Bitter Compounds Database

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Bitter Compounds Database

metasource: Fairsharing.org
version: FAIRsharing.org: BitterDB; Bitter Compounds Database; DOI: https://doi.org/10.25504/FAIRsharing.d8bfx4; Last edited: Jan. 8, 2019, 1:12 p.m.; Last accessed: Jan 03 2022 7:07 p.m.

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BitterDB

metasource: Fairsharing.org
version: FAIRsharing.org: BitterDB; Bitter Compounds Database; DOI: https://doi.org/10.25504/FAIRsharing.d8bfx4; Last edited: Jan. 8, 2019, 1:12 p.m.; Last accessed: Jan 03 2022 7:07 p.m.

metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657

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Other names: BitterDB

BitterDB is a free and searchable database of bitter compounds. Compounds can be searched by name, chemical structure, similarity to other bitter compounds, association with a particular human bitter taste receptor, and so on. The database also contains information on mutations in bitter taste re- ceptors that were shown to influence receptor activation by bitter compounds. The aim of BitterDB is to facilitate studying the chemical features associated with bitterness.

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Publications

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BitterDB: a database of bitter compounds
PMID: 21940398

metasource: Fairsharing.org
version: FAIRsharing.org: BitterDB; Bitter Compounds Database; DOI: https://doi.org/10.25504/FAIRsharing.d8bfx4; Last edited: Jan. 8, 2019, 1:12 p.m.; Last accessed: Jan 03 2022 7:07 p.m.

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http://dx.doi.org/10.1093/nar/GKR755

metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657

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• BitterDB: a database of bitter compounds PubMed citations: 71.

  71 articles citing: BitterDB: a database of bitter compounds

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  Identify Bitter Peptides by Using Deep Representation Learning Features. PMID:35887225

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  A survey on computational taste predictors. PMID:35637881

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  HSP90 Modulates T2R Bitter Taste Receptor Nitric Oxide Production and Innate Immune Responses in Human Airway Epithelial Cells and Macrophages. PMID:35563784

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  PlantMolecularTasteDB: A Database of Taste Active Phytochemicals. PMID:35095484

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  Tartary Buckwheat: A New Plant-Based Ingredient to Enrich Corn-Based Gluten-Free Formulations. PMID:34828896

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  Chemoinformatics View on Bitter Taste Receptor Agonists in Food. PMID:34762411

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  T2R bitter taste receptors regulate apoptosis and may be associated with survival in head and neck squamous cell carcinoma. PMID:34717036

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  An update on extra-oral bitter taste receptors. PMID:34674725

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  Bitter Taste and Olfactory Receptors: Beyond Chemical Sensing in the Tongue and the Nose. PMID:34173018

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  Evolutionary shifts in taste coding in the fruit pest Drosophila suzukii. PMID:33616529

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  Intense bitterness of molecules: Machine learning for expediting drug discovery. PMID:33510862

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  FlavorGraph: a large-scale food-chemical graph for generating food representations and recommending food pairings. PMID:33441585

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  Modulation of Food Intake by Differential TAS2R Stimulation in Rat. PMID:33321802

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  RecipeDB: a resource for exploring recipes. PMID:33238002

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  Quantitative prediction of the bitterness of atomoxetine hydrochloride and taste-masked using hydroxypropyl-β-cyclodextrin: A biosensor evaluation and interaction study. PMID:32952672

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  Beer and Consumer Response Using Biometrics: Associations Assessment of Beer Compounds and Elicited Emotions. PMID:32580405

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  Bitter taste receptors stimulate phagocytosis in human macrophages through calcium, nitric oxide, and cyclic-GMP signaling. PMID:32172302

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  Molecular Logic and Evolution of Bitter Taste in Drosophila. PMID:31839451

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  TAS2R38 bitter taste receptor and attainment of exceptional longevity. PMID:31792278

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  Effect of Bitter Compounds on the Expression of Bitter Taste Receptor T2R7 Downstream Signaling Effectors in cT2R7/pDisplay-Gα16/gust44/pcDNA3.1 (+) Cells. PMID:31781630

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  Regional Variation of Bitter Taste and Aftertaste in Humans. PMID:31541607

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  Bitter tastants and artificial sweeteners activate a subset of epithelial cells in acute tissue slices of the rat trachea. PMID:31222082

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  Mechanisms Underlying the Anti-Depressive Effects of Regular Tea Consumption. PMID:31212946

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  Influences of Psychological Traits and PROP Taster Status on Familiarity with and Choice of Phenol-Rich Foods and Beverages. PMID:31200523

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  Dual binding mode of "bitter sugars" to their human bitter taste receptor target. PMID:31186454

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  A natural point mutation in the bitter taste receptor TAS2R16 causes inverse agonism of arbutin in lemur gustation. PMID:31161904

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  BitterSweet: Building machine learning models for predicting the bitter and sweet taste of small molecules. PMID:31073241

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  Beyond the Flavour: The Potential Druggability of Chemosensory G Protein-Coupled Receptors. PMID:30897734

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  e-Sweet: A Machine-Learning Based Platform for the Prediction of Sweetener and Its Relative Sweetness. PMID:30761295

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  BitterDB: taste ligands and receptors database in 2019. PMID:30357384

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  Identification of bitter components from Artemisia princeps Pamp. PMID:30263232

