:33692198
Multipathogen Analysis of IgA and IgG Antigen Specificity for Selected Pathogens in Milk Produced by Women From Diverse Geographical Regions: The INSPIRE Study. PMID:33643297
Metabolic Versatility of Mycobacterium tuberculosis during Infection and Dormancy. PMID:33540752
A snapshot of translation in Mycobacterium tuberculosis during exponential growth and nutrient starvation revealed by ribosome profiling. PMID:33535039
Zn2+ Intoxication of Mycobacterium marinum during Dictyostelium discoideum Infection Is Counteracted by Induction of the Pathogen Zn2+ Exporter CtpC. PMID:33531393
Mycobacterium smegmatis does not display functional redundancy in nitrate reductase enzymes. PMID:33471823
De Novo Cobalamin Biosynthesis, Transport, and Assimilation and Cobalamin-Mediated Regulation of Methionine Biosynthesis in Mycobacterium smegmatis. PMID:33468593
In silico analysis of epitope-based vaccine candidate against tuberculosis using reverse vaccinology. PMID:33441913
A Multi-Pronged Computational Pipeline for Prioritizing Drug Target Strategies for Latent Tuberculosis. PMID:33381491
Identification and in silico functional prediction of lineage-specific SNPs distributed in DosR-related proteins and resuscitation-promoting factor proteins of Mycobacterium tuberculosis. PMID:33364506
Recent Advances in the Development of Protein- and Peptide-Based Subunit Vaccines against Tuberculosis. PMID:33333744
Handling the Hurdles on the Way to Anti-tuberculosis Drug Development. PMID:33330374
PathExt: a general framework for path-based mining of omics-integrated biological networks. PMID:33305329
ESX secretion system: The gatekeepers of mycobacterial survivability and pathogenesis. PMID:33174865
Mechanisms of Antibiotic Tolerance in Mycobacterium avium Complex: Lessons From Related Mycobacteria. PMID:33101247
Predicting antimicrobial resistance using conserved genes. PMID:33075053
Lineage-Specific Proteomic Signatures in the Mycobacterium tuberculosis Complex Reveal Differential Abundance of Proteins Involved in Virulence, DNA Repair, CRISPR-Cas, Bioenergetics and Lipid Metabolism. PMID:33072011
Conserved ESX-1 Substrates EspE and EspF Are Virulence Factors That Regulate Gene Expression. PMID:32900815
Modeling Tubercular ESX-1 Secretion Using Mycobacterium marinum. PMID:32878966
Mycobacterium tuberculosis Rv0991c Is a Redox-Regulated Molecular Chaperone. PMID:32843553
First insight into the whole-genome sequence variations in Mycobacterium bovis BCG-1 (Russia) vaccine seed lots and their progeny clinical isolates from children with BCG-induced adverse events. PMID:32811436
Dataset of complete genome assembly and analysis of mycobacterium tuberculosis strain SIT745/EAI1-MYS. PMID:32671154
Cryo-EM structure of arabinosyltransferase EmbB from Mycobacterium smegmatis. PMID:32636380
Two interacting ATPases protect Mycobacterium tuberculosis from glycerol and nitric oxide toxicity. PMID:32482725
Revisiting the expression signature of pks15/1 unveils regulatory patterns controlling phenolphtiocerol and phenolglycolipid production in pathogenic mycobacteria. PMID:32379829
Dynamics of within-host Mycobacterium tuberculosis diversity and heteroresistance during treatment. PMID:32361247
Identifying nucleic acid-associated proteins in Mycobacterium smegmatis by mass spectrometry-based proteomics. PMID:32293251
GenomegaMap: Within-Species Genome-Wide dN/dS Estimation from over 10,000 Genomes. PMID:32167543
Integrative proteomic and glycoproteomic profiling of Mycobacterium tuberculosis culture filtrate. PMID:32126063
Phylogenomic assessment of drug-resistant Mycobacterium tuberculosis strains from Beira, Mozambique. PMID:32063558
CtpB is a plasma membrane copper (I) transporting P-type ATPase of Mycobacterium tuberculosis. PMID:32054527
Construction and Use of Transposon MycoTetOP 2 for Isolation of Conditional Mycobacteria Mutants. PMID:32038540
Discovery of a novel dehydratase of the fatty acid synthase type II critical for ketomycolic acid biosynthesis and virulence of Mycobacterium tuberculosis. PMID:32034201
In Silico Strategies in Tuberculosis Drug Discovery. PMID:32033144
EspM Is a Conserved Transcription Factor That Regulates Gene Expression in Response to the ESX-1 System. PMID:32019792
Phosphoproteomic Approaches to Discover Novel Substrates of Mycobacterial Ser/Thr Protein Kinases. PMID:31839597
Transcriptomic Signatures Predict Regulators of Drug Synergy and Clinical Regimen Efficacy against Tuberculosis. PMID:31719182
Mabellini: a genome-wide database for understanding the structural proteome and evaluating prospective antimicrobial targets of the emerging pathogen Mycobacterium abscessus. PMID:31681953
