SIGnaling Network Open Resource
Names
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SIGnaling Network Open Resource
metasource: Fairsharing.org
version: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
SIGNOR
metasource: Fairsharing.org
version: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
metasource: bio.tools
version: extracted_at: 2022-11-04T11:27:25.336129
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
signor
metasource: bio.tools
version: extracted_at: 2022-11-04T11:27:25.336129
Names
More detailed information about this field from each metasource.
SIGnaling Network Open Resource
metasource: Fairsharing.orgversion: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
SIGNOR
metasource: Fairsharing.orgversion: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
metasource: bio.tools
version: extracted_at: 2022-11-04T11:27:25.336129
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
signor
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:27:25.336129
Names
More detailed information about this field from each metasource.
SIGnaling Network Open Resource
metasource: Fairsharing.orgversion: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
SIGNOR
metasource: Fairsharing.orgversion: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
metasource: bio.tools
version: extracted_at: 2022-11-04T11:27:25.336129
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
signor
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:27:25.336129
The SIGnaling Network Open Resource. The core of SIGNOR is a collection of approximately 12,000 manually-annotated causal relationships between over 2800 human proteins participating in signal transduction. Other entities annotated in SIGNOR are complexes, chemicals, phenotypes and stimuli.
Description
More detailed information about this field from each metasource.
The SIGnaling Network Open Resource. The core of SIGNOR is a collection of approximately 12,000 manually-annotated causal relationships between over 2800 human proteins participating in signal transduction. Other entities annotated in SIGNOR are complexes, chemicals, phenotypes and stimuli.
metasource: BiŌkeanós-Medsourcingversion: 0.0.1:2022-11-04T13:34:25.975929
SIGNOR, the SIGnaling Network Open Resource, organizes and stores in a structured format signaling information published in the scientific literature. The captured information is stored as binary causative relationships between biological entities and can be represented graphically as activity flow. The entire network can be freely downloaded and used to support logic modeling or to interpret high content datasets. Each relationship is linked to the literature reporting the experimental evidence. In addition each node is annotated with the chemical inhibitors that modulate its activity. The signaling information is mapped to the human proteome even if the experimental evidence is based on experiments on mammalian model organisms.
metasource: Fairsharing.orgversion: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
SIGNOR, the SIGnaling Network Open Resource is a new database designed to facilitate the storage and analysis of causal interactions, i.e. interactions where a source entity has an effect (up-regulation, down-regulation, etc.) on a target entity. An on-going curation effort in our group aims at making SIGNOR a prominent resource in the biological community by offering a comprehensive network of experimentally validated functional relationships between signalling proteins. At the time of writing, the core of SIGNOR is a collection of approximately 12000 manually-annotated causal relationships between proteins and other biological entities that participate in signal transduction. Each relationship is linked to the literature reporting the experimental evidence and it is assigned a score. More than 4,900 modified residues causing a change in protein concentration or activity have been curated and linked to the modifying enzymes (about 351 human kinases and 94 phosphatases). Additional modifications such as ubiquitinations, sumoylations, acetylations and their effect on the modified target proteins are also annotated. This wealth of structured information can support experimental approaches based on multi-parametric analysis of cell systems after physiological or pathological perturbations and to assemble large logic models.
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
A tool collects manually-annotated logic relationships between molecules that participate in signal transduction.
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:27:25.336129
Webpage:
https://signor.uniroma2.itWebpage
More detailed information about this field from each metasource.
https://signor.uniroma2.it
metasource: BiŌkeanós-Medsourcingversion: 0.0.1:2022-11-04T13:34:25.975929
https://signor.uniroma2.it/user_guide.php
metasource: Fairsharing.orgversion: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
http://signor.uniroma2.it/
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
metasource: bio.tools
version: extracted_at: 2022-11-04T11:27:25.336129
Licence:
Name: Creative Commons Attribution-ShareAlike v4.0Licence name
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Creative Commons Attribution-ShareAlike v4.0
metasource: BiŌkeanós-Medsourcingversion: 0.0.1:2022-11-04T13:34:25.975929
CC-BY-SA-4.0
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:27:25.336129
Licence URL
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https://signor.uniroma2.it/user_guide.php
metasource: BiŌkeanós-Medsourcingversion: 0.0.1:2022-11-04T13:34:25.975929
Publications:
Publications
More detailed information about this field from each metasource.
