Chromium Epigenomics Toxicology

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Chromium Epigenomics Toxicology

metasource: Fairsharing.org
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EpiCrDB

metasource: Fairsharing.org
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Other names: EpiCrDB

The Chromium Epigenomics Toxicology (EpiCrDB) database contains a variety of epigenomics experimental assays relating to research on how Cr(VI) perturbs chromatin organization and dynamics. This data is used in reseach into how its toxicity may be attributed to epigenetic carcinogenicity. Manually-annotated sample and experiment metadata is included to facilitate FAIR data access. Hexavalent chromium [Cr(VI)] compounds are well-established respiratory carcinogens utilized in industrial processes. While inhalation exposure constitutes an occupational risk affecting mostly chromium workers, environmental exposure from drinking water contamination is a widespread gastrointestinal carcinogen, affecting millions of people throughout the world. The mechanism of action of Cr(VI) at the molecular level is poorly understood.

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Publications

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Chromium disrupts chromatin organization and CTCF access to its cognate sites in promoters of differentially expressed genes
PMID: 29561703

metasource: Fairsharing.org
version: None

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Formaldehyde-Assisted Isolation of Regulatory Elements (FAIRE) analysis uncovers broad changes in chromatin structure resulting from hexavalent chromium exposure
PMID: 24837440

metasource: Fairsharing.org
version: None

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Chromium exposure disrupts chromatin architecture upsetting the mechanisms that regulate transcription
PMID: 30935235

metasource: Fairsharing.org
version: None

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• Chromium disrupts chromatin organization and CTCF access to its cognate sites in promoters of differentially expressed genes PubMed citations: 8.

  8 articles citing: Chromium disrupts chromatin organization and CTCF access to its cognate sites in promoters of differentially expressed genes

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  Alcohol induced increases in sperm Histone H3 lysine 4 trimethylation correlate with increased placental CTCF occupancy and altered developmental programming. PMID:35614060

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  Hexavalent chromium disrupts chromatin architecture. PMID:34274487

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  Hexavalent chromium promotes differential binding of CTCF to its cognate sites in Euchromatin. PMID:33319643

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  The Promises and Challenges of Toxico-Epigenomics: Environmental Chemicals and Their Impacts on the Epigenome. PMID:31950866

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  p53 activation by Cr(VI): a transcriptionally limited response induced by ATR kinase in S-phase. PMID:31388677

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  Chromium exposure disrupts chromatin architecture upsetting the mechanisms that regulate transcription. PMID:30935235

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  The Effect of Hexavalent Chromium on the Incidence and Mortality of Human Cancers: A Meta-Analysis Based on Published Epidemiological Cohort Studies. PMID:30778374

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  Targeting Transcription Factors for Cancer Treatment. PMID:29921764
• Formaldehyde-Assisted Isolation of Regulatory Elements (FAIRE) analysis uncovers broad changes in chromatin structure resulting from hexavalent chromium exposure PubMed citations: 7.

  7 articles citing: Formaldehyde-Assisted Isolation of Regulatory Elements (FAIRE) analysis uncovers broad changes in chromatin structure resulting from hexavalent chromium exposure

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  Induction of NUPR1 and AP‑1 contributes to the carcinogenic potential of nickel. PMID:33649793

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  Hexavalent chromium promotes differential binding of CTCF to its cognate sites in Euchromatin. PMID:33319643

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  Molecular and epigenetic mechanisms of Cr(VI)-induced carcinogenesis. PMID:31228494

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  Chromium exposure disrupts chromatin architecture upsetting the mechanisms that regulate transcription. PMID:30935235

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  Chromium disrupts chromatin organization and CTCF access to its cognate sites in promoters of differentially expressed genes. PMID:29561703

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  Hexavalent Chromium (Cr(VI)) Down-Regulates Acetylation of Histone H4 at Lysine 16 through Induction of Stressor Protein Nupr1. PMID:27285315

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  Long-term Coexposure to Hexavalent Chromium and B[a]P Causes Tissue-Specific Differential Biological Effects in Liver and Gastrointestinal Tract of Mice. PMID:25820237
• Chromium exposure disrupts chromatin architecture upsetting the mechanisms that regulate transcription PubMed citations: 0.

  0 articles citing: Chromium exposure disrupts chromatin architecture upsetting the mechanisms that regulate transcription

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assay

metasource: Fairsharing.org
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chromatin immunoprecipitation - dna sequencing

metasource: Fairsharing.org
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chromatin structure variation

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assay chromatin immunoprecipitation - dna sequencing chromatin structure variation