TDR Targets 6: driving drug discovery for human pathogens through intensive chemogenomic data integration. PMID:31680154
New insights into the mycobacterial PE and PPE proteins provide a framework for future research. PMID:31661176
The sensor kinase MtrB of Mycobacterium tuberculosis regulates hypoxic survival and establishment of infection. PMID:31653701
Mycobacterium tuberculosis β-Carbonic Anhydrases: Novel Targets for Developing Antituberculosis Drugs. PMID:31627429
Machine Learning Predicts Accurately Mycobacterium tuberculosis Drug Resistance From Whole Genome Sequencing Data. PMID:31616478
Rv0100, a proposed acyl carrier protein in Mycobacterium tuberculosis: expression, purification and crystallization. PMID:31584013
Towards next-generation diagnostics for tuberculosis: identification of novel molecular targets by large-scale comparative genomics. PMID:31580405
Protein kinase B controls Mycobacterium tuberculosis growth via phosphorylation of the transcriptional regulator Lsr2 at threonine 112. PMID:31562654
Identification of New MmpL3 Inhibitors by Untargeted and Targeted Mutant Screens Defines MmpL3 Domains with Differential Resistance. PMID:31405862
Targeting extracellular glycans: tuning multimeric boronic acids for pathogen-selective killing of Mycobacterium tuberculosis. PMID:31360399
An essential bifunctional enzyme in Mycobacterium tuberculosis for itaconate dissimilation and leucine catabolism. PMID:31320588
Kinetics of formation and reactivity of the persulfide in the one-cysteine peroxiredoxin from Mycobacterium tuberculosis. PMID:31311857
MycoResistance: a curated resource of drug resistance molecules in Mycobacteria. PMID:31290951
Metabolomics Studies To Decipher Stress Responses in Mycobacterium smegmatis Point to a Putative Pathway of Methylated Amine Biosynthesis. PMID:31138627
Mycobacterium smegmatis HtrA Blocks the Toxic Activity of a Putative Cell Wall Amidase. PMID:31116989
Chemical disarming of isoniazid resistance in Mycobacterium tuberculosis. PMID:31061116
MnoSR Is a Bona Fide Two-Component System Involved in Methylotrophic Metabolism in Mycobacterium smegmatis. PMID:31003982
Comparative analysis of homologous aminopeptidase PepN from pathogenic and non-pathogenic mycobacteria reveals divergent traits. PMID:30969995
Deciphering Within-Host Microevolution of Mycobacterium tuberculosis through Whole-Genome Sequencing: the Phenotypic Impact and Way Forward. PMID:30918049
Dual RNA-Seq of Human Leprosy Lesions Identifies Bacterial Determinants Linked to Host Immune Response. PMID:30917313
MmpL Proteins in Physiology and Pathogenesis of M. tuberculosis. PMID:30841535
A New ESX-1 Substrate in Mycobacterium marinum That Is Required for Hemolysis but Not Host Cell Lysis. PMID:30833360
Path-seq identifies an essential mycolate remodeling program for mycobacterial host adaptation. PMID:30833303
Insights on Mycobacterium leprae Efflux Pumps and Their Implications in Drug Resistance and Virulence. PMID:30619157
Genome-wide mapping of Topoisomerase I activity sites reveal its role in chromosome segregation. PMID:30566665
Genome analysis of Mycobacterium avium subspecies hominissuis strain 109. PMID:30512015
LipG a bifunctional phospholipase/thioesterase involved in mycobacterial envelope remodeling. PMID:30487163
Suppression of Th1 Priming by TLR2 Agonists during Cutaneous Immunization Is Mediated by Recruited CCR2+ Monocytes. PMID:30455402
PPE37 Is Essential for Mycobacterium tuberculosis Heme-Iron Acquisition (HIA), and a Defective PPE37 in Mycobacterium bovis BCG Prevents HIA. PMID:30455201
Carbonic Anhydrase Inhibitors as Novel Drugs against Mycobacterial β-Carbonic Anhydrases: An Update on In Vitro and In Vivo Studies. PMID:30413024
A phylogenomic study quantifies competing mechanisms for pseudogenization in prokaryotes-The Mycobacterium leprae case. PMID:30383852
Structural Prediction and Mutational Analysis of Rv3906c Gene of Mycobacterium tuberculosis H37Rv to Determine Its Essentiality in Survival. PMID:30186322
Quantitative N-Terminal Footprinting of Pathogenic Mycobacteria Reveals Differential Protein Acetylation. PMID:30080413
Unexpected Genomic and Phenotypic Diversity of Mycobacterium africanum Lineage 5 Affects Drug Resistance, Protein Secretion, and Immunogenicity. PMID:30010947
Sequencing and Annotation of the Genome of Mycobacterium tuberculosis MYC004, a Strain Causing Meningitis in Mexico. PMID:29930042
RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection. PMID:29912964