SIGNOR: a database of causal relationships between biological entities
PMID: 26467481
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
metasource: Fairsharing.org
version: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
SIGNOR 2.0, the SIGnaling Network Open Resource 2.0: 2019 update
PMID: 31665520
metasource: bio.tools
version: extracted_at: 2022-11-04T11:27:25.336129
SIGNOR: A Database of Causal Relationships Between Biological Entities-A Short Guide to Searching and Browsing
PMID: 28654729
metasource: bio.tools
version: extracted_at: 2022-11-04T11:27:25.336129
http://dx.doi.org/10.1093/nar/gkv1048
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
metasource: bio.tools
version: extracted_at: 2022-11-04T11:27:25.336129
Publications
More detailed information about this field from each metasource.
SIGNOR: a database of causal relationships between biological entities
PMID: 26467481
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
metasource: Fairsharing.org
version: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
SIGNOR 2.0, the SIGnaling Network Open Resource 2.0: 2019 update
PMID: 31665520
metasource: bio.tools
version: extracted_at: 2022-11-04T11:27:25.336129
SIGNOR: A Database of Causal Relationships Between Biological Entities-A Short Guide to Searching and Browsing
PMID: 28654729
metasource: bio.tools
version: extracted_at: 2022-11-04T11:27:25.336129
http://dx.doi.org/10.1093/nar/gkv1048
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
metasource: bio.tools
version: extracted_at: 2022-11-04T11:27:25.336129
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SIGNOR: a database of causal relationships between biological entities
PubMed citations: 104.
104 articles citing: SIGNOR: a database of causal relationships between biological entities
The close interaction between hypoxia-related proteins and metastasis in pancarcinomas. PMID:35773405
A Resource to Infer Molecular Paths Linking Cancer Mutations to Perturbation of Cell Metabolism. PMID:35664677
Targeting Cell Death Mechanism Specifically in Triple Negative Breast Cancer Cell Lines. PMID:35563174
Pulmonary Inflammatory Response in Lethal COVID-19 Reveals Potential Therapeutic Targets and Drugs in Phases III/IV Clinical Trials. PMID:35422702
Patient-specific Boolean models of signalling networks guide personalised treatments. PMID:35164900
A knowledge graph to interpret clinical proteomics data. PMID:35102292
Network controllability solutions for computational drug repurposing using genetic algorithms. PMID:35082323
Logical and experimental modeling of cytokine and eicosanoid signaling in psoriatic keratinocytes. PMID:34877506
Oestrogen Activates the MAP3K1 Cascade and β-Catenin to Promote Granulosa-like Cell Fate in a Human Testis-Derived Cell Line. PMID:34576208
The role of metadata in reproducible computational research. PMID:34553169
Proteogenomic characterization of pancreatic ductal adenocarcinoma. PMID:34534465
Identification of key proteins in the signaling crossroads between wound healing and cancer hallmark phenotypes. PMID:34446793
Inference of kinase-signaling networks in human myeloid cell line models by Phosphoproteomics using kinase activity enrichment analysis (KAEA). PMID:34238254
Assembling Disease Networks From Causal Interaction Resources. PMID:34178043
Measuring pathway database coverage of the phosphoproteome. PMID:34113485
Combining Mass Spectrometry-Based Phosphoproteomics with a Network-Based Approach to Reveal FLT3-Dependent Mechanisms of Chemoresistance. PMID:33925552
Histamine, Metabolic Remodelling and Angiogenesis: A Systems Level Approach. PMID:33799732
Two novel qualitative transcriptional signatures robustly applicable to non-research-oriented colorectal cancer samples with low-quality RNA. PMID:33719152
Omics-Driven Biotechnology for Industrial Applications. PMID:33708762
Proteogenomic and metabolomic characterization of human glioblastoma. PMID:33577785
CausalBuilder: bringing the MI2CAST causal interaction annotation standard to the curator. PMID:33547799
Identification of Genes Universally Differentially Expressed in Gastric Cancer. PMID:33542925
GeneWalk identifies relevant gene functions for a biological context using network representation learning. PMID:33526072