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  PhytoMolecularTasteDB: An integrative database on the "molecular taste" of Indian medicinal plants. PMID:30246068

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  In silico design of novel proton-pump inhibitors with reduced adverse effects. PMID:29845582

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  BitterSweetForest: A Random Forest Based Binary Classifier to Predict Bitterness and Sweetness of Chemical Compounds. PMID:29696137

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  e-Bitter: Bitterant Prediction by the Consensus Voting From the Machine-Learning Methods. PMID:29651416

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  The Role of Quinine-Responsive Taste Receptor Family 2 in Airway Immune Defense and Chronic Rhinosinusitis. PMID:29643854

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  Taste Receptor Polymorphisms and Immune Response: A Review of Receptor Genotypic-Phenotypic Variations and Their Relevance to Chronic Rhinosinusitis. PMID:29564227

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  Independent Evolution of Strychnine Recognition by Bitter Taste Receptor Subtypes. PMID:29552563

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  Molecular Features Underlying Selectivity in Chicken Bitter Taste Receptors. PMID:29445727

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  Biomimetic Sensors for the Senses: Towards Better Understanding of Taste and Odor Sensation. PMID:29232897

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  Bitter Taste Responses of Gustducin-positive Taste Cells in Mouse Fungiform and Circumvallate Papillae. PMID:29113930

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  FlavorDB: a database of flavor molecules. PMID:29059383

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  Identification of a specific agonist of human TAS2R14 from Radix Bupleuri through virtual screening, functional evaluation and binding studies. PMID:28939897

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  Bitter or not? BitterPredict, a tool for predicting taste from chemical structure. PMID:28935887

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  The human bitter taste receptor T2R38 is broadly tuned for bacterial compounds. PMID:28902853

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  Ligand binding modes from low resolution GPCR models and mutagenesis: chicken bitter taste receptor as a test-case. PMID:28811548

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  Extraoral Taste Receptor Discovery: New Light on Ayurvedic Pharmacology. PMID:28642799

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  From Cell to Beak: In-Vitro and In-Vivo Characterization of Chicken Bitter Taste Thresholds. PMID:28513558

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  Anti-cancer stemness and anti-invasive activity of bitter taste receptors, TAS2R8 and TAS2R10, in human neuroblastoma cells. PMID:28467517

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  Flavones modulate respiratory epithelial innate immunity: Anti-inflammatory effects and activation of the T2R14 receptor. PMID:28373278

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  Immunopathogenesis of Chronic Rhinosinusitis and Nasal Polyposis. PMID:27959637

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  Variation in ligand responses of the bitter taste receptors TAS2R1 and TAS2R4 among New World monkeys. PMID:27733116

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  Correlation of T2R38 taste phenotype and in vitro biofilm formation from nonpolypoid chronic rhinosinusitis patients. PMID:27309535

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  Comprehensive Analysis of Mouse Bitter Taste Receptors Reveals Different Molecular Receptive Ranges for Orthologous Receptors in Mice and Humans. PMID:27226572

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  Regulation of Adipogenesis by Quinine through the ERK/S6 Pathway. PMID:27089323

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  BitterX: a tool for understanding bitter taste in humans. PMID:27040075

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  GPCRdb: an information system for G protein-coupled receptors. PMID:26582914

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  Modulation of the Bitter Taste to Reduce Calorie Intake. PMID:26424036

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  The Bitter Taste Receptor Agonist Quinine Reduces Calorie Intake and Increases the Postprandial Release of Cholecystokinin in Healthy Subjects. PMID:26351252

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  Development of a molecular method for the rapid screening and identification of the three functionally relevant polymorphisms in the human TAS2R38 receptor gene in studies of sensitivity to the bitter taste of PROP. PMID:26090297

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  Sequence Analysis of Bitter Taste Receptor Gene Repertoires in Different Ruminant Species. PMID:26061084

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  A functional comparison of the domestic cat bitter receptors Tas2r38 and Tas2r43 with their human orthologs. PMID:26037485

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  Physical approaches to masking bitter taste: lessons from food and pharmaceuticals. PMID:25205460

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  Expanding the fragrance chemical space for virtual screening. PMID:24876890

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  Bitter and sweet taste receptors regulate human upper respiratory innate immunity. PMID:24531552

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  Bitter tasting compounds dilate airways by inhibiting airway smooth muscle calcium oscillations and calcium sensitivity. PMID:24117140

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  GWAS of human bitter taste perception identifies new loci and reveals additional complexity of bitter taste genetics. PMID:23966204

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  Prodrugs for masking bitter taste of antibacterial drugs--a computational approach. PMID:23420399

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  The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands. PMID:23283334

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  Bitter taste receptor polymorphisms and human aging. PMID:23133589

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  Responsiveness to 6-n-propylthiouracil (PROP) is associated with salivary levels of two specific basic proline-rich proteins in humans. PMID:22312435
• http://dx.doi.org/10.1093/nar/GKR755

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receptor

metasource: Fairsharing.org
version: FAIRsharing.org: BitterDB; Bitter Compounds Database; DOI: https://doi.org/10.25504/FAIRsharing.d8bfx4; Last edited: Jan. 8, 2019, 1:12 p.m.; Last accessed: Jan 03 2022 7:07 p.m.

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structure databases

metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657

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small molecules

metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657

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receptor structure small molecule