A complete high-quality MinION nanopore assembly of an extensively drug-resistant Mycobacterium tuberculosis Beijing lineage strain identifies novel variation in repetitive PE/PPE gene regions. PMID:29906261
HadD, a novel fatty acid synthase type II protein, is essential for alpha- and epoxy-mycolic acid biosynthesis and mycobacterial fitness. PMID:29662082
Esx Paralogs Are Functionally Equivalent to ESX-1 Proteins but Are Dispensable for Virulence in Mycobacterium marinum. PMID:29555701
TIBLE: a web-based, freely accessible resource for small-molecule binding data for mycobacterial species. PMID:29220433
WhiB6 regulation of ESX-1 gene expression is controlled by a negative feedback loop in Mycobacterium marinum. PMID:29180415
Identification of novel antigen candidates for a tuberculosis vaccine in the adult zebrafish (Danio rerio). PMID:28742838
Rv3852 (H-NS) of Mycobacterium tuberculosis Is Not Involved in Nucleoid Compaction and Virulence Regulation. PMID:28559300
Esx Systems and the Mycobacterial Cell Envelope: What's the Connection? PMID:28461452
Protein Bioinformatics Databases and Resources. PMID:28150231
A Nonsense Mutation in Mycobacterium marinum That Is Suppressible by a Novel Mechanism. PMID:27789543
Mycobacterium tuberculosis Zinc Metalloprotease-1 Assists Mycobacterial Dissemination in Zebrafish. PMID:27621726
MycoBASE: expanding the functional annotation coverage of mycobacterial genomes. PMID:26704706
Differential roles of the hemerythrin-like proteins of Mycobacterium smegmatis in hydrogen peroxide and erythromycin susceptibility. PMID:26607739
Characterization of Mycobacterium smegmatis sigF mutant and its regulon: overexpression of SigF antagonist (MSMEG_1803) in M. smegmatis mimics sigF mutant phenotype, loss of pigmentation, and sensitivity to oxidative stress. PMID:26434659
GtrA Protein Rv3789 Is Required for Arabinosylation of Arabinogalactan in Mycobacterium tuberculosis. PMID:26369580
Distinct Responses of Mycobacterium smegmatis to Exposure to Low and High Levels of Hydrogen Peroxide. PMID:26225431
Essential Role of the ESX-5 Secretion System in Outer Membrane Permeability of Pathogenic Mycobacteria. PMID:25938982
Homeostasis of N-α-terminal acetylation of EsxA correlates with virulence in Mycobacterium marinum. PMID:25135684
Correlation of phenotypic profiles using targeted proteomics identifies mycobacterial esx-1 substrates. PMID:25106450
Quantitative mass spectrometry reveals plasticity of metabolic networks in Mycobacterium smegmatis. PMID:24997995
The role of transcriptional regulation in maintaining the availability of mycobacterial adenylate cyclases. PMID:24688874
Comparative genomics for mycobacterial peptidoglycan remodelling enzymes reveals extensive genetic multiplicity. PMID:24661741
A novel ESX-1 locus reveals that surface-associated ESX-1 substrates mediate virulence in Mycobacterium marinum. PMID:24610712
Revealing of Mycobacterium marinum transcriptome by RNA-seq. PMID:24098731
Differential detergent extraction of mycobacterium marinum cell envelope proteins identifies an extensively modified threonine-rich outer membrane protein with channel activity. PMID:23457249
Bioinformatic identification of Mycobacterium tuberculosis proteins likely to target host cell mitochondria: virulence factors? PMID:23259719
Specific chaperones for the type VII protein secretion pathway. PMID:22843727
Direct detection of bacterial protein secretion using whole colony proteomics. PMID:22580590
Tags:
Tags
More detailed information about this field from each metasource.
genome
metasource: Fairsharing.org
version: FAIRsharing.org: MycoBrowser tuberculosis; MycoBrowser tuberculosis; DOI: https://doi.org/10.25504/FAIRsharing.6s44n0; Last edited: April 26, 2021, 9:31 a.m.; Last accessed: Jan 03 2022 7:06 p.m.
region
metasource: Fairsharing.org
version: FAIRsharing.org: MycoBrowser tuberculosis; MycoBrowser tuberculosis; DOI: https://doi.org/10.25504/FAIRsharing.6s44n0; Last edited: April 26, 2021, 9:31 a.m.; Last accessed: Jan 03 2022 7:06 p.m.
Tags
More detailed information about this field from each metasource.
genome
metasource: Fairsharing.orgversion: FAIRsharing.org: MycoBrowser tuberculosis; MycoBrowser tuberculosis; DOI: https://doi.org/10.25504/FAIRsharing.6s44n0; Last edited: April 26, 2021, 9:31 a.m.; Last accessed: Jan 03 2022 7:06 p.m.
region
metasource: Fairsharing.orgversion: FAIRsharing.org: MycoBrowser tuberculosis; MycoBrowser tuberculosis; DOI: https://doi.org/10.25504/FAIRsharing.6s44n0; Last edited: April 26, 2021, 9:31 a.m.; Last accessed: Jan 03 2022 7:06 p.m.
Need help integrating and/or managing biomedical data?