Personalized logical models to investigate cancer response to BRAF treatments in melanomas and colorectal cancers. PMID:33507915
Profiling transcriptomic changes and signaling pathways in atopic dermatitis by integrative analyses on multiple databases. PMID:33438050
SmartGraph: a network pharmacology investigation platform. PMID:33430980
Global gene methylation profiling of common warts caused by human papillomaviruses infection. PMID:33424347
The status of causality in biological databases: data resources and data retrieval possibilities to support logical modeling. PMID:33378765
A Middle-Out Modeling Strategy to Extend a Colon Cancer Logical Model Improves Drug Synergy Predictions in Epithelial-Derived Cancer Cell Lines. PMID:33195403
Preclinical validation of therapeutic targets predicted by tensor factorization on heterogeneous graphs. PMID:33106501
A practical guide to mechanistic systems modeling in biology using a logic-based approach. PMID:33064138
Single-Cell RNA Sequencing Analysis Reveals a Crucial Role for CTHRC1 (Collagen Triple Helix Repeat Containing 1) Cardiac Fibroblasts After Myocardial Infarction. PMID:32972203
Strategies to Enhance Logic Modeling-Based Cell Line-Specific Drug Synergy Prediction. PMID:32848834
Knowledge-primed neural networks enable biologically interpretable deep learning on single-cell sequencing data. PMID:32746932
A generalizable data-driven multicellular model of pancreatic ductal adenocarcinoma. PMID:32696951
Using phosphoproteomics data to understand cellular signaling: a comprehensive guide to bioinformatics resources. PMID:32676006
Genome-wide identification of methylated CpG sites in nongenital cutaneous warts. PMID:32641122
The Minimum Information about a Molecular Interaction CAusal STatement (MI2CAST). PMID:32637990
MIPPIE: the mouse integrated protein-protein interaction reference. PMID:32496562
piNET: a versatile web platform for downstream analysis and visualization of proteomics data. PMID:32469073
RESTful API for iPTMnet: a resource for protein post-translational modification network discovery. PMID:32395768
Bioinformatics Methods for Mass Spectrometry-Based Proteomics Data Analysis. PMID:32326049
Comprehensive Map of the Regulated Cell Death Signaling Network: A Powerful Analytical Tool for Studying Diseases. PMID:32316560
Setting the basis of best practices and standards for curation and annotation of logical models in biology-highlights of the [BC]2 2019 CoLoMoTo/SysMod Workshop. PMID:32313939
Transcriptome analysis of HPV-induced warts and healthy skin in humans. PMID:32151264
DISNET: a framework for extracting phenotypic disease information from public sources. PMID:32110491
Collective intelligence defines biological functions in Wikipedia as communities in the hidden protein connection network. PMID:32069277
A census of pathway maps in cancer systems biology. PMID:32066900
Proteogenomic Characterization of Endometrial Carcinoma. PMID:32059776
Epigenome-wide analysis of common warts reveals aberrant promoter methylation. PMID:32038103
Metabolic reprogramming of fibro/adipogenic progenitors facilitates muscle regeneration. PMID:32019766
Reconstructing kinase network topologies from phosphoproteomics data reveals cancer-associated rewiring. PMID:31959955
Combined network pharmacology and virtual reverse pharmacology approaches for identification of potential targets to treat vascular dementia. PMID:31937840
Genome-Wide Tiling Array Analysis of HPV-Induced Warts Reveals Aberrant Methylation of Protein-Coding and Non-Coding Regions. PMID:31892232
PAX8 expression in high-grade serous ovarian cancer positively regulates attachment to ECM via Integrin β3. PMID:31832016
pathDIP 4: an extended pathway annotations and enrichment analysis resource for human, model organisms and domesticated species. PMID:31733064
The Cytoscape BioGateway App: explorative network building from the BioGateway triple store. PMID:31710663
'One DB to rule them all'-the RING: a Regulatory INteraction Graph combining TFs, genes/proteins, SNPs, diseases and drugs. PMID:31682269
SIGNOR 2.0, the SIGnaling Network Open Resource 2.0: 2019 update. PMID:31665520
Myo-REG: A Portal for Signaling Interactions in Muscle Regeneration. PMID:31611808
CancerGeneNet: linking driver genes to cancer hallmarks. PMID:31598703
Genome-Wide CpG Island Methylation Profiles of Cutaneous Skin with and without HPV Infection. PMID:31569353
A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases. PMID:31494632
Five-Feature Model for Developing the Classifier for Synergistic vs. Antagonistic Drug Combinations Built by XGBoost. PMID:31338106
Fibro-adipogenic progenitors of dystrophic mice are insensitive to NOTCH regulation of adipogenesis. PMID:31239312
Re-curation and rational enrichment of knowledge graphs in Biological Expression Language. PMID:31225582
Analysis of the Human Kinome and Phosphatome by Mass Cytometry Reveals Overexpression-Induced Effects on Cancer-Related Signaling. PMID:31101498
CausalTAB: the PSI-MITAB 2.8 updated format for signalling data representation and dissemination. PMID:30793173
Combining CDKN1A gene expression and genome-wide SNPs in a twin cohort to gain insight into the heritability of individual radiosensitivity. PMID:30706161
Program and Book of the 15th Interuniversity Institute of Myology Meeting - Assisi (Italy), 2018. PMID:30662694
Network spectra for drug-target identification in complex diseases: new guns against old foes. PMID:30596144
ComPath: an ecosystem for exploring, analyzing, and curating mappings across pathway databases. PMID:30564458
Gene Regulatory Network Modeling of Macrophage Differentiation Corroborates the Continuum Hypothesis of Polarization States. PMID:30546316
Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue. PMID:30478315
Clustering approaches for visual knowledge exploration in molecular interaction networks. PMID:30157777
Integrated proteomic and phosphoproteomic analyses of cisplatin-sensitive and resistant bladder cancer cells reveal CDK2 network as a key therapeutic target. PMID:30145203
Reconstructing phosphorylation signalling networks from quantitative phosphoproteomic data. PMID:30072490
Developments in toxicogenomics: understanding and predicting compound-induced toxicity from gene expression data. PMID:29917034
Group I Paks support muscle regeneration and counteract cancer-associated muscle atrophy. PMID:29781585
Streamlined Tandem Mass Tag (SL-TMT) Protocol: An Efficient Strategy for Quantitative (Phospho)proteome Profiling Using Tandem Mass Tag-Synchronous Precursor Selection-MS3. PMID:29734811
Identification of four differentially methylated genes as prognostic signatures for stage I lung adenocarcinoma. PMID:29713243
Signalling maps in cancer research: construction and data analysis. PMID:29688383
SPV: a JavaScript Signaling Pathway Visualizer. PMID:29590303
Network-based integration of multi-omics data for prioritizing cancer genes. PMID:29547932
Inferring hidden causal relations between pathway members using reduced Google matrix of directed biological networks. PMID:29370181
A novel algorithm for finding optimal driver nodes to target control complex networks and its applications for drug targets identification. PMID:29363426
Phosphoproteomics-Based Profiling of Kinase Activities in Cancer Cells. PMID:29344887
iPTMnet: an integrated resource for protein post-translational modification network discovery. PMID:29145615
DISNOR: a disease network open resource. PMID:29036667
Widespread Post-transcriptional Attenuation of Genomic Copy-Number Variation in Cancer. PMID:29032074
Statistically controlled identification of differentially expressed genes in one-to-one cell line comparisons of the CMAP database for drug repositioning. PMID:28962576
Controlling Directed Protein Interaction Networks in Cancer. PMID:28871116
Regulation of myoblast differentiation by metabolic perturbations induced by metformin. PMID:28859084
Logic Modeling in Quantitative Systems Pharmacology. PMID:28681552
CausalR: extracting mechanistic sense from genome scale data. PMID:28666369
NaviCom: a web application to create interactive molecular network portraits using multi-level omics data. PMID:28415074
Tenofovir and adefovir down-regulate mitochondrial chaperone TRAP1 and succinate dehydrogenase subunit B to metabolically reprogram glucose metabolism and induce nephrotoxicity. PMID:28397817
Benchmarking substrate-based kinase activity inference using phosphoproteomic data. PMID:28200105
Influence of node abundance on signaling network state and dynamics analyzed by mass cytometry. PMID:28092656
Deep Phosphoproteomic Measurements Pinpointing Drug Induced Protective Mechanisms in Neuronal Cells. PMID:28066266
Identification of critical paralog groups with indispensable roles in the regulation of signaling flow. PMID:27922122
XTalkDB: a database of signaling pathway crosstalk. PMID:27899583
The cell-autonomous mechanisms underlying the activity of metformin as an anticancer drug. PMID:27875520
An individualized prognostic signature and multi‑omics distinction for early stage hepatocellular carcinoma patients with surgical resection. PMID:27006471 -
SIGNOR 2.0, the SIGnaling Network Open Resource 2.0: 2019 update
PubMed citations: 67.
67 articles citing: SIGNOR 2.0, the SIGnaling Network Open Resource 2.0: 2019 update
Boolean modelling as a logic-based dynamic approach in systems medicine. PMID:35782730
The close interaction between hypoxia-related proteins and metastasis in pancarcinomas. PMID:35773405
Biomineralization associated alkaline phosphatase as a potential marker of bone metastasis in the patients with invasive breast cancer. PMID:35770272
KNIME workflow for retrieving causal drug and protein interactions, building networks, and performing topological enrichment analysis demonstrated by a DILI case study. PMID:35692045
Comparison of methods and resources for cell-cell communication inference from single-cell RNA-Seq data. PMID:35680885
A Resource to Infer Molecular Paths Linking Cancer Mutations to Perturbation of Cell Metabolism. PMID:35664677
Artificial neural networks enable genome-scale simulations of intracellular signaling. PMID:35654811
Monitoring of inflammation using novel biosensor mouse model reveals tissue- and sex-specific responses to Western diet. PMID:35466363
Improving reusability along the data life cycle: a regulatory circuits case study. PMID:35346379
Roles and Regulation of BCL-xL in Hematological Malignancies. PMID:35216310
Computational Models for Clinical Applications in Personalized Medicine-Guidelines and Recommendations for Data Integration and Model Validation. PMID:35207655
A mutation in transmembrane protein 135 impairs lipid metabolism in mouse eyecups. PMID:35031662
Transcription Factor Activation Profiles (TFAP) identify compounds promoting differentiation of Acute Myeloid Leukemia cell lines. PMID:35013135
Metal transporter Slc30a1 controls pharyngeal neural crest differentiation via the zinc-Snai2-Jag1 cascade. PMID:34977877
Unraveling unique and common cell type-specific mechanisms in glioblastoma multiforme. PMID:34976314
Transcriptomic Changes Highly Similar to Alzheimer's Disease Are Observed in a Subpopulation of Individuals During Normal Brain Aging. PMID:34924992
Analyzing causal relationships in proteomic profiles using CausalPath. PMID:34877547
Network analytics for drug repurposing in COVID-19. PMID:34864885
Network Biology Approaches to Achieve Precision Medicine in Inflammatory Bowel Disease. PMID:34745229
Complex Portal 2022: new curation frontiers. PMID:34718729
Prognostic Significance of Dysregulated Epigenomic and Chromatin Modifiers in Cervical Cancer. PMID:34685645
NPCDR: natural product-based drug combination and its disease-specific molecular regulation. PMID:34664659
COVID19 Disease Map, a computational knowledge repository of virus-host interaction mechanisms. PMID:34664389
STAT1: a novel candidate biomarker and potential therapeutic target of the recurrent aphthous stomatitis. PMID:34649540
Convergent Canonical Pathways in Autism Spectrum Disorder from Proteomic, Transcriptomic and DNA Methylation Data. PMID:34639097
SignaLink3: a multi-layered resource to uncover tissue-specific signaling networks. PMID:34634810
Using BioPAX-Parser (BiP) to enrich lists of genes or proteins with pathway data. PMID:34592927
COVIDium: a COVID-19 resource compendium. PMID:34585731
NDEx: Accessing Network Models and Streamlining Network Biology Workflows. PMID:34570431
Enzymes in the Cholesterol Synthesis Pathway: Interactomics in the Cancer Context. PMID:34440098
PathExNET: A tool for extracting pathway expression networks from gene expression statistics. PMID:34429851
Expanding the potential genes of inborn errors of immunity through protein interactions. PMID:34391382
NetControl4BioMed: A web-based platform for controllability analysis of protein-protein interaction networks. PMID:34352070
CFTR Lifecycle Map-A Systems Medicine Model of CFTR Maturation to Predict Possible Active Compound Combinations. PMID:34299207
Assembling Disease Networks From Causal Interaction Resources. PMID:34178043
Genome-scale mechanistic modeling of signaling pathways made easy: A bioconductor/cytoscape/web server framework for the analysis of omic data. PMID:34136096
Portrait of DNA methylated genes predictive of poor prognosis in head and neck cancer and the implication for targeted therapy. PMID:33976322
Proteomic Studies of Primary Acute Myeloid Leukemia Cells Derived from Patients Before and during Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid and Valproic Acid. PMID:33946813
Combining Mass Spectrometry-Based Phosphoproteomics with a Network-Based Approach to Reveal FLT3-Dependent Mechanisms of Chemoresistance. PMID:33925552
A Resource for the Network Representation of Cell Perturbations Caused by SARS-CoV-2 Infection. PMID:33809949
Bioinformatic Analysis of Structure and Function of LIM Domains of Human Zyxin Family Proteins. PMID:33808029
Quantitative Proteomic Approach Reveals Altered Metabolic Pathways in Response to the Inhibition of Lysine Deacetylases in A549 Cells under Normoxia and Hypoxia. PMID:33806075
Data-Driven Math Model of FLT3-ITD Acute Myeloid Leukemia Reveals Potential Therapeutic Targets. PMID:33799721
Integrated intra- and intercellular signaling knowledge for multicellular omics analysis. PMID:33749993
Analysing the yeast complexome-the Complex Portal rising to the challenge. PMID:33677561
Integrating Patient-Specific Information into Logic Models of Complex Diseases: Application to Acute Myeloid Leukemia. PMID:33578936
Proteogenomic and metabolomic characterization of human glioblastoma. PMID:33577785
CausalBuilder: bringing the MI2CAST causal interaction annotation standard to the curator. PMID:33547799
Verteporfin treatment controls morphology, phenotype, and global gene expression for cells of the human nucleus pulposus. PMID:33392449
Plant miR171 modulates mTOR pathway in HEK293 cells by targeting GNA12. PMID:33386590
The status of causality in biological databases: data resources and data retrieval possibilities to support logical modeling. PMID:33378765
Biological characteristics of aging in human acute myeloid leukemia cells: the possible importance of aldehyde dehydrogenase, the cytoskeleton and altered transcriptional regulation. PMID:33349623
Towards a unified open access dataset of molecular interactions. PMID:33262342
Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. PMID:33259812
The IMEx coronavirus interactome: an evolving map of Coronaviridae-host molecular interactions. PMID:33206959
IL6-mediated HCoV-host interactome regulatory network and GO/Pathway enrichment analysis. PMID:32997660
Network and Systems Medicine: Position Paper of the European Collaboration on Science and Technology Action on Open Multiscale Systems Medicine. PMID:32954378
CaNDis: a web server for investigation of causal relationships between diseases, drugs and drug targets. PMID:32871004
Strategies to Enhance Logic Modeling-Based Cell Line-Specific Drug Synergy Prediction. PMID:32848834
Implications of Insulin-Like Growth Factor-1 in Skeletal Muscle and Various Diseases. PMID:32722232
The Minimum Information about a Molecular Interaction CAusal STatement (MI2CAST). PMID:32637990
Identification of Differentially Methylated CpG Sites in Fibroblasts from Keloid Scars. PMID:32605309
The IMEx Coronavirus interactome: an evolving map of Coronaviridae-Host molecular interactions. PMID:32587962
Hypoxia-Induced miR-675-5p Supports β-Catenin Nuclear Localization by Regulating GSK3-β Activity in Colorectal Cancer Cell Lines. PMID:32481626
miR-622 is a novel potential biomarker of breast carcinoma and impairs motility of breast cancer cells through targeting NUAK1 kinase. PMID:32418991
Adipogenesis of skeletal muscle fibro/adipogenic progenitors is affected by the WNT5a/GSK3/β-catenin axis. PMID:32382110
The 27th annual Nucleic Acids Research database issue and molecular biology database collection. PMID:31906604 -
SIGNOR: A Database of Causal Relationships Between Biological Entities-A Short Guide to Searching and Browsing
PubMed citations: 5.
5 articles citing: SIGNOR: A Database of Causal Relationships Between Biological Entities-A Short Guide to Searching and Browsing
MasterPATH: network analysis of functional genomics screening data. PMID:32928103
Transcriptomic analysis on the effects of melatonin in gastrointestinal carcinomas. PMID:32689938
Using phosphoproteomics data to understand cellular signaling: a comprehensive guide to bioinformatics resources. PMID:32676006
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities. PMID:31031003
DISNOR: a disease network open resource. PMID:29036667 - http://dx.doi.org/10.1093/nar/gkv1048
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biocuration
metasource: Fairsharing.org
version: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
computational predictions
metasource: Fairsharing.org
version: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
gene functional annotation
metasource: Fairsharing.org
version: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
gene-disease association
metasource: Fairsharing.org
version: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
literature curation
metasource: Fairsharing.org
version: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
molecular interaction
metasource: Fairsharing.org
version: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
network model
metasource: Fairsharing.org
version: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
protein interaction
metasource: Fairsharing.org
version: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
proteome
metasource: Fairsharing.org
version: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
signaling
metasource: Fairsharing.org
version: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
metabolic and signaling pathways
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
signalling pathways
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
molecular interactions, pathways and networks
metasource: bio.tools
version: extracted_at: 2022-11-04T11:27:25.336129
rare diseases
metasource: bio.tools
version: extracted_at: 2022-11-04T11:27:25.336129
Tags
More detailed information about this field from each metasource.
biocuration
metasource: Fairsharing.orgversion: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
computational predictions
metasource: Fairsharing.orgversion: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
gene functional annotation
metasource: Fairsharing.orgversion: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
gene-disease association
metasource: Fairsharing.orgversion: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
literature curation
metasource: Fairsharing.orgversion: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
molecular interaction
metasource: Fairsharing.orgversion: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
network model
metasource: Fairsharing.orgversion: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
protein interaction
metasource: Fairsharing.orgversion: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
proteome
metasource: Fairsharing.orgversion: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
signaling
metasource: Fairsharing.orgversion: FAIRsharing.org: SIGNOR; SIGnaling Network Open Resource; DOI: https://doi.org/10.25504/FAIRsharing.ss78t4; Last edited: Feb. 4, 2021, 2:47 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
metabolic and signaling pathways
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
signalling pathways
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
molecular interactions, pathways and networks
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:27:25.336129
rare diseases
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:27:25.336129
biocuration computational predictions gene functional annotation gene-disease association literature curation molecular interaction network model protein interaction proteome signaling metabolic and signaling pathways signalling pathways molecular interactions, pathways and networks rare diseases
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